Abstract:
:Activation of naive CD8(+) T cells in the presence of interleukin-4 modulates their CD8 co-receptor expression and functional differentiation, resulting in the generation of CD8(low) cells that produce type 2 cytokines and display poor cytolytic and anti-tumour activity. Although this CD8(low) phenotype becomes stable after about a week and can persist with further stimulation in vitro, it is not known whether it can be maintained long term in vivo. Here we report that CD8(low) cells derived from oval-bumin(257-264) -specific T-cell receptor-transgenic CD8(+) T cells activated in the presence of interleukin-4 could be detected in the spleen for at least 4 months after adoptive transfer into normal mice. A significant proportion of the long-term surviving cells retained their CD8(low) phenotype in vivo and after clonal re-activation in vitro. Although long-term surviving CD8(low) cells lacked detectable cytolytic activity or perforin expression, they showed some anti-tumour function in vivo. The persistence of functional cells with a CD8(low) phenotype in vivo raises the possibility that such cells can contribute to effector or regulatory responses to tumours or pathogens.
journal_name
Immunologyjournal_title
Immunologyauthors
Olver S,Apte SH,Baz A,Kelso A,Kienzle Ndoi
10.1111/imm.12068subject
Has Abstractpub_date
2013-06-01 00:00:00pages
187-96issue
2eissn
0019-2805issn
1365-2567journal_volume
139pub_type
杂志文章相关文献
IMMUNOLOGY文献大全abstract::The differentiation mechanisms that force thymocytes into the T-cell receptor (TCR)-alpha beta or TCR-gamma delta lineage are poorly understood, but rearrangement processes in the TCR-alpha/delta locus are likely to play an important role. It is assumed that the TCR-delta gene is deleted prior to V alpha-J alpha rearr...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1046/j.1365-2567.1998.00417.x
更新日期:1998-02-01 00:00:00
abstract::Susceptibility to collagen-induced arthritis (CIA), a murine model of autoimmune arthritis, is strongly linked to only two major histocompatibility complex (MHC) haplotypes, H-2q and H-2r. In order to identify the determinants of type II collagen (CII) required to induce arthritis in H-2r-bearing mice, B10.RIII mice w...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1995-04-01 00:00:00
abstract::CD40/CD154 interaction is essential for both humoral and cellular immune response. We investigated whether this interaction could be altered in patients with kidney failure who are known to present an impaired immune response. To that aim, we measured the levels of the soluble form of CD40 (sCD40), which is known to i...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1046/j.1365-2567.2003.01716.x
更新日期:2003-09-01 00:00:00
abstract::The effects of a single dose of cyclophosphamide (ranging from 12 x 5 mg/m2 to 500 mg/m2) on rat spleens have been studied using quantitative morphometric techniques. The results obtained show that a single dose of cyclophosphamide (500 mg/m2) caused the destruction of primary and secondary follicles and less extensiv...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1980-05-01 00:00:00
abstract::A soluble form of Fc epsilon RII/CD23 is spontaneously released from most lymphoblastoid cell lines established by the Epstein-Barr virus (EBV). Such a product was purified on an IgE-Sepharose column and its pyrogenic effect was investigated in rabbits. This preparation induced a monophasic fever in rabbits, with a pe...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1991-08-01 00:00:00
abstract::It is increasingly becoming clear that various immune cells are infected by the very pathogens that they are supposed to attack. Although many mechanisms for microbial entry exist, it appears that a common route of entry shared by certain bacteria, viruses and parasites involves cellular lipid-rich microdomains someti...
journal_title:Immunology
pub_type: 杂志文章,评审
doi:10.1046/j.1365-2567.2001.01173.x
更新日期:2001-01-01 00:00:00
abstract::Initial stages of tumour growth are not easily accessible to investigation. Therefore an experimental procedure was developed to mimic tumorigenesis as closely as possible. BALB/c mice received intraperitoneally exponentially increasing numbers of irradiated syngeneic ADJ-PC-5 plasmacytoma cells. The initial injection...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1982-11-01 00:00:00
abstract::Interleukin-19 (IL-19) plays an important role in asthma by stimulating T helper type 2 (Th2) cytokine production. Interestingly, IL-4, a key Th2 cytokine, in turn up-regulates IL-19 expression in bronchial epithelial cells, so forming a positive feedback loop. In atopic dermatitis (AD), another Th2 disease closely re...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12339
更新日期:2014-12-01 00:00:00
abstract::Homogenates from human lung contained a preformed slow reacting substance (pSRS). The pattern of contraction on the guinea-pig ileum by pSRS was indistinguishable from that of SRS-A. The activity of pSRS could not be attributed to the presence of K+, Na+, Ca2+ and Mg2+ ions, or any prostaglandin including PGF2 or its ...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1976-11-01 00:00:00
abstract::This study examines the expression of mRNA for the Th2 cytokine, interleukin-4 (IL-4). Peripheral blood mononuclear cells from deer infected with Mycobacterium bovis or vaccinated with live or killed M. bovis bacillus Calmette-Guérin (BCG) were cultured with mycobacterial antigens. IL-4 mRNA production was assayed usi...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.1996.tb00014.x
更新日期:1996-06-01 00:00:00
abstract::The kinetics of anti-paternal alloantibody production in syngeneically and allogeneically mated mice previously immunized with allogenic spleen cells has been investigated. In allogeneically mated females, total and cytotoxic alloantibody levels increased during the final 3 days of pregnancy to reach maximal levels ar...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1982-05-01 00:00:00
abstract::Basophils are implicated in the pathogenesis of the late-phase allergic reaction, but the mechanisms by which circulating basophils adhere to vascular endothelium and migrate to lesional sites remain unclear. In order to assess the biological similarity of the basophilic cell line KU-812 to normal human basophils, we ...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1994-07-01 00:00:00
abstract::Cytotoxic T-lymphocyte antigen-4 (CTLA-4) is an important molecule in the down-regulation of T-cell activation. A study was undertaken to evaluate the association of the CTLA-4 gene polymorphisms -319C/T, +49A/G, (AT)(n), CT60A/G and Jo31G/T with the levels of membrane CTLA-4 (mCTLA-4) and cytoplasmic CTLA-4 (cCTLA-4)...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2009.03083.x
更新日期:2009-09-01 00:00:00
abstract::The studies were designed to investigate the effect of ageing and low protein (4%) diet on antibody-dependent cell-mediated cytotoxicity (ADCC) and IgA concentration in the intestine. Both ADCC activity and IgA concentration were shown to reach mature levels at 17 weeks old. The effect of ageing was greater on ADCC ac...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1981-07-01 00:00:00
abstract::B lymphocyte-induced maturation protein-1 (Blimp-1), the transcription factor encoded by the gene Prdm1, plays a number of crucial roles in the adaptive immune system, which result in the maintenance of key effector functions of B- and T-cells. Emerging clinical data, as well as mechanistic evidence from mouse studies...
journal_title:Immunology
pub_type: 杂志文章,评审
doi:10.1111/imm.13249
更新日期:2020-12-01 00:00:00
abstract::Cytotoxic T-lymphocytes (CTL) play an important role in the control of human immunodeficiency virus (HIV) and of human cytomegalovirus (HCMV) infection. Following highly active antiretroviral therapy (HAART), most studies have demonstrated a decline in the frequency of HIV-specific CTL. We analysed the effect of HAART...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2006.02334.x
更新日期:2006-05-01 00:00:00
abstract::The localization of Thy-1, MRC OX 2 and Ia antigens as defined by monoclonal antibodies MRC OX 7, MRC OX 2 and MRC OX 6 was determined by an indirect immunoperoxidase technique on cryostat sections of rat ovaries. Thy-1 antigen was present significantly in the theca interna of growing antral follicles. Developing corp...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1983-03-01 00:00:00
abstract::Rapid expulsion of the nematode Trichinella spiralis from immune rats is associated with an increase in volume of intestinal exudate and the presence of large numbers of tissue mucosal mast cells (MMC) and eosinophils. We have measured the concentrations of leukotrienes (LT) C4 (LTC4) and B4 (LTB4) in gut perfusates a...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1987-03-01 00:00:00
abstract::The existence of competing and blocking IgG antibodies and their interrelationship with IgE antibodies was investigated in the IgE immune response of CBA/J mice to bee venom phospholipase A2 (PLA2) and keyhole limpet haemocyanin (KLH). Minute doses of antigen induced high titres of both IgE and IgG antibodies, whereas...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1995-02-01 00:00:00
abstract::The CD4-specific monoclonal antibody (mAb) CC26, when tested on a total of 143 cattle, failed to react with T cells from 16% of animals and gave reduced intensity staining in a further 35% of animals. The results of family studies with groups of half- and full-siblings indicated that CC26 recognizes an allele of CD4 w...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1994-12-01 00:00:00
abstract::B-lymphocyte maturation is considered to be independent of the thymus. However, there is circumstantial evidence suggesting that it may be impaired in nude animals that lack the thymus. Our study shows that the proportion of immature B-lymphocyte subsets (CD90(high) IgM(high) and CD90(high) IgM(low)) was significantly...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2005.02226.x
更新日期:2005-11-01 00:00:00
abstract::We have examined the distribution of the complement (C) regulatory proteins CD59, membrane cofactor protein (MCP) and decay-accelerating factor (DAF) on mature sperm and compared expression of these proteins in parallel both during spermatogenesis and in the prostate. Enhanced immunoperoxidase staining and radioimmuno...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1994-03-01 00:00:00
abstract::An experiments in mice with a range of human serum albumin (HSA) molecules acylated to various degrees with side-chains of 6--20 carbon atoms, the greatest antibody responses against HSA were induced by highly acylated HSA with side-chains of intermediate length (C10--14). Similar results were obtained in rats but in ...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1980-03-01 00:00:00
abstract::Lymphoid cells in decidualized uterine endometrium in early human pregnancy may be essential for successful implantation and placentation. Endometrial granulocytes are prominent in early pregnancy decidua and express some T-cell associated surface antigens (CD2+, CD7+), but little is known of their function. We report...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1987-10-01 00:00:00
abstract::Bile acids (BAs) play important roles not only in lipid metabolism, but also in signal transduction. TGR5, a transmembrane receptor of BAs, is an immunomodulative factor, but its detailed mechanism remains unclear. Here, we aimed to delineate how BAs operate in immunological responses via the TGR5 pathway in human mon...
journal_title:Immunology
pub_type: 临床试验,杂志文章
doi:10.1111/imm.12045
更新日期:2013-05-01 00:00:00
abstract::To further investigate the immunomodulatory effects of dietary lipids, rats were fed on a low-fat diet or on high-fat diets that contained hydrogenated coconut, olive, safflower, evening primrose or fish oil as the principal fat source. The fish oil diet decreased the level of expression of CD2, CD11a, CD18 and CD44 o...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1046/j.1365-2567.1998.00474.x
更新日期:1998-05-01 00:00:00
abstract::Anti-Gal is the most abundant natural antibody in humans, constituting ~ 1% of immunoglobulins. Anti-Gal is naturally produced also in apes and Old World monkeys. The ligand of anti-Gal is a carbohydrate antigen called the 'α-gal epitope' with the structure Galα1-3Galβ1-4GlcNAc-R. The α-gal epitope is present as a maj...
journal_title:Immunology
pub_type: 杂志文章,评审
doi:10.1111/imm.12110
更新日期:2013-09-01 00:00:00
abstract::Studies have demonstrated that the anti-tumour effect of natural killer (NK) cells is successful for patients with several cancers. Although interleukin-32 (IL-32) is endogenously expressed in NK cells, cytolytic function of NK cells against cancer cells has not been fully demonstrated. In the present study, we found ...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2011.03513.x
更新日期:2012-01-01 00:00:00
abstract::Supernatants of IL-2-activated mononuclear cells (MNC) that displayed an optimal lymphokine-activated killer (LAK) cell activity at 48-72 hr in culture were found to contain increased levels of tumour necrosis factor alpha (TNF alpha), interleukin-1 alpha (IL-1 alpha) and interferon-gamma (IFN-gamma) when compared wit...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1989-12-01 00:00:00
abstract::The cell-cell interactions for CD23 expression and soluble (s)CD23 release from peripheral blood lymphocytes (PBL), as well as purified cells (B, T cells, monocytes) of atopic donors, were studied. Cells either stimulated combined and subsequently separated or stimulated after separation were analysed. IL-4, IL-2, phy...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1989-12-01 00:00:00