当前位置： SCI文献检索 > EBioMedicine期刊下所有文献 > SARS-CoV-2 leads to a small vessel endotheliitis in the heart.

SARS-CoV-2 leads to a small vessel endotheliitis in the heart.

Abstract：

BACKGROUND:SARS-CoV-2 infection (COVID-19 disease) can induce systemic vascular involvement contributing to morbidity and mortality. SARS-CoV-2 targets epithelial and endothelial cells through the ACE2 receptor. The anatomical involvement of the coronary tree is not explored yet. METHODS:Cardiac autopsy tissue of the entire coronary tree (main coronary arteries, epicardial arterioles/venules, epicardial capillaries) and epicardial nerves were analyzed in COVID-19 patients (n = 6). All anatomical regions were immunohistochemically tested for ACE2, TMPRSS2, CD147, CD45, CD3, CD4, CD8, CD68 and IL-6. COVID-19 negative patients with cardiovascular disease (n = 3) and influenza A (n = 6) served as controls. FINDINGS:COVID-19 positive patients showed strong ACE2 / TMPRSS2 expression in capillaries and less in arterioles/venules. The main coronary arteries were virtually devoid of ACE2 receptor and had only mild intimal inflammation. Epicardial capillaries had a prominent lympho-monocytic endotheliitis, which was less pronounced in arterioles/venules. The lymphocytic-monocytic infiltrate strongly expressed CD4, CD45, CD68. Peri/epicardial nerves had strong ACE2 expression and lympho-monocytic inflammation. COVID-19 negative patients showed minimal vascular ACE2 expression and lacked endotheliitis or inflammatory reaction. INTERPRETATION:ACE2 / TMPRSS2 expression and lymphomonocytic inflammation in COVID-19 disease increases crescentically towards the small vessels suggesting that COVID-19-induced endotheliitis is a small vessel vasculitis not involving the main coronaries. The inflammatory neuropathy of epicardial nerves in COVID-19 disease provides further evidence of an angio- and neurotrophic affinity of SARS-COV2 and might potentially contribute to the understanding of the high prevalence of cardiac complications such as myocardial injury and arrhythmias in COVID-19. FUNDING:No external funding was necessary for this study.

journal_name

EBioMedicine

journal_title

EBioMedicine

authors

Maccio U,Zinkernagel AS,Shambat SM,Zeng X,Cathomas G,Ruschitzka F,Schuepbach RA,Moch H,Varga Z

doi

10.1016/j.ebiom.2020.103182

subject

Has Abstract

pub_date

2021-01-01 00:00:00

pages

103182

issn

2352-3964

pii

S2352-3964(20)30558-2

journal_volume

pub_type

杂志文章

在线工具

SARS-CoV-2 leads to a small vessel endotheliitis in the heart.