当前位置： SCI文献检索 > EBioMedicine期刊下所有文献 > Improving B-mode ultrasound diagnostic performance for focal liver lesions using deep learning: A multicentre study.

Improving B-mode ultrasound diagnostic performance for focal liver lesions using deep learning: A multicentre study.

Abstract：

BACKGROUND:The diagnosis performance of B-mode ultrasound (US) for focal liver lesions (FLLs) is relatively limited. We aimed to develop a deep convolutional neural network of US (DCNN-US) for aiding radiologists in classification of malignant from benign FLLs. MATERIALS AND METHODS:This study was conducted in 13 hospitals and finally 2143 patients with 24,343 US images were enrolled. Patients who had non-cystic FLLs with pathological results were enrolled. The FLLs from 11 hospitals were randomly divided into training and internal validations (IV) cohorts with a 4:1 ratio for developing and evaluating DCNN-US. Diagnostic performance of the model was verified using external validation (EV) cohort from another two hospitals. The diagnosis value of DCNN-US was compared with that of contrast enhanced computed tomography (CT)/magnetic resonance image (MRI) and 236 radiologists, respectively. FINDINGS:The AUC of ModelLBC for FLLs was 0.924 (95% CI: 0.889-0.959) in the EV cohort. The diagnostic sensitivity and specificity of ModelLBC were superior to 15-year skilled radiologists (86.5% vs 76.1%, p = 0.0084 and 85.5% vs 76.9%, p = 0.0051, respectively). Accuracy of ModelLBC was comparable to that of contrast enhanced CT (both 84.7%) but inferior to contrast enhanced MRI (87.9%) for lesions detected by US. INTERPRETATION:DCNN-US with high sensitivity and specificity in diagnosing FLLs shows its potential to assist less-experienced radiologists in improving their performance and lowering their dependence on sectional imaging in liver cancer diagnosis.

journal_name

EBioMedicine

journal_title

EBioMedicine

authors

Yang Q,Wei J,Hao X,Kong D,Yu X,Jiang T,Xi J,Cai W,Luo Y,Jing X,Yang Y,Cheng Z,Wu J,Zhang H,Liao J,Zhou P,Song Y,Zhang Y,Han Z,Cheng W,Tang L,Liu F,Dou J,Zheng R,Yu J,Tian J,Liang P

doi

10.1016/j.ebiom.2020.102777

subject

Has Abstract

pub_date

2020-06-01 00:00:00

pages

102777

issn

2352-3964

pii

S2352-3964(20)30152-3

journal_volume

56

pub_type

杂志文章

相关文献

EBioMedicine文献大全
  • Artificial intelligence-assisted prediction of preeclampsia: Development and external validation of a nationwide health insurance dataset of the BPJS Kesehatan in Indonesia.

    abstract：BACKGROUND:We developed and validated an artificial intelligence (AI)-assisted prediction of preeclampsia applied to a nationwide health insurance dataset in Indonesia. METHODS:The BPJS Kesehatan dataset have been preprocessed using a nested case-control design into preeclampsia/eclampsia (n = 3318) and normotensive p...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.102710

    authors： Sufriyana H,Wu YW,Su EC

    更新日期：2020-04-01 00:00:00

  • Discovery, validation and sequencing of urinary peptides for diagnosis of liver fibrosis-A multicentre study.

    abstract：BACKGROUND:Liver fibrosis is a consequence of chronic inflammation and is associated with protein changes within the hepatocytes structure. In this study, we aimed to investigate if this is reflected by the urinary proteome and can be explored to diagnose liver fibrosis in patients with chronic liver disease. METHODS:...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.103083

    authors： Bannaga AS,Metzger J,Kyrou I,Voigtländer T,Book T,Melgarejo J,Latosinska A,Pejchinovski M,Staessen JA,Mischak H,Manns MP,Arasaradnam RP

    更新日期：2020-12-01 00:00:00

  • Building the Evidence Base of Blood-Based Biomarkers for Early Detection of Cancer: A Rapid Systematic Mapping Review.

    abstract：BACKGROUND:The Early Cancer Detection Consortium is developing a blood-test to screen the general population for early identification of cancer, and has therefore conducted a systematic mapping review to identify blood-based biomarkers that could be used for early identification of cancer. METHODS:A mapping review wit...

    journal_title：EBioMedicine

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.ebiom.2016.07.004

    authors： Uttley L,Whiteman BL,Woods HB,Harnan S,Philips ST,Cree IA,Early Cancer Detection Consortium.

    更新日期：2016-08-01 00:00:00

  • Large Isoform of Mammalian Relative of DnaJ is a Major Determinant of Human Susceptibility to HIV-1 Infection.

    abstract：:Individual differences in susceptibility to human immunodeficiency virus type 1 (HIV-1) infection have been of interest for decades. We aimed to determine the contribution of large isoform of Mammalian DnaJ (MRJ-L), a HIV-1 Vpr-interacting cellular protein, to this natural variation. Expression of MRJ-L in monocyte-de...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2014.10.002

    authors： Chiang YP,Sheng WH,Shao PL,Chi YH,Chen YM,Huang SW,Shih HM,Chang LY,Lu CY,Chang SC,Hung CC,Huang LM

    更新日期：2014-10-07 00:00:00

  • Elevated microRNA-141-3p in placenta of non-diabetic macrosomia regulate trophoblast proliferation.

    abstract：BACKGROUND:Several studies have reported microRNAs (miRNAs) could regulate the placental development, though the role and mechanism of miRNAs in the development of non-diabetic macrosomia (NDFMS) remains unclear. METHODS:To identify the aberrantly expressed key miRNAs in placenta of NDFMS, we employed a strategy consi...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2018.11.002

    authors： Guo D,Jiang H,Chen Y,Yang J,Fu Z,Li J,Han X,Wu X,Xia Y,Wang X,Chen L,Tang Q,Wu W

    更新日期：2018-12-01 00:00:00

  • Quantification, epitope mapping and genotype cross-reactivity of hepatitis B preS-specific antibodies in subjects vaccinated with different dosage regimens of BM32.

    abstract：BACKGROUND:Chronic hepatitis B virus (HBV) infections are a global health problem. There is a need for therapeutic strategies blocking continuous infection of liver cells. The grass pollen allergy vaccine BM32 containing the preS domain of the large HBV surface protein (LHBs) as immunogenic carrier induced IgG antibodi...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.102953

    authors： Tulaeva I,Cornelius C,Zieglmayer P,Zieglmayer R,Schmutz R,Lemell P,Weber M,Focke-Tejkl M,Karaulov A,Henning R,Valenta R

    更新日期：2020-09-01 00:00:00

  • Transcription factor EB regulates cardiovascular homeostasis.

    abstract：:Cardiovascular diseases (CVDs) are the leading cause of death and a major cause of disability globally. Transcription factor EB (TFEB), as a member of the microphthalmia transcription factor (MITF) family, has been demonstrated to be a master regulator of autophagy and lysosomal biogenesis. Emerging studies suggest th...

    journal_title：EBioMedicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ebiom.2020.103207

    authors： Lu H,Sun J,Hamblin MH,Chen YE,Fan Y

    更新日期：2021-01-01 00:00:00

  • Development and validation of a magnetic resonance imaging-based model for the prediction of distant metastasis before initial treatment of nasopharyngeal carcinoma: A retrospective cohort study.

    abstract：BACKGROUND:We aimed to identify a magnetic resonance imaging (MRI)-based model for assessment of the risk of individual distant metastasis (DM) before initial treatment of nasopharyngeal carcinoma (NPC). METHODS:This retrospective cohort analysis included 176 patients with NPC. Using the PyRadiomics platform, we extra...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.01.013

    authors： Zhang L,Dong D,Li H,Tian J,Ouyang F,Mo X,Zhang B,Luo X,Lian Z,Pei S,Dong Y,Huang W,Liang C,Liu J,Zhang S

    更新日期：2019-02-01 00:00:00

  • Molecular subtyping of cancer and nomination of kinase candidates for inhibition with phosphoproteomics: Reanalysis of CPTAC ovarian cancer.

    abstract：BACKGROUND:Molecular subtyping of cancer aimed to predict patient overall survival (OS) and nominate drug targets for patient treatments is central to precision oncology. Owing to the rapid development of phosphoproteomics, we can now measure thousands of phosphoproteins in human cancer tissues. However, limited studie...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2018.12.039

    authors： Tong M,Yu C,Zhan D,Zhang M,Zhen B,Zhu W,Wang Y,Wu C,He F,Qin J,Li T

    更新日期：2019-02-01 00:00:00

  • Kininogen supports inflammation and bacterial spreading during Streptococccus Pyogenes Sepsis.

    abstract：BACKGROUND:High-molecular-weight kininogen is a cofactor of the human contact system, an inflammatory response mechanism that is activated during sepsis. It has been shown that high-molecular-weight kininogen contributes to endotoxemia, but is not critical for local host defense during pneumonia by Gram-negative bacter...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.102908

    authors： Köhler J,Maletzki C,Koczan D,Frank M,Springer A,Steffen C,Revenko AS,MacLeod AR,Mikkat S,Kreikemeyer B,Oehmcke-Hecht S

    更新日期：2020-08-01 00:00:00

  • Protective role of GPR120 in the maintenance of pregnancy by promoting decidualization via regulation of glucose metabolism.

    abstract：BACKGROUND:Intake of ω-3 PUFAs have been demonstrated to have positive effects on pregnancy outcome, whose receptor, GPR120, regulates several cellular functions including differentiation, metabolism and immune reaction. However, whether GPR120 is involved in decidualization and pregnancy remains unknown. METHODS:Deci...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2018.12.019

    authors： Huang J,Xue M,Zhang J,Yu H,Gu Y,Du M,Ye W,Wan B,Jin M,Zhang Y

    更新日期：2019-01-01 00:00:00

  • O-glycans truncation modulates gastric cancer cell signaling and transcription leading to a more aggressive phenotype.

    abstract：BACKGROUND:Changes in glycosylation are known to play critical roles during gastric carcinogenesis. Expression of truncated O-glycans, such as the Sialyl-Tn (STn) antigen, is a common feature shared by many cancers and is associated with cancer aggressiveness and poor-prognosis. METHODS:Glycoengineered cell lines were...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.01.017

    authors： Freitas D,Campos D,Gomes J,Pinto F,Macedo JA,Matos R,Mereiter S,Pinto MT,Polónia A,Gartner F,Magalhães A,Reis CA

    更新日期：2019-02-01 00:00:00

  • Therapeutic Targeting of Autophagy.

    abstract：:Autophagy is a catabolic process that facilitates nutrient recycling via degradation of damaged organelles and proteins through lysosomal mediated degradation. Alterations in this complex, and tightly regulated process, lead to disease. Autophagy is widely accepted as cytoprotective against neurodegenerative diseases ...

    journal_title：EBioMedicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ebiom.2016.10.034

    authors： Towers CG,Thorburn A

    更新日期：2016-12-01 00:00:00

  • Functional Characterization of Native, High-Affinity GABAA Receptors in Human Pancreatic β Cells.

    abstract：:In human pancreatic islets, the neurotransmitter γ-aminobutyric acid (GABA) is an extracellular signaling molecule synthesized by and released from the insulin-secreting β cells. The effective, physiological GABA concentration range within human islets is unknown. Here we use native GABAA receptors in human islet β ce...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2018.03.014

    authors： Korol SV,Jin Z,Jin Y,Bhandage AK,Tengholm A,Gandasi NR,Barg S,Espes D,Carlsson PO,Laver D,Birnir B

    更新日期：2018-04-01 00:00:00

  • A dysregulated bile acid-gut microbiota axis contributes to obesity susceptibility.

    abstract：BACKGROUND:The composition of the bile acid (BA) pool is closely associated with obesity and is modified by gut microbiota. Perturbations of gut microbiota shape the BA composition, which, in turn, may alter important BA signaling and affect host metabolism. METHODS:We investigated BA composition of high BMI subjects ...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.102766

    authors： Wei M,Huang F,Zhao L,Zhang Y,Yang W,Wang S,Li M,Han X,Ge K,Qu C,Rajani C,Xie G,Zheng X,Zhao A,Bian Z,Jia W

    更新日期：2020-05-01 00:00:00

  • Mild Electrical Stimulation with Heat Shock Reduces Visceral Adiposity and Improves Metabolic Abnormalities in Subjects with Metabolic Syndrome or Type 2 Diabetes: Randomized Crossover Trials.

    abstract：BACKGROUND:The induction of heat shock protein (HSP) 72 by mild electrical stimulation with heat shock (MES + HS), which improves visceral adiposity and insulin resistance in mice, may be beneficial in treating metabolic syndrome (MS) or type 2 diabetes mellitus (T2DM). METHODS:Using open-label crossover trials, 40 su...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2014.11.001

    authors： Kondo T,Ono K,Kitano S,Matsuyama R,Goto R,Suico MA,Kawasaki S,Igata M,Kawashima J,Motoshima H,Matsumura T,Kai H,Araki E

    更新日期：2014-11-11 00:00:00

  • Accumulation of mitochondrial 7S DNA in idiopathic and LRRK2 associated Parkinson's disease.

    abstract：BACKGROUND:Both idiopathic and familial Parkinson's disease are associated with mitochondrial dysfunction. Mitochondria have their own mitochondrial DNA (mtDNA) and previous studies have reported that the release of mtDNA is a biomarker of Parkinson's disease. METHODS:We have now investigated the relationship between ...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.09.015

    authors： Podlesniy P,Puigròs M,Serra N,Fernández-Santiago R,Ezquerra M,Tolosa E,Trullas R

    更新日期：2019-10-01 00:00:00

  • A Single Human Papillomavirus Vaccine Dose Improves B Cell Memory in Previously Infected Subjects.

    abstract：:Although licensed human papillomavirus (HPV) vaccines are most efficacious in persons never infected with HPV, they also reduce infection and disease in previously infected subjects, indicating natural immunity is not entirely protective against HPV re-infection. The aim of this exploratory study was to examine the B ...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2016.06.042

    authors： Scherer EM,Smith RA,Gallego DF,Carter JJ,Wipf GC,Hoyos M,Stern M,Thurston T,Trinklein ND,Wald A,Galloway DA

    更新日期：2016-08-01 00:00:00

  • The Human Glioblastoma Cell Culture Resource: Validated Cell Models Representing All Molecular Subtypes.

    abstract：:Glioblastoma (GBM) is the most frequent and malignant form of primary brain tumor. GBM is essentially incurable and its resistance to therapy is attributed to a subpopulation of cells called glioma stem cells (GSCs). To meet the present shortage of relevant GBM cell (GC) lines we developed a library of annotated and v...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2015.08.026

    authors： Xie Y,Bergström T,Jiang Y,Johansson P,Marinescu VD,Lindberg N,Segerman A,Wicher G,Niklasson M,Baskaran S,Sreedharan S,Everlien I,Kastemar M,Hermansson A,Elfineh L,Libard S,Holland EC,Hesselager G,Alafuzoff I,Westerm

    更新日期：2015-08-15 00:00:00

  • The Effect of Mutations on Drug Sensitivity and Kinase Activity of Fibroblast Growth Factor Receptors: A Combined Experimental and Theoretical Study.

    abstract：:Fibroblast growth factor receptors (FGFRs) are recognized therapeutic targets in cancer. We here describe insights underpinning the impact of mutations on FGFR1 and FGFR3 kinase activity and drug efficacy, using a combination of computational calculations and experimental approaches including cellular studies, X-ray c...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2015.02.009

    authors： Bunney TD,Wan S,Thiyagarajan N,Sutto L,Williams SV,Ashford P,Koss H,Knowles MA,Gervasio FL,Coveney PV,Katan M

    更新日期：2015-03-01 00:00:00

  • Visual Restoration after Cataract Surgery Promotes Functional and Structural Brain Recovery.

    abstract：BACKGROUND:Visual function and brain function decline concurrently with aging. Notably, cataract patients often present with accelerated age-related decreases in brain function, but the underlying mechanisms are still unclear. Optical structures of the anterior segment of the eyes, such as the lens and cornea, can be r...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2018.03.002

    authors： Lin H,Zhang L,Lin D,Chen W,Zhu Y,Chen C,Chan KC,Liu Y,Chen W

    更新日期：2018-04-01 00:00:00

  • Gut microbiota from colorectal cancer patients enhances the progression of intestinal adenoma in Apcmin/+ mice.

    abstract：BACKGROUND:Accumulating evidence points to a close relationship between gut dysbiosis and colorectal cancer (CRC). As >90% of CRC develop from adenoma, we aimed to investigate the crucial role of imbalanced gut microbiota on the progression of intestinal adenoma. METHODS:The Apcmin/+ mice gavage with phosphate-buffere...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.09.021

    authors： Li L,Li X,Zhong W,Yang M,Xu M,Sun Y,Ma J,Liu T,Song X,Dong W,Liu X,Chen Y,Liu Y,Abla Z,Liu W,Wang B,Jiang K,Cao H

    更新日期：2019-10-01 00:00:00

  • Galactosylation and Sialylation Levels of IgG Predict Relapse in Patients With PR3-ANCA Associated Vasculitis.

    abstract：OBJECTIVE:The objective of our study is to investigate the Fc glycosylation profiles of both antigen-specific IgG targeted against proteinase 3 (PR3-ANCA) and total IgG as prognostic markers of relapse in patients with Granulomatosis with Polyangiitis (GPA). METHODS:Seventy-five patients with GPA and a PR3-ANCA rise d...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2017.01.033

    authors： Kemna MJ,Plomp R,van Paassen P,Koeleman CAM,Jansen BC,Damoiseaux JGMC,Cohen Tervaert JW,Wuhrer M

    更新日期：2017-03-01 00:00:00

  • Exercise Increases 24-h Fat Oxidation Only When It Is Performed Before Breakfast.

    abstract：BACKGROUND:As part of the growing lifestyle diversity in modern society, there is wide variation in the time of day individuals choose to exercise. Recent surveys in the US and Japan have reported that on weekdays, more people exercise in the evening, with fewer individuals exercising in the morning or afternoon. Exerc...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2015.10.029

    authors： Iwayama K,Kurihara R,Nabekura Y,Kawabuchi R,Park I,Kobayashi M,Ogata H,Kayaba M,Satoh M,Tokuyama K

    更新日期：2015-10-30 00:00:00

  • Three kinds of corneal host cells contribute differently to corneal neovascularization.

    abstract：BACKGROUND:Corneal neovascularization (angiogenesis and lymphangiogenesis) compromises corneal transparency and transplant survival, however, the molecular mechanisms of corneal host epithelial and stromal cells in neovascularization have not yet been fully elucidated. Furthermore, the contribution and mechanism of cor...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.05.026

    authors： Yu H,Sun L,Cui J,Li Y,Yan Y,Wei X,Wang C,Song F,Jiang W,Liu Y,Ge H,Qian H,Li X,Tang X,Liu P

    更新日期：2019-06-01 00:00:00

  • Base Excision Repair Gene Polymorphisms and Wilms Tumor Susceptibility.

    abstract：:Base excision repair (BER) is the main mechanism to repair endogenous DNA lesions caused by reactive oxygen species. BER deficiency is linked with cancer susceptibility and premature aging. Single nucleotide polymorphisms (SNPs) within BER genes have been implicated in various human malignancies. Nevertheless, a compr...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2018.06.018

    authors： Zhu J,Jia W,Wu C,Fu W,Xia H,Liu G,He J

    更新日期：2018-07-01 00:00:00

  • Anti-Depressant Fluoxetine Reveals its Therapeutic Effect Via Astrocytes.

    abstract：:Although psychotropic drugs act on neurons and glial cells, how glia respond, and whether glial responses are involved in therapeutic effects are poorly understood. Here, we show that fluoxetine (FLX), an anti-depressant, mediates its anti-depressive effect by increasing the gliotransmission of ATP. FLX increased ATP ...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2018.05.036

    authors： Kinoshita M,Hirayama Y,Fujishita K,Shibata K,Shinozaki Y,Shigetomi E,Takeda A,Le HPN,Hayashi H,Hiasa M,Moriyama Y,Ikenaka K,Tanaka KF,Koizumi S

    更新日期：2018-06-01 00:00:00

  • TGFb1 suppresses the activation of distinct dNK subpopulations in preeclampsia.

    abstract：BACKGROUND:Decidual natural killer (dNK) cells are the predominant lymphocytes accumulated at the maternal-fetal interface. Regulatory mechanism of dNK cells in preeclampsia, a gestational complication characterized by high blood pressure and increased proteinuria occurring after 20 weeks pregnancy, is not completely u...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2018.12.015

    authors： Zhang J,Dunk CE,Shynlova O,Caniggia I,Lye SJ

    更新日期：2019-01-01 00:00:00

  • Probiotic With or Without Fiber Controls Body Fat Mass, Associated With Serum Zonulin, in Overweight and Obese Adults-Randomized Controlled Trial.

    abstract：BACKGROUND:The gut microbiota is interlinked with obesity, but direct evidence of effects of its modulation on body fat mass is still scarce. We investigated the possible effects of Bifidobacterium animalisssp. lactis 420 (B420) and the dietary fiber Litesse® Ultra polydextrose (LU) on body fat mass and other obesity-r...

    journal_title：EBioMedicine

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ebiom.2016.10.036

    authors： Stenman LK,Lehtinen MJ,Meland N,Christensen JE,Yeung N,Saarinen MT,Courtney M,Burcelin R,Lähdeaho ML,Linros J,Apter D,Scheinin M,Kloster Smerud H,Rissanen A,Lahtinen S

    更新日期：2016-11-01 00:00:00

  • FoxO3a inhibiting expression of EPS8 to prevent progression of NSCLC: A new negative loop of EGFR signaling.

    abstract：BACKGROUND:The resistance to EGF receptor (EGFR) tyrosine kinase inhibitors (TKI) is a major challenge in the treatment of non-small cell lung cancer (NSCLC). Understanding the molecular mechanisms behind resistance is therefore an important issue. Here we assessed the role of EGFR pathway substrate 8 (EPS8) and Forkhe...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.01.053

    authors： Wen Q,Jiao X,Kuang F,Hou B,Zhu Y,Guo W,Sun G,Ba Y,Yu D,Wang D,Zhang F,Qiao HC,Wang S,Tang S,Qiao H

    更新日期：2019-02-01 00:00:00