Abstract：
:A highly purified preparation of double-stranded RNA, obtained from virus-like particles in Penicillium cultures, was found to affert humoral immune responses in mice differentially depending on its time of administration in realtion to antigen. Double-stranded RNA administered with antigen, or a few hours after antigen, produced a variable degree of enhancement of plaque-forming cell numbers or agglutinating antibody levels depending on the antigen involved. Administration of double-stranded RNA 24 hours before antigen invariably produced a suppressed response. In mice which were either specifically hyporesponsive (tolerant) or non-specifically hyporesponsive (due to age or immunosuppressive drugs) double-stranded RNA administered with antigen resulted in a nearly normal immune response.
journal_name
Immunologyjournal_title
Immunologyauthors
Cunnington PG,Naysmith JDkeywords:
subject
Has Abstractpub_date
1975-03-01 00:00:00pages
451-68issue
3eissn
0019-2805issn
1365-2567journal_volume
28pub_type
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