Abstract：
:We studied proliferative responses of bovine T lymphocytes to foot-and-mouth disease virus (FMDV) serotypes A, O and C as well as to three peptides including the two major B-cell epitopes of FMDV (VP1[141-156] and VP1[200-213]). Peripheral blood mononuclear cells (PBMC) from cattle previously vaccinated with monovalent vaccine responded to both homotypic and heterotypic virus strains. Of 14 FMDV-specific bovine T-cell clones, which were prepared from PBMC of an animal vaccinated with the trivalent vaccine, 11 reacted to each of the three serotypes A, O and C. This indicates that several T-cell epitopes might be conserved among these serotypes. PBMC from one of two cattle immunized with VP1[141-156]KLH, one of two cattle immunized with VP1[200-213]KLH and two of three cattle immunized with CC-VP1[200-213]-PPS-VP1[141-156]-PCG responded to the homotypic virus strain. After immunizations with VP1[200-213]KLH also heterotypic responses were found. Thus, it appears that these two B-cell sites include T-cell determinants that are recognized by some cattle. However, when proliferative responses of PBMC from an animal vaccinated with the trivalent vaccine were tested, no responses were found to VP1[141-156] and VP1[200-213], whereas the response was very poor to CC-VP1[200-213]-PPS-VP1[141-156]-PCG. These results suggest that these sequences do not represent dominant T-cell epitopes and/or that T-cell reactivity towards these synthetic peptides does not completely cover the T-cell reactivity towards the fragments present after processing of the whole virus.
journal_name
Immunologyjournal_title
Immunologyauthors
van Lierop MJ,van Maanen K,Meloen RH,Rutten VP,de Jong MA,Hensen EJkeywords:
subject
Has Abstractpub_date
1992-03-01 00:00:00pages
406-13issue
3eissn
0019-2805issn
1365-2567journal_volume
75pub_type
杂志文章相关文献
IMMUNOLOGY文献大全abstract：:Chicken antibodies (immunoglobulin Y; IgY) to the alpha Gal epitope (galactose alpha-1,3-galactose) bind to alpha Gal antigens of mouse and porcine tissues and endothelial cells in vitro and block human anti-alpha Gal antibody binding, complement activation and antibody-dependent cell-mediated lysis mechanisms. The ac...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.2000.00136.x
更新日期：2000-12-01 00:00:00
abstract：:It was found that spleen cells from mice injected i.v. with large doses of BCG respond to PHA stimulation less intensely than do normal spleen cells. We were able to show that nylon wool column purified BCG treated T cells also had a low PHA reactivity. Unfractionated spleen cells, adherent cells or T-enriched populat...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1978-03-01 00:00:00
abstract：:Interaction between CD27 and its ligand CD70 provides a second signal for T-cell proliferation and tumour necrosis factor-alpha (TNF-alpha) production. Whereas CD27 is broadly expressed during T-cell development, expression of CD70 in vivo is restricted. To determine when CD27 CD70 interactions can occur in immune rea...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1997.00134.x
更新日期：1997-01-01 00:00:00
abstract：:Supernatants of IL-2-activated mononuclear cells (MNC) that displayed an optimal lymphokine-activated killer (LAK) cell activity at 48-72 hr in culture were found to contain increased levels of tumour necrosis factor alpha (TNF alpha), interleukin-1 alpha (IL-1 alpha) and interferon-gamma (IFN-gamma) when compared wit...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1989-12-01 00:00:00
abstract：:Successful elimination of the hepatitis C virus (HCV) during acute infection has been linked to strong HCV-specific in vitro T-cell proliferation, whereas T cells from patients with chronic hepatitis C respond only weakly to HCV antigens. Lipid-coupled peptides are immunostimulants, which might provide a basis for nov...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.2001.01209.x
更新日期：2001-04-01 00:00:00
abstract：:The effect of E. coli lipopolysaccharide (LPS) on the induction of both hapten-specific immunity and tolerance was studied in an in vivo system utilizing putative T-cell dependent (TD) or T-cell independent (TI) challenge antigens. The administration of LPS 1 day prior to challenge preempted the response of C3D2 mice ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1979-11-01 00:00:00
abstract：:Therapeutic vaccination using T-cell receptor (TCR) peptides from V genes commonly expressed by potentially pathogenic T cells remains an approach of interest for treatment of multiple sclerosis (MS) and other autoimmune diseases. We developed a trivalent TCR vaccine containing complementarity determining region (CDR)...
journal_title：Immunology
pub_type： 临床试验,杂志文章
doi：10.1111/j.1365-2567.2007.02703.x
更新日期：2008-01-01 00:00:00
abstract：:Monoclonal antibodies (MAb) against sequential or conformational epitopes on foot-and-mouth disease virus (FMDV) passively protected neonatal syngeneic (BALB/c) mice at dilutions at which they could not neutralize virus infectivity in vitro. The B2, D9, 1C6 and 4C9 MAb, against the Group 1 (sequential) and Group 2 (co...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1986-07-01 00:00:00
abstract：:Studies in long-term non-progressors (LTNP) have suggested that the quality of the CD8(+) response may involve protective human leucocyte antigen (HLA) class I alleles. However, studies examining the expansion ability of different functional CD8(+) T cells and their association with HLA class I alleles are lacking. LT...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2011.03490.x
更新日期：2011-11-01 00:00:00
abstract：:Mouse peritoneal macrophages (M phi) expressed enhanced tumoricidal activity upon in vitro stimulation either with the lymphokine M phi-activating factor (MAF) or with fibroblast interferon (IFN-beta). In contrast, M phi suppressive activity on lymphoproliferation was not affected by MAF pretreatment, but was drastica...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1983-11-01 00:00:00
abstract：:Epidermal keratinocytes are induced to express MHC class II molecules in a variety of disease states associated with immune activity. To investigate the mechanism of this process we have exposed murine and rat keratinocytes to a variety of lymphokines and monitored changes in their MHC molecule expression. Murine cult...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:Infection of nude mice with Mesocestoides corti results in spleen enlargement, with a decrease in percentage positive, but overall increase in Thy-1 positive cells. A low frequency of both parasite antigen-specific and alloantigen-reactive T-cell clones were isolated from the spleen, mesenteric lymph nodes, peritoneal...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1985-02-01 00:00:00
abstract：:Recent suggestions of a thymic origin or thymo-dependent differentiation of tissue mast cells prompted an investigation in the athymic nude (nu/nu) mouse. The outbred nu/nu examined were found to possess mast cells in at least comparable numbers to the phenotypically normal nu/+. These nu/nu were superior to nu/+ as r...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1977-01-01 00:00:00
abstract：:The role of endogenously mediated fever and exogenous hyperthermia as modulators of immune functions remains poorly understood. It is known that fever is mediated by several cytokines, including interleukin-1 alpha and interleukin-1 beta (IL-1 alpha and IL-1 beta), interleukin-6 (IL-6), tumour necrosis factor-alpha (T...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1991-07-01 00:00:00
abstract：:In this paper we report that treatment with 17 beta-oestradiol depresses cutaneous delayed-type hypersensitivity (DTH) to oxazolone (OXA) in female oophorectomized NZB/W mice. Analysis of the parental strains revealed that this oestrogen-induced inhibition of DTH mice is a trait inherited from the healthy NZW and not ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1989-06-01 00:00:00
abstract：:The adoptive transfer of immunity by means of spleen and lymph node cells has been analysed in rabbits of defined major histocompatibility (RLA) types and immunoglobulin (Ig) allotypes. Previous results had shown that chimaeras formed by transplanting adult cells into RLA-matched newborn hosts become stable B-lymphocy...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:Following immunization with various lambda Bence-Jones proteins, over 100 hybridomas were established. A majority of the monoclonal antibodies (McAb) produced were demonstrated to recognize epitopes common to all lambda chains or unique to the immunogen. Twenty-nine McAb exhibited profiles of 'restricted' reactivity. ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1986-11-01 00:00:00
abstract：:To define the role of memory T cells in a non-persistent viral infection, we have delineated the phenotype of memory CD8+ T cells specific for influenza A virus (FluA; matrix protein M158-66) based on the expression of several memory/effector lineage markers and relevant chemokine receptors. We found a majority of Flu...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2005.02135.x
更新日期：2005-06-01 00:00:00
abstract：:Immunization with intact IgG has allowed the isolation of four hybridomas producing antibodies recognizing epitopes expressed within subpopulations of human kappa light chains unrelated to known polymorphisms (Km) and previously defined V-region subgroups. The V-region-associated epitopes recognized are conformation-d...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1985-06-01 00:00:00
abstract：:Expression of CD45RO on intraepithelial lymphocytes (IEL) bearing the T-cell receptor (TcR) alpha/beta or gamma/delta was studied in situ by three-colour immunofluorescence on jejunal tissue sections from 21 patients with coeliac disease and eight controls. CD45RA-TcR alpha/beta+ IEL expressed CD45RO significantly mor...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1990-12-01 00:00:00
abstract：:Summary Diverse immunotherapy approaches have achieved success in controlling individual aspects of immune responses in animal models. Transfer of such immunotherapies to clinical trials has obtained some success in patients, with clinical responses observed or effective antigen specific immune responses achieved, but...
journal_title：Immunology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2567.2004.02001.x
更新日期：2005-01-01 00:00:00
abstract：:The role of gut-derived CD4+ T cells in clearance of Pseudomonas aeruginosa from the lung was studied by cell transfer experiments. Mesenteric lymph node cells from unimmunized rats, or rats orally immunized with either killed P. aeruginosa or Helicobacter pylori, were transferred to naive rats which were subsequently...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1994-11-01 00:00:00
abstract：:Allergic diseases are frequently exacerbated between midnight and early morning, suggesting a role for the biological clock. Mast cells (MC) and eosinophils are the main effector cells of allergic diseases and some MC-specific or eosinophil-specific markers, such as tryptase or eosinophil cationic protein, exhibit cir...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.12157
更新日期：2013-12-01 00:00:00
abstract：:The members of the tumour necrosis factor (TNF) superfamily of cytokines play important roles in the regulation of various immune-cell functions. Likewise, induction of cell death by apoptosis is indispensable for the normal functioning of the immune system. There are two major pathways of apoptosis induction. The int...
journal_title：Immunology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2567.2009.03058.x
更新日期：2009-06-01 00:00:00
abstract：:Anti-CD20 monoclonal antibodies are promising for the treatment of B-cell malignancies such as chronic lymphocytic leukaemia and autoimmune diseases where auto-antibodies play an important role. Anti-CD20 such as rituximab (RTX) mediates B-cell depletion through mechanisms such as complement-mediated cytotoxicity and ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2011.03434.x
更新日期：2011-06-01 00:00:00
abstract：:The activity of Nocardia water-soluble mitogen (NWSM) and LPS were compared in several experimental systems, since both compounds are B-cell mitogens and polyclonal activators in vitro. The results reported here demonstrated that NWSM like LPS also has a strong adjuvant activity in vivo if administered in saline with ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1977-06-01 00:00:00
abstract：:All but one of nine Acholeplasma strains were susceptible to killing by gnotobiotic-calf serum while all but one of fifteen Mycoplasma strains were resistant. The mechanism of killing was examined using inhibitors of complement, viz. EDTA. MgEGTA. epsilon-amino caproic acid, and also by desalting serum and adding MgCl...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1980-11-01 00:00:00
abstract：:The soluble cytoplasmic fraction of an homogenate from peritoneal rat mast cells, demonstrated a considerable amount of catalytic activity which promotes the transfer of phosphate from creatine phosphate to ADP. The plasma membrane, mitochondrial and microsomal fractions show negligible amounts of the catalyst. Enzyme...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1980-03-01 00:00:00
abstract：:The ultimate outcome of T cell receptor recognition is determined by the context in which the antigen is encountered. In this fashion both antigen-presenting cells and T cells must integrate multiple environmental cues in the form of pathogen-associated molecular patterns, cytokines and accessory molecule signals. The...
journal_title：Immunology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2567.2009.03125.x
更新日期：2009-08-01 00:00:00
abstract：:We have studied activation-induced changes in intracellular calcium [Ca2+]i, interleukin-2 (IL-2) secretion, and clonal abortion of the human leukaemic T-cell line Jurkat and three T-cell receptor (TcR)/CD3 receptor negative clones deficient for the TcR alpha, TcR beta and CD3 gamma chains respectively, as well as thr...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1993-03-01 00:00:00
