Abstract：
:Anti-idiotypic sera (aIds) were raised in C57BL/6 mice against monoclonal antibodies (McAbs) which bind poly(Tyr,Glu)-poly(DLAla)--poly(Lys)--abbreviated to (T,G)-A--L--and (Tyr-Tyr-Glu-Glu)-poly(DLAla)--poly(Lys)--abbreviated to (T-T-G-G)-A--L--(nos. 103 and 160) and McAbs which react only with (T-T-G-G)-A--L (nos. 100 and 114). Anti-Id antibodies against 103 McAb reacted with (T,G)-A--L specific antibodies and specifically inhibited their binding to iodinated antigen. Similarly, conventional antibodies against the major idiotypes of (T,G)-A--L-specific antibodies inhibited the binding of 103 McAb to antigen. It is therefore suggested that 103 McAb shares major idiotypes with (T,G)-A--L-specific polyclonal antibodies of C3H.SW origin. Anti-Ids against 114 McAb also inhibited the binding of (T,G)-A--L-specific antibodies to antigen, but the binding of 114 McAb could not be inhibited by conventional aIds. Therefore, idiotypes of 103 and 114 McAbs define idiotypic determinants expressed on two different subpopulations of (T,G)-A--L-specific antibodies: those that carry major idiotypes and those which express idiotypic determinants other than the major one (minor Ids). Anti-idiotypic sera against McAbs nos. 100 and 160 reacted with the homologous idiotypes and not with the major idiotypes of (T,G)-A--L-specific antibodies. In addition to the aforementioned specificities we could define cross-reactive idiotypes (private) shared by McAbs nos. 100, 103 and 114 McAbs nos. 160 and 114. The analysis of idiotypes expressed on anti-(T,G)-A--L McAbs enabled the detection of new antigen binding site related idiotypic determinants in addition to the major idiotypes which were immunodominant in the polyclonal anti-(T,G)-A--L antibodies.
journal_name
Immunologyjournal_title
Immunologyauthors
Parhami-Seren B,Eshhar Z,Mozes Esubject
Has Abstractpub_date
1984-02-01 00:00:00pages
367-76issue
2eissn
0019-2805issn
1365-2567journal_volume
51pub_type
杂志文章相关文献
IMMUNOLOGY文献大全abstract：:The role of Peyer's patches in the local intestinal and serum antibody responses to keyhole limpet haemocyanin (KLH) was studied in rabbits with chronically isolated ileal loops. Four weekly doses of 400 microgram KLH were administered into loops prepared with and without Peyer's patches. Isotype-specific IgA and IgG ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1981-03-01 00:00:00
abstract：:The cell-cell interactions for CD23 expression and soluble (s)CD23 release from peripheral blood lymphocytes (PBL), as well as purified cells (B, T cells, monocytes) of atopic donors, were studied. Cells either stimulated combined and subsequently separated or stimulated after separation were analysed. IL-4, IL-2, phy...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1989-12-01 00:00:00
abstract：:Rabbit IgG and its Fab, Fc and pFc' fragments, prepared by papain or peptic digestion, were assayed for binding to homologous peritoneal macrophages. The binding affinity of IgG for the peritoneal macrophages (Ka = 5.9 +/- 1.6 x 10(5) L/M) was comparable to that recorded with alveolar macrophages (7.6 +/- 1.8 x 10(5) ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1979-03-01 00:00:00
abstract：:The microfibrillar protein (MFP) of foetal bovine ligamentum nuchae elastic fibres was prepared and used to produce a monospecific antiserum. Indirect immunofluorescence studies employing the specific antiserum demonstrated its selectivity for MFP associated with elastic fibres. The antiserum was demonstrated to react...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1977-09-01 00:00:00
abstract：:It has been demonstrated that the single autosomal recessive lpr and gld genes are responsible for the accumulation of unusual T-cell subsets. Although these subsets have been assigned to the T-cell lineage, they share certain antigenic cell surface markers with mature B lymphocytes. Consequently the maturational path...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1991-02-01 00:00:00
abstract：:The association between three major spondyloarthritic diseases, ankylosing spondylitis, Reiter's syndrome, and reactive arthritis, and the major histocompatibility complex (MHC) class 1 antigen HLA-B27 is well documented. The hypothesis of cross-reactivity between HLA-B27 and the antecedent infection-causing Gram-nega...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1992-11-01 00:00:00
abstract：:An investigation was made of the properties of cytotoxic T cells induced by Con A and exposure to LCM virus-infected cells. As a basis for such studies, the optimal conditions for in vitro Con A stimulation of in vivo LCM virus-primed C3H mouse splenocytes were determined. The most potent cytotoxicity was obtained whe...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1979-10-01 00:00:00
abstract：:Lymphocyte activation requires signal transduction mediated by reversible phosphorylation. Changing profiles of phosphorylated intermediates relate to the progressive series of transduction pathways in cells moving from G0 to G1, and thereafter through the cell cycle. We have previously shown that transient inhibition...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1992-08-01 00:00:00
abstract：:The effect of disodium cromoglycate (DSCG) upon human immunoglobulin (Ig) isotypes and IgG subclasses production by purified B cells was studied. DSCG enhanced IgM, IgG1, IgG2, IgG3, IgG4 and IgA production in a dose-dependent fashion, while DSCG failed to induce IgE production at any concentrations tested by purified...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1991-05-01 00:00:00
abstract：:The fate of allogeneic lymphocytes (AO or DA) transferred to non-immune PVG recipients was studied in the light of previous evidence (Heslop & McNeilage, 1983; Rolstad & Ford, 1983) that allogeneic lymphocytes can be rapidly destroyed in certain strain combinations of rats and mice by a mechanism that is distinct from...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:Free fatty acids (FFA) were tested for their effects on in vitro thymus-dependent (TD) and thymus-independent (TI) immune responses. Murine T cells proliferating in one-way mixed leucocyte reactions (MLR) were extremely sensitive to inhibition by exogenous stearic acid (18:0) but were only moderately affected by oleic...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1985-12-01 00:00:00
abstract：:The members of the tumour necrosis factor (TNF) superfamily of cytokines play important roles in the regulation of various immune-cell functions. Likewise, induction of cell death by apoptosis is indispensable for the normal functioning of the immune system. There are two major pathways of apoptosis induction. The int...
journal_title：Immunology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2567.2009.03058.x
更新日期：2009-06-01 00:00:00
abstract：:We studied proliferative responses of bovine T lymphocytes to foot-and-mouth disease virus (FMDV) serotypes A, O and C as well as to three peptides including the two major B-cell epitopes of FMDV (VP1[141-156] and VP1[200-213]). Peripheral blood mononuclear cells (PBMC) from cattle previously vaccinated with monovalen...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1992-03-01 00:00:00
abstract：:Male lymphocytic choriomeningitis (LCM) virus-carrier mice were mated to uninfected females and their offsprings tested for (i) LCMV virus and (ii) their potential to generate LCM virus-specific cytotoxic T cells. Among about 500 offspring tested no example of antigen-independent inheritance of tolerance to LCM virus ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1984-06-01 00:00:00
abstract：:During acute Trypanosoma cruzi infection in mice, many leucocytes undergo apoptosis. Although apoptosis has been ascribed to increased levels of nitric oxide (NO) and Fas-FasL interaction, the importance of this phenomenon in modulating the host response against T. cruzi is unknown. Herein, the role of NO- and Fas-Fas...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.2001.01216.x
更新日期：2001-05-01 00:00:00
abstract：:An autoreactive T-cell clone, MTg9B3, specific for mouse thyroglobulin, has been characterized. This clone has properties consistent with it an being autoreactive T helper cell. It is I-A restricted, with a surface phenotype of Thy 1+, L3T4+, Ly2-, and produces a number of non-specific lymphokine activities following ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1986-05-01 00:00:00
abstract：:CD45 has been recognized as an important player in regulating signalling in lymphocytes. However, compared with tyrosine kinases, phosphatases are still poorly understood in terms of the details of their specificity and regulation. Here, the recent progress in understanding the biology of the first recognized receptor...
journal_title：Immunology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2567.2005.02265.x
更新日期：2006-02-01 00:00:00
abstract：:In our efforts to identify products that might be used for active immunotherapy in human immunodeficiency virus (HIV) infection, we have studied synthetic peptides derived from the CD4 attachment site of gp120. Two peptides have emerged with particularly interesting properties. The first (B138) is linear and spans the...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1992-04-01 00:00:00
abstract：:Haptenated murine Langerhans' cells (LCs) have been reported to induce contact sensitivity when injected via the subcutaneous, intraperitoneal and, in some instances, the intravenous route. Similar studies were undertaken to elucidate the role of the LC in the induction of contact sensitivity in the guinea-pig. The su...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1987-12-01 00:00:00
abstract：:The generation of effective immunity requires that antigen-specific T cells are activated, clonally expanded and ultimately eliminated by apoptosis. The involvement of CD95-mediated apoptosis in T-cell elimination is well established, but the conditions which regulate the death pathway under normal circumstances are s...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1999.00925.x
更新日期：1999-12-01 00:00:00
abstract：:Peptides HNB-92-169 and 116-169, tyr, derivatives of the C-terminal part of bovine myelin basic protein, sensitize rabbits for experimental allergic encephalomyelitis (EAE). Dissolving these peptides in heat-inactivated normal guinea-pig, human, or monkey serum immediately before emulsification with Freund's complete ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1976-04-01 00:00:00
abstract：:Adoptive transfer of T-cells is a promising therapy for many cancers. To enhance tumour recognition by T-cells, chimeric antigen receptors (CARs) consisting of signalling domains fused to receptors that recognize tumour-associated antigens can be expressed in T-cells. While CAR T-cells have shown clinical success for ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.13187
更新日期：2020-07-01 00:00:00
abstract：:The in vitro frequency and proliferative capacity of B cells and B-cell precursors in old mice was assessed. The mitogenic response to the B-cell mitogens lipopolysaccharide (LPS) and dextran sulphate decline later and at a slower rate than the T-cell response to phytohaemagglutinin and concanavalin A. The response to...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1979-06-01 00:00:00
abstract：:The natural response of immunocompetent adult animals to antigen inhalation is the development of T-lymphocyte mediated tolerance, particularly in the IgE-antibody class (Holt & Sedgwick, 1987). It has been suggested that this process functions as a protective mechanism to limit sensitization to aeroallergens. In the ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1988-04-01 00:00:00
abstract：:Dengue virus (DENV) infection causes dengue fever, dengue haemorrhagic fever, or dengue shock syndrome. Mast cells have been speculated to play a role in DENV disease although their precise roles are unclear. In this study, we used mast cell-deficient Kit(W-sh/W-sh) mice to investigate the involvement of mast cells af...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.12492
更新日期：2015-09-01 00:00:00
abstract：:Ligation of T-cell receptor (TCR) causes mature T cells to proliferate or, on re-exposure to antigen, can cause them to die by activation-induced cell death (AICD). In proliferative responses, costimulatory and adhesive interactions are required and activation of protein kinase C (PKC) has been shown to be essential. ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1996.515580.x
更新日期：1996-04-01 00:00:00
abstract：:The distribution of T lymphocytes expressing the different polypeptides of the leucocyte common antigen (LCA) family detected by CD45R and UCHL1 antibodies has been studied in normal lymphoid tissues. In the thymus most cortical thymocytes express UCHL1 and co-express CD4 and CD8. The more mature membrane CD3+ (mainly...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1989-04-01 00:00:00
abstract：:Levels of IgA and IgG antibodies were measured in uterine and vaginal secretions to examine the effect of uterine immunization on the genital tract humoral immune system. When ovariectomized animals were immunized on Day 0 and boosted 13 days later by placing sheep erythrocytes (SRBC) directly in the uterine lumen (UT...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1989-09-01 00:00:00
abstract：:Vitamin A and its active metabolite retinoic acid are essential for the development and function of many tissues including the immune system. The induction of mucosal homing receptors on T and B cells by mucosal dendritic cells (DC) depends on the presence of vitamin A. Recent studies indicate that also the differenti...
journal_title：Immunology
pub_type： 杂志文章,评审
doi：10.1111/imm.12228
更新日期：2014-05-01 00:00:00
abstract：:Therapeutic vaccination using T-cell receptor (TCR) peptides from V genes commonly expressed by potentially pathogenic T cells remains an approach of interest for treatment of multiple sclerosis (MS) and other autoimmune diseases. We developed a trivalent TCR vaccine containing complementarity determining region (CDR)...
journal_title：Immunology
pub_type： 临床试验,杂志文章
doi：10.1111/j.1365-2567.2007.02703.x
更新日期：2008-01-01 00:00:00
