Abstract：
:Today, most investigations of the plant metabolome tend to be based on either nuclear magnetic resonance (NMR) spectroscopy or mass spectrometry (MS), with or without hyphenation with chromatography. Although less sensitive than MS, NMR provides a powerful complementary technique for the identification and quantification of metabolites in plant extracts. NMR spectroscopy, well appreciated by phytochemists as a particularly information-rich method, showed recent paradigm shift for the improving of metabolome(s) structural and functional characterization and for advancing the understanding of many biological processes. Furthermore, two dimensional NMR (2D NMR) experiments and the use of chemometric data analysis of NMR spectra have proven highly effective at identifying novel and known metabolites that correlate with changes in genotype or phenotype. In this review, we provide an overview of the development of NMR in the field of metabolomics with special focus on 2D NMR spectroscopic techniques and their applications in phytomedicines quality control analysis and drug discovery from natural sources, raising more attention at its potential to reduce the gap between the pace of natural products research and modern drug discovery demand.
journal_name
J Adv Resjournal_title
Journal of advanced researchauthors
Mahrous EA,Farag MAdoi
10.1016/j.jare.2014.10.003subject
Has Abstractpub_date
2015-01-01 00:00:00pages
3-15issue
1eissn
2090-1232issn
2090-1224pii
S2090-1232(14)00126-Xjournal_volume
6pub_type
杂志文章,评审abstract：:The present study aimed to investigate the mode of action of nano-CaPs in vivo as a therapy for solid tumor in mice. To achieve this goal, Ehrlich Ascites Carcinoma (EAC) was transplanted into 85 Swiss male albino mice. After nine days, the mice were divided into 9 groups. Groups 1 and 2 were allocated as the EAC cont...
journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2015.04.001
更新日期：2016-01-01 00:00:00
abstract：:The increase in prevalence of antimicrobial-resistant bacteria (ARB) is currently a serious threat, thus there is a need for new antimicrobial compounds to combat infections caused by these ARB. An antimicrobial-producing bacterium, Burkholderia paludis was recently isolated and was able to produce a type of sideropho...
journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2017.05.007
更新日期：2017-07-01 00:00:00
abstract：:Inflammatory breast cancer (IBC) is a highly metastatic and fatal form of breast cancer. In fact, IBC is characterized by specific morphological, phenotypic, and biological properties that distinguish it from non-IBC. The aggressive behavior of IBC being more common among young women and the low survival rate alarmed ...
journal_title：Journal of advanced research
pub_type： 杂志文章,评审
doi：10.1016/j.jare.2013.06.004
更新日期：2014-09-01 00:00:00
abstract：:Clinical assessment of functional disability is an integral part of management in patients with low back pain (LBP). The range of spinal motion is one of LBP disability measure. The aim of this study was to investigate the validity of spinal range of motion as a predictable measure of disability and to analyze the int...
journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2012.01.002
更新日期：2013-01-01 00:00:00
abstract：:Subacute cutaneous lupus erythematosus (SCLE) is characterized by particular cutaneous manifestations such as non-scaring plaques mainly in sunlight exposed parts of the body along with specific serum autoantibodies (i.e. antinuclear antibodies (ANA), Ro/SSa, La/SSb). It is considered either idiopathic or drug induced...
journal_title：Journal of advanced research
pub_type： 杂志文章,评审
doi：10.1016/j.jare.2016.04.001
更新日期：2016-09-01 00:00:00
abstract：:This work aimed to evaluate the analgesic efficacy of intra-articular injection of magnesium sulphate (4%) compared with equivalent volume of bupivacaine (0.5%) after outpatient knee arthroscopic meniscectomy. Forty patients were randomly assigned to two groups. Group M (n = 20) received intra-articular magnesium sulp...
journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2012.07.001
更新日期：2013-07-01 00:00:00
abstract：:Alpha-Synuclein (aSyn) is a chameleon-like protein. Its overexpression and intracellular deposition defines neurodegenerative α-synucleinopathies including Parkinson's disease. Whether aSyn up-regulation is the cause or the protective reaction to α-synucleinopathies remains unresolved. Remarkably, the accumulation of ...
journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2020.01.009
更新日期：2020-01-22 00:00:00
abstract：:This study aimed to conduct a systematic review and meta-analysis of prospective studies discussing TNF-α -308 polymorphism and male infertility. This study was conformed to Preferred Reported Items for Systematic Reviews and Meta-Analyses guidelines. PubMed, Embase and Scopus databases were searched to identify relev...
journal_title：Journal of advanced research
pub_type： 杂志文章,评审
doi：10.1016/j.jare.2015.07.001
更新日期：2016-03-01 00:00:00
abstract：:Organic agriculture as well as good agricultural practices (GAPs) intrigues the concern of both consumers and producers of agricultural commodities. Bio-preparates of various rhizospheric microorganisms (RMOs) are potential sources of biological inputs supporting plant nutrition and health. The response of open-field ...
journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2012.11.004
更新日期：2014-01-01 00:00:00
abstract：:Inflammation and oxidative stress are two faces of one coin in end stage renal disease patients (ESRD) on maintenance hemodialysis. Their interconnection induces anemia complicated with erythropoietin hyporesponsiveness. The biochemical bases behind the resistance to erythropoietin therapy with frequent hemoglobinemia...
journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2016.02.004
更新日期：2016-05-01 00:00:00
abstract：:World population is expected to reach 9.7 billion by 2050, which makes a great challenge the achievement of food security. The use of urease inhibitors in agricultural practices has long been explored as one of the strategies to guarantee food supply in enough amounts. This is due to the fact that urea, one of the mos...
journal_title：Journal of advanced research
pub_type： 杂志文章,评审
doi：10.1016/j.jare.2018.04.001
更新日期：2018-04-17 00:00:00
abstract：:Renal cell carcinoma is rarely diagnosed during pregnancy. Its management is a real challenge due to the sparse literature and lack of standard guidelines. In this situation, the diagnosis is often delayed as the clinical presentation might resemble other pregnancy-related disorders but it should be one of the diagnos...
journal_title：Journal of advanced research
pub_type： 杂志文章,评审
doi：10.1016/j.jare.2016.03.007
更新日期：2016-07-01 00:00:00
abstract：:In this paper, we studied the progression of shallow water waves relevant to the variable coefficient Korteweg-de Vries (vcKdV) equation. We investigated two kinds of cases: when the dispersion and nonlinearity coefficients are proportional, and when they are not linearly dependent. In the first case, it was shown tha...
journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2014.02.004
更新日期：2015-07-01 00:00:00
abstract：Background:The vascular endothelium represents a fundamental mechanical and biological barrier for the maintenance of vascular homeostasis along the entire vascular tree. Changes in its integrity are associated to several cardiovascular diseases, including hypertension, atherosclerosis, hyperhomocysteinemia, diabetes, ...
journal_title：Journal of advanced research
pub_type： 杂志文章,评审
doi：10.1016/j.jare.2020.05.015
更新日期：2020-05-19 00:00:00
abstract：:Breast cancer (BC) incidence is progressively increasing in Egypt. However, there is insufficient knowledge of the acquired somatic mutations in Egyptian BC patients which limit our understanding of its progression. To the best of our knowledge, this is the first Egyptian cohort to sequence a multiple-gene panel of ca...
journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2020.04.001
更新日期：2020-04-03 00:00:00
abstract：:Kresoxim-methyl and its two thermolabile metabolites, BF 490-2 and BF 490-9, were analyzed in pear using a pepper leaf matrix protection to maintain the metabolites inside the gas chromatography system. Samples were extracted with a mixture of ethyl acetate and n-hexane (1:1, v/v) and purified and/or separated using a...
journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2013.05.003
更新日期：2014-05-01 00:00:00
abstract：:Life is the interplay between structural-functional integrity of biological systems and the influence of the external environment. To understand this interplay, it is useful to examine an animal model that competes with harsh environment. The dromedary camel is the best model that thrives under severe environment with...
journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2013.03.004
更新日期：2014-03-01 00:00:00
abstract：:Necrophagous insects are mostly known through forensic entomology. Indeed, experimental data investigating the effect of temperature on larval development underlies post-mortem interval estimations. However, such developmental studies rarely considered the behavior of maggots. In contrast, previous results supposed th...
journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2018.12.001
更新日期：2018-12-08 00:00:00
abstract：:Peyronie's disease is characterized by fibrous plaque formation of the tunica albuginea, causing penile deformity and fertility problems. The aim of the present study was to investigate alterations in the extracellular matrix in Peyronie's disease. The study used tissues collected by surgical procedure from individual...
journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2017.06.004
更新日期：2017-07-01 00:00:00
abstract：:Climate change is an emerging global issue. It is expected to have significant impacts both in Egypt and around the world. Thus, the country is in need for taking action to prepare for the unavoidable effects of climate change, including the increase in water stress, the rise in sea level, and the rapidly increasing g...
journal_title：Journal of advanced research
pub_type： 杂志文章,评审
doi：10.1016/j.jare.2013.06.009
更新日期：2014-11-01 00:00:00
abstract：:Transplanted neural stem cells promote neural tissue regeneration and functional recovery primarily by releasing paracrine factors. Exosomes act as important secreted paracrine molecules to deliver therapeutic agents involved in cellular functions. Here, we focused on the role of exosomes (hNSC-Exo) derived from human...
journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2020.05.017
更新日期：2020-05-25 00:00:00
abstract：:This study was carried out to investigate the prevalence and monthly intensity of Rhinoestrus (R) spp. among donkeys slaughtered at Giza Zoo abattoir, Egypt. A total of 144 donkeys were examined at postmortem through two visits per month from January 2010 to December 2010. All donkeys were infested with one or more la...
journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2014.12.003
更新日期：2015-11-01 00:00:00
abstract：Introduction:Defecation is a complex process that is difficult to study and analyze. Objectives:Here, we present new analytical tools to calculate frictional force and tension during expulsion of the Fecobionics simulated stool in human subjects. Methods:The 12-cm-long Fecobionics device contained pressure sensors, m...
journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2020.07.002
更新日期：2020-07-11 00:00:00
abstract：:The present study aimed to develop the predictive models of average tool-workpiece interface temperature in hard turning of AISI 1060 steels by coated carbide insert. The Response Surface Methodology (RSM) and Artificial Neural Network (ANN) were employed to predict the temperature in respect of cutting speed, feed ra...
journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2016.05.004
更新日期：2016-11-01 00:00:00
abstract：:A combination of gel-casting and polymeric foam infiltration methods is used in this study to prepare porous bodies of hydroxyapatite (HA), to provide a better control over the microstructures of samples. These scaffolds were prepared by impregnating a body of porous polyurethane foam with slurry containing HA powder,...
journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2015.06.006
更新日期：2016-03-01 00:00:00
abstract：Introduction:Numerous studies have shown the ability of low-energy acoustic waves such as focused ultrasound or shockwave to transiently open blood-brain barrier (BBB) and facilitate drug delivery to the brain. Preclinical and clinical evidences have well demonstrated the efficacy and safety in treating various brain d...
journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2020.06.012
更新日期：2020-06-21 00:00:00
abstract：:The paper presents a novel technique to detect Denial of Service (DoS) attacks applied by misbehaving nodes in wireless networks with the presence of hidden nodes employing the widely used IEEE 802.11 Distributed Coordination Function (DCF) protocols described in the IEEE standard [1]. Attacker nodes alter the IEEE 80...
journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2013.11.001
更新日期：2014-07-01 00:00:00
abstract：:The signaling properties of the gasotransmitter molecule hydrogen sulfide (H2S), which is endogenously generated in plant cells, are mainly observed during persulfidation, a protein post-translational modification (PTM) that affects redox-sensitive cysteine residues. There is growing experimental evidence that H2S in ...
journal_title：Journal of advanced research
pub_type： 杂志文章,评审
doi：10.1016/j.jare.2020.03.011
更新日期：2020-03-29 00:00:00
abstract：:A novel simple, direct and selective gas chromatography-mass spectrometry (GC/MS) procedure was developed for the determination of the antihistamine drug dimenhydrinate (DMH) in presence of six of its related substances and potential impurities, namely, diphenylmethane, diphenylmethanol, benzophenone, orphenadrine, ca...
journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2015.01.010
更新日期：2016-01-01 00:00:00
abstract：:The objective of this paper is to study the optimal control problem for the fractional tuberculosis (TB) infection model including the impact of diabetes and resistant strains. The governed model consists of 14 fractional-order (FO) equations. Four control variables are presented to minimize the cost of interventions....
journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2019.01.007
更新日期：2019-01-19 00:00:00
