当前位置： SCI文献检索 > EBioMedicine期刊下所有文献 > Artificial intelligence-assisted prediction of preeclampsia: Development and external validation of a nationwide health insurance dataset of the BPJS Kesehatan in Indonesia.

Artificial intelligence-assisted prediction of preeclampsia: Development and external validation of a nationwide health insurance dataset of the BPJS Kesehatan in Indonesia.

Abstract：

BACKGROUND:We developed and validated an artificial intelligence (AI)-assisted prediction of preeclampsia applied to a nationwide health insurance dataset in Indonesia. METHODS:The BPJS Kesehatan dataset have been preprocessed using a nested case-control design into preeclampsia/eclampsia (n = 3318) and normotensive pregnant women (n = 19,883) from all women with one pregnancy. The dataset provided 95 features consisting of demographic variables and medical histories started from 24 months to event and ended by delivery as the event. Six algorithms were compared by area under the receiver operating characteristics curve (AUROC) with a subgroup analysis by time to the event. We compared our model to similar prediction models from systematically reviewed studies. In addition, we conducted a text mining analysis based on natural language processing techniques to interpret our modeling results. FINDINGS:The best model consisted of 17 predictors extracted by a random forest algorithm. Nine∼12 months to the event was the period that had the best AUROC in external validation by either geographical (0.88, 95% confidence interval (CI) 0.88-0.89) or temporal split (0.86, 95% CI 0.85-0.86). We compared this model to prediction models in seven studies from 869 records in PUBMED, EMBASE, and SCOPUS. This model outperformed the previous models in terms of the precision, sensitivity, and specificity in all validation sets. INTERPRETATION:Our low-cost model improved preliminary prediction to decide pregnant women that will be predicted by the models with high specificity and advanced predictors. FUNDING:This work was supported by grant no. MOST108-2221-E-038-018 from the Ministry of Science and Technology of Taiwan.

journal_name

EBioMedicine

journal_title

EBioMedicine

authors

Sufriyana H,Wu YW,Su EC

doi

10.1016/j.ebiom.2020.102710

subject

Has Abstract

pub_date

2020-04-01 00:00:00

pages

102710

issn

2352-3964

pii

S2352-3964(20)30085-2

journal_volume

54

pub_type

杂志文章

相关文献

EBioMedicine文献大全
  • Mitochondria in acute myocardial infarction and cardioprotection.

    abstract：:Acute myocardial infarction (AMI) and the heart failure (HF) that often follows are among the leading causes of death and disability worldwide. As such, new treatments are needed to protect the myocardium against the damaging effects of the acute ischaemia and reperfusion injury (IRI) that occurs in AMI, in order to r...

    journal_title：EBioMedicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ebiom.2020.102884

    authors： Ramachandra CJA,Hernandez-Resendiz S,Crespo-Avilan GE,Lin YH,Hausenloy DJ

    更新日期：2020-07-01 00:00:00

  • Gene signatures of quiescent glioblastoma cells reveal mesenchymal shift and interactions with niche microenvironment.

    abstract：BACKGROUND:Glioblastoma (GBM), a highly malignant brain tumor, invariably recurs after therapy. Quiescent GBM cells represent a potential source of tumor recurrence, but little is known about their molecular underpinnings. METHODS:Patient-derived GBM cells were engineered by CRISPR/Cas9-assisted knock-in of an inducib...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.03.064

    authors： Tejero R,Huang Y,Katsyv I,Kluge M,Lin JY,Tome-Garcia J,Daviaud N,Wang Y,Zhang B,Tsankova NM,Friedel CC,Zou H,Friedel RH

    更新日期：2019-04-01 00:00:00

  • Transcriptomics and Targeted Proteomics Analysis to Gain Insights Into the Immune-control Mechanisms of HIV-1 Infected Elite Controllers.

    abstract：:A small subset of HIV-1 infected individuals, the "Elite Controllers" (EC), can control viral replication and restrain progression to immunodeficiency without antiretroviral therapy (ART). In this study, a cross-sectional transcriptomics and targeted proteomics analysis were performed in a well-defined Swedish cohort ...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2017.11.031

    authors： Zhang W,Ambikan AT,Sperk M,van Domselaar R,Nowak P,Noyan K,Russom A,Sönnerborg A,Neogi U

    更新日期：2018-01-01 00:00:00

  • Impact of the host environment on the antitubercular action of pyrazinamide.

    abstract：:Pyrazinamide remains the only drug in the tuberculosis pharmacopeia to drastically shorten first-line therapy from nine to six months. Due to its unparalleled ability to sterilize non-replicating bacilli and reduce relapse rates, PZA is expected to be irreplaceable in future therapies against tuberculosis. While the m...

    journal_title：EBioMedicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ebiom.2019.10.014

    authors： Lamont EA,Baughn AD

    更新日期：2019-11-01 00:00:00

  • A New Metastatic Lymph Node Classification-based Survival Predicting Model in Patients With Small Bowel Adenocarcinoma: A Derivation and Validation Study.

    abstract：BACKGROUND:Current methods of lymph node (LN) staging are controversial in predicting the survival of SBA. We aimed to develop an alternative LN-classification-based nomogram to individualize SBA prognosis. METHODS:Based on the data from the Surveillance, Epidemiology, and End Results (SEER) database of patients diagn...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2018.05.022

    authors： Wu S,Chen JN,Zhang QW,Tang CT,Zhang XT,Tang MY,Li XB,Ge ZZ

    更新日期：2018-06-01 00:00:00

  • Erythroid Adhesion Molecules in Sickle Cell Anaemia Infants: Insights Into Early Pathophysiology.

    abstract：:Sickle cell anaemia (SCA) results from a single mutation in the β globin gene. It is seldom symptomatic in the first semester of life. We analysed the expression pattern of 9 adhesion molecules on red blood cells, in a cohort of 54 SCA and 17 non-SCA very young infants of comparable age (median 144 days, 81-196). Haem...

    journal_title：EBioMedicine

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.ebiom.2014.12.006

    authors： Brousse V,Colin Y,Pereira C,Arnaud C,Odièvre MH,Boutemy A,Guitton C,de Montalembert M,Lapouméroulie C,Picot J,Le Van Kim C,El Nemer W

    更新日期：2014-12-18 00:00:00

  • Integrated epigenomic profiling reveals endogenous retrovirus reactivation in renal cell carcinoma.

    abstract：BACKGROUND:Transcriptional dysregulation drives cancer formation but the underlying mechanisms are still poorly understood. Renal cell carcinoma (RCC) is the most common malignant kidney tumor which canonically activates the hypoxia-inducible transcription factor (HIF) pathway. Despite intensive study, novel therapeuti...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.01.063

    authors： Siebenthall KT,Miller CP,Vierstra JD,Mathieu J,Tretiakova M,Reynolds A,Sandstrom R,Rynes E,Haugen E,Johnson A,Nelson J,Bates D,Diegel M,Dunn D,Frerker M,Buckley M,Kaul R,Zheng Y,Himmelfarb J,Ruohola-Baker H,Akiles

    更新日期：2019-03-01 00:00:00

  • A miR-567-PIK3AP1-PI3K/AKT-c-Myc feedback loop regulates tumour growth and chemoresistance in gastric cancer.

    abstract：BACKGROUND:Gastric cancer (GC) ranks the fifth most common cancer, and chemotherapy is one of the most common treatments for GC. However, chemoresistance limits the effectiveness of chemotherapy and leads to treatment failure. This study aims to investigate the biological effect of miR-567 on gastric tumourigenesis and...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.05.003

    authors： Zhang F,Li K,Yao X,Wang H,Li W,Wu J,Li M,Zhou R,Xu L,Zhao L

    更新日期：2019-06-01 00:00:00

  • Organoid modelling identifies that DACH1 functions as a tumour promoter in colorectal cancer by modulating BMP signalling.

    abstract：BACKGROUND:Dachshund homologue 1 (DACH1) is highly expressed in LGR5+ intestinal stem cells and colorectal tumours. However, the roles of DACH1 in intestinal cell stemness and colorectal tumorigenesis remain largely undefined. METHODS:We used immunohistochemistry, western blotting and quantitative real-time PCR to ana...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.102800

    authors： Hu X,Zhang L,Li Y,Ma X,Dai W,Gao X,Rao X,Fu G,Wang R,Pan M,Guo Q,Xu X,Zhou Y,Gao J,Zhang Z,Cai S,Peng J,Hua G

    更新日期：2020-06-01 00:00:00

  • Persistence of monocyte activation under treatment in people followed since acute HIV-1 infection relative to participants at high or low risk of HIV infection.

    abstract：BACKGROUND:Interpretation of the increase in certain inflammatory markers in virally suppressed HIV-infected individuals must rely on an appropriate uninfected control group well characterized for non-HIV-related factors that contribute to chronic inflammation, e.g. smoking, alcohol consumption, or being overweight. We...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.103129

    authors： Novelli S,Lécuroux C,Goujard C,Reynes J,Villemant A,Blum L,Essat A,Avettand-Fenoël V,Launay O,Molina JM,Bourgeois C,Meyer L

    更新日期：2020-12-01 00:00:00

  • Sodium Butyrate Inhibits Inflammation and Maintains Epithelium Barrier Integrity in a TNBS-induced Inflammatory Bowel Disease Mice Model.

    abstract：:G Protein Coupled Receptor 109A (GPR109A), which belongs to the G protein coupled receptor family, can be activated by niacin, butyrate, and β-hydroxybutyric acid. Here, we assessed the anti-inflammatory activity of sodium butyrate (SB) on 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis mice, an experimenta...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2018.03.030

    authors： Chen G,Ran X,Li B,Li Y,He D,Huang B,Fu S,Liu J,Wang W

    更新日期：2018-04-01 00:00:00

  • Canonical WNT pathway is activated in the airway epithelium in chronic obstructive pulmonary disease.

    abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is a devastating lung disease, mainly due to cigarette smoking, which represents the third cause of mortality worldwide. The mechanisms driving its epithelial salient features remain largely elusive. We aimed to evaluate the activation and the role of the canonica...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.103034

    authors： Carlier FM,Dupasquier S,Ambroise J,Detry B,Lecocq M,Biétry-Claudet C,Boukala Y,Gala JL,Bouzin C,Verleden SE,Hoton D,Gohy S,Bearzatto B,Pilette C

    更新日期：2020-11-01 00:00:00

  • Exosome Derived From Human Umbilical Cord Mesenchymal Stem Cell Mediates MiR-181c Attenuating Burn-induced Excessive Inflammation.

    abstract：:Mesenchymal stem cell (MSC)-derived exosomes have diverse functions in regulating wound healing and inflammation; however, the molecular mechanism of human umbilical cord MSC (hUCMSC)-derived exosomes in regulating burn-induced inflammation is not well understood. We found that burn injury significantly increased the ...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2016.04.030

    authors： Li X,Liu L,Yang J,Yu Y,Chai J,Wang L,Ma L,Yin H

    更新日期：2016-06-01 00:00:00

  • Development of a preoperative prediction nomogram for lymph node metastasis in colorectal cancer based on a novel serum miRNA signature and CT scans.

    abstract：BACKGROUND:Preoperative prediction of lymph node (LN) status is of crucial importance for appropriate treatment planning in patients with colorectal cancer (CRC). In this study, we sought to develop and validate a non-invasive nomogram model to preoperatively predict LN metastasis in CRC. METHODS:Development of the no...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2018.09.052

    authors： Qu A,Yang Y,Zhang X,Wang W,Liu Y,Zheng G,Du L,Wang C

    更新日期：2018-11-01 00:00:00

  • Vitamin K Dependent Protection of Renal Function in Multi-ethnic Population Studies.

    abstract：BACKGROUND:Following activation by vitamin K (VK), matrix Gla protein (MGP) inhibits arterial calcification, but its role in preserving renal function remains unknown. METHODS:In 1166 white Flemish (mean age, 38.2 years) and 714 South Africans (49.2% black; 40.6 years), we correlated estimated glomerular filtration (e...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2016.01.011

    authors： Wei FF,Drummen NE,Schutte AE,Thijs L,Jacobs L,Petit T,Yang WY,Smith W,Zhang ZY,Gu YM,Kuznetsova T,Verhamme P,Allegaert K,Schutte R,Lerut E,Evenepoel P,Vermeer C,Staessen JA

    更新日期：2016-01-13 00:00:00

  • Quantification, epitope mapping and genotype cross-reactivity of hepatitis B preS-specific antibodies in subjects vaccinated with different dosage regimens of BM32.

    abstract：BACKGROUND:Chronic hepatitis B virus (HBV) infections are a global health problem. There is a need for therapeutic strategies blocking continuous infection of liver cells. The grass pollen allergy vaccine BM32 containing the preS domain of the large HBV surface protein (LHBs) as immunogenic carrier induced IgG antibodi...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.102953

    authors： Tulaeva I,Cornelius C,Zieglmayer P,Zieglmayer R,Schmutz R,Lemell P,Weber M,Focke-Tejkl M,Karaulov A,Henning R,Valenta R

    更新日期：2020-09-01 00:00:00

  • The neuropeptide calcitonin gene-related peptide alpha is essential for bone healing.

    abstract：BACKGROUND:Impaired fracture healing represents an ongoing clinical challenge, as treatment options remain limited. Calcitonin gene-related peptide (CGRP), a neuropeptide targeted by emerging anti-migraine drugs, is also expressed in sensory nerve fibres innervating bone tissue. METHOD:Bone healing following a femoral...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.102970

    authors： Appelt J,Baranowsky A,Jahn D,Yorgan T,Köhli P,Otto E,Farahani SK,Graef F,Fuchs M,Herrera A,Amling M,Schinke T,Frosch KH,Duda GN,Tsitsilonis S,Keller J

    更新日期：2020-09-01 00:00:00

  • Combination of apoptotic T cell induction and self-peptide administration for therapy of experimental autoimmune encephalomyelitis.

    abstract：BACKGROUND:Clinical trials on multiple sclerosis with repeated injections of monoclonal antibodies depleting CD4+ T cells have not resulted in much success as a disease therapy. Here, we developed an immunotherapy for EAE in mice by combining a transient depletion of T cells together with the administration of neuron d...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.05.005

    authors： Kasagi S,Wang D,Zhang P,Zanvit P,Chen H,Zhang D,Li J,Che L,Maruyama T,Nakatsukasa H,Wu R,Jin W,Sun L,Chen W

    更新日期：2019-06-01 00:00:00

  • Diagnostic Performance of Plasma DNA Methylation Profiles in Lung Cancer, Pulmonary Fibrosis and COPD.

    abstract：:Disease-specific alterations of the cell-free DNA methylation status are frequently found in serum samples and are currently considered to be suitable biomarkers. Candidate markers were identified by bisulfite conversion-based genome-wide methylation screening of lung tissue from lung cancer, fibrotic ILD, and COPD. c...

    journal_title：EBioMedicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ebiom.2015.06.025

    authors： Wielscher M,Vierlinger K,Kegler U,Ziesche R,Gsur A,Weinhäusel A

    更新日期：2015-07-02 00:00:00

  • Neurobiological Correlates and Predictors of Two Distinct Personality Trait Pathways to Escalated Alcohol Use.

    abstract：BACKGROUND:The delineation of the behavioral neurobiological mechanisms underlying the heterogeneous pathways for alcohol use disorders (AUDs) is ostensibly imperative for the development of more cost-effective treatments predicated on better understanding of this complex psychopathology. METHODS:1) Forty-eight high a...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2017.11.025

    authors： Shakra MA,Leyton M,Moghnieh H,Pruessner J,Dagher A,Pihl R

    更新日期：2018-01-01 00:00:00

  • Repurposing Cationic Amphiphilic Antihistamines for Cancer Treatment.

    abstract：:Non-small cell lung cancer (NSCLC) is one of the deadliest cancers worldwide. In search for new NSCLC treatment options, we screened a cationic amphiphilic drug (CAD) library for cytotoxicity against NSCLC cells and identified several CAD antihistamines as inducers of lysosomal cell death. We then performed a cohort s...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2016.06.013

    authors： Ellegaard AM,Dehlendorff C,Vind AC,Anand A,Cederkvist L,Petersen NHT,Nylandsted J,Stenvang J,Mellemgaard A,Østerlind K,Friis S,Jäättelä M

    更新日期：2016-07-01 00:00:00

  • EHD1 impairs decidualization by regulating the Wnt4/β-catenin signaling pathway in recurrent implantation failure.

    abstract：BACKGROUND:Recurrent implantation failure (RIF) remains a critical and challenging problem in assisted reproductive technology mainly due to impaired decidualization. The endocytic and transcytotic activity in the endometrium are crucial for decidualization. The most representative endocytic gene is the C-terminal Eps1...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.10.018

    authors： Zhou Q,Yan G,Ding L,Liu J,Yu X,Kong S,Zhang M,Wang Z,Liu Y,Jiang Y,Kong N,Sun J,Sun H

    更新日期：2019-12-01 00:00:00

  • Gut microbiota from colorectal cancer patients enhances the progression of intestinal adenoma in Apcmin/+ mice.

    abstract：BACKGROUND:Accumulating evidence points to a close relationship between gut dysbiosis and colorectal cancer (CRC). As >90% of CRC develop from adenoma, we aimed to investigate the crucial role of imbalanced gut microbiota on the progression of intestinal adenoma. METHODS:The Apcmin/+ mice gavage with phosphate-buffere...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.09.021

    authors： Li L,Li X,Zhong W,Yang M,Xu M,Sun Y,Ma J,Liu T,Song X,Dong W,Liu X,Chen Y,Liu Y,Abla Z,Liu W,Wang B,Jiang K,Cao H

    更新日期：2019-10-01 00:00:00

  • Kininogen supports inflammation and bacterial spreading during Streptococccus Pyogenes Sepsis.

    abstract：BACKGROUND:High-molecular-weight kininogen is a cofactor of the human contact system, an inflammatory response mechanism that is activated during sepsis. It has been shown that high-molecular-weight kininogen contributes to endotoxemia, but is not critical for local host defense during pneumonia by Gram-negative bacter...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.102908

    authors： Köhler J,Maletzki C,Koczan D,Frank M,Springer A,Steffen C,Revenko AS,MacLeod AR,Mikkat S,Kreikemeyer B,Oehmcke-Hecht S

    更新日期：2020-08-01 00:00:00

  • SARS-CoV-2 leads to a small vessel endotheliitis in the heart.

    abstract：BACKGROUND:SARS-CoV-2 infection (COVID-19 disease) can induce systemic vascular involvement contributing to morbidity and mortality. SARS-CoV-2 targets epithelial and endothelial cells through the ACE2 receptor. The anatomical involvement of the coronary tree is not explored yet. METHODS:Cardiac autopsy tissue of the ...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.103182

    authors： Maccio U,Zinkernagel AS,Shambat SM,Zeng X,Cathomas G,Ruschitzka F,Schuepbach RA,Moch H,Varga Z

    更新日期：2021-01-01 00:00:00

  • Modeling polymorphic ventricular tachycardia at rest using patient-specific induced pluripotent stem cell-derived cardiomyocytes.

    abstract：BACKGROUND:While mutations in the cardiac type 2 ryanodine receptor (RyR2) have been linked to exercise-induced or catecholaminergic polymorphic ventricular tachycardia (CPVT), its association with polymorphic ventricular tachycardia (PMVT) occurring at rest is unclear. We aimed at constructing a patient-specific human...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.103024

    authors： Sleiman Y,Souidi M,Kumar R,Yang E,Jaffré F,Zhou T,Bernardin A,Reiken S,Cazorla O,Kajava AV,Moreau A,Pasquié JL,Marks AR,Lerman BB,Chen S,Cheung JW,Evans T,Lacampagne A,Meli AC

    更新日期：2020-10-01 00:00:00

  • Therapeutic vulnerabilities in the DNA damage response for the treatment of ATRX mutant neuroblastoma.

    abstract：BACKGROUND:In neuroblastoma, genetic alterations in ATRX, define a distinct poor outcome patient subgroup. Despite the need for new therapies, there is a lack of available models and a dearth of pre-clinical research. METHODS:To evaluate the impact of ATRX loss of function (LoF) in neuroblastoma, we utilized CRISPR-Ca...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.102971

    authors： George SL,Lorenzi F,King D,Hartlieb S,Campbell J,Pemberton H,Toprak UH,Barker K,Tall J,da Costa BM,van den Boogaard ML,Dolman MEM,Molenaar JJ,Bryant HE,Westermann F,Lord CJ,Chesler L

    更新日期：2020-09-01 00:00:00

  • Emergence of human infection with Jingmen tick virus in China: A retrospective study.

    abstract：BACKGROUND:A tick-borne segmented RNA virus called Jingmen tick virus (JMTV) was recently identified, variants of which were detected in a non-human primate host and fatal patients with Crimean-Congo haemorrhagic fever. We investigated its infectivity and pathogenicity for humans. METHODS:We obtained skin-biopsy, bloo...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.04.004

    authors： Jia N,Liu HB,Ni XB,Bell-Sakyi L,Zheng YC,Song JL,Li J,Jiang BG,Wang Q,Sun Y,Wei R,Yuan TT,Xia LY,Chu YL,Wei W,Li LF,Ye JL,Lv QY,Cui XM,Guan Y,Tong YG,Jiang JF,Lam TT,Cao WC

    更新日期：2019-05-01 00:00:00

  • Patient-specific organotypic blood vessels as an in vitro model for anti-angiogenic drug response testing in renal cell carcinoma.

    abstract：BACKGROUND:Anti-angiogenic treatment failure is often attributed to drug resistance, unsuccessful drug delivery, and tumor heterogeneity. Recent studies have speculated that anti-angiogenic treatments may fail due to characteristics inherent to tumor-associated blood vessels. Tumor-associated blood vessels are phenotyp...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.03.026

    authors： Jiménez-Torres JA,Virumbrales-Muñoz M,Sung KE,Lee MH,Abel EJ,Beebe DJ

    更新日期：2019-04-01 00:00:00

  • Long non-coding RNA CDKN2B-AS1 contributes to atherosclerotic plaque formation by forming RNA-DNA triplex in the CDKN2B promoter.

    abstract：BACKGROUND:Atherosclerosis involves a slow process of plaque formation on the walls of arteries, and comprises a leading cause of cardiovascular disease. Long non-coding RNAs (lncRNAs) have been implicated in the pathogenesis of atherosclerosis. In this study, we aim to explore the possible involvement of lncRNA 'cycli...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.102694

    authors： Ou M,Li X,Zhao S,Cui S,Tu J

    更新日期：2020-05-01 00:00:00