Following TRAIL's path in the immune system.

abstract：:This study addresses the question of whether human peripheral CD4+ CD45RA+ T cells possess antigen-specific immune memory. CD4+ CD45RA+ T cells were isolated by a combination of positive and negative selection. Putative CD4+ CD45RA+ cells expressed CD45RA (98.9%) and contained < 0.1% CD4+ CD45RO+ and < 0.5% CD4+ CD45R...

journal_title：Immunology

authors： Richards D,Chapman MD,Sasama J,Lee TH,Kemeny DM

更新日期：1997-07-01 00:00:00

abstract：:Adoptive transfer of anti-Listeria resistance by Listeria-immune spleen T cells was markedly reduced by pretreatment of the cells with monoclonal anti-Lyt 2.2 and complement (Lyt 2+C); pretreatment of cells with monoclonal anti-L3T4 and complement (L3T4+C) had a lesser effect on their ability to transfer resistance. L...

journal_title：Immunology

authors： Czuprynski CJ,Brown JF

更新日期：1987-02-01 00:00:00

abstract：:Previous studies have highlighted the importance of CD4+ T cells in regulation of IgA responses and have indicated a functional heterogeneity among these cells between inductive (Peyer's patch) and effector (lamina propria) sites in the intestine. To determine whether these functional differences could be accounted fo...

journal_title：Immunology

authors： Bao S,Goldstone S,Husband AJ

更新日期：1993-12-01 00:00:00

abstract：:Attempts were made to break the tolerance of lymph node B cells to deaggregated human gamma globulin. Using allotype-congenic mice, lymph node cells from virgin or tolerant (5 mg) CBA/Igb donors were transferred tonormal CBA/Iga recipients and the proportion of responding donor B cells estimated 1 and 13 days later. T...

journal_title：Immunology

authors： Elson CJ,Taylor RB

更新日期：1977-11-01 00:00:00

abstract：:Vitamin A and its active metabolite retinoic acid are essential for the development and function of many tissues including the immune system. The induction of mucosal homing receptors on T and B cells by mucosal dendritic cells (DC) depends on the presence of vitamin A. Recent studies indicate that also the differenti...

journal_title：Immunology

authors： Beijer MR,Kraal G,den Haan JM

更新日期：2014-05-01 00:00:00

abstract：:The migration of immune cells through the extracellular matrix (ECM) towards inflammatory sites is co-ordinated by receptors recognizing ECM glycoproteins, chemokines and proinflammatory cytokines. In this context, galectins are secreted to the extracellular milieu, where they recognize poly-N-acetyllactosamine chains...

journal_title：Immunology

authors： Rabinovich GA,Ariel A,Hershkoviz R,Hirabayashi J,Kasai KI,Lider O

更新日期：1999-05-01 00:00:00

abstract：:Trypanosoma cruzi, the causative agent of Chagas' disease, is a protozoan parasite that infects humans and other mammals in Central and Latin America. Several alterations of the immune response after infection have been described, such as severe immunosuppression of both cellular and humoral responses and massive poly...

journal_title：Immunology

authors： Da Silva AC,Espinoza AG,Taibi A,Ouaissi A,Minoprio P

更新日期：1998-06-01 00:00:00

abstract：:Excessive and dysregulated inflammation is known to contribute to disease progression. HSP90 is an intracellular chaperone known to regulate inflammatory processes including the NLRP3 inflammasome and secretion of the pro-inflammatory cytokine interleukin(IL)-1β. Here, primarily using an in vitro inflammasome ASC spec...

journal_title：Immunology

authors： Nizami S,Arunasalam K,Green J,Cook J,Lawrence CB,Zarganes-Tzitzikas T,Davis JB,Di Daniel E,Brough D

更新日期：2021-01-01 00:00:00

abstract：:Therapeutic vaccination using T-cell receptor (TCR) peptides from V genes commonly expressed by potentially pathogenic T cells remains an approach of interest for treatment of multiple sclerosis (MS) and other autoimmune diseases. We developed a trivalent TCR vaccine containing complementarity determining region (CDR)...

journal_title：Immunology

authors： Vandenbark AA,Culbertson NE,Bartholomew RM,Huan J,Agotsch M,LaTocha D,Yadav V,Mass M,Whitham R,Lovera J,Milano J,Theofan G,Chou YK,Offner H,Bourdette DN

更新日期：2008-01-01 00:00:00

abstract：:Vitamins A and E and select flavonoids in the family of catechins are well-defined small molecules that, if proven to possess immunomodulatory properties, hold promise as vaccine adjuvants and various therapies. In an effort to determine the in vivo immunomodulatory properties of these molecules, we found that althoug...

journal_title：Immunology

authors： Patel S,Akalkotkar A,Bivona JJ 3rd,Lee JY,Park YK,Yu M,Colpitts SL,Vajdy M

更新日期：2016-08-01 00:00:00

abstract：:Activation of naive CD8(+) T cells in the presence of interleukin-4 modulates their CD8 co-receptor expression and functional differentiation, resulting in the generation of CD8(low) cells that produce type 2 cytokines and display poor cytolytic and anti-tumour activity. Although this CD8(low) phenotype becomes stable...

journal_title：Immunology

authors： Olver S,Apte SH,Baz A,Kelso A,Kienzle N

更新日期：2013-06-01 00:00:00

abstract：:The fungus metabolite cyclosporin A is a small cyclic peptide acting as a novel antilymphocytic agent. It is effective following either parenteral or oral administration in mice, rats and guinea-pigs. The suppressive effect after short and prolonged treatment on plaque-forming cells, the inhibition of the secondary hu...

journal_title：Immunology

authors： Borel JF,Feurer C,Magnée C,Stähelin H

更新日期：1977-06-01 00:00:00

abstract：:The effects of a variety of agents on the mouse antibody response to sheep red cells (SRC) and Escherichia coli lipopolysaccharide (LPS) were investigated. Agents formed two broad groups according to the time-dependence of their effects. Class I agents inhibited responses if given at any time over a broad period from ...

journal_title：Immunology

authors： Berenbaum MC

更新日期：1979-02-01 00:00:00

abstract：:The gut immune system and its modification by diet have been implicated in the pathogenesis of type 1 diabetes (T1D). Therefore, we investigated gut immune status in non-diabetes-prone LEW.1AR1 and diabetes-prone LEW.1AR1-iddm rats and evaluated the effect of a low antigen, hydrolysed casein (HC)-based diet on gut imm...

journal_title：Immunology

authors： Crookshank JA,Patrick C,Wang GS,Noel JA,Scott FW

更新日期：2015-07-01 00:00:00

abstract：:Cholera toxin (CT) or its subunits were given orally to mice and division of intestinal intraepithelial lymphocytes (IEL) in vivo measured by double immunofluorescence using 5-bromo-2'-deoxyuridine (BRdU) and membrane alpha beta T-cell receptors (TCR) or gamma delta TCR staining in frozen sections. Cholera toxin (10 m...

journal_title：Immunology

authors： Penney I,Kilshaw PJ,MacDonald TT

更新日期：1996-09-01 00:00:00

abstract：:A superantigen (Streptococcus pyogenes mitogen-2; SPM-2) that stimulates human helper T cells bearing unique types of variable domains of T-cell receptor beta-chain (TCR V beta) was isolated from the culture supernatant of S. pyogenes strain T12. The active molecule isolated by diethylaminoethyl (DEAE)-cellulose chrom...

journal_title：Immunology

authors： Rikiishi H,Okamoto S,Sugawara S,Tamura K,Liu ZX,Kumagai K

更新日期：1997-07-01 00:00:00

abstract：:Infection of nude mice with Mesocestoides corti results in spleen enlargement, with a decrease in percentage positive, but overall increase in Thy-1 positive cells. A low frequency of both parasite antigen-specific and alloantigen-reactive T-cell clones were isolated from the spleen, mesenteric lymph nodes, peritoneal...

journal_title：Immunology

authors： Sanderson CJ,Strath M

更新日期：1985-02-01 00:00:00

abstract：:C57Bl/6 (B6) mice produced highly developed granulomata in the lung 3 or 4 weeks after intravenous injection with oil-associated BCG cell walls (CW), but C3H/He (C3H) mice did not. The potential to develop granulomata is genetically controlled (Yamamoto & Kakinuma, 1978). It is probable that the genes control only T-c...

journal_title：Immunology

authors： Kakinuma M,Onoé K,Okada M,Kimura T,Kato K,Okuyama H,Morikawa K,Yamamoto K

更新日期：1981-05-01 00:00:00

abstract：:Formation of osteoclasts and consequent joint destruction are hallmarks of rheumatoid arthritis (RA). Here we show that LIGHT, a member of the tumour necrosis factor (TNF) superfamily, induced the differentiation into tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells (MNCs) of CD14(+) monocytes ...

journal_title：Immunology

authors： Ishida S,Yamane S,Nakano S,Yanagimoto T,Hanamoto Y,Maeda-Tanimura M,Toyosaki-Maeda T,Ishizaki J,Matsuo Y,Fukui N,Itoh T,Ochi T,Suzuki R

更新日期：2009-09-01 00:00:00

abstract：:Down-regulated chemerin expression has been reported to correlate with poor prognosis of several types of cancer including melanoma. All-trans retinoic acid (atRA) is a potent inducer of chemerin, and we previously reported that atRA inhibited murine melanoma growth through enhancement of anti-tumor T-cell immunity. H...

journal_title：Immunology

authors： Song Y,Yin W,Dan Y,Sheng J,Zeng Y,He R

更新日期：2019-07-01 00:00:00

abstract：:Signal transducers and activators of transcription (STATs) are key molecular determinants of T-cell fate and effector function. Several inflammatory diseases are characterized by an altered balance of T-cell phenotypes and cytokine secretion. STATs, therefore, represent viable therapeutic targets in numerous pathologi...

journal_title：Immunology

authors： Sadreev II,Chen MZQ,Umezawa Y,Biktashev VN,Kemper C,Salakhieva DV,Welsh GI,Kotov NV

更新日期：2018-04-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic, synovial inflammation affecting multiple joints, finally leading to extra-articular lesions for which limited effective treatment options are currently available. Interleukin-34 (IL-34), recently discovered as the second colony-stimul...

journal_title：Immunology

authors： Zhou RP,Wu XS,Xie YY,Dai BB,Hu W,Ge JF,Chen FH

更新日期：2016-12-01 00:00:00

abstract：:Mycobacterium leprae-specific immunoglobulin G1 (IgG1) antibodies in patients with leprosy show a direct correlation with bacterial load (rho=0.748; P<0002) suggesting that IgG1 B-cell responses may be surrogate markers of disease progression. To investigate if this upregulation was a general feature of IgG1 responses...

journal_title：Immunology

authors： Hussain R,Dockrell HM,Chiang TJ

更新日期：1999-04-01 00:00:00

abstract：:I have briefly reviewed the factors that motivated me to change my views about the existence and importance of suppressor/regulatory T cells and to devote the majority of my laboratory efforts to this newly revitalized area of immunologic research. I am optimistic that manipulation of regulatory T-cell function will s...

journal_title：Immunology

authors： Shevach EM

更新日期：2008-01-01 00:00:00

abstract：:Previous studies have shown that depletion of Langerhans' cells (LC) from murine epidermis by the superantigen, staphylococcal enterotoxin A (SEA) involves interleukin-1alpha (IL-1alpha) and is inhibitable by agents that block G-protein-associated kinases. The purpose of this study was to determine whether specific ki...

journal_title：Immunology

authors： Shankar G,Johnson J,Kuschel L,Richins M,Burnham K

更新日期：1999-02-01 00:00:00

abstract：:The role of genetic factors associated with the immunoglobulin heavy chain locus (Igh) in the development of benign monoclonal gammapathy (BMG), a benign B-cell proliferative disorder, was investigated in six Igh congenic mouse strains during ageing. The strains used had a C57BL or BALB background: C57BL/6, BALB.Igb a...

journal_title：Immunology

authors： van den Akker TW,de Glopper-van der Veer E,Radl J,Benner R

更新日期：1988-09-01 00:00:00

abstract：:Bisphenol A (BPA) and p-nonylphenol (NP) are representative endocrine disruptors (EDs) that may have adverse effects on human health. The influence of these compounds on allergic immune responses remains unclear. In this study, we have examined the effects of BPA and NP on production of interleukin-4 (IL-4), a pro-inf...

journal_title：Immunology

authors： Lee MH,Chung SW,Kang BY,Park J,Lee CH,Hwang SY,Kim TS

更新日期：2003-05-01 00:00:00

abstract：:To study the influence of macrophages on the migration and distribution of lymphocytes in the spleen, macrophages were eliminated from the spleen of mice by injection of liposomes in which DMDP was encapsulated. This leads to an elimination of macrophages in both the red pulp and marginal zone of the spleen within 1-2...

journal_title：Immunology

authors： Kraal G,Rodrigues H,Hoeben K,Van Rooijen N

更新日期：1989-10-01 00:00:00

abstract：:The epigenetic regulation of transcription factor genes is critical for T-cell lineage specification. A specific methylation pattern within a conserved region of the lineage specifying transcription factor gene FOXP3, the Treg-specific demethylated region (TSDR), is restricted to regulatory T (Treg) cells and is requi...

journal_title：Immunology

authors： Kehrmann J,Tatura R,Zeschnigk M,Probst-Kepper M,Geffers R,Steinmann J,Buer J

更新日期：2014-07-01 00:00:00

abstract：:The aim of this study is to investigate the clinical significance of the ratio between interleukin-17 (IL-17) secreting cell and FOXP3-positive regulatory T cell (FOXP3(+) Treg) infiltration in renal allograft tissues with acute T-cell-mediated rejection (ATCMR). Fifty-six patients with biopsy-proven ATCMR were includ...

journal_title：Immunology

authors： Chung BH,Oh HJ,Piao SG,Hwang HS,Sun IO,Choi SR,Park HS,Choi BS,Choi YJ,Park CW,Kim YS,Cho ML,Yang CW

更新日期：2012-07-01 00:00:00