abstract：BACKGROUND:SARS-CoV-2 infection (COVID-19 disease) can induce systemic vascular involvement contributing to morbidity and mortality. SARS-CoV-2 targets epithelial and endothelial cells through the ACE2 receptor. The anatomical involvement of the coronary tree is not explored yet. METHODS:Cardiac autopsy tissue of the ...

journal_title：EBioMedicine

authors： Maccio U,Zinkernagel AS,Shambat SM,Zeng X,Cathomas G,Ruschitzka F,Schuepbach RA,Moch H,Varga Z

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Early diagnosis of coronavirus disease 2019 (COVID-19) is of the utmost importance but remains challenging. The objective of the current study was to characterize exhaled breath from mechanically ventilated adults with COVID-19. METHODS:In this prospective observational study, we used real-time, online, pro...

journal_title：EBioMedicine

authors： Grassin-Delyle S,Roquencourt C,Moine P,Saffroy G,Carn S,Heming N,Fleuriet J,Salvator H,Naline E,Couderc LJ,Devillier P,Thévenot EA,Annane D,Garches COVID-19 Collaborative Group RECORDS Collaborators and Exhalomics® Collaborator

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Besides long-term trans-differentiation into neural cells, benefits of stem cell therapy (SCT) in ischemic stroke may include secretion of protective factors, which partly reflects extracellular vesicle (EVs) released by stem cell. However, the mechanism(s) by which stem cells/EVs limit stroke injury have ye...

journal_title：EBioMedicine

authors： Barzegar M,Wang Y,Eshaq RS,Yun JW,Boyer CJ,Cananzi SG,White LA,Chernyshev O,Kelley RE,Minagar A,Stokes KY,Lu XH,Alexander JS

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:We developed and validated an integrated radiomic-clinicopathologic nomogram (RadClip) for post-surgical biochemical recurrence free survival (bRFS) and adverse pathology (AP) prediction in men with prostate cancer (PCa). RadClip was further compared against extant prognostics tools like CAPRA and Decipher. ...

journal_title：EBioMedicine

authors： Li L,Shiradkar R,Leo P,Algohary A,Fu P,Tirumani SH,Mahran A,Buzzy C,Obmann VC,Mansoori B,El-Fahmawi A,Shahait M,Tewari A,Magi-Galluzzi C,Lee D,Lal P,Ponsky L,Klein E,Purysko AS,Madabhushi A

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:The human gut microbiota has emerged as a key factor in the development of obesity. Certain probiotic strains have shown anti-obesity effects. The objective of this study was to investigate whether Bifidobacterium longum APC1472 has anti-obesity effects in high-fat diet (HFD)-induced obese mice and whether B...

journal_title：EBioMedicine

authors： Schellekens H,Torres-Fuentes C,van de Wouw M,Long-Smith CM,Mitchell A,Strain C,Berding K,Bastiaanssen TFS,Rea K,Golubeva AV,Arboleya S,Verpaalen M,Pusceddu MM,Murphy A,Fouhy F,Murphy K,Ross P,Roy BL,Stanton C,Dinan

更新日期：2021-01-01 00:00:00

abstract：:Cardiovascular diseases (CVDs) are the leading cause of death and a major cause of disability globally. Transcription factor EB (TFEB), as a member of the microphthalmia transcription factor (MITF) family, has been demonstrated to be a master regulator of autophagy and lysosomal biogenesis. Emerging studies suggest th...

journal_title：EBioMedicine

authors： Lu H,Sun J,Hamblin MH,Chen YE,Fan Y

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:α4β7 is a gut-homing integrin heterodimer that can act as a non-essential binding molecule for HIV. A previous study in heterosexual African women found that individuals with higher proportions of α4β7 expressing CD4+ T cells were more likely to become infected with HIV, as well as present with faster diseas...

journal_title：EBioMedicine

authors： Martin AR,Patel EU,Kirby C,Astemborski J,Kirk GD,Mehta SH,Marshall K,Janes H,Clayton A,Corey L,Hammer SM,Sobieszczyk ME,Arthos J,Cicala C,Redd AD,Quinn TC

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Interpretation of the increase in certain inflammatory markers in virally suppressed HIV-infected individuals must rely on an appropriate uninfected control group well characterized for non-HIV-related factors that contribute to chronic inflammation, e.g. smoking, alcohol consumption, or being overweight. We...

journal_title：EBioMedicine

authors： Novelli S,Lécuroux C,Goujard C,Reynes J,Villemant A,Blum L,Essat A,Avettand-Fenoël V,Launay O,Molina JM,Bourgeois C,Meyer L

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:The rapid spread of SARS-CoV-2, the causative agent of Coronavirus disease 2019 (COVID-19), has been accompanied by the emergence of distinct viral clades, though their clinical significance remains unclear. Here, we aimed to investigate the phylogenetic characteristics of SARS-CoV-2 infections in Chicago, I...

journal_title：EBioMedicine

authors： Lorenzo-Redondo R,Nam HH,Roberts SC,Simons LM,Jennings LJ,Qi C,Achenbach CJ,Hauser AR,Ison MG,Hultquist JF,Ozer EA

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Due to the lack of protective immunity of humans towards the newly emerged SARS-CoV-2, this virus has caused a massive pandemic across the world resulting in hundreds of thousands of deaths. Thus, a vaccine is urgently needed to contain the spread of the virus. METHODS:Here, we describe Newcastle disease vi...

journal_title：EBioMedicine

authors： Sun W,Leist SR,McCroskery S,Liu Y,Slamanig S,Oliva J,Amanat F,Schäfer A,Dinnon KH 3rd,García-Sastre A,Krammer F,Baric RS,Palese P

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Liver fibrosis is a consequence of chronic inflammation and is associated with protein changes within the hepatocytes structure. In this study, we aimed to investigate if this is reflected by the urinary proteome and can be explored to diagnose liver fibrosis in patients with chronic liver disease. METHODS:...

journal_title：EBioMedicine

authors： Bannaga AS,Metzger J,Kyrou I,Voigtländer T,Book T,Melgarejo J,Latosinska A,Pejchinovski M,Staessen JA,Mischak H,Manns MP,Arasaradnam RP

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Intra-tumour heterogeneity in lymphoid malignancies encompasses selection of genetic events and epigenetic regulation of transcriptional programs. Clonal-related neoplastic cell populations are unsteadily subjected to immune editing and metabolic adaptations within different tissue microenvironments. How tis...

journal_title：EBioMedicine

authors： Sangaletti S,Iannelli F,Zanardi F,Cancila V,Portararo P,Botti L,Vacca D,Chiodoni C,Di Napoli A,Valenti C,Rizzello C,Vegliante MC,Pisati F,Gulino A,Ponzoni M,Colombo MP,Tripodo C

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is a devastating lung disease, mainly due to cigarette smoking, which represents the third cause of mortality worldwide. The mechanisms driving its epithelial salient features remain largely elusive. We aimed to evaluate the activation and the role of the canonica...

journal_title：EBioMedicine

authors： Carlier FM,Dupasquier S,Ambroise J,Detry B,Lecocq M,Biétry-Claudet C,Boukala Y,Gala JL,Bouzin C,Verleden SE,Hoton D,Gohy S,Bearzatto B,Pilette C

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Robust prognostic stratification of patients with oropharyngeal squamous cell carcinoma (OPSCC) is important for developing individualized treatment plans. This study was conducted to develop and validate a clinically feasible prognostic classifier based on transcriptome-wide gene expression profiles. METHO...

journal_title：EBioMedicine

authors： Liu X,Liu P,Chernock RD,Kuhs KAL,Lewis JS Jr,Luo J,Gay HA,Thorstad WL,Wang X

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Cancer of unknown primary (CUP), representing approximately 3-5% of all malignancies, is defined as metastatic cancer where a primary site of origin cannot be found despite a standard diagnostic workup. Because knowledge of a patient's primary cancer remains fundamental to their treatment, CUP patients are s...

journal_title：EBioMedicine

authors： Zhao Y,Pan Z,Namburi S,Pattison A,Posner A,Balachander S,Paisie CA,Reddi HV,Rueter J,Gill AJ,Fox S,Raghav KPS,Flynn WF,Tothill RW,Li S,Karuturi RKM,George J

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Ex-vivo lung perfusion (EVLP) is an innovative platform for assessing donor lungs in the pre-transplant window. In this study, we demonstrate an extension of its utility by administering the anti-CD20 monoclonal antibody, Rituximab, during EVLP. We hypothesized that this would lead to targeted depletion of a...

journal_title：EBioMedicine

authors： Ku TJY,Ribeiro RVP,Ferreira VH,Galasso M,Keshavjee S,Kumar D,Cypel M,Humar A

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:While mutations in the cardiac type 2 ryanodine receptor (RyR2) have been linked to exercise-induced or catecholaminergic polymorphic ventricular tachycardia (CPVT), its association with polymorphic ventricular tachycardia (PMVT) occurring at rest is unclear. We aimed at constructing a patient-specific human...

journal_title：EBioMedicine

authors： Sleiman Y,Souidi M,Kumar R,Yang E,Jaffré F,Zhou T,Bernardin A,Reiken S,Cazorla O,Kajava AV,Moreau A,Pasquié JL,Marks AR,Lerman BB,Chen S,Cheung JW,Evans T,Lacampagne A,Meli AC

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Chronic hepatitis B virus (HBV) infections are a global health problem. There is a need for therapeutic strategies blocking continuous infection of liver cells. The grass pollen allergy vaccine BM32 containing the preS domain of the large HBV surface protein (LHBs) as immunogenic carrier induced IgG antibodi...

journal_title：EBioMedicine

authors： Tulaeva I,Cornelius C,Zieglmayer P,Zieglmayer R,Schmutz R,Lemell P,Weber M,Focke-Tejkl M,Karaulov A,Henning R,Valenta R

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:In neuroblastoma, genetic alterations in ATRX, define a distinct poor outcome patient subgroup. Despite the need for new therapies, there is a lack of available models and a dearth of pre-clinical research. METHODS:To evaluate the impact of ATRX loss of function (LoF) in neuroblastoma, we utilized CRISPR-Ca...

journal_title：EBioMedicine

authors： George SL,Lorenzi F,King D,Hartlieb S,Campbell J,Pemberton H,Toprak UH,Barker K,Tall J,da Costa BM,van den Boogaard ML,Dolman MEM,Molenaar JJ,Bryant HE,Westermann F,Lord CJ,Chesler L

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Evidence is accruing to suggest that microbiota-gut-brain signalling plays a regulatory role in cardiorespiratory physiology. Chronic intermittent hypoxia (CIH), modelling human sleep apnoea, affects gut microbiota composition and elicits cardiorespiratory morbidity. We investigated if treatment with prebiot...

journal_title：EBioMedicine

authors： O'Connor KM,Lucking EF,Bastiaanssen TFS,Peterson VL,Crispie F,Cotter PD,Clarke G,Cryan JF,O'Halloran KD

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Impaired fracture healing represents an ongoing clinical challenge, as treatment options remain limited. Calcitonin gene-related peptide (CGRP), a neuropeptide targeted by emerging anti-migraine drugs, is also expressed in sensory nerve fibres innervating bone tissue. METHOD:Bone healing following a femoral...

journal_title：EBioMedicine

authors： Appelt J,Baranowsky A,Jahn D,Yorgan T,Köhli P,Otto E,Farahani SK,Graef F,Fuchs M,Herrera A,Amling M,Schinke T,Frosch KH,Duda GN,Tsitsilonis S,Keller J

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:High-molecular-weight kininogen is a cofactor of the human contact system, an inflammatory response mechanism that is activated during sepsis. It has been shown that high-molecular-weight kininogen contributes to endotoxemia, but is not critical for local host defense during pneumonia by Gram-negative bacter...

journal_title：EBioMedicine

authors： Köhler J,Maletzki C,Koczan D,Frank M,Springer A,Steffen C,Revenko AS,MacLeod AR,Mikkat S,Kreikemeyer B,Oehmcke-Hecht S

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Gene therapy has held promises for treating specific genetic diseases. However, the key to clinical application depends on effective gene delivery. METHODS:Using a large animal model, we developed two pharmaceutical formulations for gene delivery in the pigs' vagina, which were made up of poly (β-amino este...

journal_title：EBioMedicine

authors： Niu G,Jin Z,Zhang C,He D,Gao X,Zou C,Zhang W,Ding J,Das BC,Severinov K,Hitzeroth II,Debata PR,Ma X,Tian X,Gao Q,Wu J,You Z,Tian R,Cui Z,Fan W,Xie W,Huang Z,Cao C,Xu W,Xie H,Xu H,Tang X,Wang Y,Yu Z

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Subcellular localization and function of L-type calcium channels (LTCCs) play an important role in regulating contraction of cardiomyocytes. Understanding how this is affected by the disruption of transverse tubules during heart failure could lead to new insights into the disease. METHODS:Cardiomyocytes wer...

journal_title：EBioMedicine

authors： Sanchez-Alonso JL,Loucks A,Schobesberger S,van Cromvoirt AM,Poulet C,Chowdhury RA,Trayanova N,Gorelik J

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Tumour budding and poorly differentiated clusters (PDC) represent forms of tumour invasion. We hypothesised that T-cell densities (reflecting adaptive anti-tumour immunity) might be inversely associated with tumour budding and PDC in colorectal carcinoma. METHODS:Utilising 915 colon and rectal carcinomas in...

journal_title：EBioMedicine

authors： Fujiyoshi K,Väyrynen JP,Borowsky J,Papke DJ Jr,Arima K,Haruki K,Kishikawa J,Akimoto N,Ugai T,Lau MC,Gu S,Shi S,Zhao M,Da Silva AFL,Twombly TS,Nan H,Meyerhardt JA,Song M,Zhang X,Wu K,Chan AT,Fuchs CS,Lennerz JK

更新日期：2020-07-01 00:00:00

abstract：:Acute myocardial infarction (AMI) and the heart failure (HF) that often follows are among the leading causes of death and disability worldwide. As such, new treatments are needed to protect the myocardium against the damaging effects of the acute ischaemia and reperfusion injury (IRI) that occurs in AMI, in order to r...

journal_title：EBioMedicine

authors： Ramachandra CJA,Hernandez-Resendiz S,Crespo-Avilan GE,Lin YH,Hausenloy DJ

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:The diagnosis performance of B-mode ultrasound (US) for focal liver lesions (FLLs) is relatively limited. We aimed to develop a deep convolutional neural network of US (DCNN-US) for aiding radiologists in classification of malignant from benign FLLs. MATERIALS AND METHODS:This study was conducted in 13 hosp...

journal_title：EBioMedicine

authors： Yang Q,Wei J,Hao X,Kong D,Yu X,Jiang T,Xi J,Cai W,Luo Y,Jing X,Yang Y,Cheng Z,Wu J,Zhang H,Liao J,Zhou P,Song Y,Zhang Y,Han Z,Cheng W,Tang L,Liu F,Dou J,Zheng R,Yu J,Tian J,Liang P

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Dachshund homologue 1 (DACH1) is highly expressed in LGR5+ intestinal stem cells and colorectal tumours. However, the roles of DACH1 in intestinal cell stemness and colorectal tumorigenesis remain largely undefined. METHODS:We used immunohistochemistry, western blotting and quantitative real-time PCR to ana...

journal_title：EBioMedicine

authors： Hu X,Zhang L,Li Y,Ma X,Dai W,Gao X,Rao X,Fu G,Wang R,Pan M,Guo Q,Xu X,Zhou Y,Gao J,Zhang Z,Cai S,Peng J,Hua G

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Salmonella causes intracellular infections in humans. Besides quinolones, third generation cephalosporins are first line drugs used for salmonellosis therapy. An unresolved anomaly of this practice involves high relapse rates associated to quinolone- or cephalosporin-susceptible Salmonella isolates in patien...

journal_title：EBioMedicine

authors： Castanheira S,López-Escarpa D,Pucciarelli MG,Cestero JJ,Baquero F,García-Del Portillo F

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:The dynamic changes of lymphocyte subsets and cytokines profiles of patients with novel coronavirus disease (COVID-19) and their correlation with the disease severity remain unclear. METHODS:Peripheral blood samples were longitudinally collected from 40 confirmed COVID-19 patients and examined for lymphocyt...

journal_title：EBioMedicine

authors： Liu J,Li S,Liu J,Liang B,Wang X,Wang H,Li W,Tong Q,Yi J,Zhao L,Xiong L,Guo C,Tian J,Luo J,Yao J,Pang R,Shen H,Peng C,Liu T,Zhang Q,Wu J,Xu L,Lu S,Wang B,Weng Z,Han C,Zhu H,Zhou R,Zhou H,Chen X,

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:The composition of the bile acid (BA) pool is closely associated with obesity and is modified by gut microbiota. Perturbations of gut microbiota shape the BA composition, which, in turn, may alter important BA signaling and affect host metabolism. METHODS:We investigated BA composition of high BMI subjects ...

journal_title：EBioMedicine

authors： Wei M,Huang F,Zhao L,Zhang Y,Yang W,Wang S,Li M,Han X,Ge K,Qu C,Rajani C,Xie G,Zheng X,Zhao A,Bian Z,Jia W

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Atherosclerosis involves a slow process of plaque formation on the walls of arteries, and comprises a leading cause of cardiovascular disease. Long non-coding RNAs (lncRNAs) have been implicated in the pathogenesis of atherosclerosis. In this study, we aim to explore the possible involvement of lncRNA 'cycli...

journal_title：EBioMedicine

authors： Ou M,Li X,Zhao S,Cui S,Tu J

更新日期：2020-05-01 00:00:00

abstract：:Antibody-mediated humoral immunity is thought to play a central role in mediating the immunopathogenesis of acute DENV infection, but limited data are available on the diversity, specificity, and functionality of the antibody response at the molecular level elicited by primary or secondary DENV infection. In order to ...

journal_title：EBioMedicine

authors： Waickman AT,Gromowski GD,Rutvisuttinunt W,Li T,Siegfried H,Victor K,Kuklis C,Gomootsukavadee M,McCracken MK,Gabriel B,Mathew A,Grinyo I Escuer A,Fouch ME,Liang J,Fernandez S,Davidson E,Doranz BJ,Srikiatkhachorn A,Endy

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:We developed and validated an artificial intelligence (AI)-assisted prediction of preeclampsia applied to a nationwide health insurance dataset in Indonesia. METHODS:The BPJS Kesehatan dataset have been preprocessed using a nested case-control design into preeclampsia/eclampsia (n = 3318) and normotensive p...

journal_title：EBioMedicine

authors： Sufriyana H,Wu YW,Su EC

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:The 5-year survival rate of patients with pancreatic ductal adenocarcinoma (PDAC) is around 5% due to the fact that the majority of patients present with advanced disease that is treatment resistant. Familial pancreatic cancer (FPC) is a rare disorder that is defined as a family with at least two affected fi...

journal_title：EBioMedicine

authors： Earl J,Galindo-Pumariño C,Encinas J,Barreto E,Castillo ME,Pachón V,Ferreiro R,Rodríguez-Garrote M,González-Martínez S,Ramon Y Cajal T,Diaz LR,Chirivella-Gonzalez I,Rodriguez M,de Castro EM,García-Seisdedos D,Muñoz G,Rosa

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Intervertebral disc degeneration (IDD) is a major contributor to lower back pain, however, the molecular and pathogenetic mechanisms underlying IDD are poorly understood. As a high-risk factor for IDD, compression stress was reported to induce apoptosis of nucleus pulposus (NP) cells and extracellular matrix...

journal_title：EBioMedicine

authors： Xiang Q,Kang L,Wang J,Liao Z,Song Y,Zhao K,Wang K,Yang C,Zhang Y

更新日期：2020-03-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) shows remarkable propensity to metastasize. This predilection to escape from the primary tumor is driven by paracrine and autocrine mechanisms that guide cancer cells through a multi-step process concluding with colonization in distant tissues. Although cell-intrinsic features s...

journal_title：EBioMedicine

authors： Thomas SK,Lee J,Beatty GL

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Because the regenerative ability of intervertebral discs (IVDs) is restricted, defects caused by discectomy may induce insufficient tissue repair leading to further IVD degeneration. An acellular bioresorbable biomaterial based on ultra-purified alginate (UPAL) gel was developed to fill the IVD cavity and pr...

journal_title：EBioMedicine

authors： Ukeba D,Sudo H,Tsujimoto T,Ura K,Yamada K,Iwasaki N

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Neurodegenerative diseases are incurable disorders caused by progressive neuronal cell death. Retinitis pigmentosa (RP) is a blinding neurodegenerative disease that results in photoreceptor death and progresses to the loss of the entire retinal network. We previously found that proteomic analysis of the adja...

journal_title：EBioMedicine

authors： Wert KJ,Velez G,Kanchustambham VL,Shankar V,Evans LP,Sengillo JD,Zare RN,Bassuk AG,Tsang SH,Mahajan VB

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Acute myeloid leukaemia (AML) is a malignant haematological tumour with high heterogeneity and mortality. A reliable prognostic assessment is critical for treatment strategies. However, the current prognostic evaluation system of AML is insufficient. METHODS:Genome-wide univariate Cox regression analysis wa...

journal_title：EBioMedicine

authors： Fu Y,Xu M,Cui Z,Yang Z,Zhang Z,Yin X,Huang X,Zhou M,Wang X,Chen C

更新日期：2020-02-01 00:00:00