听力与言语-语言病理学

行为科学

医学伦理学

你正在浏览EBioMedicine期刊下所有文献
  • Metabolomics of exhaled breath in critically ill COVID-19 patients: A pilot study.

    abstract:BACKGROUND:Early diagnosis of coronavirus disease 2019 (COVID-19) is of the utmost importance but remains challenging. The objective of the current study was to characterize exhaled breath from mechanically ventilated adults with COVID-19. METHODS:In this prospective observational study, we used real-time, online, pro...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2020.103154

    authors: Grassin-Delyle S,Roquencourt C,Moine P,Saffroy G,Carn S,Heming N,Fleuriet J,Salvator H,Naline E,Couderc LJ,Devillier P,Thévenot EA,Annane D,Garches COVID-19 Collaborative Group RECORDS Collaborators and Exhalomics® Collaborator

    更新日期:2021-01-01 00:00:00

  • A novel imaging based Nomogram for predicting post-surgical biochemical recurrence and adverse pathology of prostate cancer from pre-operative bi-parametric MRI.

    abstract:BACKGROUND:We developed and validated an integrated radiomic-clinicopathologic nomogram (RadClip) for post-surgical biochemical recurrence free survival (bRFS) and adverse pathology (AP) prediction in men with prostate cancer (PCa). RadClip was further compared against extant prognostics tools like CAPRA and Decipher. ...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2020.103163

    authors: Li L,Shiradkar R,Leo P,Algohary A,Fu P,Tirumani SH,Mahran A,Buzzy C,Obmann VC,Mansoori B,El-Fahmawi A,Shahait M,Tewari A,Magi-Galluzzi C,Lee D,Lal P,Ponsky L,Klein E,Purysko AS,Madabhushi A

    更新日期:2021-01-01 00:00:00

  • Human placental mesenchymal stem cells improve stroke outcomes via extracellular vesicles-mediated preservation of cerebral blood flow.

    abstract:BACKGROUND:Besides long-term trans-differentiation into neural cells, benefits of stem cell therapy (SCT) in ischemic stroke may include secretion of protective factors, which partly reflects extracellular vesicle (EVs) released by stem cell. However, the mechanism(s) by which stem cells/EVs limit stroke injury have ye...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2020.103161

    authors: Barzegar M,Wang Y,Eshaq RS,Yun JW,Boyer CJ,Cananzi SG,White LA,Chernyshev O,Kelley RE,Minagar A,Stokes KY,Lu XH,Alexander JS

    更新日期:2021-01-01 00:00:00

  • Bifidobacterium longum counters the effects of obesity: Partial successful translation from rodent to human.

    abstract:BACKGROUND:The human gut microbiota has emerged as a key factor in the development of obesity. Certain probiotic strains have shown anti-obesity effects. The objective of this study was to investigate whether Bifidobacterium longum APC1472 has anti-obesity effects in high-fat diet (HFD)-induced obese mice and whether B...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2020.103176

    authors: Schellekens H,Torres-Fuentes C,van de Wouw M,Long-Smith CM,Mitchell A,Strain C,Berding K,Bastiaanssen TFS,Rea K,Golubeva AV,Arboleya S,Verpaalen M,Pusceddu MM,Murphy A,Fouhy F,Murphy K,Ross P,Roy BL,Stanton C,Dinan

    更新日期:2021-01-01 00:00:00

  • Transcription factor EB regulates cardiovascular homeostasis.

    abstract::Cardiovascular diseases (CVDs) are the leading cause of death and a major cause of disability globally. Transcription factor EB (TFEB), as a member of the microphthalmia transcription factor (MITF) family, has been demonstrated to be a master regulator of autophagy and lysosomal biogenesis. Emerging studies suggest th...

    journal_title:EBioMedicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.ebiom.2020.103207

    authors: Lu H,Sun J,Hamblin MH,Chen YE,Fan Y

    更新日期:2021-01-01 00:00:00

  • SARS-CoV-2 leads to a small vessel endotheliitis in the heart.

    abstract:BACKGROUND:SARS-CoV-2 infection (COVID-19 disease) can induce systemic vascular involvement contributing to morbidity and mortality. SARS-CoV-2 targets epithelial and endothelial cells through the ACE2 receptor. The anatomical involvement of the coronary tree is not explored yet. METHODS:Cardiac autopsy tissue of the ...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2020.103182

    authors: Maccio U,Zinkernagel AS,Shambat SM,Zeng X,Cathomas G,Ruschitzka F,Schuepbach RA,Moch H,Varga Z

    更新日期:2021-01-01 00:00:00

  • Discovery, validation and sequencing of urinary peptides for diagnosis of liver fibrosis-A multicentre study.

    abstract:BACKGROUND:Liver fibrosis is a consequence of chronic inflammation and is associated with protein changes within the hepatocytes structure. In this study, we aimed to investigate if this is reflected by the urinary proteome and can be explored to diagnose liver fibrosis in patients with chronic liver disease. METHODS:...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2020.103083

    authors: Bannaga AS,Metzger J,Kyrou I,Voigtländer T,Book T,Melgarejo J,Latosinska A,Pejchinovski M,Staessen JA,Mischak H,Manns MP,Arasaradnam RP

    更新日期:2020-12-01 00:00:00

  • The association of α4β7 expression with HIV acquisition and disease progression in people who inject drugs and men who have sex with men: Case control studies.

    abstract:BACKGROUND:α4β7 is a gut-homing integrin heterodimer that can act as a non-essential binding molecule for HIV. A previous study in heterosexual African women found that individuals with higher proportions of α4β7 expressing CD4+ T cells were more likely to become infected with HIV, as well as present with faster diseas...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2020.103102

    authors: Martin AR,Patel EU,Kirby C,Astemborski J,Kirk GD,Mehta SH,Marshall K,Janes H,Clayton A,Corey L,Hammer SM,Sobieszczyk ME,Arthos J,Cicala C,Redd AD,Quinn TC

    更新日期:2020-12-01 00:00:00

  • A clade of SARS-CoV-2 viruses associated with lower viral loads in patient upper airways.

    abstract:BACKGROUND:The rapid spread of SARS-CoV-2, the causative agent of Coronavirus disease 2019 (COVID-19), has been accompanied by the emergence of distinct viral clades, though their clinical significance remains unclear. Here, we aimed to investigate the phylogenetic characteristics of SARS-CoV-2 infections in Chicago, I...

    journal_title:EBioMedicine

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.ebiom.2020.103112

    authors: Lorenzo-Redondo R,Nam HH,Roberts SC,Simons LM,Jennings LJ,Qi C,Achenbach CJ,Hauser AR,Ison MG,Hultquist JF,Ozer EA

    更新日期:2020-12-01 00:00:00

  • Newcastle disease virus (NDV) expressing the spike protein of SARS-CoV-2 as a live virus vaccine candidate.

    abstract:BACKGROUND:Due to the lack of protective immunity of humans towards the newly emerged SARS-CoV-2, this virus has caused a massive pandemic across the world resulting in hundreds of thousands of deaths. Thus, a vaccine is urgently needed to contain the spread of the virus. METHODS:Here, we describe Newcastle disease vi...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2020.103132

    authors: Sun W,Leist SR,McCroskery S,Liu Y,Slamanig S,Oliva J,Amanat F,Schäfer A,Dinnon KH 3rd,García-Sastre A,Krammer F,Baric RS,Palese P

    更新日期:2020-12-01 00:00:00

  • Persistence of monocyte activation under treatment in people followed since acute HIV-1 infection relative to participants at high or low risk of HIV infection.

    abstract:BACKGROUND:Interpretation of the increase in certain inflammatory markers in virally suppressed HIV-infected individuals must rely on an appropriate uninfected control group well characterized for non-HIV-related factors that contribute to chronic inflammation, e.g. smoking, alcohol consumption, or being overweight. We...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2020.103129

    authors: Novelli S,Lécuroux C,Goujard C,Reynes J,Villemant A,Blum L,Essat A,Avettand-Fenoël V,Launay O,Molina JM,Bourgeois C,Meyer L

    更新日期:2020-12-01 00:00:00

  • A prognostic gene expression signature for oropharyngeal squamous cell carcinoma.

    abstract:BACKGROUND:Robust prognostic stratification of patients with oropharyngeal squamous cell carcinoma (OPSCC) is important for developing individualized treatment plans. This study was conducted to develop and validate a clinically feasible prognostic classifier based on transcriptome-wide gene expression profiles. METHO...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2020.102805

    authors: Liu X,Liu P,Chernock RD,Kuhs KAL,Lewis JS Jr,Luo J,Gay HA,Thorstad WL,Wang X

    更新日期:2020-11-01 00:00:00

  • CUP-AI-Dx: A tool for inferring cancer tissue of origin and molecular subtype using RNA gene-expression data and artificial intelligence.

    abstract:BACKGROUND:Cancer of unknown primary (CUP), representing approximately 3-5% of all malignancies, is defined as metastatic cancer where a primary site of origin cannot be found despite a standard diagnostic workup. Because knowledge of a patient's primary cancer remains fundamental to their treatment, CUP patients are s...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2020.103030

    authors: Zhao Y,Pan Z,Namburi S,Pattison A,Posner A,Balachander S,Paisie CA,Reddi HV,Rueter J,Gill AJ,Fox S,Raghav KPS,Flynn WF,Tothill RW,Li S,Karuturi RKM,George J

    更新日期:2020-11-01 00:00:00

  • Canonical WNT pathway is activated in the airway epithelium in chronic obstructive pulmonary disease.

    abstract:BACKGROUND:Chronic obstructive pulmonary disease (COPD) is a devastating lung disease, mainly due to cigarette smoking, which represents the third cause of mortality worldwide. The mechanisms driving its epithelial salient features remain largely elusive. We aimed to evaluate the activation and the role of the canonica...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2020.103034

    authors: Carlier FM,Dupasquier S,Ambroise J,Detry B,Lecocq M,Biétry-Claudet C,Boukala Y,Gala JL,Bouzin C,Verleden SE,Hoton D,Gohy S,Bearzatto B,Pilette C

    更新日期:2020-11-01 00:00:00

  • Intra-tumour heterogeneity of diffuse large B-cell lymphoma involves the induction of diversified stroma-tumour interfaces.

    abstract:BACKGROUND:Intra-tumour heterogeneity in lymphoid malignancies encompasses selection of genetic events and epigenetic regulation of transcriptional programs. Clonal-related neoplastic cell populations are unsteadily subjected to immune editing and metabolic adaptations within different tissue microenvironments. How tis...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2020.103055

    authors: Sangaletti S,Iannelli F,Zanardi F,Cancila V,Portararo P,Botti L,Vacca D,Chiodoni C,Di Napoli A,Valenti C,Rizzello C,Vegliante MC,Pisati F,Gulino A,Ponzoni M,Colombo MP,Tripodo C

    更新日期:2020-11-01 00:00:00

  • Ex-vivo delivery of monoclonal antibody (Rituximab) to treat human donor lungs prior to transplantation.

    abstract:BACKGROUND:Ex-vivo lung perfusion (EVLP) is an innovative platform for assessing donor lungs in the pre-transplant window. In this study, we demonstrate an extension of its utility by administering the anti-CD20 monoclonal antibody, Rituximab, during EVLP. We hypothesized that this would lead to targeted depletion of a...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2020.102994

    authors: Ku TJY,Ribeiro RVP,Ferreira VH,Galasso M,Keshavjee S,Kumar D,Cypel M,Humar A

    更新日期:2020-10-01 00:00:00

  • Modeling polymorphic ventricular tachycardia at rest using patient-specific induced pluripotent stem cell-derived cardiomyocytes.

    abstract:BACKGROUND:While mutations in the cardiac type 2 ryanodine receptor (RyR2) have been linked to exercise-induced or catecholaminergic polymorphic ventricular tachycardia (CPVT), its association with polymorphic ventricular tachycardia (PMVT) occurring at rest is unclear. We aimed at constructing a patient-specific human...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2020.103024

    authors: Sleiman Y,Souidi M,Kumar R,Yang E,Jaffré F,Zhou T,Bernardin A,Reiken S,Cazorla O,Kajava AV,Moreau A,Pasquié JL,Marks AR,Lerman BB,Chen S,Cheung JW,Evans T,Lacampagne A,Meli AC

    更新日期:2020-10-01 00:00:00

  • Therapeutic vulnerabilities in the DNA damage response for the treatment of ATRX mutant neuroblastoma.

    abstract:BACKGROUND:In neuroblastoma, genetic alterations in ATRX, define a distinct poor outcome patient subgroup. Despite the need for new therapies, there is a lack of available models and a dearth of pre-clinical research. METHODS:To evaluate the impact of ATRX loss of function (LoF) in neuroblastoma, we utilized CRISPR-Ca...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2020.102971

    authors: George SL,Lorenzi F,King D,Hartlieb S,Campbell J,Pemberton H,Toprak UH,Barker K,Tall J,da Costa BM,van den Boogaard ML,Dolman MEM,Molenaar JJ,Bryant HE,Westermann F,Lord CJ,Chesler L

    更新日期:2020-09-01 00:00:00

  • The neuropeptide calcitonin gene-related peptide alpha is essential for bone healing.

    abstract:BACKGROUND:Impaired fracture healing represents an ongoing clinical challenge, as treatment options remain limited. Calcitonin gene-related peptide (CGRP), a neuropeptide targeted by emerging anti-migraine drugs, is also expressed in sensory nerve fibres innervating bone tissue. METHOD:Bone healing following a femoral...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2020.102970

    authors: Appelt J,Baranowsky A,Jahn D,Yorgan T,Köhli P,Otto E,Farahani SK,Graef F,Fuchs M,Herrera A,Amling M,Schinke T,Frosch KH,Duda GN,Tsitsilonis S,Keller J

    更新日期:2020-09-01 00:00:00

  • Quantification, epitope mapping and genotype cross-reactivity of hepatitis B preS-specific antibodies in subjects vaccinated with different dosage regimens of BM32.

    abstract:BACKGROUND:Chronic hepatitis B virus (HBV) infections are a global health problem. There is a need for therapeutic strategies blocking continuous infection of liver cells. The grass pollen allergy vaccine BM32 containing the preS domain of the large HBV surface protein (LHBs) as immunogenic carrier induced IgG antibodi...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2020.102953

    authors: Tulaeva I,Cornelius C,Zieglmayer P,Zieglmayer R,Schmutz R,Lemell P,Weber M,Focke-Tejkl M,Karaulov A,Henning R,Valenta R

    更新日期:2020-09-01 00:00:00

  • Prebiotic administration modulates gut microbiota and faecal short-chain fatty acid concentrations but does not prevent chronic intermittent hypoxia-induced apnoea and hypertension in adult rats.

    abstract:BACKGROUND:Evidence is accruing to suggest that microbiota-gut-brain signalling plays a regulatory role in cardiorespiratory physiology. Chronic intermittent hypoxia (CIH), modelling human sleep apnoea, affects gut microbiota composition and elicits cardiorespiratory morbidity. We investigated if treatment with prebiot...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2020.102968

    authors: O'Connor KM,Lucking EF,Bastiaanssen TFS,Peterson VL,Crispie F,Cotter PD,Clarke G,Cryan JF,O'Halloran KD

    更新日期:2020-09-01 00:00:00

  • Kininogen supports inflammation and bacterial spreading during Streptococccus Pyogenes Sepsis.

    abstract:BACKGROUND:High-molecular-weight kininogen is a cofactor of the human contact system, an inflammatory response mechanism that is activated during sepsis. It has been shown that high-molecular-weight kininogen contributes to endotoxemia, but is not critical for local host defense during pneumonia by Gram-negative bacter...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2020.102908

    authors: Köhler J,Maletzki C,Koczan D,Frank M,Springer A,Steffen C,Revenko AS,MacLeod AR,Mikkat S,Kreikemeyer B,Oehmcke-Hecht S

    更新日期:2020-08-01 00:00:00

  • An effective vaginal gel to deliver CRISPR/Cas9 system encapsulated in poly (β-amino ester) nanoparticles for vaginal gene therapy.

    abstract:BACKGROUND:Gene therapy has held promises for treating specific genetic diseases. However, the key to clinical application depends on effective gene delivery. METHODS:Using a large animal model, we developed two pharmaceutical formulations for gene delivery in the pigs' vagina, which were made up of poly (β-amino este...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2020.102897

    authors: Niu G,Jin Z,Zhang C,He D,Gao X,Zou C,Zhang W,Ding J,Das BC,Severinov K,Hitzeroth II,Debata PR,Ma X,Tian X,Gao Q,Wu J,You Z,Tian R,Cui Z,Fan W,Xie W,Huang Z,Cao C,Xu W,Xie H,Xu H,Tang X,Wang Y,Yu Z

    更新日期:2020-08-01 00:00:00

  • Nanoscale regulation of L-type calcium channels differentiates between ischemic and dilated cardiomyopathies.

    abstract:BACKGROUND:Subcellular localization and function of L-type calcium channels (LTCCs) play an important role in regulating contraction of cardiomyocytes. Understanding how this is affected by the disruption of transverse tubules during heart failure could lead to new insights into the disease. METHODS:Cardiomyocytes wer...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2020.102845

    authors: Sanchez-Alonso JL,Loucks A,Schobesberger S,van Cromvoirt AM,Poulet C,Chowdhury RA,Trayanova N,Gorelik J

    更新日期:2020-07-01 00:00:00

  • Tumour budding, poorly differentiated clusters, and T-cell response in colorectal cancer.

    abstract:BACKGROUND:Tumour budding and poorly differentiated clusters (PDC) represent forms of tumour invasion. We hypothesised that T-cell densities (reflecting adaptive anti-tumour immunity) might be inversely associated with tumour budding and PDC in colorectal carcinoma. METHODS:Utilising 915 colon and rectal carcinomas in...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2020.102860

    authors: Fujiyoshi K,Väyrynen JP,Borowsky J,Papke DJ Jr,Arima K,Haruki K,Kishikawa J,Akimoto N,Ugai T,Lau MC,Gu S,Shi S,Zhao M,Da Silva AFL,Twombly TS,Nan H,Meyerhardt JA,Song M,Zhang X,Wu K,Chan AT,Fuchs CS,Lennerz JK

    更新日期:2020-07-01 00:00:00

  • Mitochondria in acute myocardial infarction and cardioprotection.

    abstract::Acute myocardial infarction (AMI) and the heart failure (HF) that often follows are among the leading causes of death and disability worldwide. As such, new treatments are needed to protect the myocardium against the damaging effects of the acute ischaemia and reperfusion injury (IRI) that occurs in AMI, in order to r...

    journal_title:EBioMedicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.ebiom.2020.102884

    authors: Ramachandra CJA,Hernandez-Resendiz S,Crespo-Avilan GE,Lin YH,Hausenloy DJ

    更新日期:2020-07-01 00:00:00

  • Improving B-mode ultrasound diagnostic performance for focal liver lesions using deep learning: A multicentre study.

    abstract:BACKGROUND:The diagnosis performance of B-mode ultrasound (US) for focal liver lesions (FLLs) is relatively limited. We aimed to develop a deep convolutional neural network of US (DCNN-US) for aiding radiologists in classification of malignant from benign FLLs. MATERIALS AND METHODS:This study was conducted in 13 hosp...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2020.102777

    authors: Yang Q,Wei J,Hao X,Kong D,Yu X,Jiang T,Xi J,Cai W,Luo Y,Jing X,Yang Y,Cheng Z,Wu J,Zhang H,Liao J,Zhou P,Song Y,Zhang Y,Han Z,Cheng W,Tang L,Liu F,Dou J,Zheng R,Yu J,Tian J,Liang P

    更新日期:2020-06-01 00:00:00

  • Organoid modelling identifies that DACH1 functions as a tumour promoter in colorectal cancer by modulating BMP signalling.

    abstract:BACKGROUND:Dachshund homologue 1 (DACH1) is highly expressed in LGR5+ intestinal stem cells and colorectal tumours. However, the roles of DACH1 in intestinal cell stemness and colorectal tumorigenesis remain largely undefined. METHODS:We used immunohistochemistry, western blotting and quantitative real-time PCR to ana...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2020.102800

    authors: Hu X,Zhang L,Li Y,Ma X,Dai W,Gao X,Rao X,Fu G,Wang R,Pan M,Guo Q,Xu X,Zhou Y,Gao J,Zhang Z,Cai S,Peng J,Hua G

    更新日期:2020-06-01 00:00:00

  • Long non-coding RNA CDKN2B-AS1 contributes to atherosclerotic plaque formation by forming RNA-DNA triplex in the CDKN2B promoter.

    abstract:BACKGROUND:Atherosclerosis involves a slow process of plaque formation on the walls of arteries, and comprises a leading cause of cardiovascular disease. Long non-coding RNAs (lncRNAs) have been implicated in the pathogenesis of atherosclerosis. In this study, we aim to explore the possible involvement of lncRNA 'cycli...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2020.102694

    authors: Ou M,Li X,Zhao S,Cui S,Tu J

    更新日期:2020-05-01 00:00:00

  • An alternative penicillin-binding protein involved in Salmonella relapses following ceftriaxone therapy.

    abstract:BACKGROUND:Salmonella causes intracellular infections in humans. Besides quinolones, third generation cephalosporins are first line drugs used for salmonellosis therapy. An unresolved anomaly of this practice involves high relapse rates associated to quinolone- or cephalosporin-susceptible Salmonella isolates in patien...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2020.102771

    authors: Castanheira S,López-Escarpa D,Pucciarelli MG,Cestero JJ,Baquero F,García-Del Portillo F

    更新日期:2020-05-01 00:00:00

  • Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients.

    abstract:BACKGROUND:The dynamic changes of lymphocyte subsets and cytokines profiles of patients with novel coronavirus disease (COVID-19) and their correlation with the disease severity remain unclear. METHODS:Peripheral blood samples were longitudinally collected from 40 confirmed COVID-19 patients and examined for lymphocyt...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2020.102763

    authors: Liu J,Li S,Liu J,Liang B,Wang X,Wang H,Li W,Tong Q,Yi J,Zhao L,Xiong L,Guo C,Tian J,Luo J,Yao J,Pang R,Shen H,Peng C,Liu T,Zhang Q,Wu J,Xu L,Lu S,Wang B,Weng Z,Han C,Zhu H,Zhou R,Zhou H,Chen X,

    更新日期:2020-05-01 00:00:00

  • A dysregulated bile acid-gut microbiota axis contributes to obesity susceptibility.

    abstract:BACKGROUND:The composition of the bile acid (BA) pool is closely associated with obesity and is modified by gut microbiota. Perturbations of gut microbiota shape the BA composition, which, in turn, may alter important BA signaling and affect host metabolism. METHODS:We investigated BA composition of high BMI subjects ...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2020.102766

    authors: Wei M,Huang F,Zhao L,Zhang Y,Yang W,Wang S,Li M,Han X,Ge K,Qu C,Rajani C,Xie G,Zheng X,Zhao A,Bian Z,Jia W

    更新日期:2020-05-01 00:00:00

  • Artificial intelligence-assisted prediction of preeclampsia: Development and external validation of a nationwide health insurance dataset of the BPJS Kesehatan in Indonesia.

    abstract:BACKGROUND:We developed and validated an artificial intelligence (AI)-assisted prediction of preeclampsia applied to a nationwide health insurance dataset in Indonesia. METHODS:The BPJS Kesehatan dataset have been preprocessed using a nested case-control design into preeclampsia/eclampsia (n = 3318) and normotensive p...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2020.102710

    authors: Sufriyana H,Wu YW,Su EC

    更新日期:2020-04-01 00:00:00

  • Transcriptional and clonal characterization of B cell plasmablast diversity following primary and secondary natural DENV infection.

    abstract::Antibody-mediated humoral immunity is thought to play a central role in mediating the immunopathogenesis of acute DENV infection, but limited data are available on the diversity, specificity, and functionality of the antibody response at the molecular level elicited by primary or secondary DENV infection. In order to ...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2020.102733

    authors: Waickman AT,Gromowski GD,Rutvisuttinunt W,Li T,Siegfried H,Victor K,Kuklis C,Gomootsukavadee M,McCracken MK,Gabriel B,Mathew A,Grinyo I Escuer A,Fouch ME,Liang J,Fernandez S,Davidson E,Doranz BJ,Srikiatkhachorn A,Endy

    更新日期:2020-04-01 00:00:00

  • A comprehensive analysis of candidate genes in familial pancreatic cancer families reveals a high frequency of potentially pathogenic germline variants.

    abstract:BACKGROUND:The 5-year survival rate of patients with pancreatic ductal adenocarcinoma (PDAC) is around 5% due to the fact that the majority of patients present with advanced disease that is treatment resistant. Familial pancreatic cancer (FPC) is a rare disorder that is defined as a family with at least two affected fi...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2020.102675

    authors: Earl J,Galindo-Pumariño C,Encinas J,Barreto E,Castillo ME,Pachón V,Ferreiro R,Rodríguez-Garrote M,González-Martínez S,Ramon Y Cajal T,Diaz LR,Chirivella-Gonzalez I,Rodriguez M,de Castro EM,García-Seisdedos D,Muñoz G,Rosa

    更新日期:2020-03-01 00:00:00

  • CircRNA-CIDN mitigated compression loading-induced damage in human nucleus pulposus cells via miR-34a-5p/SIRT1 axis.

    abstract:BACKGROUND:Intervertebral disc degeneration (IDD) is a major contributor to lower back pain, however, the molecular and pathogenetic mechanisms underlying IDD are poorly understood. As a high-risk factor for IDD, compression stress was reported to induce apoptosis of nucleus pulposus (NP) cells and extracellular matrix...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2020.102679

    authors: Xiang Q,Kang L,Wang J,Liao Z,Song Y,Zhao K,Wang K,Yang C,Zhang Y

    更新日期:2020-03-01 00:00:00

  • Paracrine and cell autonomous signalling in pancreatic cancer progression and metastasis.

    abstract::Pancreatic ductal adenocarcinoma (PDAC) shows remarkable propensity to metastasize. This predilection to escape from the primary tumor is driven by paracrine and autocrine mechanisms that guide cancer cells through a multi-step process concluding with colonization in distant tissues. Although cell-intrinsic features s...

    journal_title:EBioMedicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.ebiom.2020.102662

    authors: Thomas SK,Lee J,Beatty GL

    更新日期:2020-03-01 00:00:00

  • Bone marrow mesenchymal stem cells combined with ultra-purified alginate gel as a regenerative therapeutic strategy after discectomy for degenerated intervertebral discs.

    abstract:BACKGROUND:Because the regenerative ability of intervertebral discs (IVDs) is restricted, defects caused by discectomy may induce insufficient tissue repair leading to further IVD degeneration. An acellular bioresorbable biomaterial based on ultra-purified alginate (UPAL) gel was developed to fill the IVD cavity and pr...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2020.102698

    authors: Ukeba D,Sudo H,Tsujimoto T,Ura K,Yamada K,Iwasaki N

    更新日期:2020-03-01 00:00:00

  • A panel of five plasma proteins for the early diagnosis of hepatitis B virus-related hepatocellular carcinoma in individuals at risk.

    abstract:BACKGROUND:To improve the early diagnosis of hepatocellular carcinoma (HCC), more effective diagnostic biomarkers are needed. A combination of biomarkers is reported to distinguish individuals with early-stage HCC from at-risk individuals. METHODS:Participants in this study were recruited from six hospitals in China. ...

    journal_title:EBioMedicine

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ebiom.2020.102638

    authors: Cheng K,Shi J,Liu Z,Jia Y,Qin Q,Zhang H,Wan S,Niu Z,Lu L,Sun J,Xue J,Lu C,Wei X,Guo L,Zhang F,Zhou D,Tang Y,Hu Y,Huang Y,Chen Y,Lau WY,Cheng S,Liu S

    更新日期:2020-02-01 00:00:00

  • Metabolite therapy guided by liquid biopsy proteomics delays retinal neurodegeneration.

    abstract:BACKGROUND:Neurodegenerative diseases are incurable disorders caused by progressive neuronal cell death. Retinitis pigmentosa (RP) is a blinding neurodegenerative disease that results in photoreceptor death and progresses to the loss of the entire retinal network. We previously found that proteomic analysis of the adja...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2020.102636

    authors: Wert KJ,Velez G,Kanchustambham VL,Shankar V,Evans LP,Sengillo JD,Zare RN,Bassuk AG,Tsang SH,Mahajan VB

    更新日期:2020-02-01 00:00:00

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