Abstract：
:Murine macrophage Fc receptor function has been studied with the membrane-impermeable sulphydryl-blocking reagent p-chloromercuribenzenesulphonic acid (PCMBSA). Antibody-dependent endocytosis of fluorescein-labelled immune complexes was studied with video intensification microscopy. PCMBSA was found to inhibit the endocytosis of immune complexes at 10 nM. Control experiments indicate that the inhibition is due to an effect upon the cell, not the immune complex. Furthermore, specificity is suggested by the fact that complement-mediated and latex bead phagocytosis were not affected. 203Hg-PCMBSA labelled three macrophage proteins of molecular weight (MW) 25,000, 35,000 and 50,000. A 25,000 MW PCMBSA-binding protein has been found that is specifically immunoprecipitated by an anti-Fc receptor antibody. These studies suggest that perturbation of a cell surface sulphydryl group(s) of one of the three major PCMBSA binding membrane proteins, possibly an Fc receptor-associated protein, blocks a molecular signal required for antibody-dependent endocytosis.
journal_name
Immunologyjournal_title
Immunologyauthors
Petty HRsubject
Has Abstractpub_date
1987-02-01 00:00:00pages
269-73issue
2eissn
0019-2805issn
1365-2567journal_volume
60pub_type
杂志文章相关文献
IMMUNOLOGY文献大全abstract：:During the immune response to H-2 and Mls alloantigens, murine lymphocytes showed altered sensitivity to polyclonal mitogens. The reactivity to the T-cell mitogen PHA followed a similar pattern in both H-2 and Mls-immunized mice while the reactivity to the B-cell mitogen LPS was contrasting in the two groups. In the f...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1979-08-01 00:00:00
abstract：:Large doses of hydrocortisone, cyclophosphamide, and methotrexate injected subcutaneously, and whole-body irradiation (500 rads) caused a reduction in the number of peritoneal cells (PE cells) obtained after intraperitoneal injection of the treated mice with proteose-peptone. The same dose of cyclophosphamide and irra...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1975-01-01 00:00:00
abstract：:Degradation of the extracellular matrix plays an important role in rheumatoid articular destruction. Rheumatoid synovial fibroblasts secrete a large amount of matrix-degrading metalloproteinases (MMPs), which initiate tissue damage by proteolytic degradation of collagens and proteoglycans. Cytokines, such as interleuk...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1996.d01-789.x
更新日期：1996-12-01 00:00:00
abstract：:Affinity-purified polyclonal anti-double-stranded DNA (anti-dsDNA) antibodies from patients with systemic lupus erythematosus (SLE) exert a cytostatic effect on cultured rat glomerular mesangial cells (MC). The cognate antigens expressed on the surface of MC have been proved to be acidic ribosomal phosphoproteins (P p...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1996-03-01 00:00:00
abstract：:Cytokines and their receptors represent key targets for therapeutic intervention. Ligands are being used to supplement cell numbers that become depleted as a result of disease (organ failure, infection) or subsequent disease treatments (i.e. chemotherapy). Conversely, the inhibition of target cell binding by cytokines...
journal_title：Immunology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2567.2004.01886.x
更新日期：2004-06-01 00:00:00
abstract：:CD44, a cell adhesion molecule, exists in multiple isoforms that are generated by RNA alternative splicing. CD44 isoforms containing exon V6 (CD44 V6) have been associated with tumorigenesis and metastasis. We investigated the association between human B-cell activation and CD44 V6 isoform expression by analysing its ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1995-09-01 00:00:00
abstract：:Nod-like receptors are a family of innate immune receptors that link cytosolic sensing of microbial and danger stimuli to the activation of immune responses. Two Nod-like receptor family members, Nod1 and Nod2, recognize bacterial peptidoglycan and activate immune responses via nuclear factor-κB (NF-κB) and mitogen-ac...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.12307
更新日期：2014-10-01 00:00:00
abstract：:During acute Trypanosoma cruzi infection in mice, many leucocytes undergo apoptosis. Although apoptosis has been ascribed to increased levels of nitric oxide (NO) and Fas-FasL interaction, the importance of this phenomenon in modulating the host response against T. cruzi is unknown. Herein, the role of NO- and Fas-Fas...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.2001.01216.x
更新日期：2001-05-01 00:00:00
abstract：:Following immunization with various lambda Bence-Jones proteins, over 100 hybridomas were established. A majority of the monoclonal antibodies (McAb) produced were demonstrated to recognize epitopes common to all lambda chains or unique to the immunogen. Twenty-nine McAb exhibited profiles of 'restricted' reactivity. ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1986-11-01 00:00:00
abstract：:Splenic immune responses having varying dependence on accessory cell co-operation have been studied after infection of mice with Friend virus. Infection has no effect on cell proliferation or antibody production in cultures stimulated with E. coli lipopolysaccharide. The response in vivo to type III pneumococcal polys...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1978-04-01 00:00:00
abstract：:Functionally defined mouse Lyt-1 and Lyt-2 cell sets were selected from peripheral lymph nodes by cytotoxic elimination with anti-Lyt monoclonal antibodies. The selected populations were labelled with 51Cr or [3H]-adenosine and traced in syngeneic recipients at 1, 24, 45 and 65 hr after intravenous injection. Recovere...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1984-06-01 00:00:00
abstract：:Alveolar macrophages (AM) present antigen poorly to CD4+ T cells and respond weakly to interferon-gamma (IFN-gamma) for up-regulation of major histocompatibility complex (MHC) class II and costimulatory molecule expression. In atopic asthma, however, AM exhibit enhanced antigen-presenting cell (APC) activity. Since gr...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1999.00862.x
更新日期：1999-09-01 00:00:00
abstract：:The rat popliteal lymph node was studied from 1 hr to 8 days after the footpad injection of either sheep erythrocytes or syngeneic rat erythrocytes. The following were measured relative to the contralateral (unstimulated) lymph node: (i) blood flow; (ii) lymph node weight; (iii) influx of lymphocytes from the blood; (...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1981-09-01 00:00:00
abstract：:Levels of IgA and IgG antibodies were measured in uterine and vaginal secretions to examine the effect of uterine immunization on the genital tract humoral immune system. When ovariectomized animals were immunized on Day 0 and boosted 13 days later by placing sheep erythrocytes (SRBC) directly in the uterine lumen (UT...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1989-09-01 00:00:00
abstract：:Salmonella enterica serovar Typhimurium (S. typhimurium) causes a localized enteric infection and its elimination is dependent on a T helper type 1 immune response. However, the mechanism of the protective immune response against the pathogen in gut-associated lymphoid tissue (GALT) at an early stage of the infection ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2010.03310.x
更新日期：2010-11-01 00:00:00
abstract：:Aspergillus fumigatus is often associated in asthmatic patients with the exacerbation of asthma symptoms. The pathomechanism of this phenomenon has not been fully understood. Here, we evaluated the immunological mechanisms and the role of the prostaglandin D2 / Chemoattractant Receptor-Homologous Molecule Expressed on...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.12234
更新日期：2014-05-01 00:00:00
abstract：:During attempts to generate Sendai virus-specific T-cell hybridomas, a number of autoreactive T-cell hybridomas were produced. These hybrids secrete IL-2 in response to class II-positive syngeneic cells in the absence of added Sendai virus. Class II molecules on the stimulator cells are involved since monoclonal anti-...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1988-02-01 00:00:00
abstract：:Repetitive stimulation of naïve T cells by immature splenic dendritic cells (DC) can result in the differentiation of T-cell lines with regulatory properties. In the present study we identified a population of DC in the mucosae that exhibit the plasmacytoid phenotype, secrete interferon-alpha (IFN-alpha) following sti...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.2003.01606.x
更新日期：2003-04-01 00:00:00
abstract：:A plasmid that contained the cytomegalovirus (CMV)-promoter-driven lacZ reporter gene (pCMV-lacZ) remained in the epaxial muscle of five of eight goldfish as covalently closed circles, the most functional form of plasmid, for at least 70 days at 22 degrees. It was not present in the gills or elsewhere by polymerase ch...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1999.00688.x
更新日期：1999-02-01 00:00:00
abstract：:The biochemical analysis of murine Fc gamma RI has been difficult because this receptor is co-expressed with other Fc receptors on the cell surface of myeloid cells and all precipitate together with immune complexes. To overcome this problem and to study cells which expressed Fc gamma RI and only this Fc receptor, sta...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1993-03-01 00:00:00
abstract：:Summary Diverse immunotherapy approaches have achieved success in controlling individual aspects of immune responses in animal models. Transfer of such immunotherapies to clinical trials has obtained some success in patients, with clinical responses observed or effective antigen specific immune responses achieved, but...
journal_title：Immunology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2567.2004.02001.x
更新日期：2005-01-01 00:00:00
abstract：:The role of reactive nitrogen intermediates (RNI) in the antimicrobial activities of neutrophils from various mammalian species is unclear. However, it has been reported that rodent neutrophils possess the inducible form of nitric oxide synthase and that inflammatory neutrophils from rats produce potentially antimicro...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：:The effect of E. coli lipopolysaccharide (LPS) on the induction of both hapten-specific immunity and tolerance was studied in an in vivo system utilizing putative T-cell dependent (TD) or T-cell independent (TI) challenge antigens. The administration of LPS 1 day prior to challenge preempted the response of C3D2 mice ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1979-11-01 00:00:00
abstract：:The ability of freshly isolated primary human alveolar epithelial cells (type II pneumocytes) to induce leucocyte migration across an endothelial monolayer was investigated. Three-way factorial analysis of variance (ANOVA) demonstrated that resting alveolar endothelial cells (AEC) could produce detectable quantities o...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.2001.01172.x
更新日期：2001-02-01 00:00:00
abstract：:Purified pertussis toxin (PPT) is a potent mitogen for human T lymphocytes and is shown to cause rapid calcium mobilization in resting T cells, a T-cell line and CD3- lymphocytes with natural killer (NK) activity. In resting T cells the PPT activation is associated with cytoplasmic alkalinization. A similar rise in in...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1988-07-01 00:00:00
abstract：:We have previously reported that the 20-mer peptide p2340 (amino acids 2340-2359), of human thyroglobulin (Tg) has the unique feature that it causes experimental autoimmune thyroiditis (EAT) in mouse strains bearing high-responder (HR) or low-responder (LR) MHC haplotypes in Tg-induced EAT. In this study, we have empl...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2011.03538.x
更新日期：2012-03-01 00:00:00
abstract：:Susceptibility to collagen-induced arthritis (CIA), a murine model of autoimmune arthritis, is strongly linked to only two major histocompatibility complex (MHC) haplotypes, H-2q and H-2r. In order to identify the determinants of type II collagen (CII) required to induce arthritis in H-2r-bearing mice, B10.RIII mice w...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1995-04-01 00:00:00
abstract：:Monoclonal antibodies were produced following immunization of mice with live infective larvae of Brugia malayi. One of these, 46.08.76, is an antibody that promotes adherence of mouse peritoneal macrophages and human peripheral blood leucocytes to the infective larvae of B. malayi and Wuchereria bancrofti, respectivel...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1988-05-01 00:00:00
abstract：:Recent studies employing reverse transription-polymerase chain reaction (RT-PCR) have demonstrated the intrathymic presence of mRNA for various autoantigens, including thyroglobulin (Tg). Deliberations on the mechanisms of central tolerance usually assume that this approach detects intact mRNA transcripts that can be ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2005.02119.x
更新日期：2005-05-01 00:00:00
abstract：:Stimulation of human polymorphonuclear granulocytes with the calcium-ionophore A23187 and opsonized zymosan leads to the release of leukotrienes. The cell-free supernatants of the stimulated cells revealed gamma-glutamyl-transpeptidase and dipeptidase activity which induced the metabolism of exogeneously added LTC4 an...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1985-05-01 00:00:00
