An integrated view of the regulation of NKG2D ligands.

abstract：:In the rat strain combination of DA into PVG, an orthotopic liver graft has the ability to abrogate an existing state of sensitization against donor (DA) antigens. Fifty-four percent of PVG rats sensitized against DA by skin grafting accepted a DA liver graft permanently, and about half of these became systemically to...

journal_title：Immunology

authors： Kamada N,Shinomiya T

更新日期：1985-05-01 00:00:00

abstract：:Class switching and plasma cell differentiation occur at a high level within all mucosa-associated lymphoid tissues. The different classes of membrane immunoglobulin heavy chains are associated with the Igα/Igβ heterodimer within the B-cell receptor (BCR). Whether BCR isotypes convey specific signals adapted to the co...

journal_title：Immunology

authors： Amin R,Carrion C,Decourt C,Pinaud E,Cogné M

更新日期：2012-05-01 00:00:00

abstract：:Oxidized low-density lipoprotein (OxLDL) plays a crucial role in the development of atherosclerosis. Carbamylated LDL has been suggested to promote atherogenesis in patients with chronic kidney disease. Here we observed that plasma IgG and IgM antibodies to carbamylated epitopes were associated with IgG and IgM antibo...

journal_title：Immunology

authors： Kummu O,Turunen SP,Prus P,Lehtimäki J,Veneskoski M,Wang C,Hörkkö S

更新日期：2014-03-01 00:00:00

abstract：:A 185,000 MW glycoprotein antigen derived from Streptococcus mutans was digested with subtilisin. Purification by reversed phase high-powered liquid chromatography (HPLC) resulted in a homogeneous 20,000 MW protein which possesses the streptococcal antigen (SA) I and II determinants. This protein was immunogenic in mi...

journal_title：Immunology

authors： Mitchell CG,Lehner T

更新日期：1989-02-01 00:00:00

abstract：:Mast cell secretory granules contain unique tryptic and chymotryptic serine proteases that differ between species and tissues. Direct comparison of these proteases in single-cell types has been hindered by the difficulty of obtaining adequate numbers of pure mast cells. In this study, we were able to compare tryptic a...

journal_title：Immunology

authors： Caughey GH,Lazarus SC,Viro NF,Gold WM,Nadel JA

更新日期：1988-02-01 00:00:00

abstract：:This study examines the expression of mRNA for the Th2 cytokine, interleukin-4 (IL-4). Peripheral blood mononuclear cells from deer infected with Mycobacterium bovis or vaccinated with live or killed M. bovis bacillus Calmette-Guérin (BCG) were cultured with mycobacterial antigens. IL-4 mRNA production was assayed usi...

journal_title：Immunology

authors： Hook S,Griffin F,Mackintosh C,Buchan G

更新日期：1996-06-01 00:00:00

abstract：:Gammadelta T cells are unique, and their localization at sites of infection is considered critical in immune defence. We demonstrate the accumulation of gammadelta T cells in rat regional popliteal lymph nodes (PLNi) starting 2 days after inoculation of cytomegalovirus (CMV) into the footpad. Early-appearance PLNi gam...

journal_title：Immunology

authors： Dyugovskaya L,Hirsh M,Ginsburg H

更新日期：2003-02-01 00:00:00

abstract：:The present study aimed to determine whether the frequency of double positive (DP) thymocytes expressing alphabeta T-cell receptor (TCR) clonotypes at the time of selection regulates peripheral CD4 T-cell compartment size. Scid recipients were inoculated with various ratios of TCR Calpha(0/0) and wild-type bone marrow...

journal_title：Immunology

authors： Reed AJ,Zarrabi Y,Perate AL,Jeganathan A,Naji A,Noorchashm H

更新日期：2005-11-01 00:00:00

abstract：:The immunological outcome of infections and vaccinations is largely determined during the initial first days in which antigen-presenting cells instruct T cells to expand and differentiate into effector and memory cells. Besides the essential stimulation of the T-cell receptor complex a plethora of co-stimulatory signa...

journal_title：Immunology

authors： Bathke B,Pätzold J,Kassub R,Giessel R,Lämmermann K,Hinterberger M,Brinkmann K,Chaplin P,Suter M,Hochrein H,Lauterbach H

更新日期：2018-06-01 00:00:00

abstract：:Activation of human eosinophils by platelet-activating factor (PAF) involves multiple signal transduction pathways. Among these, protein kinase C has been demonstrated both to mediate respiratory burst and to suppress an alternative pathway of activation of respiratory burst and arachidonic acid metabolism in eosinoph...

journal_title：Immunology

authors： Dent G,Munoz NM,Zhu X,Rühlmann E,Magnussen H,Leff AR,Rabe KF

更新日期：2000-06-01 00:00:00

abstract：:The phospholipid platelet-activating factor 1-0-hexadecyl-2-acetyl-SN-glycero-3-phosphorylcholine (AGEPC) initiates platelet function by interacting specifically with 1399 +/- 498 (mean +/- SD) high-affinity membrane receptors per platelet. In studies designated to characterize the high affinity binding site, AGEPC-hu...

journal_title：Immunology

authors： Valone FH

更新日期：1984-05-01 00:00:00

abstract：:Bovine Concanavalin A-induced suppressor cells were generated from lymphocytes which were non-adherent to anti-immunoglobulin coated dishes and cells possessing receptors for peanut agglutinin. Bovine lymphocytes, preincubated with 25 microgram/ml of Con A for 40-45 hr, could suppress the responses of autologous cells...

journal_title：Immunology

authors： Smith WG,Usinger WR,Splitter GA

更新日期：1981-05-01 00:00:00

abstract：:It is now well accepted that sex hormones have immunoregulatory activity and may prevent exacerbations in multiple sclerosis during pregnancy. Our previous studies demonstrated that oestrogen (17β-oestradiol; E(2) ) protection against experimental autoimmune encephalomyelitis (EAE) is mediated mainly through oestrogen...

journal_title：Immunology

authors： Bodhankar S,Vandenbark AA,Offner H

更新日期：2012-12-01 00:00:00

abstract：:To define the role of memory T cells in a non-persistent viral infection, we have delineated the phenotype of memory CD8+ T cells specific for influenza A virus (FluA; matrix protein M158-66) based on the expression of several memory/effector lineage markers and relevant chemokine receptors. We found a majority of Flu...

journal_title：Immunology

authors： Hoji A,Rinaldo CR Jr

更新日期：2005-06-01 00:00:00

abstract：:MUC1 is a transmembrane mucin that is expressed on ductal epithelial cells and epithelial malignancies and has been proposed as a target antigen for immunotherapy. The expression of MUC1 has recently been reported on T and B cells. In this study we demonstrate that following activation in vivo or activation by differe...

journal_title：Immunology

authors： Correa I,Plunkett T,Vlad A,Mungul A,Candelora-Kettel J,Burchell JM,Taylor-Papadimitriou J,Finn OJ

更新日期：2003-01-01 00:00:00

abstract：:Immunoglobulin G4 (IgG4) antibodies have been known for some time to be functionally monovalent. Recently, the structural basis for this monovalency has been elucidated: the in vivo exchange of IgG half-molecules (one H-plus one L-chain) among IgG4. This process results in bispecific antibodies that in most situations...

journal_title：Immunology

authors： Aalberse RC,Schuurman J

更新日期：2002-01-01 00:00:00

abstract：:Metabolism of ss-DNA in Swiss Webster mice and NZB/W mice was studied. The delay in intra-hepatic catabolism of ssDNA in old NZB/W female mice seems to correlate with the presence of increased anti-DNA antibodies; similar to effects produced in Swiss Webster mice that have been pretreated with a small dose of carbon b...

journal_title：Immunology

authors： Chia D,Dorsch C,Barnett EV,Levy L

更新日期：1977-03-01 00:00:00

abstract：:In general, the majority of bacteria are pre-inflammatory when injected in experimental animals. However, Mycobacterium leprae has no inflammatory effect when injected into mouse footpad, but using the delipidated mycobacteria we observed a mild significant increase in footpad oedema. Other mycobacteria, Mycobacterium...

journal_title：Immunology

authors： Moura AC,Mariano M

更新日期：1996-12-01 00:00:00

abstract：:Previous studies have shown that the degradation of soluble immune complexes or aggregates (AIgG) by normal peritoneal macrophages can be enhanced by complement. The enhancement of degradation was shown to be at least in part dependent on the number of C3b molecules bound per complex. The present investigations indica...

journal_title：Immunology

authors： Daha MR,Van Es LA

更新日期：1983-09-01 00:00:00

abstract：:The secondary humoral response evoked in W/Fu rats by the weakly immunogenic soluble Gross cell surface antigen (GCSAa) extracted from the syngeneic (C58NT)D lymphoma can be enhanced when GCSAa is presented in liposomes, and this requires the antigen to be strongly associated with the phospholipid bilayers. In order t...

journal_title：Immunology

authors： Bakouche O,Gerlier D

更新日期：1986-07-01 00:00:00

abstract：:Large doses of hydrocortisone, cyclophosphamide, and methotrexate injected subcutaneously, and whole-body irradiation (500 rads) caused a reduction in the number of peritoneal cells (PE cells) obtained after intraperitoneal injection of the treated mice with proteose-peptone. The same dose of cyclophosphamide and irra...

journal_title：Immunology

authors： Gadeberg OV,Rhodes JM,Larsen SO

更新日期：1975-01-01 00:00:00

abstract：:Autophagy plays an important role in maintaining intracellular homeostasis by promoting the transit of cytoplasmic material, such as proteins, organelles and pathogens, for degradation within acidic organelles. Yet, in immune cells, autophagy pathways serve an additional role in facilitating intracellular surveillance...

journal_title：Immunology

authors： Crotzer VL,Blum JS

更新日期：2010-09-01 00:00:00

abstract：:The chemokine receptor CCR7 is crucial for migration of mature dendritic cells (DC) directed toward secondary lymphoid organs; however, there is little knowledge about the function of the homeostatic chemokine receptor CXCR4 in DC and its contribution to directional migration of DC during inflammation. By comparing th...

journal_title：Immunology

authors： Humrich JY,Humrich JH,Averbeck M,Thumann P,Termeer C,Kämpgen E,Schuler G,Jenne L

更新日期：2006-02-01 00:00:00

abstract：:Immunoregulatory CD4(-)  CD8(-) (double-negative; DN) T cells exhibit a unique antigen-specific mode of suppression, yet the ontogeny of DN T cells remains enigmatic. We have recently shown that 3A9 T-cell receptor (TCR) transgenic mice bear a high proportion of immunoregulatory 3A9 DN T cells, facilitating their stud...

journal_title：Immunology

authors： Dugas V,Chabot-Roy G,Beauchamp C,Guimont-Desrochers F,Hillhouse EE,Liston A,Lesage S

更新日期：2013-05-01 00:00:00

abstract：:Adrenaline is a catecholamine hormone secreted by the adrenal medulla in response to acute stress. Previous studies have shown that adrenaline suppresses the nitric oxide (NO) response of murine macrophages (M phi s) stimulated in vitro with lipopolysaccharide (LPS). We have now extended these studies to examine the e...

journal_title：Immunology

authors： Zinyama RB,Bancroft GJ,Sigola LB

更新日期：2001-12-01 00:00:00

abstract：:Bone marrow cells from mice were cultured in vitro in the presence of interleukin-3 (IL-3). After 2 weeks, the majority of the cells differentiated towards mast cells as judged by morphological and biochemical criteria. When populations of 99% IL-3-dependent mast cells (IL-3 MC) were tested for their anti-tumour activ...

journal_title：Immunology

authors： Ghiara P,Boraschi D,Villa L,Scapigliati G,Taddei C,Tagliabue A

更新日期：1985-06-01 00:00:00

abstract：:The interference of two simultaneous skin test reactions of intermediate strength has been studied in the guinea-pig, using four different antigens, i.e. ovalbumin, horse cytochrome c, PPD and oxazolone. Skin test reactions were evaluated at 4, 24 and 48 h by measuring three parameters: increase in skin thickness, dia...

journal_title：Immunology

authors： Von Blomberg M,Boerrigter GH,Scheper RJ

更新日期：1978-08-01 00:00:00

abstract：:Accumulating evidence indicates that B cells may undergo sequential rearrangements at the light chain loci, despite already expressing light chain receptors. This phenomenon may occur in the bone marrow and, perhaps, in germinal centers. As immunoglobulin (Ig)kappa light chains usually rearrange before Iglambda light ...

journal_title：Immunology

authors： Perfetti V,Vignarelli MC,Palladini G,Navazza V,Giachino C,Merlini G

更新日期：2004-07-01 00:00:00

abstract：:Two dermatophyte strains, Trichophyton quinckeanum and Trichophyton rubrum, were highly susceptible to in vitro killing by components of the H2O2-peroxidase-halide system. Both strains were, however, resistant to relatively high concentrations of reagent H2O2 or H2O2 enzymatically generated by glucose and glucose oxid...

journal_title：Immunology

authors： Calderon RA,Shennan GI

更新日期：1987-07-01 00:00:00

abstract：:Humans and other mammals coexist with a diverse array of microbes colonizing the intestine, termed the microflora. The relationship is symbiotic, with the microbes benefiting from a stable environment and nutrient supply, and the host gaining competitive exclusion of pathogens and continuously maintenance of the gut i...

journal_title：Immunology

authors： Zeuthen LH,Fink LN,Frokiaer H

更新日期：2008-02-01 00:00:00