abstract：:Montelukast is a leukotriene receptor antagonist that is known to prevent allergic rhinitis and asthma. Blocking the Cysteinyl leukotrienes receptor (CysLTR1), one of the primary receptors of leukotrienes, has been demonstrated to be efficacious in ameliorating experimental autoimmune encephalomyelitis (EAE), an anima...

journal_title：Immunology

authors： Han B,Zhang YY,Ye ZQ,Xiao Y,Rasouli J,Wu WC,Ye SM,Guo XY,Zhu L,Rostami A,Wang LB,Zhang Y,Li X

更新日期：2021-01-22 00:00:00

abstract：:Excessive and dysregulated inflammation is known to contribute to disease progression. HSP90 is an intracellular chaperone known to regulate inflammatory processes including the NLRP3 inflammasome and secretion of the pro-inflammatory cytokine interleukin(IL)-1β. Here, primarily using an in vitro inflammasome ASC spec...

journal_title：Immunology

authors： Nizami S,Arunasalam K,Green J,Cook J,Lawrence CB,Zarganes-Tzitzikas T,Davis JB,Di Daniel E,Brough D

更新日期：2021-01-01 00:00:00

abstract：:Killer cell immunoglobulin-like receptors (KIRs) interact with polymorphic human leucocyte antigen (HLA) class I molecules, modulating natural killer (NK) cell functions and affecting both the susceptibility and outcome of immune-mediated diseases. The KIR locus is highly diverse in gene content, copy number and allel...

journal_title：Immunology

authors： Tao S,Kichula KM,Harrison GF,Farias TDJ,Palmer WH,Leaton LA,Hajar CGN,Zefarina Z,Edinur HA,Zhu F,Norman PJ

更新日期：2020-12-06 00:00:00

abstract：:B lymphocyte-induced maturation protein-1 (Blimp-1), the transcription factor encoded by the gene Prdm1, plays a number of crucial roles in the adaptive immune system, which result in the maintenance of key effector functions of B- and T-cells. Emerging clinical data, as well as mechanistic evidence from mouse studies...

journal_title：Immunology

authors： Ulmert I,Henriques-Oliveira L,Pereira CF,Lahl K

更新日期：2020-12-01 00:00:00

abstract：:Group 2 innate lymphoid cells (ILC2s) are an important component of the innate immune system that execute important effector functions at barrier surfaces, such as lung and skin. Like T helper type 2 cells, ILC2s are able to release high amounts of type 2 cytokines that are essential in inducing allergic inflammation ...

journal_title：Immunology

authors： Lei A,He Y,Yang Q,Li X,Li R

更新日期：2020-09-01 00:00:00

abstract：:Adoptive transfer of T-cells is a promising therapy for many cancers. To enhance tumour recognition by T-cells, chimeric antigen receptors (CARs) consisting of signalling domains fused to receptors that recognize tumour-associated antigens can be expressed in T-cells. While CAR T-cells have shown clinical success for ...

journal_title：Immunology

authors： Parriott G,Deal K,Crean S,Richardson E,Nylen E,Barber A

更新日期：2020-07-01 00:00:00

abstract：:The liver is a front-line immune tissue that plays a major role in the detection, capture and clearance of pathogens and foreign antigens entering the bloodstream, especially from the gut. Our largest internal organ maintains this immune barrier in the face of constant exposure to external but harmless antigens throug...

journal_title：Immunology

authors： Stamataki Z,Swadling L

更新日期：2020-06-01 00:00:00

abstract：:Signaling by Kit has been extensively studied in hematopoietic cells and is essential for the survival, proliferation and maintenance of hematopoietic stem and progenitor cells. In addition to the activation of intrinsic signaling pathways, Kit has been shown to interact with lineage-restricted type I cytokine recepto...

journal_title：Immunology

authors： Sethumadhavan A,Mani M

更新日期：2020-04-01 00:00:00

abstract：:Monocyte-derived macrophages (MDMs) generated from peripheral blood monocytes are widely used to model human macrophages for in vitro studies. However, the possible impact of different isolation methods on the resulting MDM phenotype is poorly described. We aimed to investigate the effects of three commonly used monoc...

journal_title：Immunology

authors： Nielsen MC,Andersen MN,Møller HJ

更新日期：2020-01-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune chronic inflammatory disease of unknown etiology, although genetic and environmental factors appear to contribute to its pathogenesis. Specifically, infectious processes are associated with SLE onset and exacerbation. However, we are far from a complete understanding...

journal_title：Immunology

authors： Illescas-Montes R,Corona-Castro CC,Melguizo-Rodríguez L,Ruiz C,Costela-Ruiz VJ

更新日期：2019-11-01 00:00:00

abstract：:Studies with gene-deficient and gnotobiotic mice have identified many host and microbial factors that contribute to induced colitis, but information on whether specific factors determine susceptibility under more physiological conditions is lacking. Using wild-type strains that differ in their IgA response but harbor ...

journal_title：Immunology

authors： Gupta S,Basu S,Bal V,Rath S,George A

更新日期：2019-09-01 00:00:00

abstract：:Down-regulated chemerin expression has been reported to correlate with poor prognosis of several types of cancer including melanoma. All-trans retinoic acid (atRA) is a potent inducer of chemerin, and we previously reported that atRA inhibited murine melanoma growth through enhancement of anti-tumor T-cell immunity. H...

journal_title：Immunology

authors： Song Y,Yin W,Dan Y,Sheng J,Zeng Y,He R

更新日期：2019-07-01 00:00:00

abstract：:Innate immune responses vary in a circadian manner, and more recent investigations aim to understand the underlying molecular mechanisms. Cytokine production varies significantly over the course of a day depending on the time of stimulation by pathogens or Toll-like receptor ligands, and multiple signaling pathways li...

journal_title：Immunology

authors： Geiger SS,Curtis AM,O'Neill LAJ,Siegel RM

更新日期：2019-06-01 00:00:00

abstract：:Mouse models of multiple sclerosis (MS) have shown the importance of interleukin-10 (IL-10) -producing regulatory B (Breg) cells in dampening disease activity and inhibiting disease initiation and progression. In MS and other autoimmune diseases decreased frequency and functionality of Breg cells correlate with diseas...

journal_title：Immunology

authors： Lundqvist S,Modvig S,Fischer EA,Frederiksen JL,Degn M

更新日期：2019-03-01 00:00:00

abstract：:Alteration in the frequency of monocyte subsets is a hallmark of tuberculosis-diabetes co-morbidity (TB-DM). To study this association, we examined the plasma levels of sCD14, sCD163, C-reactive protein (CRP) and soluble tissue factor (sTF) in individuals with TB-DM, TB or diabetes mellitus (DM), and in healthy contro...

journal_title：Immunology

authors： Kumar NP,Moideen K,Bhootra Y,Nancy A,Viswanathan V,Shruthi BS,Sivakumar S,Natarajan M,Kornfeld H,Babu S

更新日期：2019-03-01 00:00:00

abstract：:Macrophage (MΦ) polarization is triggered during the innate immune response to defend against microbial pathogens, but can also contribute to disease pathogenesis. In a previous study, we found that interleukin-15 (IL-15) -derived classically activated macrophages (M1 MΦ) have enhanced antimicrobial activity, whereas ...

journal_title：Immunology

authors： Montoya D,Mehta M,Ferguson BG,Teles RMB,Krutzik SR,Cruz D,Pellegrini M,Modlin RL

更新日期：2019-02-01 00:00:00

abstract：:T helper type 17 (Th17) cells and regulatory T (Treg) cells are two distinct T-cell subsets with opposite effects on immune functions. While Th17 cells are a key effector in the immune response and play critical roles in the development of autoimmunity and inflammation, Treg cells orchestrate the overall immune respon...

journal_title：Immunology

authors： Liu C,Yang H,Shi W,Wang T,Ruan Q

更新日期：2018-12-01 00:00:00

abstract：:Trypanosoma cruzi, the aetiological agent of Chagas disease, has a highly efficient detoxification system to deal with the oxidative burst imposed by its host. One of the antioxidant enzymes involved is the cytosolic tryparedoxin peroxidase (c-TXNPx), which catalyses the reduction to hydrogen peroxide, small-chain org...

journal_title：Immunology

authors： Girard MC,Acevedo GR,López L,Ossowski MS,Piñeyro MD,Grosso JP,Fernandez M,Hernández Vasquez Y,Robello C,Gómez KA

更新日期：2018-11-01 00:00:00

abstract：:Acquisition of T-cell central tolerance involves distinct pathways of self-antigen presentation to thymocytes. One pathway termed indirect presentation requires a self-antigen transfer step from thymic epithelial cells (TECs) to bone marrow-derived cells before the self-antigen is presented to thymocytes. The role of ...

journal_title：Immunology

authors： Yap JY,Wirasinha RC,Chan A,Howard DR,Goodnow CC,Daley SR

更新日期：2018-07-01 00:00:00

abstract：:The immunological outcome of infections and vaccinations is largely determined during the initial first days in which antigen-presenting cells instruct T cells to expand and differentiate into effector and memory cells. Besides the essential stimulation of the T-cell receptor complex a plethora of co-stimulatory signa...

journal_title：Immunology

authors： Bathke B,Pätzold J,Kassub R,Giessel R,Lämmermann K,Hinterberger M,Brinkmann K,Chaplin P,Suter M,Hochrein H,Lauterbach H

更新日期：2018-06-01 00:00:00

abstract：:Signal transducers and activators of transcription (STATs) are key molecular determinants of T-cell fate and effector function. Several inflammatory diseases are characterized by an altered balance of T-cell phenotypes and cytokine secretion. STATs, therefore, represent viable therapeutic targets in numerous pathologi...

journal_title：Immunology

authors： Sadreev II,Chen MZQ,Umezawa Y,Biktashev VN,Kemper C,Salakhieva DV,Welsh GI,Kotov NV

更新日期：2018-04-01 00:00:00

abstract：:Programmed death-1 (PD-1) plays an important role in protecting against inflammation and myocyte damage in T-cell-mediated myocarditis. To understand whether fibrinogen-like protein-2 (FGL2) can affect the role of the PD-1/PD-L1 pathway in experimental autoimmune myocarditis (EAM), we investigated cardiac function in ...

journal_title：Immunology

authors： Zheng Z,Yu Y,Potla R,Wu Y,Wu H

更新日期：2018-02-01 00:00:00

abstract：:The intestinal lamina propria (LP) contains antigen-presenting cells with features of dendritic cells and macrophages, collectively referred to as mononuclear phagocytes (MNPs). Association of MNPs with the epithelium is thought to play an important role in multiple facets of intestinal immunity including imprinting M...

journal_title：Immunology

authors： McDonald KG,Wheeler LW,McDole JR,Joerger S,Gustafsson JK,Kulkarni DH,Knoop KA,Williams IR,Miller MJ,Newberry RD

更新日期：2017-12-01 00:00:00

abstract：:Antibodies to neuronal antigens are associated with many neurological diseases including paraneoplastic neurological disorders, epilepsy, amyotrophic lateral sclerosis and multiple sclerosis. Immunization with neuronal antigens such as neurofilament light (NF-L), a neuronal intermediate filament in axons, has been sho...

journal_title：Immunology

authors： Puentes F,van der Star BJ,Boomkamp SD,Kipp M,Boon L,Bosca I,Raffel J,Gnanapavan S,van der Valk P,Stephenson J,Barnett SC,Baker D,Amor S

更新日期：2017-12-01 00:00:00

abstract：:Interleukin 27 (IL-27) has been identified as a potent cytokine in the differentiation of type 1 regulatory T (Tr1) cells through interactions with several key elements, including transcription factors such as aryl hydrocarbon receptor and IL-21. Autocrine production of IL-21 is known to be important for maintaining I...

journal_title：Immunology

authors： Nadya NA,Tezuka H,Ohteki T,Matsuda S,Azuma M,Nagai S

更新日期：2017-11-01 00:00:00

abstract：:All-trans retinoic acid (atRA), the main biologically active metabolite of vitamin A, has been implicated in immunoregulation and anti-cancer. A recent finding that vitamin A could decrease the risk of melanoma in humans indicates the beneficial role of atRA in melanoma. However, it remains unknown whether topical app...

journal_title：Immunology

authors： Yin W,Song Y,Liu Q,Wu Y,He R

更新日期：2017-10-01 00:00:00

abstract：:We aimed to establish a panel of MHC-peptide multimers suitable as a positive control in the detection of HLA A*0201 restricted antigen specific T cells (ASTC) by flow cytometry. MHC Dextramers were loaded with HLA A*0201 binding peptides from viral antigens and melanoma targets identified from a literature search and...

journal_title：Immunology

authors： Fløe A,Løppke C,Hilberg O,Wejse C,Brix L,Jacobsen K

更新日期：2017-10-01 00:00:00

abstract：:CD4 T cells help immune responses, but knowledge of how memory CD4 T cells are regulated and how they regulate adaptive immune responses and induce immunopathology is limited. Using adoptive transfer of virus-specific CD4 T cells, we show that naive CD4 T cells undergo substantial expansion following infection, but ca...

journal_title：Immunology

authors： Bhattacharyya M,Madden P,Henning N,Gregory S,Aid M,Martinot AJ,Barouch DH,Penaloza-MacMaster P

更新日期：2017-10-01 00:00:00

abstract：:Marginal zone (MZ) B cells are positioned within the spleen to capture blood-borne antigen and immune complexes and deliver them to follicular dendritic cells in the B-cell follicles. We show that within the spleens of aged mice antigen capture by MZ B cells, and their ability to shuttle between the follicle and MZ, w...

journal_title：Immunology

authors： Turner VM,Mabbott NA

更新日期：2017-07-01 00:00:00

abstract：:Lymph nodes (LN) are secondary lymphoid organs spread throughout the lymphatic system. They function to filter pathogenic material from the lymphatic fluid to maintain the health of the organism. Subcapsular sinus macrophages (SCSM) are among the first-responders within the LN due to their strategic location within th...

journal_title：Immunology

authors： Turner VM,Mabbott NA

更新日期：2017-06-01 00:00:00

abstract：:T cells play a key role in the pathogenesis of type 1 diabetes, and targeting the CD3 component of the T-cell receptor complex provides one therapeutic approach. Anti-CD3 treatment can reverse overt disease in spontaneously diabetic non-obese diabetic mice, an effect proposed to, at least in part, be caused by a selec...

journal_title：Immunology

authors： Wallberg M,Recino A,Phillips J,Howie D,Vienne M,Paluch C,Azuma M,Wong FS,Waldmann H,Cooke A

更新日期：2017-06-01 00:00:00

abstract：:Burkholderia pseudomallei is the causative agent of melioidosis, an infectious disease with high incidence and mortality in South East Asia and northern Australia. To date there is no protective vaccine and antibiotic treatment is prolonged and not always effective. Most people living in endemic areas have been expose...

journal_title：Immunology

authors： Nithichanon A,Gourlay LJ,Bancroft GJ,Ato M,Takahashi Y,Lertmemongkolchai G

更新日期：2017-05-01 00:00:00

abstract：:The MHC class I and II antigen processing and presentation pathways display peptides to circulating CD8+ cytotoxic and CD4+ helper T cells respectively to enable pathogens and transformed cells to be identified. Once detected, T cells become activated and either directly kill the infected / transformed cells (CD8+ cyt...

journal_title：Immunology

authors： Reeves E,James E

更新日期：2017-01-01 00:00:00

abstract：:T lymphocytes are a critical component of the adaptive immune system mediating protection against infection and malignancy, but also implicated in many immune pathologies. Upon recognition of specific antigens T cells clonally expand, traffic to inflamed sites and acquire effector functions, such as the capacity to ki...

journal_title：Immunology

authors： Dimeloe S,Burgener AV,Grählert J,Hess C

更新日期：2017-01-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic, synovial inflammation affecting multiple joints, finally leading to extra-articular lesions for which limited effective treatment options are currently available. Interleukin-34 (IL-34), recently discovered as the second colony-stimul...

journal_title：Immunology

authors： Zhou RP,Wu XS,Xie YY,Dai BB,Hu W,Ge JF,Chen FH

更新日期：2016-12-01 00:00:00

abstract：:Bone-marrow-derived macrophages are divided into two phenotypically and functionally distinct subsets, M1 and M2 macrophages. Recently, it was shown that adoptive transfer of M2-polarized peritoneal macrophages reduced the severity of experimental colitis in mice. However, it is still unclear whether peritoneal macrop...

journal_title：Immunology

authors： Oishi S,Takano R,Tamura S,Tani S,Iwaizumi M,Hamaya Y,Takagaki K,Nagata T,Seto S,Horii T,Osawa S,Furuta T,Miyajima H,Sugimoto K

更新日期：2016-11-01 00:00:00

abstract：:The role of oral-associated lymphoid tissues during induction of oral tolerance still remains elusive. Therefore, the aim was to compare T-cell activation and induction of tolerance to ovalbumin (OVA) presented through either of two routes; deposited into the oral cavity, or the stomach, thereby bypassing the oral cav...

journal_title：Immunology

authors： Bankvall M,Östberg AK,Jontell M,Wold A,Östman S

更新日期：2016-09-01 00:00:00

abstract：:MicroRNAs (miRNAs) regulate many aspects of helper T cell (Th) development and function. Here we found that they are required for the suppression of interleukin-9 (IL-9) expression in Th9 cells and other Th subsets. Two highly related miRNAs (miR-15b and miR-16) that we previously found to play an important role in re...

journal_title：Immunology

authors： Singh Y,Garden OA,Lang F,Cobb BS

更新日期：2016-09-01 00:00:00

abstract：:Vitamins A and E and select flavonoids in the family of catechins are well-defined small molecules that, if proven to possess immunomodulatory properties, hold promise as vaccine adjuvants and various therapies. In an effort to determine the in vivo immunomodulatory properties of these molecules, we found that althoug...

journal_title：Immunology

authors： Patel S,Akalkotkar A,Bivona JJ 3rd,Lee JY,Park YK,Yu M,Colpitts SL,Vajdy M

更新日期：2016-08-01 00:00:00

abstract：:Interleukin-8 (IL-8) is a pro-angiogenic cytokine associated with aggressive prostate cancer (CaP). We detected high levels of IL-8 in sera from patients with CaP compared with healthy controls and patients with benign prostatic hypertrophy. This study examines the role of IL-8 in the pathogenesis of metastatic prosta...

journal_title：Immunology

authors： Aalinkeel R,Nair B,Chen CK,Mahajan SD,Reynolds JL,Zhang H,Sun H,Sykes DE,Chadha KC,Turowski SG,Bothwell KD,Seshadri M,Cheng C,Schwartz SA

更新日期：2016-08-01 00:00:00