A comparative study on the humoral immune responses in germ-free and conventional mice.

abstract：:Epididymitis represents a serious threat to male fertility and usually develops following secondary bacterial infection of the epididymis such as urinary tract infections or sexually transmitted diseases. Surprisingly, very little is known about the innate host response triggered by bacterial infection in the male rep...

journal_title：Immunology

authors： Mühlbauer M,Cheely AW,Yenugu S,Jobin C

更新日期：2008-06-01 00:00:00

abstract：:Using immunohistological techniques, class 1 products of the major histocompatibility complex (MHC) have been demonstrated on various forms of human extra-villous trophoblast in placental tissues taken from first, second and third trimester pregnancies. This contrasts with the absence of class 1 MHC antigens on all fo...

journal_title：Immunology

authors： Redman CW,McMichael AJ,Stirrat GM,Sunderland CA,Ting A

更新日期：1984-07-01 00:00:00

abstract：:The selective cytotoxicity of the lysosomotropic methyl esters of leucine or its lysosomal condensation product leucyl-leucine has been used to investigate the effect of cytolytic cells on the clonal outgrowth, cellular proliferation and antibody secretion of Epstein-Barr virus (EBV)-transformed human B cells. Large g...

journal_title：Immunology

authors： Ohlin M,Danielsson L,Carlsson R,Borrebaeck CA

更新日期：1989-04-01 00:00:00

abstract：:The effect of different macrophage populations and supernatants derived from these macrophages on Con-A induced lymphocyte activation in macrophage depleted lymph node cells has been investigated. All macrophage populations tested were able to restore the lymphocytic response to Con A. Macrophages of different origin ...

journal_title：Immunology

authors： Knop J

更新日期：1980-10-01 00:00:00

abstract：:The activity of Nocardia water-soluble mitogen (NWSM) and LPS were compared in several experimental systems, since both compounds are B-cell mitogens and polyclonal activators in vitro. The results reported here demonstrated that NWSM like LPS also has a strong adjuvant activity in vivo if administered in saline with ...

journal_title：Immunology

authors： Lowy I,Bona C,Ciorbaru R,Chedid L

更新日期：1977-06-01 00:00:00

abstract：:Marmosets are natural blood chimeras, this condition resulting from the high frequency of fraternal twinning and the consistent development of placental vasular anastomoses between the two embryos. Identification of chimerism by sex-chromosome analysis of cultured blood lymphocytes provided a means of determining the ...

journal_title：Immunology

authors： Niblack GD,Kateley JR,Gengozian N

更新日期：1977-02-01 00:00:00

abstract：:Norovirus (NoV) -derived virus-like particles (VLPs) resemble empty shells of the virus and NoV P-particles contain only protruding domains of the NoV capsid. Both NoV-derived subviral particles show similar functionality and antigenicity in vitro and are considered to be potential vaccine candidates against NoV gastr...

journal_title：Immunology

authors： Tamminen K,Huhti L,Koho T,Lappalainen S,Hytönen VP,Vesikari T,Blazevic V

更新日期：2012-01-01 00:00:00

abstract：:We report that interleukin (IL)-4 and IL-10 can significantly up- or down-regulate CXC chemokine receptor 4 (CXCR4) expression on CD4+ T lymphocytes, respectively. Stromal cell-derived factor-1alpha (SDF-1alpha)-induced CD4+ T-lymphocyte chemotaxis was also correspondingly regulated by IL-4 and IL-10. IL-4 and IL-10 u...

journal_title：Immunology

authors： Jinquan T,Quan S,Jacobi HH,Madsen HO,Glue C,Skov PS,Malling HJ,Poulsen LK

更新日期：2000-03-01 00:00:00

abstract：:Neutrophils make up an essential part of the innate immune system, and are involved both in the initial responses to pathogens, and in orchestrating later immune responses. Neutrophils recognize pathogens through pattern-recognition receptors (PRRs), which are activated by microbial motifs. The Nod-like receptors (nuc...

journal_title：Immunology

authors： Ekman AK,Cardell LO

更新日期：2010-05-01 00:00:00

abstract：:Antisera were prepared against a variety of chicken tissues with a view to detecting antigens specific for subpopulations of T and B cells at different maturation stages. By appropriate absorption analysis, the following antigens were defined: (a) thymus organ-specific antigen (CTOA); (b) T lymphocyte-specific antigen...

journal_title：Immunology

authors： Boyd RL,Ward HA

更新日期：1978-01-01 00:00:00

abstract：:In the present study, we have analysed the phenotype of EphB2 and/or EphB3 deficient thymocytes confirming and extending previous studies on the role of this family of molecules in T-cell differentiation. In all mutant thymuses statistically significant reduced cell contents were observed. This reduction of thymic cel...

journal_title：Immunology

authors： Alfaro D,Muñoz JJ,García-Ceca J,Cejalvo T,Jiménez E,Zapata A

更新日期：2008-09-01 00:00:00

abstract：:Guinea-pigs immunized with homogenates of unfed larvae and nymphs of the tick Rhipicephalus appendiculatus developed significant levels of protective immunity to infestation with adults of this species. The mean engorged weight of female ticks feeding on immunized animals (181.96 +/- 05.63 mg and 170.11 +/- 11.54 mg) ...

journal_title：Immunology

authors： Varma MG,Heller-Haupt A,Trinder PK,Langi AO

更新日期：1990-09-01 00:00:00

abstract：:Gammadelta T cells are unique, and their localization at sites of infection is considered critical in immune defence. We demonstrate the accumulation of gammadelta T cells in rat regional popliteal lymph nodes (PLNi) starting 2 days after inoculation of cytomegalovirus (CMV) into the footpad. Early-appearance PLNi gam...

journal_title：Immunology

authors： Dyugovskaya L,Hirsh M,Ginsburg H

更新日期：2003-02-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection is a global health problem characterized by a high rate of chronic infection, which may in part be due to a defect in myeloid dendritic cells (mDCs). This defect appears to be remedied by treatment with interferon-α (IFN-α) -based antiviral therapies; however, the molecular mechanisms...

journal_title：Immunology

authors： Ma L,Zhou Y,Zhang Y,Li Y,Guo Y,He Y,Wang J,Lian J,Hao C,Moorman JP,Yao ZQ,Zhou Y,Jia Z

更新日期：2014-12-01 00:00:00

abstract：:This study describes a subtractive hybridization analysis to identify differences in gene expression between sibling Th memory clones, elicited by virus infection and expressing identical T-cell receptor (TCR)-alphabeta rearrangements but distinct lymphokine phenotype: clone Bpp9 secretes interleukin (IL)-4, IL-5 and ...

journal_title：Immunology

authors： Graham CM,Thomas DB

更新日期：2004-10-01 00:00:00

abstract：:Induction of all forms of protective immunity by oral immunization with subunit vaccines is an ideal goal for the development of novel vaccines, but creates several theoretical problems from the point of view of antigen processing mechanisms. We show here that incorporation of the protein antigen ovalbumin (OVA) in li...

journal_title：Immunology

authors： Mowat AM,Donachie AM,Reid G,Jarrett O

更新日期：1991-03-01 00:00:00

abstract：:Recent suggestions of a thymic origin or thymo-dependent differentiation of tissue mast cells prompted an investigation in the athymic nude (nu/nu) mouse. The outbred nu/nu examined were found to possess mast cells in at least comparable numbers to the phenotypically normal nu/+. These nu/nu were superior to nu/+ as r...

journal_title：Immunology

authors： Lynch NR,Prin J,Salomon JC

更新日期：1977-01-01 00:00:00

abstract：:The discovery that corticosteroids can alter leucocyte distribution implies that suppression of PFC in the spleen is not necessarily indicative of suppression of the antibody response as a whole. Therefore we have examined IgM and IgG serum antibodies and PFC in the thymus, spleen, femoral marrow, popliteal, thoracic ...

journal_title：Immunology

authors： Dracott BN,Smith CE

更新日期：1979-10-01 00:00:00

abstract：:One of the hallmarks of systemic autoimmune diseases, such as systemic lupus erythematosus (SLE), is the immune response to nuclear autoantigens. Several studies have proposed that dendritic cells may acquire the nuclear autoantigens from the apoptotic cells to initiate the systemic autoimmune responses. To examine th...

journal_title：Immunology

authors： Suen JL,Chuang YH,Chiang BL

更新日期：2002-07-01 00:00:00

abstract：:Following prescapular lymphadenectomy, the cellular composition of afferent (peripheral) lymph from eight out of 13 calves in which the afferent and efferent lymphatic ducts had anastomosed was examined using monoclonal antibodies (mAb) specific for bovine lymphoid populations. Afferent lymph leucocytes (ALL) consiste...

journal_title：Immunology

authors： Emery DL,MacHugh ND,Ellis JA

更新日期：1987-10-01 00:00:00

abstract：:Osteopontin (OPN) is important for the function of fibroblasts, macrophages and lymphocytes during inflammation and wound healing. In recent studies of experimental colitis we demonstrated exacerbated tissue destruction in OPN-null mice, associated with reduced tumour necrosis factor-alpha expression and increased mye...

journal_title：Immunology

authors： Koh A,da Silva AP,Bansal AK,Bansal M,Sun C,Lee H,Glogauer M,Sodek J,Zohar R

更新日期：2007-12-01 00:00:00

abstract：:A serum factor, believed to be an IgG autoantibody, in certain patients with lepromatous leprosy inhibits the proliferation of mitogen-stimulated lymphocytes. To investigate which stage of the cell cycle was inhibited, we examined the effect of these sera on the kinetics of lymphocyte activation induced by several mit...

journal_title：Immunology

authors： Poulton TA,Gallagher A,Beck JS

更新日期：1989-11-01 00:00:00

abstract：:Ligation of T-cell receptor (TCR) causes mature T cells to proliferate or, on re-exposure to antigen, can cause them to die by activation-induced cell death (AICD). In proliferative responses, costimulatory and adhesive interactions are required and activation of protein kinase C (PKC) has been shown to be essential. ...

journal_title：Immunology

authors： Tchilian EZ,Anderson G,Moore NC,Owen JJ,Jenkinson EJ

更新日期：1996-04-01 00:00:00

abstract：:CD4 T cells help immune responses, but knowledge of how memory CD4 T cells are regulated and how they regulate adaptive immune responses and induce immunopathology is limited. Using adoptive transfer of virus-specific CD4 T cells, we show that naive CD4 T cells undergo substantial expansion following infection, but ca...

journal_title：Immunology

authors： Bhattacharyya M,Madden P,Henning N,Gregory S,Aid M,Martinot AJ,Barouch DH,Penaloza-MacMaster P

更新日期：2017-10-01 00:00:00

abstract：:Anti-idiotypic sera (aIds) were raised in C57BL/6 mice against monoclonal antibodies (McAbs) which bind poly(Tyr,Glu)-poly(DLAla)--poly(Lys)--abbreviated to (T,G)-A--L--and (Tyr-Tyr-Glu-Glu)-poly(DLAla)--poly(Lys)--abbreviated to (T-T-G-G)-A--L--(nos. 103 and 160) and McAbs which react only with (T-T-G-G)-A--L (nos. 1...

journal_title：Immunology

authors： Parhami-Seren B,Eshhar Z,Mozes E

更新日期：1984-02-01 00:00:00

abstract：:Antigenic encounter by T cells induces immunological synapse formation and T-cell activation. Using different concentrations of toxic shock syndrome toxin-1 (TSST-1) as stimulus, we examined the capacities of dendritic cells (DC) and macrophages (Mphi) to prime syngeneic naive T cells. DCs were, under all experimental...

journal_title：Immunology

authors： Rothoeft T,Gonschorek A,Bartz H,Anhenn O,Schauer U

更新日期：2003-12-01 00:00:00

abstract：:Chronic antigenic stimulation leads to gradual accumulation of late-differentiated, antigen-specific, oligoclonal T cells, particularly within the CD8(+) T-cell compartment. They are characterized by critically shortened telomeres, loss of CD28 and/or gain of CD57 expression and are defined as either CD8(+) CD28(-) or...

journal_title：Immunology

authors： Strioga M,Pasukoniene V,Characiejus D

更新日期：2011-09-01 00:00:00

abstract：:Cutaneous delayed hypersensitivity reactions to collagen in guinea-pigs were partially but specifically suppressed if the animals had been pretreated with collagen and Freund's incomplete adjuvant. Such animals responded normally to skin-reactive factor prepared with ovalbumin. Lymphoid cells from animals with normal ...

journal_title：Immunology

authors： Gentner GJ,Adelmann BC

更新日期：1976-07-01 00:00:00

abstract：:The ultimate outcome of T-cell recognition of peptide-major histocompatibility complex (MHC) complexes is determined by the molecular context in which antigen presentation is provided. The paradigm is that, after exposure to peptides presented by steady-state dendritic cells (DCs), inhibitory signals dominate, leading...

journal_title：Immunology

authors： Konkel JE,Frommer F,Leech MD,Yagita H,Waisman A,Anderton SM

更新日期：2010-05-01 00:00:00

abstract：:The Mycobacterium leprae and M. tuberculosis 10,000 MW heat-shock protein homologues of GroES have previously been identified as major immunogens for human T cells. We used synthetic peptides to characterize the determinants recognized by murine T cells. The findings suggest that, despite 90% sequence identity between...

journal_title：Immunology

authors： Chua-Intra B,Ivanyi J,Hills A,Thole J,Moreno C,Vordermeier HM

更新日期：1998-01-01 00:00:00