Human osteoblast-like cells expressing MHC class II determinants stimulate allogeneic and autologous peripheral blood mononuclear cells and function as antigen-presenting cells.

abstract：:Oral administration of a protein antigen generates a serum factor that induces tolerance when transferred into naïve recipients. This serum factor has been described in rats as consisting of exosome-like structures or tolerosomes, which express major histocompatibility complex class II molecules (MHCII) and mediate an...

journal_title：Immunology

authors： Ostman S,Taube M,Telemo E

更新日期：2005-12-01 00:00:00

abstract：:A major role has been recently ascribed to the neutrophil in the resistance to infection by Listeria monocytogenes (L. monocytogenes). Here we evaluated whether such neutrophils played a role in the non-specific resistance to listeriosis that develops in hosts infected by mycobacteria. We found that the depletion of n...

journal_title：Immunology

authors： Leal IS,Appelberg R,Silva MT

更新日期：1996-11-01 00:00:00

abstract：:The requirement for activity of the enzyme ADP-ribosyl transferase (ADPRT) and changes in single-strand DNA breaks were assessed during the initial stimulation of quiescent murine splenic lymphocytes with mitogen alone, the stimulation of activated blasts with IL-2-containing medium and, for comparison, the serum stim...

journal_title：Immunology

authors： Johnstone AP,Darling D

更新日期：1985-08-01 00:00:00

abstract：:Interleukin-6 (IL-6) is a multifunctional cytokine with a broad range of activities and can affect a variety of target cells or systems in multiple ways. However, there is currently no consensus on how IL-6 directly affects the peripheral nervous tissue. We performed histopathological and immunohistochemical analyses ...

journal_title：Immunology

authors： Deretzi G,Pelidou SH,Zou LP,Quiding C,Zhu J

更新日期：1999-08-01 00:00:00

abstract：:Quantitative studies on B cells require a direct assay for antibody-forming cell (AFC) progenitor function, in which the number of AFC produced bears a simple, linear arithmetic relationship to the number of progenitors present. This might be expected under conditions where helper T-cell and accessory cell requirement...

journal_title：Immunology

authors： Schlegel RA,Fidler JM,Howard M,Shortman K

更新日期：1975-12-01 00:00:00

abstract：:We have characterized two unusual T-cell hybridomas, 1E3 and 3B8, from H-2k mice immunized with I-Ab-transfected L cells (H-2k), that are stimulated by L cells transfected with I-Ab, I-Ak or I-Eb, but not by non-transfected L cells. These hybridomas could not be stimulated by spleen cells from H-2i3, H-2k, H-2b or H-2...

journal_title：Immunology

authors： Mendiratta SK,Singh N,Bal V,Rath S

更新日期：1996-10-01 00:00:00

abstract：:Macrophages play important roles in the clearance of dying and dead cells. Typically, and perhaps simplistically, they are viewed as the professional phagocytes of apoptotic cells. Clearance by macrophages of cells undergoing apoptosis is a non-phlogistic phenomenon which is often associated with actively anti-inflamm...

journal_title：Immunology

authors： Gregory CD,Devitt A

更新日期：2004-09-01 00:00:00

abstract：:Prostaglandins are some of the main mediators which control parturition, and their production by intrauterine tissues can be up-regulated by pro-inflammatory cytokines. Anti-inflammatory cytokines may oppose these effects, and in this study we have investigated how two such cytokines affected fetal membrane function. ...

journal_title：Immunology

authors： Brown NL,Alvi SA,Elder MG,Bennett PR,Sullivan MH

更新日期：2000-01-01 00:00:00

abstract：:Large numbers of cells can be recovered from pig intestine with phenotypes suggesting lamina propria rather than intraepithelial origin. Following activation with concanavalin A these cells produced a T-cell growth factor (TCGF) activity which was not inhibited in the presence of a monoclonal antibody recognizing pig ...

journal_title：Immunology

authors： Bailey M,Hall L,Bland PW,Stokes CR

更新日期：1994-08-01 00:00:00

abstract：:The complement fragment C5a is a potent leucocyte chemoattractant and activator, mediating its effects through a G-protein-coupled receptor. Whilst the C-terminal domain of this receptor has been shown to be essential for receptor desensitization and internalization, it is not known which domains couple to the recepto...

journal_title：Immunology

authors： Auger GA,Smith BM,Pease JE,Barker MD

更新日期：2004-08-01 00:00:00

abstract：:The soluble cytoplasmic fraction of an homogenate from peritoneal rat mast cells, demonstrated a considerable amount of catalytic activity which promotes the transfer of phosphate from creatine phosphate to ADP. The plasma membrane, mitochondrial and microsomal fractions show negligible amounts of the catalyst. Enzyme...

journal_title：Immunology

authors： Magro AM

更新日期：1980-03-01 00:00:00

abstract：:Dendritic cells (DC) isolated from the lymph nodes or spleens of mice and pulsed with contact sensitizers or protein antigens stimulate primary proliferative responses by syngeneic T cells and responses to alloantigens in the mixed leucocyte reaction (MLR). Using enriched human peripheral blood DC, we attempted to sti...

journal_title：Immunology

authors： Hill S,Coates JP,Kimber I,Knight SC

更新日期：1994-10-01 00:00:00

abstract：:Five of twenty-three patients with paraproteinaemia (two IgM, three IgG) have been shown to exhibit marked classical pathway complement activation. The mechanisms of hypocomplementaemia proposed for the five patients are cryoglobulinaemia in one and in vivo immunoglobulin aggregation in the other four. Three further p...

journal_title：Immunology

authors： Naish PF,Collins C,Barratt J

更新日期：1977-10-01 00:00:00

abstract：:Susceptibility to collagen-induced arthritis (CIA), a murine model of autoimmune arthritis, is strongly linked to only two major histocompatibility complex (MHC) haplotypes, H-2q and H-2r. In order to identify the determinants of type II collagen (CII) required to induce arthritis in H-2r-bearing mice, B10.RIII mice w...

journal_title：Immunology

authors： Myers LK,Miyahara H,Terato K,Seyer JM,Stuart JM,Kang AH

更新日期：1995-04-01 00:00:00

abstract：:The plaque-forming cell (PFC) responses to sheep red blood cell (SRBC) dinitrophenyl-lysine-Ficoll (DNP-lys-Ficoll), and dinitrophenylated bovine serum albumin (DNP-BSA) have been studied in both germ-free and conventionally reared ICR mice. In germ-free mice, the IgG response to SRBC and the IgM and IgG responses to ...

journal_title：Immunology

authors： Ohwaki M,Yasutake N,Yasui H,Ogura R

更新日期：1977-01-01 00:00:00

abstract：:Peripheral blood lymphocytes (PBL) from non-immunized rabbits or from rabbits immunized several months previously with a single dose of sheep red blood cells (SRBC) were cultured at several different cell densities in the presence of antigen for 5 days. The cells were then distributed in 10 microliter microcultures at...

journal_title：Immunology

authors： Luzzati AL,Giacomini E,Lefkovits I

更新日期：1985-12-01 00:00:00

abstract：:Apolipoprotein-E (apoE) is expressed at high levels by macrophages. In addition to its role in lipid transport, macrophage-derived apoE plays an important role in immunoregulation. Previous studies have identified macrophage subpopulations that differ substantially in their ability to synthesize specific cytokines and...

journal_title：Immunology

authors： Tedla N,Glaros EN,Brunk UT,Jessup W,Garner B

更新日期：2004-11-01 00:00:00

abstract：:An investigation was made of the properties of cytotoxic T cells induced by Con A and exposure to LCM virus-infected cells. As a basis for such studies, the optimal conditions for in vitro Con A stimulation of in vivo LCM virus-primed C3H mouse splenocytes were determined. The most potent cytotoxicity was obtained whe...

journal_title：Immunology

authors： Marker O,Andersen GT

更新日期：1979-10-01 00:00:00

abstract：:The antibody response in rhino mice, which carry a mutant gene hrrh, to thymus-dependent (TD) or thymus-independent (TI) antigens was compared with that of phenotypically normal littermates. The magnitude of antibody response to TD antigens in rhino mice decreased as they grew up, whereas the antibody response to TI a...

journal_title：Immunology

authors： Takaoki M,Kawaji H

更新日期：1980-05-01 00:00:00

abstract：:alpha 1-Acid glycoprotein (AG), a serum component elevated during acute inflammation, has been implicated in the suppression of various immunological responses. Pretreatment of lymphoid cells with AG at a concentration commonly found in patients with acute inflammation results in the inhibition of mitogen induced lymp...

journal_title：Immunology

authors： Cheresh DA,Haynes DH,Distasio JA

更新日期：1984-03-01 00:00:00

abstract：:Although lymphocyte traffic through the brain is normally low, this can increase dramatically in response to infection or an autoimmune reaction. We have studied the adhesion of lymphocytes to cerebral endothelium in vitro in an attempt to model the first step of the infiltration process--that is, the initial interact...

journal_title：Immunology

authors： Hughes CC,Male DK,Lantos PL

更新日期：1988-08-01 00:00:00

abstract：:Antigenic encounter by T cells induces immunological synapse formation and T-cell activation. Using different concentrations of toxic shock syndrome toxin-1 (TSST-1) as stimulus, we examined the capacities of dendritic cells (DC) and macrophages (Mphi) to prime syngeneic naive T cells. DCs were, under all experimental...

journal_title：Immunology

authors： Rothoeft T,Gonschorek A,Bartz H,Anhenn O,Schauer U

更新日期：2003-12-01 00:00:00

abstract：:Signal transducers and activators of transcription (STATs) are key molecular determinants of T-cell fate and effector function. Several inflammatory diseases are characterized by an altered balance of T-cell phenotypes and cytokine secretion. STATs, therefore, represent viable therapeutic targets in numerous pathologi...

journal_title：Immunology

authors： Sadreev II,Chen MZQ,Umezawa Y,Biktashev VN,Kemper C,Salakhieva DV,Welsh GI,Kotov NV

更新日期：2018-04-01 00:00:00

abstract：:Runx1 transcription factor is highly expressed at a CD4/CD8-double-negative (DN) stage of thymocyte development but is down-regulated when cells proceed to the double-positive (DP) stage. In the present study, we examined whether the down-regulation of Runx1 is necessary for thymocyte differentiation from the DN to DP...

journal_title：Immunology

authors： Wong WF,Nakazato M,Watanabe T,Kohu K,Ogata T,Yoshida N,Sotomaru Y,Ito M,Araki K,Telfer J,Fukumoto M,Suzuki D,Sato T,Hozumi K,Habu S,Satake M

更新日期：2010-06-01 00:00:00

abstract：:Expression of CD45RO on intraepithelial lymphocytes (IEL) bearing the T-cell receptor (TcR) alpha/beta or gamma/delta was studied in situ by three-colour immunofluorescence on jejunal tissue sections from 21 patients with coeliac disease and eight controls. CD45RA-TcR alpha/beta+ IEL expressed CD45RO significantly mor...

journal_title：Immunology

authors： Halstensen TS,Farstad IN,Scott H,Fausa O,Brandtzaeg P

更新日期：1990-12-01 00:00:00

abstract：:Self-reactive clones, estimated by anti-V beta monoclonal antibodies (mAb) in conjunction with the Mls system, are confined to a population of intermediate (int) T-cell receptor (TCR) (or CD3) cells (i.e. TCRint cells), but are not found among TCRhigh cells. The next questions to be answered are whether autologous kil...

journal_title：Immunology

authors： Moroda T,Iiai T,Suzuki S,Tsukahara A,Tada T,Nose M,Hatakeyama K,Seki S,Takeda K,Watanabe H,Abo T

更新日期：1997-06-01 00:00:00

abstract：:The migration of lymphocytes and neutrophils into skin sites stimulated with chemotactic agonists or with cytokines known to induce leucocyte-endothelial adhesion molecules was examined in sheep. Lymphocytes, collected from efferent prefemoral lymph, labelled in vitro with [111In]oxine and reinjected intravenously, mi...

journal_title：Immunology

authors： Colditz IG,Watson DL

更新日期：1992-06-01 00:00:00

abstract：:Chronic antigenic stimulation leads to gradual accumulation of late-differentiated, antigen-specific, oligoclonal T cells, particularly within the CD8(+) T-cell compartment. They are characterized by critically shortened telomeres, loss of CD28 and/or gain of CD57 expression and are defined as either CD8(+) CD28(-) or...

journal_title：Immunology

authors： Strioga M,Pasukoniene V,Characiejus D

更新日期：2011-09-01 00:00:00

abstract：:When Trypanosoma cruzi is co-cultured with activated human lymphocytes the latter manifest a marked level of suppression in their capacity to express high-affinity interleukin-2 receptors (IL-2R). In this study we asked whether this effect could result from reduced expression of the p75 component of the IL-2R, a condi...

journal_title：Immunology

authors： Kierszenbaum F,Sztein MB

更新日期：1992-03-01 00:00:00

abstract：:Delayed hypersensitivity reactions and antibody-mediated reactions to the carrier and to the hapten have been studied in animals treated with BCG or/and trypan blue before immunization with a hapten-carrier complex. The results show that it is possible to induce, with BCG, at the beginning of the response, an antigeni...

journal_title：Immunology

authors： Neveu PJ

更新日期：1977-08-01 00:00:00