Mitochondria in acute myocardial infarction and cardioprotection.

abstract：BACKGROUND:Ex-vivo lung perfusion (EVLP) is an innovative platform for assessing donor lungs in the pre-transplant window. In this study, we demonstrate an extension of its utility by administering the anti-CD20 monoclonal antibody, Rituximab, during EVLP. We hypothesized that this would lead to targeted depletion of a...

journal_title：EBioMedicine

authors： Ku TJY,Ribeiro RVP,Ferreira VH,Galasso M,Keshavjee S,Kumar D,Cypel M,Humar A

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Urea, the end product of protein metabolism, has been considered to have negligible toxicity for a long time. Our previous study showed a depression phenotype in urea transporter (UT) B knockout mice, which suggests that abnormal urea metabolism may cause depression. The purpose of this study was to determin...

journal_title：EBioMedicine

authors： Wang H,Huang B,Wang W,Li J,Chen Y,Flynn T,Zhao M,Zhou Z,Lin X,Zhang Y,Xu M,Li K,Tian K,Yuan D,Zhou P,Hu L,Zhong D,Zhu S,Li J,Chen D,Wang K,Liang J,He Q,Sun J,Shi J,Yan L,Sands JM,Xie Z,Lian X,Xu

更新日期：2019-10-01 00:00:00

abstract：:Lysophosphatidic acid receptor 1 (LPA1) is a druggable target for treating pulmonary inflammatory diseases. However, the molecular regulation of LPA1 stability, a factor that critically impacts its biological activity, remains largely unknown. Here we identify two enzymes that regulate the balance of LPA1 ubiquitinati...

journal_title：EBioMedicine

authors： Zhao J,Wei J,Dong S,Bowser RK,Zhang L,Jacko AM,Zhao Y

更新日期：2016-08-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) shows remarkable propensity to metastasize. This predilection to escape from the primary tumor is driven by paracrine and autocrine mechanisms that guide cancer cells through a multi-step process concluding with colonization in distant tissues. Although cell-intrinsic features s...

journal_title：EBioMedicine

authors： Thomas SK,Lee J,Beatty GL

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Psoriasis is a common chronic inflammatory skin disease which lacks effective strategies for the treatment. Natural compounds with biological activities are good tools to identify new targets with therapeutic potentials. Acetyl-11-keto-β-boswellic acid (AKBA) is the most bioactive ingredient of boswellic aci...

journal_title：EBioMedicine

authors： Bai J,Gao Y,Chen L,Yin Q,Lou F,Wang Z,Xu Z,Zhou H,Li Q,Cai W,Sun Y,Niu L,Wang H,Wei Z,Lu S,Zhou A,Zhang J,Wang H

更新日期：2019-01-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a major cause of death and disability worldwide, especially in children and young adults. TBI is an example of a medical condition where there are still major lacks in diagnostics and outcome prediction. Here we apply comprehensive metabolic profiling of serum samples from TBI patients ...

journal_title：EBioMedicine

authors： Orešič M,Posti JP,Kamstrup-Nielsen MH,Takala RSK,Lingsma HF,Mattila I,Jäntti S,Katila AJ,Carpenter KLH,Ala-Seppälä H,Kyllönen A,Maanpää HR,Tallus J,Coles JP,Heino I,Frantzén J,Hutchinson PJ,Menon DK,Tenovuo O,Hyötyl

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Following activation by vitamin K (VK), matrix Gla protein (MGP) inhibits arterial calcification, but its role in preserving renal function remains unknown. METHODS:In 1166 white Flemish (mean age, 38.2 years) and 714 South Africans (49.2% black; 40.6 years), we correlated estimated glomerular filtration (e...

journal_title：EBioMedicine

authors： Wei FF,Drummen NE,Schutte AE,Thijs L,Jacobs L,Petit T,Yang WY,Smith W,Zhang ZY,Gu YM,Kuznetsova T,Verhamme P,Allegaert K,Schutte R,Lerut E,Evenepoel P,Vermeer C,Staessen JA

更新日期：2016-01-13 00:00:00

abstract：BACKGROUND:Huntington's Disease (HD) is caused by an abnormality in the HTT gene. This gene includes trinucleotide repeats ranging from 10 to 35, and when expanded beyond 39, causes HD. We previously reported that CAG repeats in the normal range had a direct and beneficial effect on brain development with higher repeat...

journal_title：EBioMedicine

authors： Lee JK,Conrad A,Epping E,Mathews K,Magnotta V,Dawson JD,Nopoulos P

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Non-small cell lung carcinomas (NSCLC) are prevalent, lethal cancers with especially grim prospects due to late-stage detection and chemoresistance. Circular RNAs (circRNAs) are non-coding RNAs that participate in tumor development. However, the role of circRNAs in NSCLC is not well known. This study investi...

journal_title：EBioMedicine

authors： Wei S,Zheng Y,Jiang Y,Li X,Geng J,Shen Y,Li Q,Wang X,Zhao C,Chen Y,Qian Z,Zhou J,Li W

更新日期：2019-06-01 00:00:00

abstract：:G Protein Coupled Receptor 109A (GPR109A), which belongs to the G protein coupled receptor family, can be activated by niacin, butyrate, and β-hydroxybutyric acid. Here, we assessed the anti-inflammatory activity of sodium butyrate (SB) on 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis mice, an experimenta...

journal_title：EBioMedicine

authors： Chen G,Ran X,Li B,Li Y,He D,Huang B,Fu S,Liu J,Wang W

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Human endogenous retroviruses HERV-W encode a pro-inflammatory protein, named MSRV-Env from its original identification in Multiple Sclerosis. Though not detected in various neurological controls, MSRV-Env was found in patients with chronic inflammatory demyelinating polyradiculoneuropathies (CIDPs). This st...

journal_title：EBioMedicine

authors： Faucard R,Madeira A,Gehin N,Authier FJ,Panaite PA,Lesage C,Burgelin I,Bertel M,Bernard C,Curtin F,Lang AB,Steck AJ,Perron H,Kuntzer T,Créange A

更新日期：2016-04-01 00:00:00

abstract：:In human pancreatic islets, the neurotransmitter γ-aminobutyric acid (GABA) is an extracellular signaling molecule synthesized by and released from the insulin-secreting β cells. The effective, physiological GABA concentration range within human islets is unknown. Here we use native GABAA receptors in human islet β ce...

journal_title：EBioMedicine

authors： Korol SV,Jin Z,Jin Y,Bhandage AK,Tengholm A,Gandasi NR,Barg S,Espes D,Carlsson PO,Laver D,Birnir B

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Non-invasive lung adenocarcinoma could benefit from limited resection, nonetheless, there is a lack of method to determine preoperative tumour invasiveness. We aimed to investigate whether folate receptor-positive circulating tumour cells (FR+-CTCs) in combination with maximum tumour diameter (MTD) determine...

journal_title：EBioMedicine

authors： Zhou Q,Geng Q,Wang L,Huang J,Liao M,Li Y,Ding Z,Yang S,Zhao H,Shen Q,Pan C,Lou J,Lu S,Chen C,Luo Q

更新日期：2019-03-01 00:00:00

abstract：PURPOSE:We present a systematic screening for identifying associations between prescribed drugs and cancer risk using the high quality Danish nationwide health registries. METHODS:We identified all patients (cases) with incident cancer in Denmark during 2000-2012 (n=278,485) and matched each case to 10 controls. Compl...

journal_title：EBioMedicine

authors： Pottegård A,Friis S,Christensen Rd,Habel LA,Gagne JJ,Hallas J

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Intra-tumour heterogeneity in lymphoid malignancies encompasses selection of genetic events and epigenetic regulation of transcriptional programs. Clonal-related neoplastic cell populations are unsteadily subjected to immune editing and metabolic adaptations within different tissue microenvironments. How tis...

journal_title：EBioMedicine

authors： Sangaletti S,Iannelli F,Zanardi F,Cancila V,Portararo P,Botti L,Vacca D,Chiodoni C,Di Napoli A,Valenti C,Rizzello C,Vegliante MC,Pisati F,Gulino A,Ponzoni M,Colombo MP,Tripodo C

更新日期：2020-11-01 00:00:00

abstract：:Anti-retroviral therapy successfully suppresses HIV-1 infection, but fails to provide a cure. During infection Type 1 IFNs normally play an essential role in viral clearance, but in vivo IFN-α only has a modest impact on HIV-1 infection, suggesting its possible targeting by HIV. Here, we report that the HIV protein, V...

journal_title：EBioMedicine

authors： Gargan S,Ahmed S,Mahony R,Bannan C,Napoletano S,O'Farrelly C,Borrow P,Bergin C,Stevenson NJ

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Individuals of low socioeconomic status experience a disproportionate burden of chronic conditions; however it is unclear whether chronic condition burden affects survival differently across socioeconomic strata. METHODS:This retrospective cohort study used health administrative data from all residents of O...

journal_title：EBioMedicine

authors： Lane NE,Maxwell CJ,Gruneir A,Bronskill SE,Wodchis WP

更新日期：2015-11-18 00:00:00

abstract：BACKGROUND:Marketing authorization holders (MAHs) are obligated to report adverse events (AEs) within 15 days (some cases 30 days) to the Pharmaceuticals and Medical Devices Agency (PMDA) of Japan. METHODS:To analyze the timeliness of AE reporting to the PMDA, 6610 reports for five categories of cardiovascular devices...

journal_title：EBioMedicine

authors： Handa N,Ishii K,Matsui Y,Ando Y

更新日期：2015-07-10 00:00:00

abstract：BACKGROUND:Neurodegenerative diseases are incurable disorders caused by progressive neuronal cell death. Retinitis pigmentosa (RP) is a blinding neurodegenerative disease that results in photoreceptor death and progresses to the loss of the entire retinal network. We previously found that proteomic analysis of the adja...

journal_title：EBioMedicine

authors： Wert KJ,Velez G,Kanchustambham VL,Shankar V,Evans LP,Sengillo JD,Zare RN,Bassuk AG,Tsang SH,Mahajan VB

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Abdominal fat mass is associated with metabolic risk whilst gluteal femoral fat is paradoxically protective. MicroRNAs are known to be necessary for adipose tissue formation and function but their role in regulating human fat distribution remains largely unexplored. METHODS:An initial microarray screen of a...

journal_title：EBioMedicine

authors： Hilton C,Neville MJ,Wittemans LBL,Todorcevic M,Pinnick KE,Pulit SL,Luan J,Kulyté A,Dahlman I,Wareham NJ,Lotta LA,Arner P,Lindgren CM,Langenberg C,Karpe F

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:The resistance to EGF receptor (EGFR) tyrosine kinase inhibitors (TKI) is a major challenge in the treatment of non-small cell lung cancer (NSCLC). Understanding the molecular mechanisms behind resistance is therefore an important issue. Here we assessed the role of EGFR pathway substrate 8 (EPS8) and Forkhe...

journal_title：EBioMedicine

authors： Wen Q,Jiao X,Kuang F,Hou B,Zhu Y,Guo W,Sun G,Ba Y,Yu D,Wang D,Zhang F,Qiao HC,Wang S,Tang S,Qiao H

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Colistin resistance mediated by mcr-1-harbouring plasmids is an emerging threat in Enterobacteriaceae, like Salmonella. Based on its major contribution to the diarrhoea burden, the epidemic state and threat of mcr-1-harbouring Salmonella in community-acquired infections should be estimated. METHODS:This ret...

journal_title：EBioMedicine

authors： Lu X,Zeng M,Xu J,Zhou H,Gu B,Li Z,Jin H,Wang X,Zhang W,Hu Y,Xiao W,Zhu B,Xu X,Kan B

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Dupuytren's disease is a common fibrotic condition of the hand that causes irreversible flexion contractures of the fingers, with no approved therapy for early stage disease. Our previous analysis of surgically-excised tissue defined tumour necrosis factor (TNF) as a potential therapeutic target. Here we ass...

journal_title：EBioMedicine

authors： Nanchahal J,Ball C,Davidson D,Williams L,Sones W,McCann FE,Cabrita M,Swettenham J,Cahoon NJ,Copsey B,Anne Francis E,Taylor PC,Black J,Barber VS,Dutton S,Feldmann M,Lamb SE

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Platelet Derived Growth Factor Receptor beta (PDGFRβ) has been associated to hepatic stellate cell activation and has been the target of multiple therapeutic studies. However, little is known concerning its use as a diagnostic agent. METHODS:Circulating PDGFRβ levels were analysed in a cohort of patients wi...

journal_title：EBioMedicine

authors： Lambrecht J,Verhulst S,Mannaerts I,Sowa JP,Best J,Canbay A,Reynaert H,van Grunsven LA

更新日期：2019-05-01 00:00:00

abstract：:This study aimed to develop and validate a prognostic nomogram for recurrence-free survival (RFS) after surgery in the absence of adjuvant therapy to guide the selection for adjuvant imatinib therapy based on Residual Neural Network (ResNet). The ResNet model was developed based on contrast-enhanced computed tomograph...

journal_title：EBioMedicine

authors： Chen T,Liu S,Li Y,Feng X,Xiong W,Zhao X,Yang Y,Zhang C,Hu Y,Chen H,Lin T,Zhao M,Liu H,Yu J,Xu Y,Zhang Y,Li G

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Gene therapy has held promises for treating specific genetic diseases. However, the key to clinical application depends on effective gene delivery. METHODS:Using a large animal model, we developed two pharmaceutical formulations for gene delivery in the pigs' vagina, which were made up of poly (β-amino este...

journal_title：EBioMedicine

authors： Niu G,Jin Z,Zhang C,He D,Gao X,Zou C,Zhang W,Ding J,Das BC,Severinov K,Hitzeroth II,Debata PR,Ma X,Tian X,Gao Q,Wu J,You Z,Tian R,Cui Z,Fan W,Xie W,Huang Z,Cao C,Xu W,Xie H,Xu H,Tang X,Wang Y,Yu Z

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Dachshund homologue 1 (DACH1) is highly expressed in LGR5+ intestinal stem cells and colorectal tumours. However, the roles of DACH1 in intestinal cell stemness and colorectal tumorigenesis remain largely undefined. METHODS:We used immunohistochemistry, western blotting and quantitative real-time PCR to ana...

journal_title：EBioMedicine

authors： Hu X,Zhang L,Li Y,Ma X,Dai W,Gao X,Rao X,Fu G,Wang R,Pan M,Guo Q,Xu X,Zhou Y,Gao J,Zhang Z,Cai S,Peng J,Hua G

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Undernutrition is a serious global problem that contributes to increased child morbidity and mortality, impaired neurocognitive development, and decreased educational and economic attainment. Current interventions are only marginally effective, and identification of associated metabolic pathways can offer ne...

journal_title：EBioMedicine

authors： Moreau GB,Ramakrishnan G,Cook HL,Fox TE,Nayak U,Ma JZ,Colgate ER,Kirkpatrick BD,Haque R,Petri WA Jr

更新日期：2019-06-01 00:00:00

abstract：:Chronic kidney disease (CKD) is a global health problem, and novel therapies to treat CKD are urgently needed. Here, we show that inhibition of G0/G1 switch 2 (G0s2) ameliorates renal inflammation in a mouse model of CKD. Renal expression of chemokine (C-C motif) ligand 2 (Ccl2) was increased in response to p65 activa...

journal_title：EBioMedicine

authors： Matsunaga N,Ikeda E,Kakimoto K,Watanabe M,Shindo N,Tsuruta A,Ikeyama H,Hamamura K,Higashi K,Yamashita T,Kondo H,Yoshida Y,Matsuda M,Ogino T,Tokushige K,Itcho K,Furuichi Y,Nakao T,Yasuda K,Doi A,Amamoto T,Aramaki

更新日期：2016-11-01 00:00:00

abstract：:Environmental exposure early in development plays a role in susceptibility to disease in later life. Here, we demonstrate that prolonged febrile seizures induced by exposure of rat pups to a hyperthermic environment enhance seizure susceptibility not only in these hyperthermia-treated rats but also in their future off...

journal_title：EBioMedicine

authors： Wu D,Feng B,Dai Y,Wu X,Chen B,Xu C,Tang Y,Wang K,Zhang S,Wang S,Luo B,Chen Z

更新日期：2017-03-01 00:00:00