Immune components of the intestinal mucosae of ageing and protein deficient mice.

abstract：:Epididymitis represents a serious threat to male fertility and usually develops following secondary bacterial infection of the epididymis such as urinary tract infections or sexually transmitted diseases. Surprisingly, very little is known about the innate host response triggered by bacterial infection in the male rep...

journal_title：Immunology

authors： Mühlbauer M,Cheely AW,Yenugu S,Jobin C

更新日期：2008-06-01 00:00:00

abstract：:Mice exposed to paramyxovirus (Sendai) generate specifically sensitized thymus-derived lymphocytes (T cells) which, in an in vitro 51Cr release assay, interact only with virus-infected target cells sharing strong transplantation antigens. Reciprocal exclusion of cytotoxic T-cell activity is found for Sendai virus, lym...

journal_title：Immunology

authors： Doherty PC,Zinkernagel RM

更新日期：1976-07-01 00:00:00

abstract：:Chemically cross-linked C-reactive protein (CRP) oligomers were prepared and characterized, and C1q binding and C activation were investigated. Purified human CRP was polymerized in the presence of both non-cleavable and cleavable cross-linking agents and further separated by Superose 12 analytical FPLC column chromat...

journal_title：Immunology

authors： Jiang H,Lint TF,Gewurz H

更新日期：1991-12-01 00:00:00

abstract：:Dengue virus (DENV) infection causes dengue fever, dengue haemorrhagic fever, or dengue shock syndrome. Mast cells have been speculated to play a role in DENV disease although their precise roles are unclear. In this study, we used mast cell-deficient Kit(W-sh/W-sh) mice to investigate the involvement of mast cells af...

journal_title：Immunology

authors： Chu YT,Wan SW,Anderson R,Lin YS

更新日期：2015-09-01 00:00:00

abstract：:T lymphocytes are a critical component of the adaptive immune system mediating protection against infection and malignancy, but also implicated in many immune pathologies. Upon recognition of specific antigens T cells clonally expand, traffic to inflamed sites and acquire effector functions, such as the capacity to ki...

journal_title：Immunology

authors： Dimeloe S,Burgener AV,Grählert J,Hess C

更新日期：2017-01-01 00:00:00

abstract：:Interleukin-6 (IL-6) is an important B-cell growth and differentiation factor. IL-6 treatment of the human lymphoblastoid cell line, SKW6.4, leads to increased IgM production. We have previously shown that IL-6 induces activation of JAK1 and JAK2 in human B cell lines. A chimeric IL-6 receptor, comprised of the intrac...

journal_title：Immunology

authors： Faris M,Kokot N,Stahl N,Nel AE

更新日期：1997-03-01 00:00:00

abstract：:The phospholipid platelet-activating factor 1-0-hexadecyl-2-acetyl-SN-glycero-3-phosphorylcholine (AGEPC) initiates platelet function by interacting specifically with 1399 +/- 498 (mean +/- SD) high-affinity membrane receptors per platelet. In studies designated to characterize the high affinity binding site, AGEPC-hu...

journal_title：Immunology

authors： Valone FH

更新日期：1984-05-01 00:00:00

abstract：:Treatment of b4b6 rabbit peripheral blood lymphocytes with b5b5 anti-b4 antibodies at 4 degrees resulted in the modulation (disappearance) ob b4 and b6 cell surface allotype after subsequent incubation in serum-free medium for 1 h at 37 degrees. A clear dose dependence on the sensitizing anti-b4 antibody was observed....

journal_title：Immunology

authors： Kimball ES,Wolf B

更新日期：1978-04-01 00:00:00

abstract：:Isolated human mononuclear cells were fractionated according to their membrane characteristics or physical properties. Adherent cells were depleted by filtration through glass columns; phagocytic cells were removed by iron treatment and cell subpopulations capable of forming rosettes with sheep erythrocytes (E), eryth...

journal_title：Immunology

authors： De Bracco MM,Isturiz MA,Manni JA

更新日期：1976-03-01 00:00:00

abstract：:Splenic immune responses having varying dependence on accessory cell co-operation have been studied after infection of mice with Friend virus. Infection has no effect on cell proliferation or antibody production in cultures stimulated with E. coli lipopolysaccharide. The response in vivo to type III pneumococcal polys...

journal_title：Immunology

authors： Dracott BN,Wedderburn N,Doenhoff MJ

更新日期：1978-04-01 00:00:00

abstract：:Lymphoid cells in decidualized uterine endometrium in early human pregnancy may be essential for successful implantation and placentation. Endometrial granulocytes are prominent in early pregnancy decidua and express some T-cell associated surface antigens (CD2+, CD7+), but little is known of their function. We report...

journal_title：Immunology

authors： Ritson A,Bulmer JN

更新日期：1987-10-01 00:00:00

abstract：:MicroRNAs (miRNAs) regulate many aspects of helper T cell (Th) development and function. Here we found that they are required for the suppression of interleukin-9 (IL-9) expression in Th9 cells and other Th subsets. Two highly related miRNAs (miR-15b and miR-16) that we previously found to play an important role in re...

journal_title：Immunology

authors： Singh Y,Garden OA,Lang F,Cobb BS

更新日期：2016-09-01 00:00:00

abstract：:In chronic inflammatory conditions, mononuclear cells infiltrate the involved connective tissue and may persist, perhaps because of binding to adhesion molecules on connective tissue cells, as well as extracellular matrix. Here we investigated whether vascular cell adhesion molecule-1 (VCAM-1) may be induced on human ...

journal_title：Immunology

authors： Gao JX,Issekutz AC

更新日期：1996-11-01 00:00:00

abstract：:Memory CD8(+) T cells regain function during a recall response, but the requirement of signals in addition to antigen during a secondary immune response is unknown. In this study, the ability of interleukin-7 (IL-7) to enhance memory CD8(+ ) CD45RA(- ) CD127(+) T-cell responses in health and in human immunodeficiency ...

journal_title：Immunology

authors： O'Connor AM,Crawley AM,Angel JB

更新日期：2010-12-01 00:00:00

abstract：:Immune synapse formation is critical for T lymphocyte activation, and mitochondria have a role in this process, by localizing close to the immune synapse, regulating intracellular calcium concentration, and providing locally required ATP. The interaction between antigen presenting cells (APCs) and T lymphocytes is a t...

journal_title：Immunology

authors： Bonifaz L,Cervantes-Silva M,Ontiveros-Dotor E,López-Villegas E,Sánchez-García F

更新日期：2014-09-23 00:00:00

abstract：:Anti-idiotypic sera (aIds) were raised in C57BL/6 mice against monoclonal antibodies (McAbs) which bind poly(Tyr,Glu)-poly(DLAla)--poly(Lys)--abbreviated to (T,G)-A--L--and (Tyr-Tyr-Glu-Glu)-poly(DLAla)--poly(Lys)--abbreviated to (T-T-G-G)-A--L--(nos. 103 and 160) and McAbs which react only with (T-T-G-G)-A--L (nos. 1...

journal_title：Immunology

authors： Parhami-Seren B,Eshhar Z,Mozes E

更新日期：1984-02-01 00:00:00

abstract：:It has previously been demonstrated that a gene on chromosome 1 in or near Mls-1 controls, on the surface of B cells, the mobility and aggregability of major histocompatibility complex (MHC) class II molecules but not the mobility or aggregability of other B-cell molecules, such as immunoglobulin (Ig) and class I anti...

journal_title：Immunology

authors： Mecheri S,Dannecker G,Dennig D,Hoffmann MK

更新日期：1991-12-01 00:00:00

abstract：:Mucosal immunization offers the potential for inducing IgA antibody responses in the vagina, the site of infection for many viruses, including herpes simplex type 2 (HSV-2). To investigate this possibility, mice were immunized intranasally with 10 micrograms glycoprotein D2 (gD2) from HSV combined with a series of adj...

journal_title：Immunology

authors： Ugozzoli M,O'Hagan DT,Ott GS

更新日期：1998-04-01 00:00:00

abstract：:To determine the influence of anti-idiotypic antibodies on the complementary idiotype (Id), the clearance kinetics, tissue distribution and fate of idiotype-anti-idiotype complexes were investigated in mice. The complexes were prepared by mixing purified radiolabelled monomeric (mIgA) or polymeric IgA (pIgA) with mono...

journal_title：Immunology

authors： Rifai A,Wu CG

更新日期：1990-04-01 00:00:00

abstract：:Purified human and murine monocytes can be activated in vitro by human recombinant IL-2 to secrete tumour necrosis factor (TNF). TNF mRNA is detected within 4 h of addition of IL-2. Signal transduction does not appear to require expression of the Tac peptide of the IL-2 receptor. IL-2 does, however, induce Tac mRNA an...

journal_title：Immunology

authors： Economou JS,McBride WH,Essner R,Rhoades K,Golub S,Holmes EC,Morton DL

更新日期：1989-08-01 00:00:00

abstract：:Lymphocyte migration into inflammatory sites involves a change from a spherical, non-motile phenotype to an irregular, constantly shape-changing, motile phenotype. We have previously shown that lymphocytes are maintained in the non-motile state by the constitutive activity of protein kinase C (PKC). In this paper we h...

journal_title：Immunology

authors： Thorp KM,Verschueren H,De Baetselier P,Southern C,Matthews N

更新日期：1996-03-01 00:00:00

abstract：:The role of genetic factors associated with the immunoglobulin heavy chain locus (Igh) in the development of benign monoclonal gammapathy (BMG), a benign B-cell proliferative disorder, was investigated in six Igh congenic mouse strains during ageing. The strains used had a C57BL or BALB background: C57BL/6, BALB.Igb a...

journal_title：Immunology

authors： van den Akker TW,de Glopper-van der Veer E,Radl J,Benner R

更新日期：1988-09-01 00:00:00

abstract：:Salmonella enterica serovar Typhimurium (S. typhimurium) causes a localized enteric infection and its elimination is dependent on a T helper type 1 immune response. However, the mechanism of the protective immune response against the pathogen in gut-associated lymphoid tissue (GALT) at an early stage of the infection ...

journal_title：Immunology

authors： Mayuzumi H,Inagaki-Ohara K,Uyttenhove C,Okamoto Y,Matsuzaki G

更新日期：2010-11-01 00:00:00

abstract：:The hepatic and splenic uptake of circulating, small-latticed immune complexes and the effect of these complexes on the hepatic mononuclear phagocyte system (MPS) were examined in mice. The small-latticed immune complexes were prepared at fifty-fold antigen excess. The clearance from circulation and uptake by the live...

journal_title：Immunology

authors： Jimenez RA,Haakenstad AO,Mannik M

更新日期：1983-02-01 00:00:00

abstract：:Although the co-stimulatory interaction between B and T cells is well defined, recent evidence suggests that B cells also have a regulatory role. Here, we show that B cells activated using anti-IgD conjugated to dextran (α-δ-dex) directly inhibit TCR-induced CD4 T cell activation, proliferation and cytokine production...

journal_title：Immunology

authors： Preciado-Llanes L,Wing JB,Foster RA,Carlring J,Lees A,Read RC,Heath AW

更新日期：2014-09-20 00:00:00

abstract：:Testing of extracts of Toxoplasma gondii (RH strain) indicated that delayed hypersensitivity as manifested by delayed skin reactions and inhibition of macrophage migration was induced only by those fractions containing RNA. ...

journal_title：Immunology

authors： Lai CH,Tizard IR,Quinn PJ,Ingram DG

更新日期：1975-04-01 00:00:00

abstract：:A major role has been recently ascribed to the neutrophil in the resistance to infection by Listeria monocytogenes (L. monocytogenes). Here we evaluated whether such neutrophils played a role in the non-specific resistance to listeriosis that develops in hosts infected by mycobacteria. We found that the depletion of n...

journal_title：Immunology

authors： Leal IS,Appelberg R,Silva MT

更新日期：1996-11-01 00:00:00

abstract：:The CD3-T-cell receptor complex is the clonotypic surface structure by which T lymphocytes recognize foreign antigens and are subsequently activated. Because of the low immunogenicity of the CD3 molecules, anti-CD3 monoclonal antibodies (mAb) are difficult to prepare and have not been available in several species. Fol...

journal_title：Immunology

authors： Yang H,Oura CA,Kirkham PA,Parkhouse RM

更新日期：1996-08-01 00:00:00

abstract：:In this study, we describe the ability of hybrid mouse monoclonal antibody (mAb) to induce monocyte-mediated cytotoxicity towards human IgA1-coated E (HuIgA1-E), and the effect of mAb binding valency on Fc gamma RI-mediated ADCC. All hybrid monospecific (ms) anti-HuIgA1 and bispecific (bs) anti-HuIgA1/HRP mAb were cap...

journal_title：Immunology

authors： Koolwijk P,Van de Winkel JG,Otten I,Bast BJ

更新日期：1992-02-01 00:00:00

abstract：:One of the hallmarks of systemic autoimmune diseases, such as systemic lupus erythematosus (SLE), is the immune response to nuclear autoantigens. Several studies have proposed that dendritic cells may acquire the nuclear autoantigens from the apoptotic cells to initiate the systemic autoimmune responses. To examine th...

journal_title：Immunology

authors： Suen JL,Chuang YH,Chiang BL

更新日期：2002-07-01 00:00:00