Abstract:
:The clinical manifestations of schistosomiasis pass by acute, sub acute and chronic stages that mirror the immune response to infection. The later includes in succession innate, TH1 and TH2 adaptive stages, with an ultimate establishment of concomitant immunity. Some patients may also develop late complications, or suffer the sequelae of co-infection with other parasites, bacteria or viruses. Acute manifestations are species-independent; occur during the early stages of invasion and migration, where infection-naivety and the host's racial and genetic setting play a major role. Sub acute manifestations occur after maturity of the parasite and settlement in target organs. They are related to the formation of granulomata around eggs or dead worms, primarily in the lower urinary tract with Schistosoma haematobium, and the colon and rectum with Schistosoma mansoni, Schistosoma japonicum, Schistosoma intercalatum and Schistosoma mekongi infection. Secondary manifestations during this stage may occur in the kidneys, liver, lungs or other ectopic sites. Chronic morbidity is attributed to the healing of granulomata by fibrosis and calcification at the sites of oval entrapment, deposition of schistosomal antigen-antibody complexes in the renal glomeruli or the development of secondary amyloidosis. Malignancy may complicate the chronic lesions in the urinary bladder or colon. Co-infection with salmonella or hepatitis viruses B or C may confound the clinical picture of schistosomiasis, while the latter may have a negative impact on the course of other co-infections as malaria, leishmaniasis and HIV. Prevention of schistosomiasis is basically geared around education and periodic mass treatment, an effective vaccine being still experimental. Praziquantel is the drug of choice in the treatment of active infection by any species, with a cure rate of 80%. Other antischistosomal drugs include metrifonate for S. haematobium, oxamniquine for S. mansoni and Artemether and, possibly, Mirazid for both. Surgical treatment may be needed for fibrotic lesions.
journal_name
J Adv Resjournal_title
Journal of advanced researchauthors
Barsoum RS,Esmat G,El-Baz Tdoi
10.1016/j.jare.2013.01.005subject
Has Abstractpub_date
2013-09-01 00:00:00pages
433-44issue
5eissn
2090-1232issn
2090-1224pii
S2090-1232(13)00006-4journal_volume
4pub_type
杂志文章,评审abstract::This work aimed to evaluate the analgesic efficacy of intra-articular injection of magnesium sulphate (4%) compared with equivalent volume of bupivacaine (0.5%) after outpatient knee arthroscopic meniscectomy. Forty patients were randomly assigned to two groups. Group M (n = 20) received intra-articular magnesium sulp...
journal_title:Journal of advanced research
pub_type: 杂志文章
doi:10.1016/j.jare.2012.07.001
更新日期:2013-07-01 00:00:00
abstract::This paper examines the deep minimum of solar cycle 23 and its potential impact on climate change. In addition, a source region of the solar winds at solar activity minimum, especially in the solar cycle 23, the deepest during the last 500 years, has been studied. Solar activities have had notable effect on palaeoclim...
journal_title:Journal of advanced research
pub_type: 杂志文章,评审
doi:10.1016/j.jare.2012.11.001
更新日期:2013-05-01 00:00:00
abstract::The association between hepatitis C virus (HCV) infection and type 2 diabetes (T2D) has been known for over 20 years. Cross-sectional and longitudinal studies have shown a higher prevalence and incidence, respectively, of T2D in patients with chronic HCV infection. HCV induces glucose metabolism alterations mostly int...
journal_title:Journal of advanced research
pub_type: 杂志文章,评审
doi:10.1016/j.jare.2016.11.003
更新日期:2017-03-01 00:00:00
abstract::Subacute cutaneous lupus erythematosus (SCLE) is characterized by particular cutaneous manifestations such as non-scaring plaques mainly in sunlight exposed parts of the body along with specific serum autoantibodies (i.e. antinuclear antibodies (ANA), Ro/SSa, La/SSb). It is considered either idiopathic or drug induced...
journal_title:Journal of advanced research
pub_type: 杂志文章,评审
doi:10.1016/j.jare.2016.04.001
更新日期:2016-09-01 00:00:00
abstract::In this research work, a comparative evaluation on the mechanical and microstructural characteristics of aluminium based single and hybrid reinforced nanocomposites was carried out. The manufacture of a single reinforced nanocomposite was conducted with the distribution of 2 wt.% nano alumina particles (avg. particle ...
journal_title:Journal of advanced research
pub_type: 杂志文章
doi:10.1016/j.jare.2017.02.005
更新日期:2017-07-01 00:00:00
abstract::The present study investigates the entrapment of terbinafine hydrochloride (TH) in ethosomal vesicles via unsonicated and sonication method. Carbopol 934P was incorporated in the best formulation, F6, obtained by sonication method. The formulated ethosomal gel obtained as such i.e. F6(∗) was exploited to achieve a zer...
journal_title:Journal of advanced research
pub_type: 杂志文章
doi:10.1016/j.jare.2016.03.003
更新日期:2016-05-01 00:00:00
abstract::Kresoxim-methyl and its two thermolabile metabolites, BF 490-2 and BF 490-9, were analyzed in pear using a pepper leaf matrix protection to maintain the metabolites inside the gas chromatography system. Samples were extracted with a mixture of ethyl acetate and n-hexane (1:1, v/v) and purified and/or separated using a...
journal_title:Journal of advanced research
pub_type: 杂志文章
doi:10.1016/j.jare.2013.05.003
更新日期:2014-05-01 00:00:00
abstract::Genetic disorders have been shown to co-occur in individual patient. A Thai boy with features of osteogenesis imperfecta (OI) and combined pituitary hormone deficiency (CPHD) was identified. The causative mutations were investigated by whole exome and Sanger sequencing. Pathogenicity and pathomechanism of the variants...
journal_title:Journal of advanced research
pub_type: 杂志文章
doi:10.1016/j.jare.2019.10.006
更新日期:2019-10-21 00:00:00
abstract::Clinical assessment of functional disability is an integral part of management in patients with low back pain (LBP). The range of spinal motion is one of LBP disability measure. The aim of this study was to investigate the validity of spinal range of motion as a predictable measure of disability and to analyze the int...
journal_title:Journal of advanced research
pub_type: 杂志文章
doi:10.1016/j.jare.2012.01.002
更新日期:2013-01-01 00:00:00
abstract::LncRNA (Long non-coding RNA) ZFAS1 (zinc finger antisense 1) functions as the oncogene in multiple cancers, including gastric cancer. However, its function and underlying mechanism in the GCA (gastric cardia adenocarcinoma), the most aggressive type of gastric cancer, remain unknown. We demonstrated here that the LncR...
journal_title:Journal of advanced research
pub_type: 杂志文章
doi:10.1016/j.jare.2020.06.006
更新日期:2020-06-24 00:00:00
abstract::In this study, the effects of various factors (weight fraction of the SiO2, Al2O3, Fe2O3, Na2O, K2O, CaO, MgO, Cl, SO3, and the Blaine of the cement particles) on the concrete compressive strength and also initial setting time have been investigated. Compressive strength and setting time tests have been carried out ba...
journal_title:Journal of advanced research
pub_type: 杂志文章
doi:10.1016/j.jare.2014.03.005
更新日期:2015-09-01 00:00:00
abstract:Introduction:Numerous studies have shown the ability of low-energy acoustic waves such as focused ultrasound or shockwave to transiently open blood-brain barrier (BBB) and facilitate drug delivery to the brain. Preclinical and clinical evidences have well demonstrated the efficacy and safety in treating various brain d...
journal_title:Journal of advanced research
pub_type: 杂志文章
doi:10.1016/j.jare.2020.06.012
更新日期:2020-06-21 00:00:00
abstract::Limited progress has been made in the quest to identify both selective and non-toxic T-type calcium channel blocking compounds. The present research work was directed toward slaking the same by identifying the selective three dimensional (3D) pharmacophore map for T-type calcium channel blockers (CCBs). Using HipHop m...
journal_title:Journal of advanced research
pub_type: 杂志文章
doi:10.1016/j.jare.2016.09.004
更新日期:2016-11-01 00:00:00
abstract::The signaling properties of the gasotransmitter molecule hydrogen sulfide (H2S), which is endogenously generated in plant cells, are mainly observed during persulfidation, a protein post-translational modification (PTM) that affects redox-sensitive cysteine residues. There is growing experimental evidence that H2S in ...
journal_title:Journal of advanced research
pub_type: 杂志文章,评审
doi:10.1016/j.jare.2020.03.011
更新日期:2020-03-29 00:00:00
abstract::This paper reveals and analyzes the frequency bifurcation phenomena in the fractional-order inductive power transfer (FOIPT) system with series-series compensation topology. Using fractional calculus theory and electric circuit theory, the circuit model of the series-series compensated FOIPT system is first proposed, ...
journal_title:Journal of advanced research
pub_type: 杂志文章,评审
doi:10.1016/j.jare.2020.04.010
更新日期:2020-04-24 00:00:00
abstract::The optimization of a novel programmable data-flow crypto processor dedicated to security applications is considered. An architecture based on assigning basic functional units to four synchronous regions was proposed in a previous work. In this paper, the problem of selecting the number of synchronous regions and the ...
journal_title:Journal of advanced research
pub_type: 杂志文章
doi:10.1016/j.jare.2017.11.002
更新日期:2017-11-04 00:00:00
abstract::World population is expected to reach 9.7 billion by 2050, which makes a great challenge the achievement of food security. The use of urease inhibitors in agricultural practices has long been explored as one of the strategies to guarantee food supply in enough amounts. This is due to the fact that urea, one of the mos...
journal_title:Journal of advanced research
pub_type: 杂志文章,评审
doi:10.1016/j.jare.2018.04.001
更新日期:2018-04-17 00:00:00
abstract::Necrophagous insects are mostly known through forensic entomology. Indeed, experimental data investigating the effect of temperature on larval development underlies post-mortem interval estimations. However, such developmental studies rarely considered the behavior of maggots. In contrast, previous results supposed th...
journal_title:Journal of advanced research
pub_type: 杂志文章
doi:10.1016/j.jare.2018.12.001
更新日期:2018-12-08 00:00:00
abstract::The dynamical properties of nanogels of xanthan gum (XG) with hydrodynamic radius controlled in a size range from 5 nm to 35 nm, were studied at the different XG concentrations in water/sodium bis-2-ethylhexyl-sulfosuccinate (AOT)/decane reverse micelles (RMs) vs. mass fraction of nano-droplet (MFD) at W = 40, using d...
journal_title:Journal of advanced research
pub_type: 杂志文章
doi:10.1016/j.jare.2016.06.009
更新日期:2016-09-01 00:00:00
abstract::The empirical distribution of the eigenvalues of the matrix XX(T) divided by its trace is evaluated, where X is a random Hankel matrix. The distribution of eigenvalues for symmetric and nonsymmetric distributions is assessed with various criteria. This yields several important properties with broad application, partic...
journal_title:Journal of advanced research
pub_type: 杂志文章
doi:10.1016/j.jare.2014.08.008
更新日期:2015-11-01 00:00:00
abstract::Carob samples from seven different Mediterranean countries (Cyprus, Greece, Italy, Spain, Turkey, Jordan and Palestine) were analyzed using Fourier Transform Infrared (FTIR) spectroscopy. Seed and flesh samples of indigenous and foreign cultivars, both authentic and commercial, were examined. The spectra were recorded...
journal_title:Journal of advanced research
pub_type: 杂志文章
doi:10.1016/j.jare.2017.12.001
更新日期:2017-12-24 00:00:00
abstract::Epilepsy is one of the most well-known neurological conditions worldwide. One-third of adult epileptic patients do not respond to antiepileptic drugs or surgical treatment and therefore suffer from the resistant type of epilepsy. Stem cells have been given substantial consideration in the field of epilepsy therapeutic...
journal_title:Journal of advanced research
pub_type: 杂志文章
doi:10.1016/j.jare.2019.01.013
更新日期:2019-01-31 00:00:00
abstract::This study was carried out to investigate the prevalence and monthly intensity of Rhinoestrus (R) spp. among donkeys slaughtered at Giza Zoo abattoir, Egypt. A total of 144 donkeys were examined at postmortem through two visits per month from January 2010 to December 2010. All donkeys were infested with one or more la...
journal_title:Journal of advanced research
pub_type: 杂志文章
doi:10.1016/j.jare.2014.12.003
更新日期:2015-11-01 00:00:00
abstract::The current study was designed to investigate the potential effect of Spirulina platensis, Arthrospira platensis, (SP) on tissue protection of Nile tilapia (Oreochromis niloticus) through estimation of P53 level. Five isonitrogenous and isocaloric rations containing graded levels of dried SP 5, 7.5,10, 15, and 20 g/kg...
journal_title:Journal of advanced research
pub_type: 杂志文章
doi:10.1016/j.jare.2013.03.009
更新日期:2014-01-01 00:00:00
abstract::Today, most investigations of the plant metabolome tend to be based on either nuclear magnetic resonance (NMR) spectroscopy or mass spectrometry (MS), with or without hyphenation with chromatography. Although less sensitive than MS, NMR provides a powerful complementary technique for the identification and quantificat...
journal_title:Journal of advanced research
pub_type: 杂志文章,评审
doi:10.1016/j.jare.2014.10.003
更新日期:2015-01-01 00:00:00
abstract:Background:The vascular endothelium represents a fundamental mechanical and biological barrier for the maintenance of vascular homeostasis along the entire vascular tree. Changes in its integrity are associated to several cardiovascular diseases, including hypertension, atherosclerosis, hyperhomocysteinemia, diabetes, ...
journal_title:Journal of advanced research
pub_type: 杂志文章,评审
doi:10.1016/j.jare.2020.05.015
更新日期:2020-05-19 00:00:00
abstract::The freshwater Testudine species have gained importance in recent years, as most of their population is threatened due to exploitation for delicacy and pet trade. In this regard, Lissemys punctata, a freshwater terrapin, predominantly distributed in Asian countries has gained its significance for the study. A pilot st...
journal_title:Journal of advanced research
pub_type: 杂志文章
doi:10.1016/j.jare.2017.10.007
更新日期:2017-11-21 00:00:00
abstract::This review covers a summary of the literature data published on the chemistry of bis-hydrazonoyl halides over the last four decades. The biological activities of some of the bis-heterocyclic compounds obtained from these bis-hydrazonoyl halides are also reviewed and discussed. ...
journal_title:Journal of advanced research
pub_type: 杂志文章,评审
doi:10.1016/j.jare.2016.09.001
更新日期:2016-11-01 00:00:00
abstract::A computational algorithm is developed for estimating accurately the attitude of a robotic arm which moves along a predetermined path. This algorithm requires preliminary input data obtained in the static mode to yield phase observables for the precise, 3-axis attitude determination of a swinging manipulator in the dy...
journal_title:Journal of advanced research
pub_type: 杂志文章
doi:10.1016/j.jare.2017.03.005
更新日期:2017-07-01 00:00:00
abstract::This study aimed to conduct a systematic review and meta-analysis of prospective studies discussing TNF-α -308 polymorphism and male infertility. This study was conformed to Preferred Reported Items for Systematic Reviews and Meta-Analyses guidelines. PubMed, Embase and Scopus databases were searched to identify relev...
journal_title:Journal of advanced research
pub_type: 杂志文章,评审
doi:10.1016/j.jare.2015.07.001
更新日期:2016-03-01 00:00:00