Abstract：
:The increase in prevalence of antimicrobial-resistant bacteria (ARB) is currently a serious threat, thus there is a need for new antimicrobial compounds to combat infections caused by these ARB. An antimicrobial-producing bacterium, Burkholderia paludis was recently isolated and was able to produce a type of siderophore with antimicrobial properties, later identified as pyochelin. The chelating ability of pyochelin has been well-characterized but not for its antimicrobial characteristics. It was found that pyochelin had MIC values (MBC values) of 3.13 µg/mL (6.26 µg/mL) and 6.26 µg/mL (25.00 µg/mL) against three Enterococcus strains and four Staphylococcus strains. Pyochelin was able to inhibit E. faecalis ATCC 700802 (a vancomycin-resistant strain) in a time and dose dependent manner via killing kinetics assay. It was demonstrated that pyochelin enhanced the production of intracellular reactive oxygen species (ROS) over time, which subsequently caused a significant increase in malondialdehyde (MDA) production (a marker for lipid peroxidation) and ultimately led to cell death by disrupting the integrity of the bacterial membrane (validated via BacLight assay). This study has revealed the mechanism of action of pyochelin as an antimicrobial agent for the first time and has shown that pyochelin might be able to combat infections caused by E. faecalis in the future.
journal_name
J Adv Resjournal_title
Journal of advanced researchauthors
Ong KS,Cheow YL,Lee SMdoi
10.1016/j.jare.2017.05.007subject
Has Abstractpub_date
2017-07-01 00:00:00pages
393-398issue
4eissn
2090-1232issn
2090-1224pii
S2090-1232(17)30058-9journal_volume
8pub_type
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journal_title：Journal of advanced research
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journal_title：Journal of advanced research
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journal_title：Journal of advanced research
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journal_title：Journal of advanced research
pub_type： 杂志文章,评审
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