Abstract：
:Inflammatory breast cancer (IBC) is a highly metastatic and fatal form of breast cancer. In fact, IBC is characterized by specific morphological, phenotypic, and biological properties that distinguish it from non-IBC. The aggressive behavior of IBC being more common among young women and the low survival rate alarmed researchers to explore the disease biology. Despite the basic and translational studies needed to understand IBC disease biology and identify specific biomarkers, studies are limited by few available IBC cell lines, experimental models, and paucity of patient samples. Above all, in the last decade, researchers were able to identify new factors that may play a crucial role in IBC progression. Among identified factors are cytokines, chemokines, growth factors, and proteases. In addition, viral infection was also suggested to participate in the etiology of IBC disease. In this review, we present novel factors suggested by different studies to contribute to the etiology of IBC and the proposed new therapeutic insights.
journal_name
J Adv Resjournal_title
Journal of advanced researchauthors
Mohamed MM,Al-Raawi D,Sabet SF,El-Shinawi Mdoi
10.1016/j.jare.2013.06.004subject
Has Abstractpub_date
2014-09-01 00:00:00pages
525-36issue
5eissn
2090-1232issn
2090-1224pii
S2090-1232(13)00083-0journal_volume
5pub_type
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journal_title：Journal of advanced research
pub_type： 杂志文章,评审
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journal_title：Journal of advanced research
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journal_title：Journal of advanced research
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journal_title：Journal of advanced research
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journal_title：Journal of advanced research
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journal_title：Journal of advanced research
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journal_title：Journal of advanced research
pub_type： 杂志文章,评审
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journal_title：Journal of advanced research
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journal_title：Journal of advanced research
pub_type： 杂志文章
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pub_type： 杂志文章,评审
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journal_title：Journal of advanced research
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journal_title：Journal of advanced research
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journal_title：Journal of advanced research
pub_type： 杂志文章,评审
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journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2018.12.001
更新日期：2018-12-08 00:00:00
