The effect of various immunosuppressive agents on mouse peritoneal macrophages and on the in vitro phagocytosis of Escherichia coli O4:K3:H5 and degradation of 125I-labelled HSA-antibody complexes by these cells.

abstract：:To evaluate the role of the high-affinity monocyte receptor for lipopolysaccharide (LPS), CD14, in the process of tolerance to LPS, the human monocytic cell line Mono-Mac-6 was cultured in the absence or presence of different amounts of LPS. The kinetics of CD14 modulation in these cells showed an initial 4-day period...

journal_title：Immunology

authors： Labeta MO,Durieux JJ,Spagnoli G,Fernandez N,Wijdenes J,Herrmann R

更新日期：1993-11-01 00:00:00

abstract：:We have recently described a bone marrow culture system which is able to maintain a portion of the precursor-T (pre-T) cell compartment of adult murine marrow in vitro, in the presence of interleukin-3 (IL-3), for at least 2 weeks. However, because growth in IL-3 might also induce the differentiation of the pre-T cell...

journal_title：Immunology

authors： Soloff RS,Dempsey D,Jennings SR,Wolcott RM,Chervenak R

更新日期：1992-06-01 00:00:00

abstract：:In order to analyse the molecular mechanism of lymphocyte activation defect in MRL/MP-lpr (MRL/1) mice, c-myc proto-oncogene expression was examined in MRL/1 lymph node cells stimulated by various agents. Since a transient increase of c-myc RNA in early hours is required for lymphocyte activation, detection of c-myc m...

journal_title：Immunology

authors： Koizumi T,Nakao Y,Matsui T,Katakami Y,Mihara K,Takahashi R,Maeda S,Sugiyama T,Fujita T

更新日期：1988-05-01 00:00:00

abstract：:The glucocorticoid-induced tumour necrosis factor receptor family related gene (GITR) has been reported to be expressed on the activated T and CD4(+)CD25(+) regulatory T cells (Treg). Signalling triggered by GITR not only neutralizes the suppressive effect of Treg cells, but also augments activation, proliferation and...

journal_title：Immunology

authors： Lee SK,Choi BK,Kim YH,Kang WJ,Kim KH,Sakaguchi S,Suh JH,Kim TY,Kwon BS

更新日期：2006-12-01 00:00:00

abstract：:Functional and phenotypic properties of porcine peripheral blood CD4/CD8 double-positive (DP) lymphocytes were examined. In cross-sectional and longitudinal studies involving a total of 103 pigs, this lymphocyte population was found to increase gradually in proportion with age, comprising < 2% of the total peripheral ...

journal_title：Immunology

authors： Zuckermann FA,Husmann RJ

更新日期：1996-03-01 00:00:00

abstract：:The non-precipitating guinea-pig IgG1 and IgG2 antibodies, produced by administration of an excessive dose of hen ovalbumin (OA), were capable of forming only certain soluble complexes having molar ratios of antibody to antigen lower than 1-5:1, which were lower than the minimum ratio of 2-5:1 shown by anti-OA antibod...

journal_title：Immunology

authors： Tamoto K,Koyama J

更新日期：1976-07-01 00:00:00

abstract：:Protein kinase C (PKC) form a key family of enzymes involved in signalling pathways that specifically phosphorylates substrates at serine/threonine residues. Phosphorylation by PKC is important in regulating a variety of cellular events such as cell proliferation and the regulation of gene expression. In the immune sy...

journal_title：Immunology

authors： Lim PS,Sutton CR,Rao S

更新日期：2015-12-01 00:00:00

abstract：:The aim of this study is to investigate the clinical significance of the ratio between interleukin-17 (IL-17) secreting cell and FOXP3-positive regulatory T cell (FOXP3(+) Treg) infiltration in renal allograft tissues with acute T-cell-mediated rejection (ATCMR). Fifty-six patients with biopsy-proven ATCMR were includ...

journal_title：Immunology

authors： Chung BH,Oh HJ,Piao SG,Hwang HS,Sun IO,Choi SR,Park HS,Choi BS,Choi YJ,Park CW,Kim YS,Cho ML,Yang CW

更新日期：2012-07-01 00:00:00

abstract：:Plasma fibronectin (FN) has been demonstrated to serve as an opsonin involved in the ingestion of foreign particles by phagocytes. This study concerns the effect of FN exposure on the respiratory burst of normal human peripheral phagocytes, using a luminol-dependent chemiluminescence (CL) assay for measurement of reac...

journal_title：Immunology

authors： Kuroiwa A,Igisu K,Yano T,Okada N,Okada H

更新日期：1988-10-01 00:00:00

abstract：:Different cell types, including dendritic cells, macrophages and Ia+ B cells, have been described to present soluble antigen (Ag) to T-cell hybridomas. However, it is still not clear whether these different cell types can act as antigen-presenting cells (APC) for complex and insoluble Ag such as viral particles. Using...

journal_title：Immunology

authors： Scheerlinck JP,Burssens G,Brys L,Michel A,Hauser P,De Baetselier P

更新日期：1991-05-01 00:00:00

abstract：:Natural killer (NK) cells have a specialized function in peripheral organs, which is determined by the organ-specific niches. We have attempted to explore whether lung NK cells display a particular phenotype according to their function in the unique pulmonary environment in health or during respiratory infection in mi...

journal_title：Immunology

authors： Wang J,Li F,Zheng M,Sun R,Wei H,Tian Z

更新日期：2012-09-01 00:00:00

abstract：:It is increasingly becoming clear that various immune cells are infected by the very pathogens that they are supposed to attack. Although many mechanisms for microbial entry exist, it appears that a common route of entry shared by certain bacteria, viruses and parasites involves cellular lipid-rich microdomains someti...

journal_title：Immunology

authors： Shin JS,Abraham SN

更新日期：2001-01-01 00:00:00

abstract：:The plaque-forming cell (PFC) responses to sheep red blood cell (SRBC) dinitrophenyl-lysine-Ficoll (DNP-lys-Ficoll), and dinitrophenylated bovine serum albumin (DNP-BSA) have been studied in both germ-free and conventionally reared ICR mice. In germ-free mice, the IgG response to SRBC and the IgM and IgG responses to ...

journal_title：Immunology

authors： Ohwaki M,Yasutake N,Yasui H,Ogura R

更新日期：1977-01-01 00:00:00

abstract：:The cellular prion protein (PrPc) is a glycosyl-phosphatidylinositol (GPI)-linked cell surface protein, which is expressed at high density on nervous tissues and at lower levels on most other solid-organ tissues. It is also expressed on peripheral blood mononuclear cells (PBMC) of all lineages. In lymphocytes, its lev...

journal_title：Immunology

authors： Morelon E,Dodelet V,Lavery P,Cashman NR,Loertscher R

更新日期：2001-02-01 00:00:00

abstract：:Therapeutic vaccination using T-cell receptor (TCR) peptides from V genes commonly expressed by potentially pathogenic T cells remains an approach of interest for treatment of multiple sclerosis (MS) and other autoimmune diseases. We developed a trivalent TCR vaccine containing complementarity determining region (CDR)...

journal_title：Immunology

authors： Vandenbark AA,Culbertson NE,Bartholomew RM,Huan J,Agotsch M,LaTocha D,Yadav V,Mass M,Whitham R,Lovera J,Milano J,Theofan G,Chou YK,Offner H,Bourdette DN

更新日期：2008-01-01 00:00:00

abstract：:CD59 is the sole characterized regulator of the complement membrane attack complex in humans. It is very widely and abundantly distributed, being present on all circulating cells, endothelia and epithelia, and in most tissues. CD59 analogues in rodents are distributed similarly. Interest in complement regulation in th...

journal_title：Immunology

authors： Hanna SM,Williams GT,Van Den Berg CW,Morgan BP

更新日期：1998-11-01 00:00:00

abstract：:Specific IgE and IgG responses to highly purified Ambrosia (ragweed) allergens, Amb a V, Amb t V and Amb p V from the artemisiifolia (short), trifida (giant) and psilostachya (western) species are strongly associated with HLA-DR2 and Dw2 (DR2.2) in allergic Caucasoid individuals. To investigate the molecular basis of ...

journal_title：Immunology

authors： Huang SK,Marsh DG

更新日期：1991-07-01 00:00:00

abstract：:The non-specific normal immunosuppressive protein (Nip) has been described in our laboratory and its biological activity was extensively studied. In the present study, further purification analyses of Nip were conducted. Fractionation of Nip by Ultrogel AcA 34 column resulted in peak (I) that displayed Nip activity in...

journal_title：Immunology

authors： Gavison-Goren R,Nelken D

更新日期：1983-08-01 00:00:00

abstract：:Incubation of sensitized mononuclear cells from patients with schistosomiasis with specific antigen containing a suspension of viable Schistosoma haematobium ova resulted in the release of a soluble factor which was chemotactic for eosinophils. Production of this substance was detectable at 24 h and demonstrated peak ...

journal_title：Immunology

authors： Wadee AA,Sher R

更新日期：1980-12-01 00:00:00

abstract：:Mouse models of multiple sclerosis (MS) have shown the importance of interleukin-10 (IL-10) -producing regulatory B (Breg) cells in dampening disease activity and inhibiting disease initiation and progression. In MS and other autoimmune diseases decreased frequency and functionality of Breg cells correlate with diseas...

journal_title：Immunology

authors： Lundqvist S,Modvig S,Fischer EA,Frederiksen JL,Degn M

更新日期：2019-03-01 00:00:00

abstract：:Recently it has been shown that selective subconjunctival macrophage depletion reduced the incidence and severity of stromal herpes simplex virus (HSV) keratitis in mice. In this study, we examined the effect of conjunctival macrophage depletion on the corneal and systemic T-cell-mediated immune response. BALB/c mice ...

journal_title：Immunology

authors： Bauer D,Schmitz A,Van Rooijen N,Steuhl KP,Heiligenhaus A

更新日期：2002-09-01 00:00:00

abstract：:Over the past years, increasing numbers of distinct subsets have been discovered and identified for a T lymphocytes' entity. Differentiation and function of each T cell subset are controlled by a specific master transcription factor. Importantly, Runt-related transcription factors, particularly Runx1 and Runx3, interp...

journal_title：Immunology

authors： Wong WF,Kohu K,Chiba T,Sato T,Satake M

更新日期：2011-02-01 00:00:00

abstract：:Immunoglobulin E is quantitatively a minor immunoglobulin class in serum, but nevertheless the major class of antibody mediating type I hypersensitivity reactions and hence, type I allergic phenomena. The bovine epsilon gene is one of the as yet uncharacterized mammalian immunoglobulin genes. We have therefore cloned ...

journal_title：Immunology

authors： Mousavi M,Rabbani H,Hammarström L

更新日期：1997-11-01 00:00:00

abstract：:The purpose of this work was to determine if the fine specificity of T cells differed between mice immunized with an antigen in a T helper 1 (Th1) cytokine-dominated environment as compared with a T helper 2 (Th2) cytokine-dominated environment. It was found that splenic T cells from mice immunized with mycobacterial ...

journal_title：Immunology

authors： Siew LK,Beech JT,Thompson SJ,Elson CJ

更新日期：1998-04-01 00:00:00

abstract：:The ability of the chemical carcinogen dimethylbenz(a)anthracene (DMBA) to deplete Langerhans' cells (LC) from murine skin is crucial to the development of antigen-specific suppression. This depletion is a consequence of the LC recognizing the DMBA as antigenic and migrating to the draining lymph nodes to attempt to e...

journal_title：Immunology

authors： Woods GM,Qu M,Ragg SJ,Muller HK

更新日期：1996-05-01 00:00:00

abstract：:The human primary and secondary IgG subclass antibody responses to keyhole limpet haemocyanin (KLH) have been measured by ELISA using IgG subclass-specific monoclonal antibodies. KLH-specific IgG1 and IgG2 antibodies were detected 3 weeks after primary immunization, and IgG1, IgG2 and IgG4 antibodies after secondary i...

journal_title：Immunology

authors： Bird P,Calvert JE,Amlot PL

更新日期：1990-03-01 00:00:00

abstract：:Testing of extracts of Toxoplasma gondii (RH strain) indicated that delayed hypersensitivity as manifested by delayed skin reactions and inhibition of macrophage migration was induced only by those fractions containing RNA. ...

journal_title：Immunology

authors： Lai CH,Tizard IR,Quinn PJ,Ingram DG

更新日期：1975-04-01 00:00:00

abstract：:Interaction between CD27 and its ligand CD70 provides a second signal for T-cell proliferation and tumour necrosis factor-alpha (TNF-alpha) production. Whereas CD27 is broadly expressed during T-cell development, expression of CD70 in vivo is restricted. To determine when CD27 CD70 interactions can occur in immune rea...

journal_title：Immunology

authors： Lens SM,Baars PA,Hooibrink B,van Oers MH,van Lier RA

更新日期：1997-01-01 00:00:00

abstract：:Anti-CD20 monoclonal antibodies are promising for the treatment of B-cell malignancies such as chronic lymphocytic leukaemia and autoimmune diseases where auto-antibodies play an important role. Anti-CD20 such as rituximab (RTX) mediates B-cell depletion through mechanisms such as complement-mediated cytotoxicity and ...

journal_title：Immunology

authors： Pedersen AE,Jungersen MB,Pedersen CD

更新日期：2011-06-01 00:00:00

abstract：:Neutrophils make up an essential part of the innate immune system, and are involved both in the initial responses to pathogens, and in orchestrating later immune responses. Neutrophils recognize pathogens through pattern-recognition receptors (PRRs), which are activated by microbial motifs. The Nod-like receptors (nuc...

journal_title：Immunology

authors： Ekman AK,Cardell LO

更新日期：2010-05-01 00:00:00