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Paracrine and cell autonomous signalling in pancreatic cancer progression and metastasis.

Abstract：

:Pancreatic ductal adenocarcinoma (PDAC) shows remarkable propensity to metastasize. This predilection to escape from the primary tumor is driven by paracrine and autocrine mechanisms that guide cancer cells through a multi-step process concluding with colonization in distant tissues. Although cell-intrinsic features support the metastatic ability of cancer cells, permissive microenvironments within the primary organ and at sites of distant metastasis may be rate-limiting. Identification of cancer cell-extrinsic factors that regulate formation of these environments lend new therapeutic targets for intervening on the metastatic cascade. In addition, the bipolar, yet fundamental, role of the immune system in the metastatic process presents therapeutic opportunities. Herein, we review the current knowledge of the metastatic cascade in PDAC, and propose that genomically stable determinants of metastasis (e.g. the pro-metastatic niche and immune system) are actionable targets for preventing, containing, and treating metastasis in PDAC.

journal_name

EBioMedicine

journal_title

EBioMedicine

authors

Thomas SK,Lee J,Beatty GL

doi

10.1016/j.ebiom.2020.102662

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

102662

issn

2352-3964

pii

S2352-3964(20)30037-2

journal_volume

53

pub_type

杂志文章,评审

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