Abstract:
:Bone marrow cells from mice were cultured in vitro in the presence of interleukin-3 (IL-3). After 2 weeks, the majority of the cells differentiated towards mast cells as judged by morphological and biochemical criteria. When populations of 99% IL-3-dependent mast cells (IL-3 MC) were tested for their anti-tumour activity in vitro, it was found that they can express natural cytotoxicity (NC) but not other natural reactivities. Moreover, the effector cells were not positive for Thy 1, Lyt 1 and Lyt 2 markers. The capability of mast cells to express NC activity seems to be related to their in vitro differentiation, since mast cell deficient W/Wv mice had normal NC activity. Thus, IL-3 MC must be added to the variety of cells capable of expressing natural anti-tumour reactivities in vitro.
journal_name
Immunologyjournal_title
Immunologyauthors
Ghiara P,Boraschi D,Villa L,Scapigliati G,Taddei C,Tagliabue Asubject
Has Abstractpub_date
1985-06-01 00:00:00pages
317-24issue
2eissn
0019-2805issn
1365-2567journal_volume
55pub_type
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