Use of the defined antigen substrate spheres system as a model for analysing possible mechanisms of inhibition-blockade of anti-tumour lymphocytotoxicity.

abstract：:We have previously demonstrated that intranasal (i.n.) administration of the major encephalitogenic peptide, Ac1-9 of myelin basic protein (MBP), inhibited T-cell responsiveness in vitro and induced tolerance in the H-2u mouse model of experimental autoimmune encephalomyelitis (EAE). The peptide analogue Ac1-9[4Y] wit...

journal_title：Immunology

authors： Metzler B,Wraith DC

更新日期：1999-06-01 00:00:00

abstract：:Thoracic duct lymphocytes (TDL) from (AS2 x AS)F1 rats previously injected with human serum albumin (HSA) were transferred to 900 r irradiated syngeneic recipients which were challenged with various doses of soluble HSA (s-HSA). TDL from partially tolerant rats, which were deficient in high avidity B cells, produced a...

journal_title：Immunology

authors： Bell EB,Shand FL

更新日期：1977-10-01 00:00:00

abstract：:The antibody response in rhino mice, which carry a mutant gene hrrh, to thymus-dependent (TD) or thymus-independent (TI) antigens was compared with that of phenotypically normal littermates. The magnitude of antibody response to TD antigens in rhino mice decreased as they grew up, whereas the antibody response to TI a...

journal_title：Immunology

authors： Takaoki M,Kawaji H

更新日期：1980-05-01 00:00:00

abstract：:Incubation of sensitized mononuclear cells from patients with schistosomiasis with specific antigen containing a suspension of viable Schistosoma haematobium ova resulted in the release of a soluble factor which was chemotactic for eosinophils. Production of this substance was detectable at 24 h and demonstrated peak ...

journal_title：Immunology

authors： Wadee AA,Sher R

更新日期：1980-12-01 00:00:00

abstract：:Previous studies have shown that depletion of Langerhans' cells (LC) from murine epidermis by the superantigen, staphylococcal enterotoxin A (SEA) involves interleukin-1alpha (IL-1alpha) and is inhibitable by agents that block G-protein-associated kinases. The purpose of this study was to determine whether specific ki...

journal_title：Immunology

authors： Shankar G,Johnson J,Kuschel L,Richins M,Burnham K

更新日期：1999-02-01 00:00:00

abstract：:Control of resistance to cyst burden following per-oral infection with Toxoplasma gondii has been mapped previously to a region of mouse chromosome 17 of approximately 140 kb. This region is contiguous with and contains the class I gene, Ld. Resistance to development of toxoplasmic encephalitis has also been reported ...

journal_title：Immunology

authors： Brown CR,Hunter CA,Estes RG,Beckmann E,Forman J,David C,Remington JS,McLeod R

更新日期：1995-07-01 00:00:00

abstract：:Collectins are a group of soluble proteins, each of which has collagenous and non-collagenous globular domains, and may be complement associated and/or have lectin activity. The complement protein C1q is structurally and functionally related to the collectins. Members of the collectin family are mannan-binding protein...

journal_title：Immunology

authors： Malhotra R,Willis AC,Lopez Bernal A,Thiel S,Sim RB

更新日期：1994-07-01 00:00:00

abstract：:Activation of lymph nodes by the T-cell mitogens PHA and Con A is correlated with a depletion of lymphatic mast cells. This result, and our earlier reports on the depletion of mast cells in lymph nodes stimulated by allogeneic and tumour cells, as well as on the elevation of mast cell number in thymus-less 'nude' mice...

journal_title：Immunology

authors： Włodarski K,Rychlik G,Mazur S

更新日期：1985-06-01 00:00:00

abstract：:The effect of stem cell factor (SCF) on histamine and tumour necrosis factor-alpha (TNF-alpha) release from rat peritoneal mast cells (PMC) was determined and the intracellular pathways involved in the potentiation of histamine secretion were investigated. The effects of SCF (2-100 ng/ml) were examined following both ...

journal_title：Immunology

authors： Lin TJ,Bissonnette EY,Hirsh A,Befus AD

更新日期：1996-10-01 00:00:00

abstract：:A critical role for leukotriene B(4) (LTB(4)) and/or platelet-activating factor (PAF) in regulating polymorphonuclear cell (PMN) trafficking to inflammatory sites has been reported in a number of experimental inflammatory models. In vitro, newly synthesized LTB(4) and PAF were shown to act in an autocrine/paracrine or...

journal_title：Immunology

authors： Bélanger C,Elimam H,Lefebvre J,Borgeat P,Marleau S

更新日期：2008-07-01 00:00:00

abstract：:The IgE immune response was studied in female athymic, nude (Lewis rnu/rnu) and euthymic (Lewis +/+) rats infected with the nematode Nippostrongylus brasiliensis. During the course of the infection, serum IgE levels were followed using an enzyme-linked immunosorbent assay technique (ELISA), while the surface expressio...

journal_title：Immunology

authors： Chen XJ,Wiedermann U,Dahlgren U,Hanson LA,Enerbäck L

更新日期：1995-11-01 00:00:00

abstract：:Corneal allografts contain few or no Ia+ Langerhans' cells and consistently fail to elicit allospecific delayed-type hypersensitivity (DTH). The present study examined the hypothesis that the inability of corneal allografts to induce allospecific DTH was the result of active suppression. However, the results indicated...

journal_title：Immunology

authors： Niederkorn JY,Mayhew E

更新日期：1993-12-01 00:00:00

abstract：:A hapten-specific lymphocyte proliferation assay, which measures the in vitro stimulation of DNA synthesis (as assessed by [3H]thymidine incorporation), was used to determine systemic immunization induced by an epicutaneously applied hapten in addition to the more commonly used method which measures ear (or footpad) s...

journal_title：Immunology

authors： Suzuki K,Kanamori S,Takada K,Kawana S

更新日期：2003-04-01 00:00:00

abstract：:Previous studies have shown that no cell-mediated immunity against LCM virus-infected cells can be detected in neonatally established LCM virus carrier mice suggesting that they are immunologically tolerant to virally-altered cell membrane antigens. In this communication experiments are described aimed at analyzing th...

journal_title：Immunology

authors： Cihak J,Lehmann-Grube F

更新日期：1978-02-01 00:00:00

abstract：:Killer cell immunoglobulin-like receptors (KIRs) interact with polymorphic human leucocyte antigen (HLA) class I molecules, modulating natural killer (NK) cell functions and affecting both the susceptibility and outcome of immune-mediated diseases. The KIR locus is highly diverse in gene content, copy number and allel...

journal_title：Immunology

authors： Tao S,Kichula KM,Harrison GF,Farias TDJ,Palmer WH,Leaton LA,Hajar CGN,Zefarina Z,Edinur HA,Zhu F,Norman PJ

更新日期：2020-12-06 00:00:00

abstract：:The glycoprotein counter-receptors for E-selectin borne on skin-homing T cells are poorly defined. In this study we have used flow cytometry to investigate the surface expression of potential carbohydrate ligands for E-selectin on HUT78, a skin-homing cutaneous T-cell lymphoma. These cells possessed high surface expre...

journal_title：Immunology

authors： Priest R,Bird MI,Malhotra R

更新日期：1998-08-01 00:00:00

abstract：:In tumour (fibrosarcoma)-inoculated mice, alterations of host resistance to Listeria monocytogenes following tumour growth were examined. Non-immune macrophage-mediated antibacterial resistance was severely suppressed up to day 4 or so after tumour inoculation, but was enhanced thereafter. On the other hand, T cell-me...

journal_title：Immunology

authors： Miyata H,Himeno K,Miake S,Nomoto K

更新日期：1981-10-01 00:00:00

abstract：:Mice fed a protein-deficient diet containing 2% ovalbumin for 6 weeks (PD) show a reduced spleen IgA plaque-forming cell (PFC) response after oral immunization with sheep red blood cells (SRBC), compared to the response of mice fed a control diet containing 20% ovalbumin (C). This reduced IgA PFC response was partiall...

journal_title：Immunology

authors： McGee DW,McMurray DN

更新日期：1988-08-01 00:00:00

abstract：:The intestinal epithelium is rich in γδ T cells and the gut is a site of residence for a wide variety of pathogens, including nematodes. Although CD4+ T-cell receptor (TCR) -αβ+ T helper type 2 T cells are essential for the expulsion of intestinal nematodes, little information is available on the function of γδ T cell...

journal_title：Immunology

authors： Inagaki-Ohara K,Sakamoto Y,Dohi T,Smith AL

更新日期：2011-12-01 00:00:00

abstract：:We have previously shown that a subset of human osteoblast-like bone surface cells (HBC) derived from explants of trabecular bone constitutively express class II major histocompatibility complex (MHC) determinants in long-term culture. We now examine the capacity of HBC to stimulate allogeneic and autologous periphera...

journal_title：Immunology

authors： Skjødt H,Møller T,Freiesleben SF

更新日期：1989-11-01 00:00:00

abstract：:Human β-defensin 3 (hBD-3) activates antigen-presenting cells through Toll-like receptors (TLRs) 1/2. Several TLR1/2 agonists have been identified but little is known about how they might differentially affect cellular activation. We compared the effects of hBD-3 with those of another TLR1/2 agonist, Pam(3) CSK(4) , i...

journal_title：Immunology

authors： Funderburg NT,Jadlowsky JK,Lederman MM,Feng Z,Weinberg A,Sieg SF

更新日期：2011-10-01 00:00:00

abstract：:The adoptive transfer of immunity by means of spleen and lymph node cells has been analysed in rabbits of defined major histocompatibility (RLA) types and immunoglobulin (Ig) allotypes. Previous results had shown that chimaeras formed by transplanting adult cells into RLA-matched newborn hosts become stable B-lymphocy...

journal_title：Immunology

authors： Claassen E,Adler LT,Saito K,Yoshio T,Adler FL

更新日期：1987-01-01 00:00:00

abstract：:Some plasmacytomas produce myeloma proteins with known antibody specificities and the secretion of these proteins by individual tumour cells can be determined using haemolytic plaque assay. After a 3 day culture of mouse plasmacytoma cells in medium containing 10% normal mouse serum, the number of plaques was reduced ...

journal_title：Immunology

authors： Kim BS,Chin DK

更新日期：1980-10-01 00:00:00

abstract：:Mouse lymph node cells cultured with Concanavalin A (Con A) in serum-free medium containing 59Fe-transferrin took up 59Fe more rapidly than cells cultured without Con-A. Uptake of iron commenced rapidly and preceded the onset of DNA synthesis in stimulated cells. Total uptake of transferrin during culture was much low...

journal_title：Immunology

authors： Brock JH,Rankin MC

更新日期：1981-06-01 00:00:00

abstract：:Tumour necrosis factor-alpha (TNF-alpha) stimulated invasion by mouse T-cell hybridomas and cytotoxic T-lymphocyte clones into rat embryo fibroblast monolayers. The effect on these highly invasive cells was limited: invasion was stimulated maximally to 130% of controls. However, when cells were pretreated with pertuss...

journal_title：Immunology

authors： La Rivière G,Klein Gebbinck JW,Schipper CA,Roos E

更新日期：1992-02-01 00:00:00

abstract：:Macrophage activating factor (MAF) is produced by antigen-stimulated lymphocytes and activates macrophages for antimicrobial function. The capacity of individual microbial antigens to evoke and regulate this response has been explored using an affinity purified antigen (TB68) of Mycobacterium tuberculosis in combinati...

journal_title：Immunology

authors： Matthews R,Scoging A,Rees AD

更新日期：1985-01-01 00:00:00

abstract：:Culture dishes precoated with thin layers of acid soluble rat tail collagen simplify conditions necessary to obtain in vitro high IgG anti-DNP responses from primed and boosted mice. In contrast to Mishell-Dutton type cultures the use of collagen precludes the need to continually rock cultures and to add nutrients. Re...

journal_title：Immunology

authors： Kemshead JT,Askonas BA

更新日期：1978-06-01 00:00:00

abstract：:Programmed death-1 (PD-1) plays an important role in protecting against inflammation and myocyte damage in T-cell-mediated myocarditis. To understand whether fibrinogen-like protein-2 (FGL2) can affect the role of the PD-1/PD-L1 pathway in experimental autoimmune myocarditis (EAM), we investigated cardiac function in ...

journal_title：Immunology

authors： Zheng Z,Yu Y,Potla R,Wu Y,Wu H

更新日期：2018-02-01 00:00:00

abstract：:Thymocytes expressing self-reactive T-cell receptors (TCR) are eliminated in the thymus through a TCR-mediated signal. This cell death signal (negative selection) generates nuclear morphological change and DNA fragmentation in thymocytes. However, the pathway leading to DNA fragmentation of thymocytes following TCR en...

journal_title：Immunology

authors： Nagata T,Kishi H,Liu QL,Matsuda T,Imanaka T,Tsukada K,Kang D,Muraguchi A

更新日期：2002-04-01 00:00:00

abstract：:Peritoneal macrophages from CBA mice incubated with recombinant murine tumour necrosis factor (TNF-alpha) are effective in killing the protozoa parasite Leishmania major in vitro. The leishmanicidal activity is directly correlated with the level of nitrite (NO2-) in the culture supernatants. The killing of intracellul...

journal_title：Immunology

authors： Liew FY,Li Y,Millott S

更新日期：1990-12-01 00:00:00