Abstract：
:A novel simple, direct and selective gas chromatography-mass spectrometry (GC/MS) procedure was developed for the determination of the antihistamine drug dimenhydrinate (DMH) in presence of six of its related substances and potential impurities, namely, diphenylmethane, diphenylmethanol, benzophenone, orphenadrine, caffeine and 8-chlorocaffeine. The method involved resolution of the underivatized compounds using a trifluoropropylmethyl polysiloxane (Rtx-200) capillary column and the mass spectrometric detection was carried out in the electron-impact (EI) mode. Excellent baseline separation of DMH and the cited related substances was achieved in less than 15 min. Quantification of the parent drug DMH was based on measuring its peak area. The reliability and analytical performance of the proposed method were validated with respect to linearity, range, precision, accuracy, specificity, robustness, detection and quantification limits. Calibration curve of DMH was linear over the range 50-500 μg/mL with determination coefficient (R (2)) = 0.9982. The proposed method was successfully applied for the assay of DMH in tablets dosage form with recoveries >96.80%.
journal_name
J Adv Resjournal_title
Journal of advanced researchauthors
Belal TS,Abdel-Hay KM,Clark CRdoi
10.1016/j.jare.2015.01.010subject
Has Abstractpub_date
2016-01-01 00:00:00pages
53-8issue
1eissn
2090-1232issn
2090-1224pii
S2090-1232(15)00022-3journal_volume
7pub_type
杂志文章abstract：:Aluminum (Al) is an element widely distributed in soils, even though Al3+ is one of the most detrimental cations to plant growth. The effect of nitric oxide (NO) precursors on indole-3-acetic acid (IAA) flow towards roots upon Al treatment is herein reported using two Triticum aestivum (wheat) cultivars with recognize...
journal_title：Journal of advanced research
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journal_title：Journal of advanced research
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journal_title：Journal of advanced research
pub_type： 杂志文章,评审
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journal_title：Journal of advanced research
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journal_title：Journal of advanced research
pub_type： 杂志文章
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journal_title：Journal of advanced research
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journal_title：Journal of advanced research
pub_type： 杂志文章,评审
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journal_title：Journal of advanced research
pub_type： 杂志文章,评审
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journal_title：Journal of advanced research
pub_type： 杂志文章,评审
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journal_title：Journal of advanced research
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doi：10.1016/j.jare.2014.05.002
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journal_title：Journal of advanced research
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journal_title：Journal of advanced research
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journal_title：Journal of advanced research
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journal_title：Journal of advanced research
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journal_title：Journal of advanced research
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journal_title：Journal of advanced research
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journal_title：Journal of advanced research
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abstract：:The dynamical properties of nanogels of xanthan gum (XG) with hydrodynamic radius controlled in a size range from 5 nm to 35 nm, were studied at the different XG concentrations in water/sodium bis-2-ethylhexyl-sulfosuccinate (AOT)/decane reverse micelles (RMs) vs. mass fraction of nano-droplet (MFD) at W = 40, using d...
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