Abstract：
:Antibody-dependent cell-mediated cytotoxicity (ADCC) of infectious bovine rhinotracheitis (IBR)-infected bovine kidney cells (MDBK) by neutrophils was demonstrated. Neutrophils from bovine and sheep mammary exudate and peripheral blood, and also from human peripheral blood, were all active in the presence of anti-IBR antibody. The component of the ruminant neutrophil granules which was responsible for cytotoxicity appeared to be cationic protein since purified cationic protein lysed the virus-infected cells and heparin inhibited cytotoxicity. Human neutrophil cytotoxicity to herpes simplex virus (HSV)-infected human Chang liver cells was also inhibited by heparin. Human neutrophil cytotoxicity to IBR-infected bovine kidney cells did not appear to be mediated by cationic protein since it was inhibited by the chelators of oxidative intermediates DMSO, thiourea, tryptophane, benzoate and mannitol, and not by heparin.
journal_name
Immunologyjournal_title
Immunologyauthors
Thorne KJ,Norman JM,Haydock SF,Lammas DA,Duffus PHsubject
Has Abstractpub_date
1984-10-01 00:00:00pages
275-82issue
2eissn
0019-2805issn
1365-2567journal_volume
53pub_type
杂志文章相关文献
IMMUNOLOGY文献大全abstract：:CD45 is known to regulate signalling through many different surface receptors in diverse haemopoietic cell types. Here we report for the first time that CD45-/- bone marrow dendritic cells (BMDC) are more activated than CD45+/+ cells and that tumour necrosis factor (TNF) and interleukin-6 (IL-6) production by BMDC and...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2006.02363.x
更新日期：2006-06-01 00:00:00
abstract：:Natural cell-mediated cytotoxicity is mediated by a family of effector cells that express cytolytic activities distinct from those generally attributed to B cells, T cells and macrophages; it includes both natural killer (NK) and natural cytotoxic (NC) activities. There is now convincing evidence to show that NC activ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1989-08-01 00:00:00
abstract：:Bovine Concanavalin A-induced suppressor cells were generated from lymphocytes which were non-adherent to anti-immunoglobulin coated dishes and cells possessing receptors for peanut agglutinin. Bovine lymphocytes, preincubated with 25 microgram/ml of Con A for 40-45 hr, could suppress the responses of autologous cells...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1981-05-01 00:00:00
abstract：:Monoclonal antibodies were produced following immunization of mice with live infective larvae of Brugia malayi. One of these, 46.08.76, is an antibody that promotes adherence of mouse peritoneal macrophages and human peripheral blood leucocytes to the infective larvae of B. malayi and Wuchereria bancrofti, respectivel...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1988-05-01 00:00:00
abstract：:Virus plaque assay (VPA) was utilized for the quantitative evaluation of activated lymphocytes. We examined what types of cells, especially which of activated T and non-T lymphocytes, were detected as infective centres after infection with vesicular stomatitis virus. Marked increases in DNA synthesis and in virus-plaq...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1977-06-01 00:00:00
abstract：:The cellular prion protein (PrPc) is a glycosyl-phosphatidylinositol (GPI)-linked cell surface protein, which is expressed at high density on nervous tissues and at lower levels on most other solid-organ tissues. It is also expressed on peripheral blood mononuclear cells (PBMC) of all lineages. In lymphocytes, its lev...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.2001.01166.x
更新日期：2001-02-01 00:00:00
abstract：:Interleukin-3 activity is produced by T cells at an early phase after antigenic stimulation, and its quantitation provides a sensitive and non-destructive method for assaying T-cell activation. It can be detected before increased uptake of [3H]thymidine into DNA occurs, and is more sensitive than measuring [3H]thymidi...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1987-12-01 00:00:00
abstract：:An adoptive transfer assay system was used to investigate the ability of serum from tolerant, liver-grafted rats to inactivate normal thoracic duct lymphocytes. PVG rats were rendered tolerant of DA alloantigens by liver grafting. Serum taken from such rats was used to treat normal PVG thoracic duct lymphocytes (TDL) ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1988-06-01 00:00:00
abstract：:The migration of leucocytes into tissues is a process mediated by leucocyte endothelial interactions, in which adhesion receptors play a crucial role. Recently, it was found that 80-90% of T cells in inflammatory skin diseases were reactive to the monoclonal antibody (mAb) HECA-452+ in contrast to inflamed non-cutaneo...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1994-03-01 00:00:00
abstract：:Osteopontin (OPN) is important for the function of fibroblasts, macrophages and lymphocytes during inflammation and wound healing. In recent studies of experimental colitis we demonstrated exacerbated tissue destruction in OPN-null mice, associated with reduced tumour necrosis factor-alpha expression and increased mye...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2007.02682.x
更新日期：2007-12-01 00:00:00
abstract：:The molecular characteristics of a serum IL-2 inhibitor were determined by fractionating active sera from normal and malaria-infected mice, and assaying inhibitory activity in blocking production and expression of IL-2 activity. Using isoelectric focusing and ion exchange chromatography, the activity resolved in a sin...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1985-09-01 00:00:00
abstract：:The defined antigen substrate spheres (DASS) system was employed for analysing reactions between solid state antibody or antigen and soluble immune complexes. Sepharose beads covalently coupled with ovalbumin were used to represent tumour cells and beads coupled with antibody against ovalbumin were used to represent a...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1975-06-01 00:00:00
abstract：:GD3, a ganglioside expressed on melanoma, is the only tumour-associated glycolipid described to date that can induce a CD1d-restricted natural killer T (NKT)-cell response. We analysed the fine specificity of GD3-reactive NKT cells and discovered that immunization with GD3 induced two populations of GD3-reactive NKT c...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2007.02760.x
更新日期：2008-01-01 00:00:00
abstract：:Gammadelta T cells are unique, and their localization at sites of infection is considered critical in immune defence. We demonstrate the accumulation of gammadelta T cells in rat regional popliteal lymph nodes (PLNi) starting 2 days after inoculation of cytomegalovirus (CMV) into the footpad. Early-appearance PLNi gam...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.2003.01568.x
更新日期：2003-02-01 00:00:00
abstract：:This paper describes attempts to isolate and characterize glycosaminoglycan (GAG)-binding molecules on the surface of lymphocytes and lymphoma cell lines and relate their expression to splenic and lymph node homing capacity. Initial binding studies with radiolabelled GAG and rosetting studies with GAG-coupled erythroc...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1991-02-01 00:00:00
abstract：:Quantitative studies on B cells require a direct assay for antibody-forming cell (AFC) progenitor function, in which the number of AFC produced bears a simple, linear arithmetic relationship to the number of progenitors present. This might be expected under conditions where helper T-cell and accessory cell requirement...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1975-12-01 00:00:00
abstract：:Binding of streptococcal antigen was compared between T8+ cells and monocytes (Mo) from DRw6+ and DRw6- subjects. Both T8+ cells and Mo from DRw6- subjects bind streptococcal antigen (SA) specifically and almost entirely at a concentration of 1000 ng per 0.1 ml. However, the DRw6+, T8+ cells bind SA at a concentration...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1984-10-01 00:00:00
abstract：:Activation of naive CD8(+) T cells in the presence of interleukin-4 modulates their CD8 co-receptor expression and functional differentiation, resulting in the generation of CD8(low) cells that produce type 2 cytokines and display poor cytolytic and anti-tumour activity. Although this CD8(low) phenotype becomes stable...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.12068
更新日期：2013-06-01 00:00:00
abstract：:Designing peptide-based vaccines for therapeutic applications in cancer immunotherapy requires detailed knowledge of the interactions between the antigenic peptide and major histocompatibility complex (MHC) in addition to that between the peptide-MHC complex and the T-cell receptor. Past efforts to immunize with high-...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2006.02434.x
更新日期：2006-11-01 00:00:00
abstract：:Peptides HNB-92-169 and 116-169, tyr, derivatives of the C-terminal part of bovine myelin basic protein, sensitize rabbits for experimental allergic encephalomyelitis (EAE). Dissolving these peptides in heat-inactivated normal guinea-pig, human, or monkey serum immediately before emulsification with Freund's complete ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1976-04-01 00:00:00
abstract：:To further investigate the immunomodulatory effects of dietary lipids, rats were fed on a low-fat diet or on high-fat diets that contained hydrogenated coconut, olive, safflower, evening primrose or fish oil as the principal fat source. The fish oil diet decreased the level of expression of CD2, CD11a, CD18 and CD44 o...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1998.00474.x
更新日期：1998-05-01 00:00:00
abstract：:Individual young adult, middle-aged, and old C57BL/6J male mice were tested for in vitro generated proliferative and cytotoxic responses to H-2 alloantigens under a variety of sensitization conditions. Proliferation in mixed lymphocyte culture (MLC) had decreased by 14 months of age (middle-aged), whether measured by ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1981-11-01 00:00:00
abstract：:Successful elimination of the hepatitis C virus (HCV) during acute infection has been linked to strong HCV-specific in vitro T-cell proliferation, whereas T cells from patients with chronic hepatitis C respond only weakly to HCV antigens. Lipid-coupled peptides are immunostimulants, which might provide a basis for nov...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.2001.01209.x
更新日期：2001-04-01 00:00:00
abstract：:The output and immunoglobulin class of antibody-containing cells (ACC) in lymph from different regions of adult sheep has been compared following intraperitoneal or subcutaneous injection of ovalbumin in Freund's complete adjuvant (FCA). Intraperitoneal injection of antigen in FCA elicited no response at all in poplit...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1981-04-01 00:00:00
abstract：:The in vitro treatment with Fusarenon-X, a mycotoxin produced by Fusarium nivale Fn 2B, depressed the mitogenic responses of mouse lymphocytes to the T-cell mitogens, phytohaemagglutinin (PHA) and concanavalin A (Con A), but to a lesser extent to B-cell mitogen, a bacterial lypopolysaccharide (LPS). The in vitro treat...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1982-04-01 00:00:00
abstract：:Infection of nude mice with Mesocestoides corti results in spleen enlargement, with a decrease in percentage positive, but overall increase in Thy-1 positive cells. A low frequency of both parasite antigen-specific and alloantigen-reactive T-cell clones were isolated from the spleen, mesenteric lymph nodes, peritoneal...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1985-02-01 00:00:00
abstract：:Hyper-immunoglobulin M (IgM) syndrome (HIGM) is a rare primary immunodeficiency characterized by elevated or normal IgM and absent or markedly decreased amounts of IgG, IgA and IgE. The X-linked form (HIGM1) is the most common type and is caused by mutations in the gene for CD40L, a T-cell surface molecule required fo...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2006.02520.x
更新日期：2007-04-01 00:00:00
abstract：:The rat popliteal lymph node was studied from 1 hr to 8 days after the footpad injection of either sheep erythrocytes or syngeneic rat erythrocytes. The following were measured relative to the contralateral (unstimulated) lymph node: (i) blood flow; (ii) lymph node weight; (iii) influx of lymphocytes from the blood; (...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1981-09-01 00:00:00
abstract：:6-Sulpho LacNAc dendritic cells (slanDC) are a major population of human blood DC that are highly pro-inflammatory, as characterized by their outstanding capacity to produce tumour necrosis factor-α and interleukin-12 (IL-12) and to prime antigen-specific T-cell responses. SlanDC were found to be present in inflamed t...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2010.03336.x
更新日期：2011-01-01 00:00:00
abstract：:Bursal and splenic lymphocytes in developing chick embryos were examined for the number of antigen binding cells (ABC) which could form rosettes with red blood cells from sheep, guinea-pig, rabbit or dinitrophenylated sheep red blood cells (DNP-SRBC). The kinetics of the development of bursal ABC to rabbit red blood c...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1979-08-01 00:00:00
