A Role For Mitochondria In Antigen Processing And Presentation.

abstract：:Prostaglandins are some of the main mediators which control parturition, and their production by intrauterine tissues can be up-regulated by pro-inflammatory cytokines. Anti-inflammatory cytokines may oppose these effects, and in this study we have investigated how two such cytokines affected fetal membrane function. ...

journal_title：Immunology

authors： Brown NL,Alvi SA,Elder MG,Bennett PR,Sullivan MH

更新日期：2000-01-01 00:00:00

abstract：:Antibodies to neuronal antigens are associated with many neurological diseases including paraneoplastic neurological disorders, epilepsy, amyotrophic lateral sclerosis and multiple sclerosis. Immunization with neuronal antigens such as neurofilament light (NF-L), a neuronal intermediate filament in axons, has been sho...

journal_title：Immunology

authors： Puentes F,van der Star BJ,Boomkamp SD,Kipp M,Boon L,Bosca I,Raffel J,Gnanapavan S,van der Valk P,Stephenson J,Barnett SC,Baker D,Amor S

更新日期：2017-12-01 00:00:00

abstract：:Much of the pathology of malaria may be due to the interactions of cytokines, especially tumour necrosis factor (TNF), with various cell types, including endothelial cells, with consequent widespread systemic effects. It has been shown previously that heat-stable exoantigens in the supernatants of blood-stage parasite...

journal_title：Immunology

authors： Bate CA,Taverne J,Davé A,Playfair JH

更新日期：1990-07-01 00:00:00

abstract：:We studied the hs1,2 transcriptional enhancer identified downstream of the human alpha1 gene of the immunoglobulin H (IgH) locus, for which two different allelic configurations (a and b) were previously reported by Southern blotting. By using a polymerase chain reaction (PCR) method we amplified minisatellites within ...

journal_title：Immunology

authors： Denizot Y,Pinaud E,Aupetit C,Le Morvan C,Magnoux E,Aldigier JC,Cogné M

更新日期：2001-05-01 00:00:00

abstract：:A highly purified preparation of double-stranded RNA, obtained from virus-like particles in Penicillium cultures, was found to affert humoral immune responses in mice differentially depending on its time of administration in realtion to antigen. Double-stranded RNA administered with antigen, or a few hours after antig...

journal_title：Immunology

authors： Cunnington PG,Naysmith JD

更新日期：1975-03-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection is a global health problem characterized by a high rate of chronic infection, which may in part be due to a defect in myeloid dendritic cells (mDCs). This defect appears to be remedied by treatment with interferon-α (IFN-α) -based antiviral therapies; however, the molecular mechanisms...

journal_title：Immunology

authors： Ma L,Zhou Y,Zhang Y,Li Y,Guo Y,He Y,Wang J,Lian J,Hao C,Moorman JP,Yao ZQ,Zhou Y,Jia Z

更新日期：2014-12-01 00:00:00

abstract：:The effects of anti-Ia antibodies and cyclosporin A (CsA) on phenotypic differentiation of murine thymocytes were assessed in organ-cultured fetal thymuses. Both agents specifically abrogated the generation of CD4+8- thymocytes. Immunohistochemical studies revealed that Ia antigen on the organ-cultured thymic epitheli...

journal_title：Immunology

authors： Takeuchi Y,Habu S,Okumura K,Suzuki G

更新日期：1989-03-01 00:00:00

abstract：:The haemolymph of the colonial ascidian Botrylloides leachii contains two haemagglutinins which have been termed HA-1 and HA-2 respectively. The HA-1 agglutinin is specific for guinea-pig erythrocytes, requires Ca2+ ions for its activity and has an apparent mol. wt. of about 200,000. It can be adsorbed by guinea-pig b...

journal_title：Immunology

authors： Schluter SF,Ey PL,Keough DR,Jenkin CR

更新日期：1981-02-01 00:00:00

abstract：:The role of reactive nitrogen intermediates (RNI) in the antimicrobial activities of neutrophils from various mammalian species is unclear. However, it has been reported that rodent neutrophils possess the inducible form of nitric oxide synthase and that inflammatory neutrophils from rats produce potentially antimicro...

journal_title：Immunology

authors： Padgett EL,Pruett SB

更新日期：1995-01-01 00:00:00

abstract：:Cocultures of dispersed human fetal liver cells with murine Swiss 3T3 fibroblasts resulted in the development of human mast cells after 1 to 4 weeks of culture. Mast cells were detected by immunohistochemistry using a murine monoclonal anti-tryptase antibody, before metachromasia appeared with toluidine blue. When sub...

journal_title：Immunology

authors： Irani AA,Craig SS,Nilsson G,Ishizaka T,Schwartz LB

更新日期：1992-09-01 00:00:00

abstract：:We have previously demonstrated that immunoglobulin A (IgA)(-/-) knockout (KO) mice exhibit levels of susceptibility to influenza virus infection that are similar to those of their normal IgA(+/+) littermates. To understand the mechanism of this apparent mucosal immunity without IgA, immunoglobulin isotype and T helpe...

journal_title：Immunology

authors： Zhang Y,Pacheco S,Acuna CL,Switzer KC,Wang Y,Gilmore X,Harriman GR,Mbawuike IN

更新日期：2002-03-01 00:00:00

abstract：:Peripheral blood mononuclear cells (PBMC) from a patient suffering from the hyper IgE syndrome were used to generate phytohaemagglutinin (PHA)-expanded T-cell clones (all CD4+, CD8-, CD23-). A selection of the clones was tested for their ability to help IgE secretion by culturing with normal B cells in the presence of...

journal_title：Immunology

authors： Quint DJ,Bolton EJ,McNamee LA,Solari R,Hissey PH,Champion BR,MacKenzie AR,Zanders ED

更新日期：1989-05-01 00:00:00

abstract：:T cells play a key role in the pathogenesis of type 1 diabetes, and targeting the CD3 component of the T-cell receptor complex provides one therapeutic approach. Anti-CD3 treatment can reverse overt disease in spontaneously diabetic non-obese diabetic mice, an effect proposed to, at least in part, be caused by a selec...

journal_title：Immunology

authors： Wallberg M,Recino A,Phillips J,Howie D,Vienne M,Paluch C,Azuma M,Wong FS,Waldmann H,Cooke A

更新日期：2017-06-01 00:00:00

abstract：:Specific IgE and IgG responses to highly purified Ambrosia (ragweed) allergens, Amb a V, Amb t V and Amb p V from the artemisiifolia (short), trifida (giant) and psilostachya (western) species are strongly associated with HLA-DR2 and Dw2 (DR2.2) in allergic Caucasoid individuals. To investigate the molecular basis of ...

journal_title：Immunology

authors： Huang SK,Marsh DG

更新日期：1991-07-01 00:00:00

abstract：:Lymphotoxin (TNF beta) and tumour necrosis factor alpha (TNF alpha) stimulate locomotion and chemotaxis of human blood neutrophils as measured in three assays. Both cytokines stimulate morphological polarization of neutrophils in suspension; both stimulate locomotion of neutrophils into micropore filters; both cause o...

journal_title：Immunology

authors： Newman I,Wilkinson PC

更新日期：1989-02-01 00:00:00

abstract：:The effector CD8(+) T cells recognize major histocompatibility complex (MHC) class I binding altered self-peptides expressed in tumour cells. Although the requirement for CD4(+) T helper type 1 (Th1) cells in regulating CD8(+) T cells has been documented, their target epitopes and functional impact in antitumour respo...

journal_title：Immunology

authors： Kikuchi T,Uehara S,Ariga H,Tokunaga T,Kariyone A,Tamura T,Takatsu K

更新日期：2006-01-01 00:00:00

abstract：:Trypanosoma cruzi, the causative agent of Chagas' disease, is a protozoan parasite that infects humans and other mammals in Central and Latin America. Several alterations of the immune response after infection have been described, such as severe immunosuppression of both cellular and humoral responses and massive poly...

journal_title：Immunology

authors： Da Silva AC,Espinoza AG,Taibi A,Ouaissi A,Minoprio P

更新日期：1998-06-01 00:00:00

abstract：:The innate immune response provides the initial defence mechanism against infection by other organisms. However, an excessive immune response will cause damage to host tissues. In an attempt to identify microRNAs (miRNAs) that regulate the innate immune response in inflammation and homeostasis, we examined the differe...

journal_title：Immunology

authors： Niu Y,Mo D,Qin L,Wang C,Li A,Zhao X,Wang X,Xiao S,Wang Q,Xie Y,He Z,Cong P,Chen Y

更新日期：2011-05-01 00:00:00

abstract：:Bursal and splenic lymphocytes in developing chick embryos were examined for the number of antigen binding cells (ABC) which could form rosettes with red blood cells from sheep, guinea-pig, rabbit or dinitrophenylated sheep red blood cells (DNP-SRBC). The kinetics of the development of bursal ABC to rabbit red blood c...

journal_title：Immunology

authors： Moriya O,Ichikawa Y

更新日期：1979-08-01 00:00:00

abstract：:Human polymorphonuclear granulocytes (PMN) generate the inflammatory mediator leukotriene B4 (LTB4) as a response to cell activation. In addition, PMN inactivate LTB4 by omega-oxidation resulting in the formation of 20-OH- and 20-COOH-LTB4. The transport of exogenous LTB4 to the metabolizing enzymes is mediated via hi...

journal_title：Immunology

authors： Brom J,König W

更新日期：1989-12-01 00:00:00

abstract：:The composition of the microbiome in health and disease has only recently become a major research focus. Although it is clear that an imbalance or dysbiosis in the microbiota is associated with disease, its interrelatedness to disease penetrance is largely unknown. Inflammatory bowel disease (IBD) is an excellent dise...

journal_title：Immunology

authors： Ray A,Dittel BN

更新日期：2015-11-01 00:00:00

abstract：:Quantitative studies on B cells require a direct assay for antibody-forming cell (AFC) progenitor function, in which the number of AFC produced bears a simple, linear arithmetic relationship to the number of progenitors present. This might be expected under conditions where helper T-cell and accessory cell requirement...

journal_title：Immunology

authors： Schlegel RA,Fidler JM,Howard M,Shortman K

更新日期：1975-12-01 00:00:00

abstract：:Tumour-associated macrophages (TAMs) represent a predominant population of inflammatory cells that present in solid tumours. TAMs are mostly characterized as alternatively activated M2-like macrophages and are known to orchestrate nearly all stages of tumour progression. Experimental investigations indicate that TAMs ...

journal_title：Immunology

authors： Tang X,Mo C,Wang Y,Wei D,Xiao H

更新日期：2013-02-01 00:00:00

abstract：:Individual young adult, middle-aged, and old C57BL/6J male mice were tested for in vitro generated proliferative and cytotoxic responses to H-2 alloantigens under a variety of sensitization conditions. Proliferation in mixed lymphocyte culture (MLC) had decreased by 14 months of age (middle-aged), whether measured by ...

journal_title：Immunology

authors： Gottesman SR,Kristie JA,Walford RL

更新日期：1981-11-01 00:00:00

abstract：:An interleukin-12 (IL-12) expression plasmid was transferred, using a gene gun, to mice infected with Leishmania major or Trypanosoma cruzi. Transfer of the IL-12 gene to susceptible BALB/c mice resulted in regression of lesion size and reduced the number of parasites in draining lymph nodes (LN) at the site of L. maj...

journal_title：Immunology

authors： Sakai T,Hisaeda H,Nakano Y,Ishikawa H,Maekawa Y,Ishii K,Nitta Y,Miyazaki J,Himeno K

更新日期：2000-04-01 00:00:00

abstract：:Homogenates from human lung contained a preformed slow reacting substance (pSRS). The pattern of contraction on the guinea-pig ileum by pSRS was indistinguishable from that of SRS-A. The activity of pSRS could not be attributed to the presence of K+, Na+, Ca2+ and Mg2+ ions, or any prostaglandin including PGF2 or its ...

journal_title：Immunology

authors： Turnbull LS,Jones DG,Kay AB

更新日期：1976-11-01 00:00:00

abstract：:Blood dendritic cells carry the terminal complement complex (TCC) on their surface, as detected by three monoclonal antibodies (mAb). Two of these mAb were generated by immunizing mice with the terminal complement complex, whereas the third was generated by immunizing mice with blood dendritic cells. All three mAb are...

journal_title：Immunology

authors： Würzner R,Xu H,Franzke A,Schulze M,Peters JH,Götze O

更新日期：1991-09-01 00:00:00

abstract：:Murine spleen cells were analysed for their capacity to lyse 51Cr-labelled antibody-sensitized erythrocytes and a human lymphoma cell line. Incubation of spleen cells with iron powder followed by removal of iron-containing cells with a magnet significantly decreased the lytic capacity of the remaining cells against er...

journal_title：Immunology

authors： Lamon EW,Pollok BA,Walia AS,Fuson EW,Williams B

更新日期：1981-08-01 00:00:00

abstract：:Monocyte-derived macrophages (MDMs) generated from peripheral blood monocytes are widely used to model human macrophages for in vitro studies. However, the possible impact of different isolation methods on the resulting MDM phenotype is poorly described. We aimed to investigate the effects of three commonly used monoc...

journal_title：Immunology

authors： Nielsen MC,Andersen MN,Møller HJ

更新日期：2020-01-01 00:00:00

abstract：:BALB/c mice injected with lyophilized vaccine from Streptococcus pneumoniae R36a (Pn) predominantly responded with antibody molecules the vast majority of which expressed the public idiotype T15 and were directed to the immunodominant epitope phosphorylcholine (PC). However, after a single immunization with Pn vaccine...

journal_title：Immunology

authors： Borghesi C,Nicoletti C

更新日期：1996-10-01 00:00:00