当前位置： SCI文献检索 > EBioMedicine期刊下所有文献 > The neuropeptide calcitonin gene-related peptide alpha is essential for bone healing.

The neuropeptide calcitonin gene-related peptide alpha is essential for bone healing.

Abstract：

BACKGROUND:Impaired fracture healing represents an ongoing clinical challenge, as treatment options remain limited. Calcitonin gene-related peptide (CGRP), a neuropeptide targeted by emerging anti-migraine drugs, is also expressed in sensory nerve fibres innervating bone tissue. METHOD:Bone healing following a femoral osteotomy stabilized with an external fixator was analysed over 21 days in αCGRP-deficient and WT mice. Bone regeneration was evaluated by serum analysis, µCT analysis, histomorphometry and genome-wide expression analysis. Bone-marrow-derived osteoblasts and osteoclasts, as well as the CGRP antagonist olcegepant were employed for mechanistic studies. FINDINGS:WT mice with a femoral fracture display increased CGRP serum levels. αCGRP mRNA expression after skeletal injury is exclusively induced in callus tissue, but not in other organs. On protein level, CGRP and its receptor, calcitonin receptor-like receptor (CRLR) complexing with RAMP1, are differentially expressed in the callus during bone regeneration. On the other hand, αCGRP-deficient mice display profoundly impaired bone regeneration characterised by a striking reduction in the number of bone-forming osteoblasts and a high rate of incomplete callus bridging and non-union. As assessed by genome-wide expression analysis, CGRP induces the expression of specific genes linked to ossification, bone remodeling and adipogenesis. This suggests that CGRP receptor-dependent PPARγ signaling plays a central role in fracture healing. INTERPRETATION:This study demonstrates an essential role of αCGRP in orchestrating callus formation and identifies CGRP receptor agonism as a potential approach to stimulate bone regeneration. Moreover, as novel agents blocking CGRP or its receptor CRLR are currently introduced clinically for the treatment of migraine disorders, their potential negative impact on bone regeneration warrants clinical investigation. FUNDING:This work was funded by grants from the Else-Kröner-Fresenius-Stiftung (EKFS), the Deutsche Forschungsgemeinschaft (DFG), and the Berlin Institute of Health (BIH).

journal_name

EBioMedicine

journal_title

EBioMedicine

authors

Appelt J,Baranowsky A,Jahn D,Yorgan T,Köhli P,Otto E,Farahani SK,Graef F,Fuchs M,Herrera A,Amling M,Schinke T,Frosch KH,Duda GN,Tsitsilonis S,Keller J

doi

10.1016/j.ebiom.2020.102970

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

102970

issn

2352-3964

pii

S2352-3964(20)30346-7

journal_volume

59

pub_type

杂志文章

相关文献

EBioMedicine文献大全
  • Endothelial FAM3A positively regulates post-ischaemic angiogenesis.

    abstract：BACKGROUND:Angiogenesis improves reperfusion to the ischaemic tissue after vascular obstruction. The underlying molecular mechanisms of post-ischaemic angiogenesis are not clear. FAM3A belongs to the family with sequence similarity 3 (FAM3) genes, but its biological function in endothelial cells in regards to vascular ...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.03.038

    authors： Xu W,Liang M,Zhang Y,Huang K,Wang C

    更新日期：2019-05-01 00:00:00

  • A comprehensive analysis of candidate genes in familial pancreatic cancer families reveals a high frequency of potentially pathogenic germline variants.

    abstract：BACKGROUND:The 5-year survival rate of patients with pancreatic ductal adenocarcinoma (PDAC) is around 5% due to the fact that the majority of patients present with advanced disease that is treatment resistant. Familial pancreatic cancer (FPC) is a rare disorder that is defined as a family with at least two affected fi...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.102675

    authors： Earl J,Galindo-Pumariño C,Encinas J,Barreto E,Castillo ME,Pachón V,Ferreiro R,Rodríguez-Garrote M,González-Martínez S,Ramon Y Cajal T,Diaz LR,Chirivella-Gonzalez I,Rodriguez M,de Castro EM,García-Seisdedos D,Muñoz G,Rosa

    更新日期：2020-03-01 00:00:00

  • Arid1a regulates insulin sensitivity and lipid metabolism.

    abstract：BACKGROUND:Although significant progress has been made in understanding the mechanisms of steatosis and insulin resistance, the physiological functions of the epigenetic regulators in these processes remain largely elusive. METHODS:Hepatocyte-specific Arid1a knockout mice were administrated with high-fat diet (HFD) fo...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.03.021

    authors： Qu YL,Deng CH,Luo Q,Shang XY,Wu JX,Shi Y,Wang L,Han ZG

    更新日期：2019-04-01 00:00:00

  • MiR-652-3p inhibition enhances endothelial repair and reduces atherosclerosis by promoting Cyclin D2 expression.

    abstract：BACKGROUND:Atherosclerosis is a hyperlipidemia-induced condition affecting the arterial wall that damages healthy endothelial cell (EC) function, leading to enhanced risk of atherothrombotic events. Certain microRNAs regulate EC dysfunction in response to hyperlipidemia and may be suitable therapeutic targets to combat...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.01.032

    authors： Huang R,Hu Z,Cao Y,Li H,Zhang H,Su W,Xu Y,Liang L,Melgiri ND,Jiang L

    更新日期：2019-02-01 00:00:00

  • HIV Transmission Networks in the San Diego-Tijuana Border Region.

    abstract：BACKGROUND:HIV sequence data can be used to reconstruct local transmission networks. Along international borders, like the San Diego-Tijuana region, understanding the dynamics of HIV transmission across reported risks, racial/ethnic groups, and geography can help direct effective prevention efforts on both sides of the...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2015.07.024

    authors： Mehta SR,Wertheim JO,Brouwer KC,Wagner KD,Chaillon A,Strathdee S,Patterson TL,Rangel MG,Vargas M,Murrell B,Garfein R,Little SJ,Smith DM

    更新日期：2015-07-18 00:00:00

  • Intratumor Heterogeneity in Primary Kidney Cancer Revealed by Metabolic Profiling of Multiple Spatially Separated Samples within Tumors.

    abstract：:Metabolic alteration constitutes a hallmark of cancer. Glycolysis and antioxidant pathways in kidney cancer are elevated, with frequent mutation of the VHL gene. Intratumor genetic heterogeneity has been recently demonstrated in kidney cancer. However, intratumor metabolic heterogeneity has not been investigated. Here...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2017.04.009

    authors： Okegawa T,Morimoto M,Nishizawa S,Kitazawa S,Honda K,Araki H,Tamura T,Ando A,Satomi Y,Nutahara K,Hara T

    更新日期：2017-05-01 00:00:00

  • Structure-guided development of a high-affinity human Programmed Cell Death-1: Implications for tumor immunotherapy.

    abstract：:Programmed Cell Death-1 (PD-1) is an inhibitory immune receptor, which plays critical roles in T cell co-inhibition and exhaustion upon binding to its ligands PD-L1 and PD-L2. We report the crystal structure of the human PD-1 ectodomain and the mapping of the PD-1 binding interface. Mutagenesis studies confirmed the c...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2017.02.004

    authors： Lázár-Molnár E,Scandiuzzi L,Basu I,Quinn T,Sylvestre E,Palmieri E,Ramagopal UA,Nathenson SG,Guha C,Almo SC

    更新日期：2017-03-01 00:00:00

  • Combination of apoptotic T cell induction and self-peptide administration for therapy of experimental autoimmune encephalomyelitis.

    abstract：BACKGROUND:Clinical trials on multiple sclerosis with repeated injections of monoclonal antibodies depleting CD4+ T cells have not resulted in much success as a disease therapy. Here, we developed an immunotherapy for EAE in mice by combining a transient depletion of T cells together with the administration of neuron d...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.05.005

    authors： Kasagi S,Wang D,Zhang P,Zanvit P,Chen H,Zhang D,Li J,Che L,Maruyama T,Nakatsukasa H,Wu R,Jin W,Sun L,Chen W

    更新日期：2019-06-01 00:00:00

  • Bach1-induced suppression of angiogenesis is dependent on the BTB domain.

    abstract：:The transcription factor Bach1 impairs angiogenesis after ischemic injury by suppressing Wnt/β-catenin signaling; however, the specific domains responsible for the anti-angiogenic effects of Bach1 remain unclear. This study determined the role of the BTB domain of Bach1 in ischemic angiogenesis. Bach1 is highly expres...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.102617

    authors： Jiang L,Jia M,Wei X,Guo J,Hao S,Mei A,Zhi X,Wang X,Li Q,Jin J,Zhang J,Li S,Meng D

    更新日期：2020-01-01 00:00:00

  • Beyond multidrug resistance: Leveraging rare variants with machine and statistical learning models in Mycobacterium tuberculosis resistance prediction.

    abstract：BACKGROUND:The diagnosis of multidrug resistant and extensively drug resistant tuberculosis is a global health priority. Whole genome sequencing of clinical Mycobacterium tuberculosis isolates promises to circumvent the long wait times and limited scope of conventional phenotypic antimicrobial susceptibility, but gaps ...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.04.016

    authors： Chen ML,Doddi A,Royer J,Freschi L,Schito M,Ezewudo M,Kohane IS,Beam A,Farhat M

    更新日期：2019-05-01 00:00:00

  • d-Ribose as a Contributor to Glycated Haemoglobin.

    abstract：:Glycated haemoglobin (HbA1c) is the most important marker of hyperglycaemia in diabetes mellitus. We show that d-ribose reacts with haemoglobin, thus yielding HbA1c. Using mass spectrometry, we detected glycation of haemoglobin with d-ribose produces 10 carboxylmethyllysines (CMLs). The first-order rate constant of fr...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2017.10.001

    authors： Chen X,Su T,Chen Y,He Y,Liu Y,Xu Y,Wei Y,Li J,He R

    更新日期：2017-11-01 00:00:00

  • CUP-AI-Dx: A tool for inferring cancer tissue of origin and molecular subtype using RNA gene-expression data and artificial intelligence.

    abstract：BACKGROUND:Cancer of unknown primary (CUP), representing approximately 3-5% of all malignancies, is defined as metastatic cancer where a primary site of origin cannot be found despite a standard diagnostic workup. Because knowledge of a patient's primary cancer remains fundamental to their treatment, CUP patients are s...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.103030

    authors： Zhao Y,Pan Z,Namburi S,Pattison A,Posner A,Balachander S,Paisie CA,Reddi HV,Rueter J,Gill AJ,Fox S,Raghav KPS,Flynn WF,Tothill RW,Li S,Karuturi RKM,George J

    更新日期：2020-11-01 00:00:00

  • Image-guided surgery of head and neck carcinoma in rabbit models by intra-operatively defining tumour-infiltrated margins and metastatic lymph nodes.

    abstract：BACKGROUND:The infiltrative nature and lymphatic metastasis of head and neck squamous cell carcinoma (HNSCC) are the main reasons leading to its poor prognosis. METHODS:A multimodal surface-enhanced resonance Raman spectroscopy (SERRS) and magnetic resonance (MR) nanoprobe, in which paramagnetic chelators and heptamet...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.10.055

    authors： Sun P,Zhang Y,Li K,Wang C,Zeng F,Zhu J,Wu Y,Tao X

    更新日期：2019-12-01 00:00:00

  • Plasma Circulating Extracellular RNAs in Left Ventricular Remodeling Post-Myocardial Infarction.

    abstract：:Despite substantial declines in mortality following myocardial infarction (MI), subsequent left ventricular remodeling (LVRm) remains a significant long-term complication. Extracellular small non-coding RNAs (exRNAs) have been associated with cardiac inflammation and fibrosis and we hypothesized that they are associat...

    journal_title：EBioMedicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ebiom.2018.05.013

    authors： Danielson KM,Shah R,Yeri A,Liu X,Camacho Garcia F,Silverman M,Tanriverdi K,Das A,Xiao C,Jerosch-Herold M,Heydari B,Abbasi S,Van Keuren-Jensen K,Freedman JE,Wang YE,Rosenzweig A,Kwong RY,Das S

    更新日期：2018-06-01 00:00:00

  • A Broadly Reactive Human Anti-hemagglutinin Stem Monoclonal Antibody That Inhibits Influenza A Virus Particle Release.

    abstract：:Many broadly reactive human monoclonal antibodies against the hemagglutinin (HA) stem of influenza A virus have been developed for therapeutic applications. These antibodies typically inhibit viral entry steps, especially the HA conformational change that is required for membrane fusion. To better understand the mecha...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2017.03.007

    authors： Yamayoshi S,Uraki R,Ito M,Kiso M,Nakatsu S,Yasuhara A,Oishi K,Sasaki T,Ikuta K,Kawaoka Y

    更新日期：2017-03-01 00:00:00

  • Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)-binding Protein (CBP)/β-Catenin Reduces Liver Fibrosis in Mice.

    abstract：:Wnt/β-catenin is involved in every aspect of embryonic development and in the pathogenesis of many human diseases, and is also implicated in organ fibrosis. However, the role of β-catenin-mediated signaling on liver fibrosis remains unclear. To explore this issue, the effects of PRI-724, a selective inhibitor of the c...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2015.10.010

    authors： Osawa Y,Oboki K,Imamura J,Kojika E,Hayashi Y,Hishima T,Saibara T,Shibasaki F,Kohara M,Kimura K

    更新日期：2015-10-08 00:00:00

  • MiR-765 functions as a tumour suppressor and eliminates lipids in clear cell renal cell carcinoma by downregulating PLP2.

    abstract：BACKGROUND:Lipid accumulation has been highlighted in cancer development and progression, but the exact mechanism remains unclear in renal cell carcinoma (RCC). MicroRNAs (miRNAs) have been confirmed to participate in the pathological processes of cancers, including tumour occurrence and inhibition. However, the role a...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.102622

    authors： Xiao W,Wang C,Chen K,Wang T,Xing J,Zhang X,Wang X

    更新日期：2020-01-01 00:00:00

  • Blood Telomere Length Attrition and Cancer Development in the Normative Aging Study Cohort.

    abstract：BACKGROUND:Accelerated telomere shortening may cause cancer via chromosomal instability, making it a potentially useful biomarker. However, publications on blood telomere length (BTL) and cancer are inconsistent. We prospectively examined BTL measures over time and cancer incidence. METHODS:We included 792 Normative A...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2015.04.008

    authors： Hou L,Joyce BT,Gao T,Liu L,Zheng Y,Penedo FJ,Liu S,Zhang W,Bergan R,Dai Q,Vokonas P,Hoxha M,Schwartz J,Baccarelli A

    更新日期：2015-04-13 00:00:00

  • A Vascular Endothelial Growth Factor-Dependent Sprouting Angiogenesis Assay Based on an In Vitro Human Blood Vessel Model for the Study of Anti-Angiogenic Drugs.

    abstract：:Angiogenesis is the formation of new capillaries from pre-existing blood vessels and participates in proper vasculature development. In pathological conditions such as cancer, abnormal angiogenesis takes place. Angiogenesis is primarily carried out by endothelial cells, the innermost layer of blood vessels. The vascul...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2017.12.014

    authors： Pauty J,Usuba R,Cheng IG,Hespel L,Takahashi H,Kato K,Kobayashi M,Nakajima H,Lee E,Yger F,Soncin F,Matsunaga YT

    更新日期：2018-01-01 00:00:00

  • Cell-Mediated Immune Predictors of Vaccine Effect on Viral Load and CD4 Count in a Phase 2 Therapeutic HIV-1 Vaccine Clinical Trial.

    abstract：BACKGROUND:In a placebo-controlled trial of the peptide-based therapeutic HIV-1 p24Gag vaccine candidate Vacc-4x, participants on combination antiretroviral therapy (cART) received six immunizations over 18weeks, followed by analytical treatment interruption (ATI) between weeks 28 and 52. Cell-mediated immune responses...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2017.09.028

    authors： Huang Y,Pantaleo G,Tapia G,Sanchez B,Zhang L,Trondsen M,Hovden AO,Pollard R,Rockstroh J,Ökvist M,Sommerfelt MA

    更新日期：2017-10-01 00:00:00

  • Spontaneous severe hypercholesterolemia and atherosclerosis lesions in rabbits with deficiency of low-density lipoprotein receptor (LDLR) on exon 7.

    abstract：:Rabbits (Oryctolagus cuniculus) have been the very frequently used as animal models in the study of human lipid metabolism and atherosclerosis, because they have similar lipoprotein metabolism to humans. Most of hyperlipidemia and atherosclerosis rabbit models are produced by feeding rabbits a high-cholesterol diet. G...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2018.09.020

    authors： Lu R,Yuan T,Wang Y,Zhang T,Yuan Y,Wu D,Zhou M,He Z,Lu Y,Chen Y,Fan J,Liang J,Cheng Y

    更新日期：2018-10-01 00:00:00

  • Flecainide in Amyotrophic Lateral Sclerosis as a Neuroprotective Strategy (FANS): A Randomized Placebo-Controlled Trial.

    abstract：BACKGROUND:Abnormalities in membrane excitability and Na(+) channel function are characteristic of amyotrophic lateral sclerosis (ALS). We aimed to examine the neuroprotective potential, safety and tolerability of the Na(+) channel blocker and membrane stabiliser flecainide in ALS. METHODS:A double-blind, placebo-cont...

    journal_title：EBioMedicine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.ebiom.2015.11.022

    authors： Park SB,Vucic S,Cheah BC,Lin CS,Kirby A,Mann KP,Zoing MC,Winhammar J,Kiernan MC

    更新日期：2015-12-01 00:00:00

  • Impaired Barrier Function and Autoantibody Generation in Malnutrition Enteropathy in Zambia.

    abstract：:Intestinal damage in malnutrition constitutes a threat to the survival of many thousands of children globally. We studied children in Lusaka, Zambia, with severe acute malnutrition (SAM) and persistent diarrhea using endoscopy, biopsy and analysis of markers and protective proteins in blood and intestinal secretions. ...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2017.07.017

    authors： Amadi B,Besa E,Zyambo K,Kaonga P,Louis-Auguste J,Chandwe K,Tarr PI,Denno DM,Nataro JP,Faubion W,Sailer A,Yeruva S,Brantner T,Murray J,Prendergast AJ,Turner JR,Kelly P

    更新日期：2017-08-01 00:00:00

  • CircRNA-CIDN mitigated compression loading-induced damage in human nucleus pulposus cells via miR-34a-5p/SIRT1 axis.

    abstract：BACKGROUND:Intervertebral disc degeneration (IDD) is a major contributor to lower back pain, however, the molecular and pathogenetic mechanisms underlying IDD are poorly understood. As a high-risk factor for IDD, compression stress was reported to induce apoptosis of nucleus pulposus (NP) cells and extracellular matrix...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.102679

    authors： Xiang Q,Kang L,Wang J,Liao Z,Song Y,Zhao K,Wang K,Yang C,Zhang Y

    更新日期：2020-03-01 00:00:00

  • MicroRNA-196a links human body fat distribution to adipose tissue extracellular matrix composition.

    abstract：BACKGROUND:Abdominal fat mass is associated with metabolic risk whilst gluteal femoral fat is paradoxically protective. MicroRNAs are known to be necessary for adipose tissue formation and function but their role in regulating human fat distribution remains largely unexplored. METHODS:An initial microarray screen of a...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.05.047

    authors： Hilton C,Neville MJ,Wittemans LBL,Todorcevic M,Pinnick KE,Pulit SL,Luan J,Kulyté A,Dahlman I,Wareham NJ,Lotta LA,Arner P,Lindgren CM,Langenberg C,Karpe F

    更新日期：2019-06-01 00:00:00

  • Next Generation DNA Sequencing of Tissues from Infected Diabetic Foot Ulcers.

    abstract：:We used next generation DNA sequencing to profile the microbiome of infected Diabetic Foot Ulcers (DFUs). The microbiota was correlated to clinical parameters and treatment outcomes to determine if directed antimicrobial therapy based on conventional microbiological cultures are relevant based on genomic analysis. Pat...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2017.06.026

    authors： Malone M,Johani K,Jensen SO,Gosbell IB,Dickson HG,Hu H,Vickery K

    更新日期：2017-07-01 00:00:00

  • Two years of treatment with the recombinant grass pollen allergy vaccine BM32 induces a continuously increasing allergen-specific IgG4 response.

    abstract：BACKGROUND:BM32, a grass pollen allergy vaccine containing four recombinant fusion proteins consisting of hepatitis B-derived PreS and hypoallergenic peptides from the major timothy grass pollen allergens adsorbed on aluminium hydroxide has been shown to be safe and to improve clinical symptoms of grass pollen allergy ...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.11.006

    authors： Eckl-Dorna J,Weber M,Stanek V,Linhart B,Ristl R,Waltl EE,Villazala-Merino S,Hummel A,Focke-Tejkl M,Froeschel R,Neubauer A,Henning R,Perkmann T,Valenta R,Niederberger V

    更新日期：2019-12-01 00:00:00

  • Emergence of human infection with Jingmen tick virus in China: A retrospective study.

    abstract：BACKGROUND:A tick-borne segmented RNA virus called Jingmen tick virus (JMTV) was recently identified, variants of which were detected in a non-human primate host and fatal patients with Crimean-Congo haemorrhagic fever. We investigated its infectivity and pathogenicity for humans. METHODS:We obtained skin-biopsy, bloo...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.04.004

    authors： Jia N,Liu HB,Ni XB,Bell-Sakyi L,Zheng YC,Song JL,Li J,Jiang BG,Wang Q,Sun Y,Wei R,Yuan TT,Xia LY,Chu YL,Wei W,Li LF,Ye JL,Lv QY,Cui XM,Guan Y,Tong YG,Jiang JF,Lam TT,Cao WC

    更新日期：2019-05-01 00:00:00

  • Exosome Derived From Human Umbilical Cord Mesenchymal Stem Cell Mediates MiR-181c Attenuating Burn-induced Excessive Inflammation.

    abstract：:Mesenchymal stem cell (MSC)-derived exosomes have diverse functions in regulating wound healing and inflammation; however, the molecular mechanism of human umbilical cord MSC (hUCMSC)-derived exosomes in regulating burn-induced inflammation is not well understood. We found that burn injury significantly increased the ...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2016.04.030

    authors： Li X,Liu L,Yang J,Yu Y,Chai J,Wang L,Ma L,Yin H

    更新日期：2016-06-01 00:00:00

  • CRISPR/Cas9 - Mediated Precise Targeted Integration In Vivo Using a Double Cut Donor with Short Homology Arms.

    abstract：:Precisely targeted genome editing is highly desired for clinical applications. However, the widely used homology-directed repair (HDR)-based genome editing strategies remain inefficient for certain in vivo applications. We here demonstrate a microhomology-mediated end-joining (MMEJ)-based strategy for precisely target...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2017.05.015

    authors： Yao X,Wang X,Liu J,Hu X,Shi L,Shen X,Ying W,Sun X,Wang X,Huang P,Yang H

    更新日期：2017-06-01 00:00:00