Tumour necrosis factor-alpha stimulates invasiveness of T-cell hybridomas and cytotoxic T-cell clones by a pertussis toxin-insensitive mechanism.

abstract：:Epididymitis represents a serious threat to male fertility and usually develops following secondary bacterial infection of the epididymis such as urinary tract infections or sexually transmitted diseases. Surprisingly, very little is known about the innate host response triggered by bacterial infection in the male rep...

journal_title：Immunology

authors： Mühlbauer M,Cheely AW,Yenugu S,Jobin C

更新日期：2008-06-01 00:00:00

abstract：:Evidence suggests that the immune and neuroendocrine systems cross talk by sharing ligands and receptors. Hormones and neuropeptides produced by the neuroendocrine system often modulate the function of lymphoid organs and immune cells. We have previously reported the intrathymic expression of somatostatin (SOM) in the...

journal_title：Immunology

authors： Silva AB,Aw D,Palmer DB

更新日期：2006-05-01 00:00:00

abstract：:Haptenated murine Langerhans' cells (LCs) have been reported to induce contact sensitivity when injected via the subcutaneous, intraperitoneal and, in some instances, the intravenous route. Similar studies were undertaken to elucidate the role of the LC in the induction of contact sensitivity in the guinea-pig. The su...

journal_title：Immunology

authors： Baker D,Parker D,Healey DG,Turk JL

更新日期：1987-12-01 00:00:00

abstract：:The interference of two simultaneous skin test reactions of intermediate strength has been studied in the guinea-pig, using four different antigens, i.e. ovalbumin, horse cytochrome c, PPD and oxazolone. Skin test reactions were evaluated at 4, 24 and 48 h by measuring three parameters: increase in skin thickness, dia...

journal_title：Immunology

authors： Von Blomberg M,Boerrigter GH,Scheper RJ

更新日期：1978-08-01 00:00:00

abstract：:The human histocompatibility leucocyte antigen (HLA) class II-associated invariant chain comprises at least four polypeptides. One of these is expressed as a membrane-bound subunit and has been designated as CD74. We investigated the expression of CD74 on B- and T-cell types utilizing monoclonal antibodies (mAb) speci...

journal_title：Immunology

authors： Wilson KM,Labeta MO,Pawelec G,Fernandez N

更新日期：1993-06-01 00:00:00

abstract：:We previously identified a cis-acting element within the 3' untranslated region of CD40 ligand messenger RNA (mRNA) that is composed of three complex binding sites and acts to increase mRNA stability in both in vitro and in vivo systems. We now demonstrate the functional consequences of the three binding sites with re...

journal_title：Immunology

authors： Laughlin J,Oghlidos S,Porter JF,Matus-Nicodemos R,Sinquett FL,Marcelli V,Covey LR

更新日期：2008-07-01 00:00:00

abstract：:We aimed to establish a panel of MHC-peptide multimers suitable as a positive control in the detection of HLA A*0201 restricted antigen specific T cells (ASTC) by flow cytometry. MHC Dextramers were loaded with HLA A*0201 binding peptides from viral antigens and melanoma targets identified from a literature search and...

journal_title：Immunology

authors： Fløe A,Løppke C,Hilberg O,Wejse C,Brix L,Jacobsen K

更新日期：2017-10-01 00:00:00

abstract：:Peroxisome proliferator activated receptor-gamma (PPARgamma) has been reported to exert anti-inflammatory properties in endotoxic shock and sepsis. One phenomenon that alters the inflammatory response to endotoxin [lipopolysaccharide (LPS)] is endotoxin tolerance, which is caused by previous exposure to endotoxin. Her...

journal_title：Immunology

authors： Zingarelli B,Fan H,Ashton S,Piraino G,Mangeshkar P,Cook JA

更新日期：2008-05-01 00:00:00

abstract：:Aspergillus fumigatus is often associated in asthmatic patients with the exacerbation of asthma symptoms. The pathomechanism of this phenomenon has not been fully understood. Here, we evaluated the immunological mechanisms and the role of the prostaglandin D2 / Chemoattractant Receptor-Homologous Molecule Expressed on...

journal_title：Immunology

authors： Liu H,Zheng M,Qiao J,Dang Y,Zhang P,Jin X

更新日期：2014-05-01 00:00:00

abstract：:An autoreactive T-cell clone, MTg9B3, specific for mouse thyroglobulin, has been characterized. This clone has properties consistent with it an being autoreactive T helper cell. It is I-A restricted, with a surface phenotype of Thy 1+, L3T4+, Ly2-, and produces a number of non-specific lymphokine activities following ...

journal_title：Immunology

authors： Champion BR,Hutchings P,Davies S,Marshall-Clarke S,Cooke A,Roitt IM

更新日期：1986-05-01 00:00:00

abstract：:The expanded CD8+ T-lymphocyte population arising in response to viral infection controls the virus but could also prove damaging to the host unless safely removed at the end of the immune response. Apoptosis provides a mechanism whereby this can be achieved, as apoptotic cells are recognized and engulfed by macrophag...

journal_title：Immunology

authors： Borthwick NJ,Bofill M,Hassan I,Panayiotidis P,Janossy G,Salmon M,Akbar AN

更新日期：1996-08-01 00:00:00

abstract：:Immunoglobulin E (IgE)-dependent mechanisms play a pivotal role in mediating allergic disease. Previously, VH-Cepsilon transcripts from blood or spleen of atopic asthmatics have been analysed for VH gene usage and patterns of somatic mutation. An over-representation of the minor VH5 family has been observed, consisten...

journal_title：Immunology

authors： Snow RE,Djukanovic R,Stevenson FK

更新日期：1999-12-01 00:00:00

abstract：:Mesangial hypercellularity is usually found in many models of nephritis characterized by monocyte/macrophage infiltration of the glomerulus. In order to examine the mechanism mediating these events, an in vitro model was used to study the effects of macrophage products on mouse mesangial cells, cultured under conditio...

journal_title：Immunology

authors： MacCarthy EP,Hsu A,Ooi YM,Ooi BS

更新日期：1985-12-01 00:00:00

abstract：:Trypanosoma cruzi, the causative agent of Chagas' disease, suppresses immune responses during the acute phase and has been shown to induce multiple cellular alterations in activated human T lymphocytes. However, no information is available regarding the effects of this parasite on human B cells. Using an in vitro cult...

journal_title：Immunology

authors： Kierszenbaum F,Moretti E,Sztein MB

更新日期：1991-10-01 00:00:00

abstract：:The adult cockroach generates an adaptive humoral immune response exhibiting specificity and immunological memory when immunized with soluble proteins. In contrast, the response induced by bacteria in holometabolous insects is non-specific and short term, generally losing activity after 72 hr. We have found that the r...

journal_title：Immunology

authors： Faulhaber LM,Karp RD

更新日期：1992-02-01 00:00:00

abstract：:The role of gut-derived CD4+ T cells in clearance of Pseudomonas aeruginosa from the lung was studied by cell transfer experiments. Mesenteric lymph node cells from unimmunized rats, or rats orally immunized with either killed P. aeruginosa or Helicobacter pylori, were transferred to naive rats which were subsequently...

journal_title：Immunology

authors： Dunkley ML,Clancy RL,Cripps AW

更新日期：1994-11-01 00:00:00

abstract：:Interleukin 27 (IL-27) has been identified as a potent cytokine in the differentiation of type 1 regulatory T (Tr1) cells through interactions with several key elements, including transcription factors such as aryl hydrocarbon receptor and IL-21. Autocrine production of IL-21 is known to be important for maintaining I...

journal_title：Immunology

authors： Nadya NA,Tezuka H,Ohteki T,Matsuda S,Azuma M,Nagai S

更新日期：2017-11-01 00:00:00

abstract：:Detection of immune complexes by inhibition of antibody-dependent cellular cytotoxicity (ADCC) is based on the principle that soluble complexes can compete with target cell-bound antibody for receptors (FcR) on cytotoxic lymphocytes. The objective of this study was to define a cytotoxicity system for the determination...

journal_title：Immunology

authors： Howat JM,Moore M,Hilton AM,Kimber I

更新日期：1979-06-01 00:00:00

abstract：:Mouse models and a recent vaccine trial have indicated the importance of T-cell immunity to the circumsporozoite protein (CSP) of malaria sporozoites. One of the major impediments for the development of a CSP-based vaccine is that human T-cell epitopes, identified on the CSP, span regions of significant point mutation...

journal_title：Immunology

authors： Zevering Y,Khamboonruang C,Good MF

更新日期：1998-07-01 00:00:00

abstract：:Summary Diverse immunotherapy approaches have achieved success in controlling individual aspects of immune responses in animal models. Transfer of such immunotherapies to clinical trials has obtained some success in patients, with clinical responses observed or effective antigen specific immune responses achieved, but...

journal_title：Immunology

authors： Crittenden MR,Thanarajasingam U,Vile RG,Gough MJ

更新日期：2005-01-01 00:00:00

abstract：:CD4(+) FOXP3(+) regulatory T (Treg) cells constitute a heterogeneous and plastic T-cell lineage that plays a pivotal role in maintaining immune homeostasis and immune tolerance. However, the fate of human Treg cells after loss of FOXP3 expression and the epigenetic mechanisms contributing to such a phenotype switch re...

journal_title：Immunology

authors： He H,Ni B,Tian Y,Tian Z,Chen Y,Liu Z,Yang X,Lv Y,Zhang Y

更新日期：2014-03-01 00:00:00

abstract：:The linker protein LAT is expressed mainly in T and natural killer (NK) cells. LAT-deficient mice have an arrest of intrathymic T-cell development at the CD4+ CD8+ stage and lack mature T cells in the periphery. However, no gross abnormality in development and function of the B and NK cells has been described. Here we...

journal_title：Immunology

authors： Oya K,Wang J,Watanabe Y,Koga R,Watanabe T

更新日期：2003-07-01 00:00:00

abstract：:The studies were designed to investigate the effect of ageing and low protein (4%) diet on antibody-dependent cell-mediated cytotoxicity (ADCC) and IgA concentration in the intestine. Both ADCC activity and IgA concentration were shown to reach mature levels at 17 weeks old. The effect of ageing was greater on ADCC ac...

journal_title：Immunology

authors： Lim TS,Messiha N,Watson RR

更新日期：1981-07-01 00:00:00

abstract：:We report the cloning of cDNA encoding the pig homologue of human integrin-associated protein (IAP or CD47). A pig CD47-specific probe was generated by polymerase chain reaction (PCR) amplification of pig leucocyte cDNA, using primers based on consensus regions among the known sequences of CD47 from different species....

journal_title：Immunology

authors： Shahein YE,de Andrés DF,Pérez de la Lastra JM

更新日期：2002-08-01 00:00:00

abstract：:It is now well accepted that sex hormones have immunoregulatory activity and may prevent exacerbations in multiple sclerosis during pregnancy. Our previous studies demonstrated that oestrogen (17β-oestradiol; E(2) ) protection against experimental autoimmune encephalomyelitis (EAE) is mediated mainly through oestrogen...

journal_title：Immunology

authors： Bodhankar S,Vandenbark AA,Offner H

更新日期：2012-12-01 00:00:00

abstract：:Corneal allografts contain few or no Ia+ Langerhans' cells and consistently fail to elicit allospecific delayed-type hypersensitivity (DTH). The present study examined the hypothesis that the inability of corneal allografts to induce allospecific DTH was the result of active suppression. However, the results indicated...

journal_title：Immunology

authors： Niederkorn JY,Mayhew E

更新日期：1993-12-01 00:00:00

abstract：:Goats were immunized with membrane fractions of the L5178Y tumour syngenic to DBA/2 mice. IgG fractions of this antiserum were made tumour specific by repeated in vitro and in vivo absorptions with normal cells and concentrated by adsorption to and elution from tumour cells. In vivo studies indicated that the accumula...

journal_title：Immunology

authors： Froese G,Berczi I,Israels LG

更新日期：1982-02-01 00:00:00

abstract：:Plasma fibronectin (FN) has been demonstrated to serve as an opsonin involved in the ingestion of foreign particles by phagocytes. This study concerns the effect of FN exposure on the respiratory burst of normal human peripheral phagocytes, using a luminol-dependent chemiluminescence (CL) assay for measurement of reac...

journal_title：Immunology

authors： Kuroiwa A,Igisu K,Yano T,Okada N,Okada H

更新日期：1988-10-01 00:00:00

abstract：:It has been reported that, in early pregnancy in mice, there is an increase in the number of immunoglobulin-secreting cells in the lymph nodes which drain the uterus. This paper describes the results of further investigations provoked by interest in these early changes. Increases in the numbers of immunoglobulin-secre...

journal_title：Immunology

authors： Hancock RJ,Popham AM,Faruki S,Dresser DW

更新日期：1985-06-01 00:00:00

abstract：:Prolonged exposure to ultraviolet light (UV) is known to lead to premature skin ageing, increased incidence of cataract and a high risk of developing skin cancers. UV-B irradiation, even if given as a single suberythemal dose, suppresses some immune responses, possibly reducing the production of T helper (Th) 1 cytoki...

journal_title：Immunology

authors： el-Ghorr AA,Norval M

更新日期：1997-09-01 00:00:00