Indirect presentation in the thymus limits naive and regulatory T-cell differentiation by promoting deletion of self-reactive thymocytes.

abstract：:Interleukin-13 (IL-13) is a cytokine which significantly enhances the proliferation and differentiation of B lymphocytes. We therefore evaluated its role in the formation of a humoral immune response in vivo. Upon oral immunization with the B subunit of Escherichia coli heat-labile enterotoxin (LT-B), rapid up-regulat...

journal_title：Immunology

authors： Bost KL,Holton RH,Cain TK,Clements JD

更新日期：1996-04-01 00:00:00

abstract：:Monoclonal antibodies were produced following immunization of mice with live infective larvae of Brugia malayi. One of these, 46.08.76, is an antibody that promotes adherence of mouse peritoneal macrophages and human peripheral blood leucocytes to the infective larvae of B. malayi and Wuchereria bancrofti, respectivel...

journal_title：Immunology

authors： Parab PB,Rajasekariah GR,Chandrashekar R,Alkan SS,Braun DG,Subrahmanyam D

更新日期：1988-05-01 00:00:00

abstract：:FTY720, a novel immunosuppressant, sequesters circulating mature lymphocytes, especially T cells, within lymph nodes and Peyer's patches by accelerating lymphocyte homing, and thereby causes lymphocyte depletion in the blood. The FTY720-induced acceleration of lymphocyte homing appears to be mediated by lymphocyte hom...

journal_title：Immunology

authors： Yanagawa Y,Masubuchi Y,Chiba K

更新日期：1998-12-01 00:00:00

abstract：:The absence of complement receptor 1 (CR1) related gene/protein y (Crry) leads to embryonic lethality as a result of unrestricted complement activation and concomitant neutrophil infiltration. Here we used Crry(-/-)C3(+/-) mice to investigate the role of Crry in the pathogenesis of immune complex glomerulonephritis (G...

journal_title：Immunology

authors： Bao L,Wang Y,Chen P,Sarav M,Haas M,Minto AW,Petkova M,Quigg RJ

更新日期：2009-09-01 00:00:00

abstract：:Interactions between heparin and protamine in normal human serum previously were found to activate the primary complement pathway and deplete the early-acting complement components. In the present investigation, the role of heparin-protamine complexes, immunoglobulins, C1q and C1-INH in this interaction was studied. H...

journal_title：Immunology

authors： Fiedel BA,Rent R,Myhrman R,Gewurz H

更新日期：1976-02-01 00:00:00

abstract：:The primary immunoglobulin repertoire of chickens is generated not by gene rearrangement but by a subsequent process of gene conversion in proliferating immature B cells within the follicles of a specialized gut-associated lymphoid organ, the bursa of Fabricius. Neonatal infection with infectious bursal disease virus ...

journal_title：Immunology

authors： Withers DR,Davison TF,Young JR

更新日期：2006-04-01 00:00:00

abstract：:2B4 (CD244) is a member of the CD2 subset of the immunoglobulin superfamily and functions as a triggering molecule on natural killer (NK) cells. Previously, we have found that 2B4-mediated activation of NK cells involves complex interactions involving LAT, Ras, Raf, ERK and p38 and that cytolytic function and cytokine...

journal_title：Immunology

authors： Chuang SS,Lee JK,Mathew PA

更新日期：2003-07-01 00:00:00

abstract：:During attempts to generate Sendai virus-specific T-cell hybridomas, a number of autoreactive T-cell hybridomas were produced. These hybrids secrete IL-2 in response to class II-positive syngeneic cells in the absence of added Sendai virus. Class II molecules on the stimulator cells are involved since monoclonal anti-...

journal_title：Immunology

authors： Pullen AM,Munro AJ

更新日期：1988-02-01 00:00:00

abstract：:Trypanosoma cruzi, the causative agent of Chagas' disease, suppresses immune responses during the acute phase and has been shown to induce multiple cellular alterations in activated human T lymphocytes. However, no information is available regarding the effects of this parasite on human B cells. Using an in vitro cult...

journal_title：Immunology

authors： Kierszenbaum F,Moretti E,Sztein MB

更新日期：1991-10-01 00:00:00

abstract：:Resveratrol is a polyphenol that acts on multiple molecular targets important for cell differentiation and activation. Dendritic cells (DCs) are a functionally diverse cell type and represent the most potent antigen-presenting cells of the immune system. In this study, we investigated resveratrol-induced effects on DC...

journal_title：Immunology

authors： Svajger U,Obermajer N,Jeras M

更新日期：2010-04-01 00:00:00

abstract：:In chronic inflammatory conditions, mononuclear cells infiltrate the involved connective tissue and may persist, perhaps because of binding to adhesion molecules on connective tissue cells, as well as extracellular matrix. Here we investigated whether vascular cell adhesion molecule-1 (VCAM-1) may be induced on human ...

journal_title：Immunology

authors： Gao JX,Issekutz AC

更新日期：1996-11-01 00:00:00

abstract：:Hyper-immunoglobulin M (IgM) syndrome (HIGM) is a rare primary immunodeficiency characterized by elevated or normal IgM and absent or markedly decreased amounts of IgG, IgA and IgE. The X-linked form (HIGM1) is the most common type and is caused by mutations in the gene for CD40L, a T-cell surface molecule required fo...

journal_title：Immunology

authors： Van Hoeyveld E,Zhang PX,De Boeck K,Fuleihan R,Bossuyt X

更新日期：2007-04-01 00:00:00

abstract：:The members of the tumour necrosis factor (TNF) superfamily of cytokines play important roles in the regulation of various immune-cell functions. Likewise, induction of cell death by apoptosis is indispensable for the normal functioning of the immune system. There are two major pathways of apoptosis induction. The int...

journal_title：Immunology

authors： Falschlehner C,Schaefer U,Walczak H

更新日期：2009-06-01 00:00:00

abstract：:Rabbit IgG and its Fab, Fc and pFc' fragments, prepared by papain or peptic digestion, were assayed for binding to homologous peritoneal macrophages. The binding affinity of IgG for the peritoneal macrophages (Ka = 5.9 +/- 1.6 x 10(5) L/M) was comparable to that recorded with alveolar macrophages (7.6 +/- 1.8 x 10(5) ...

journal_title：Immunology

authors： Ganczakowski M,Leslie RG

更新日期：1979-03-01 00:00:00

abstract：:The effect on murine immunoglobulin G (IgG) glycosylation of altering IgG production in vivo was assessed in interleukin (IL)-6 transgenic and CD4 knockout mice. C57BL/6 mice carrying the IL-6 transgene showed increased levels of circulating IgG. This was associated with decreased levels of galactose on the IgG oligos...

journal_title：Immunology

authors： Jeddi P,Keusch J,Lydyard PM,Bodman-Smith KB,Chesnutt MS,Wofsy D,Hirota H,Taga T,Delves PJ

更新日期：1999-11-01 00:00:00

abstract：:Peripheral blood mononuclear cells (PBMC) from a patient suffering from the hyper IgE syndrome were used to generate phytohaemagglutinin (PHA)-expanded T-cell clones (all CD4+, CD8-, CD23-). A selection of the clones was tested for their ability to help IgE secretion by culturing with normal B cells in the presence of...

journal_title：Immunology

authors： Quint DJ,Bolton EJ,McNamee LA,Solari R,Hissey PH,Champion BR,MacKenzie AR,Zanders ED

更新日期：1989-05-01 00:00:00

abstract：:A decrease in the number of dendritic cells (DCs) is a major cause of post-sepsis immunosuppression and opportunistic infection and is closely associated with poor prognosis. Increasing the number of DCs to replenish their numbers post sepsis can improve the condition. This therapeutic approach could improve recovery ...

journal_title：Immunology

authors： Wang HW,Yang W,Gao L,Kang JR,Qin JJ,Liu YP,Lu JY

更新日期：2015-05-01 00:00:00

abstract：:Specific IgE and IgG responses to highly purified Ambrosia (ragweed) allergens, Amb a V, Amb t V and Amb p V from the artemisiifolia (short), trifida (giant) and psilostachya (western) species are strongly associated with HLA-DR2 and Dw2 (DR2.2) in allergic Caucasoid individuals. To investigate the molecular basis of ...

journal_title：Immunology

authors： Huang SK,Marsh DG

更新日期：1991-07-01 00:00:00

abstract：:Monocyte-derived macrophages (MDMs) generated from peripheral blood monocytes are widely used to model human macrophages for in vitro studies. However, the possible impact of different isolation methods on the resulting MDM phenotype is poorly described. We aimed to investigate the effects of three commonly used monoc...

journal_title：Immunology

authors： Nielsen MC,Andersen MN,Møller HJ

更新日期：2020-01-01 00:00:00

abstract：:Bovine Concanavalin A-induced suppressor cells were generated from lymphocytes which were non-adherent to anti-immunoglobulin coated dishes and cells possessing receptors for peanut agglutinin. Bovine lymphocytes, preincubated with 25 microgram/ml of Con A for 40-45 hr, could suppress the responses of autologous cells...

journal_title：Immunology

authors： Smith WG,Usinger WR,Splitter GA

更新日期：1981-05-01 00:00:00

abstract：:The fate of allogeneic lymphocytes (AO or DA) transferred to non-immune PVG recipients was studied in the light of previous evidence (Heslop & McNeilage, 1983; Rolstad & Ford, 1983) that allogeneic lymphocytes can be rapidly destroyed in certain strain combinations of rats and mice by a mechanism that is distinct from...

journal_title：Immunology

authors： Rolstad B,Fossum S,Bazin H,Kimber I,Marshall J,Sparshott SM,Ford WL

更新日期：1985-01-01 00:00:00

abstract：:Macrophages play important roles in the clearance of dying and dead cells. Typically, and perhaps simplistically, they are viewed as the professional phagocytes of apoptotic cells. Clearance by macrophages of cells undergoing apoptosis is a non-phlogistic phenomenon which is often associated with actively anti-inflamm...

journal_title：Immunology

authors： Gregory CD,Devitt A

更新日期：2004-09-01 00:00:00

abstract：:NKG2D is one of the best characterized activating receptors and is expressed on natural killer cells and on various T-cell subsets. This receptor recognizes several different ligands that are induced by cellular stresses. In this review, we described the mechanisms controlling the expression of NKG2D ligands, with the...

journal_title：Immunology

authors： Stern-Ginossar N,Mandelboim O

更新日期：2009-09-01 00:00:00

abstract：:The complement fragment C5a is a potent leucocyte chemoattractant and activator, mediating its effects through a G-protein-coupled receptor. Whilst the C-terminal domain of this receptor has been shown to be essential for receptor desensitization and internalization, it is not known which domains couple to the recepto...

journal_title：Immunology

authors： Auger GA,Smith BM,Pease JE,Barker MD

更新日期：2004-08-01 00:00:00

abstract：:In order to examine the mechanism of specific immunity in the lung, the distribution of Ia antigens and T lymphocyte populations was determined using immunoperoxidase-staining of cryostat sections of lungs from specific pathogen-free rats. BALT was found to be divided into three regions of lymphoid tissue. The central...

journal_title：Immunology

authors： Simecka JW,Davis JK,Cassell GH

更新日期：1986-01-01 00:00:00

abstract：:Circulating CD4+ CD25+ regulatory T cells (Tregs) have been demonstrated to maintain immunotolerance and suppress the antigen-specific or antigen-non-specific T-cell responses, but their role in chronic hepatitis B (CHB) infection in humans has not been well characterized. In this study, we analysed the frequency and ...

journal_title：Immunology

authors： Peng G,Li S,Wu W,Sun Z,Chen Y,Chen Z

更新日期：2008-01-01 00:00:00

abstract：:We have produced a mouse anti-rabbit Ia monoclonal antibody (MAb) that detects an isotypic determinant on all rabbit Ia molecules. This MAb precipitates three polypeptide chains with molecular weights of 28,000, 31,000 and 35,000, corresponding to the Ia beta, Ii and alpha chains, respectively. The anti-Ia MAb inhibit...

journal_title：Immunology

authors： Lobel SA,Knight KL

更新日期：1984-01-01 00:00:00

abstract：:MCA44 is a monoclonal antibody (mAb) to guinea-pig decay-accelerating factor (DAF) and, using this mAb, tissue distribution of guinea-pig DAF was studied by immunofluorescence. Guinea-pig DAF was found to be expressed not only on the vascular endothelium but also on different types of cells, such as the tubular epithe...

journal_title：Immunology

authors： Nishikawa K,Matsuo S,Tamai H,Okada N,Okada H

更新日期：1998-10-01 00:00:00

abstract：:Rhesus macaques (Macaca mulatta) are extensively used in vaccine development. Macaques infected with simian immunodeficiency viruses (SIV) or simian-human immunodeficiency viruses (SHIV) are the best animal model currently available for acquired-immune-deficiency-syndrome-related studies. Recent results emphasize the ...

journal_title：Immunology

authors： Scinicariello F,Engleman CN,Jayashankar L,McClure HM,Attanasio R

更新日期：2004-01-01 00:00:00

abstract：:Plasma fibronectin (FN) has been demonstrated to serve as an opsonin involved in the ingestion of foreign particles by phagocytes. This study concerns the effect of FN exposure on the respiratory burst of normal human peripheral phagocytes, using a luminol-dependent chemiluminescence (CL) assay for measurement of reac...

journal_title：Immunology

authors： Kuroiwa A,Igisu K,Yano T,Okada N,Okada H

更新日期：1988-10-01 00:00:00