An analysis of those components of Toxoplasma gondii responsible for delayed hypersensitivity reactions in mice.

Abstract:

:Testing of extracts of Toxoplasma gondii (RH strain) indicated that delayed hypersensitivity as manifested by delayed skin reactions and inhibition of macrophage migration was induced only by those fractions containing RNA.

journal_name

Immunology

journal_title

Immunology

authors

Lai CH,Tizard IR,Quinn PJ,Ingram DG

keywords:

subject

Has Abstract

pub_date

1975-04-01 00:00:00

pages

611-20

issue

4

eissn

0019-2805

issn

1365-2567

journal_volume

28

pub_type

杂志文章
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    abstract::Over the past years, increasing numbers of distinct subsets have been discovered and identified for a T lymphocytes' entity. Differentiation and function of each T cell subset are controlled by a specific master transcription factor. Importantly, Runt-related transcription factors, particularly Runx1 and Runx3, interp...

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    doi:10.1111/j.1365-2567.2010.03381.x

    authors: Wong WF,Kohu K,Chiba T,Sato T,Satake M

    更新日期:2011-02-01 00:00:00

  • mTOR: taking cues from the immune microenvironment.

    abstract::The ultimate outcome of T cell receptor recognition is determined by the context in which the antigen is encountered. In this fashion both antigen-presenting cells and T cells must integrate multiple environmental cues in the form of pathogen-associated molecular patterns, cytokines and accessory molecule signals. The...

    journal_title:Immunology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2567.2009.03125.x

    authors: Delgoffe GM,Powell JD

    更新日期:2009-08-01 00:00:00

  • Phenotypic analysis of a resting subpopulation of human peripheral blood NK cells: the FcR gamma III (CD16) molecule and NK cell differentiation.

    abstract::A subpopulation of human peripheral blood natural killer (NK) cells, defined by sedimentation at Percoll high buoyant densities (P greater than 1.0635-1.0640 g/ml) and unresponsiveness to interleukin-2 (IL-2), contained two distinct populations based on the intensity of CD16 (FcR gamma III) expression, namely CD16dim ...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Warren HS,Skipsey LJ

    更新日期:1991-01-01 00:00:00

  • Identification of three distinct allelic forms of bovine CD4.

    abstract::The CD4-specific monoclonal antibody (mAb) CC26, when tested on a total of 143 cattle, failed to react with T cells from 16% of animals and gave reduced intensity staining in a further 35% of animals. The results of family studies with groups of half- and full-siblings indicated that CC26 recognizes an allele of CD4 w...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Morrison WI,Howard CJ,Hinson CJ,MacHugh ND,Sopp P

    更新日期:1994-12-01 00:00:00

  • Analysis of the basis of resistance and susceptibility of CD4+ T cells to human immunodeficiency virus (HIV)-gp120 induced anergy.

    abstract::The resistance and susceptibility of T cells to human immunodeficiency virus (HIV)-gp120 induced anergy was examined. Antigen-dependent proliferation of polyclonal T cells was markedly inhibited by gp120, whereas from the analysis of monoclonal populations, T cells resistant to the effects of gp120 could be identified...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Faith A,O'Hehir RE,Malkovsky M,Lamb JR

    更新日期:1992-06-01 00:00:00

  • Influence of antigen structure on the activation and induction of unresponsiveness in cloned human T lymphocytes.

    abstract::Using cloned human helper T lymphocytes reactive with a 24 amino acid peptide (p20) of the carboxyl terminal of the HA-1 molecule of influenza haemagglutinin we have investigated the influence of antigen structure on the activation and in the induction of antigen specific unresponsiveness of T cells. For this analysis...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Lamb JR,Feldmann M,Green N,Lerner RA

    更新日期:1986-03-01 00:00:00

  • Suppression of monocyte functions by human cytomegalovirus.

    abstract::The role of the monocyte in human cytomegalovirus (HCMV)-induced immunosuppression was examined by assessing the ability of the virus to directly suppress various monocyte accessory cell functions. Both patient-derived and laboratory-adapted strains of HCMV were capable of impairing antigen-presenting functions of pur...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Buchmeier NA,Cooper NR

    更新日期:1989-02-01 00:00:00

  • Involvement of endogenous leukotriene B4 and platelet-activating factor in polymorphonuclear leucocyte recruitment to dermal inflammatory sites in rats.

    abstract::A critical role for leukotriene B(4) (LTB(4)) and/or platelet-activating factor (PAF) in regulating polymorphonuclear cell (PMN) trafficking to inflammatory sites has been reported in a number of experimental inflammatory models. In vitro, newly synthesized LTB(4) and PAF were shown to act in an autocrine/paracrine or...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2567.2007.02767.x

    authors: Bélanger C,Elimam H,Lefebvre J,Borgeat P,Marleau S

    更新日期:2008-07-01 00:00:00

  • Interleukin-4-induced loss of CD8 expression and cytolytic function in effector CD8 T cells persists long term in vivo.

    abstract::Activation of naive CD8(+) T cells in the presence of interleukin-4 modulates their CD8 co-receptor expression and functional differentiation, resulting in the generation of CD8(low) cells that produce type 2 cytokines and display poor cytolytic and anti-tumour activity. Although this CD8(low) phenotype becomes stable...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:10.1111/imm.12068

    authors: Olver S,Apte SH,Baz A,Kelso A,Kienzle N

    更新日期:2013-06-01 00:00:00

  • Murine CD8 lymphocyte expansion in vitro by artificial antigen-presenting cells expressing CD137L (4-1BBL) is superior to CD28, and CD137L expressed on neuroblastoma expands CD8 tumour-reactive effector cells in vivo.

    abstract::The ability to expand tumour-infiltrating lymphocytes in vitro has been greatly enhanced by the use of antigen-independent mechanisms of immune cell costimulation. We have produced human, using the K562 cell line, and murine, using YAC-1 cells, artificial antigen presenting cells (aAPC) and demonstrate that these cell...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2567.2004.01853.x

    authors: Yan X,Johnson BD,Orentas RJ

    更新日期:2004-05-01 00:00:00

  • Intranasal immunization of mice with herpes simplex virus type 2 recombinant gD2: the effect of adjuvants on mucosal and serum antibody responses.

    abstract::Mucosal immunization offers the potential for inducing IgA antibody responses in the vagina, the site of infection for many viruses, including herpes simplex type 2 (HSV-2). To investigate this possibility, mice were immunized intranasally with 10 micrograms glycoprotein D2 (gD2) from HSV combined with a series of adj...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2567.1998.00441.x

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    更新日期:1998-04-01 00:00:00

  • The biological effect of three thymosin fraction 5 polypeptides in the murine mixed lymphocyte reaction.

    abstract::The biological effects of three thymosin fraction 5 polypeptides, designated as beta 10, beta 4, and alpha 1 were tested in the MLR of mouse splenocytes, lymph node cells and thymocytes against syngeneic or allogeneic stimulators. It was found that all three polypeptides, after in vivo and in vitro treatment of the re...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Baxevanis CN,Perez S,Kokkinopoulos D,Papamichail M

    更新日期:1985-04-01 00:00:00

  • MicroRNAs regulate T-cell production of interleukin-9 and identify hypoxia-inducible factor-2α as an important regulator of T helper 9 and regulatory T-cell differentiation.

    abstract::MicroRNAs (miRNAs) regulate many aspects of helper T cell (Th) development and function. Here we found that they are required for the suppression of interleukin-9 (IL-9) expression in Th9 cells and other Th subsets. Two highly related miRNAs (miR-15b and miR-16) that we previously found to play an important role in re...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:10.1111/imm.12631

    authors: Singh Y,Garden OA,Lang F,Cobb BS

    更新日期:2016-09-01 00:00:00

  • Activated macrophages pre-incubated in vitro enhance rather than suppress mitogen-stimulated lymphocyte transformation.

    abstract::It has previously been shown in mice that activated peritoneal macrophages, when first removed from the peritoneal cavity, suppress mitogen-stimulated lymphocyte transformation in vitro as measured by [3H]-thymidine incorporation. In this study, it is demonstrated that activated macrophages that have been incubated al...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Wing EJ,Remington JS

    更新日期:1980-06-01 00:00:00

  • Characterization of B-cell phenotypic changes during ileal and jejunal Peyer's patch development in sheep.

    abstract::Changes in B-cell phenotype during development of ileal and jejunal Peyer's patches (PP) of sheep were investigated using flow cytometry and immunoperoxidase-stained cryosections. On Day 104 of gestation (term at 150 days) B-cell clusters were identified in the lamina propria of the ileum. These clusters were composed...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Griebel PJ,Kennedy L,Graham T,Davis WC,Reynolds JD

    更新日期:1992-12-01 00:00:00

  • Identification of T-cell epitopes in Francisella tularensis using an ordered protein array of serological targets.

    abstract::Francisella tularensis is a Gram-negative intracellular bacterium that is the causative agent of tularaemia. Concerns regarding its use as a bioterrorism agent have led to a renewed interest in the biology of infection, host response and pathogenesis. A robust T-cell response is critical to confer protection against F...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2567.2010.03387.x

    authors: Valentino MD,Maben ZJ,Hensley LL,Woolard MD,Kawula TH,Frelinger JA,Frelinger JG

    更新日期:2011-03-01 00:00:00

  • Transplantation tolerance--a historical introduction.

    abstract::The concept of immunological tolerance--the state of specific unresponsiveness to allogeneic transplants and all manner of other antigens--began in 1945 with R.D. Owen's finding that cattle dizygotic twins are red blood cell chimeras. Peter Medawar's group in Birmingham likewise discovered, quite independently, that c...

    journal_title:Immunology

    pub_type: 历史文章,杂志文章,评审

    doi:10.1111/imm.12567

    authors: Brent L

    更新日期:2016-03-01 00:00:00

  • Anti-viral immunity induced by recombinant nucleoprotein of influenza A virus. III. Delivery of recombinant nucleoprotein to the immune system using attenuated Salmonella typhimurium as a live carrier.

    abstract::A plasmid encoding the influenza nucleoprotein gene from A/NT/60/68 virus was transduced into the attenuated Salmonella typhimurium aroA- strain SL3261. The bacterial vector expressing the viral gene product was able to induce both humoral and cell-mediated immune responses to the nucleoprotein antigen. CD4+ virus-spe...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Tite JP,Gao XM,Hughes-Jenkins CM,Lipscombe M,O'Callaghan D,Dougan G,Liew FY

    更新日期:1990-08-01 00:00:00

  • The localization of Thy-1.1, MRC OX 2 and Ia antigens in the rat ovary and fallopian tube.

    abstract::The localization of Thy-1, MRC OX 2 and Ia antigens as defined by monoclonal antibodies MRC OX 7, MRC OX 2 and MRC OX 6 was determined by an indirect immunoperoxidase technique on cryostat sections of rat ovaries. Thy-1 antigen was present significantly in the theca interna of growing antral follicles. Developing corp...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Bukovský A,Presl J,Zidovský J,Mancal P

    更新日期:1983-03-01 00:00:00

  • Nature and mechanisms of action of co-operating cells controlling human T-colony formation.

    abstract::The mechanisms of action and the nature of the co-operating cells (CC) controlling human T-lymphocyte-colony formation were investigated. Media conditioned by PHA-stimulated blood mononuclear cells (MC) were tested for their capacity to induce T-colony formation in the effluent cell population, obtained after anti (Fa...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Klein B,Caraux J,Thomas P,Goube De Laforest P

    更新日期:1982-02-01 00:00:00

  • B-cell production and differentiation in adult rats.

    abstract::The B-cell development in a group of rats was suppressed for the first 45 days of life by serial administration of rabbit anti-rat IgM and IgD antibody. Total or near total suppression of B lymphopoiesis was achieved. At 45 days, suppression was stopped by injection of IgM and IgD rat paraproteins. The sequence of B-c...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Bazin H,Platteau B,Maclennan IC,Johnson GD

    更新日期:1985-01-01 00:00:00

  • Monocyte-derived dendritic cells from horses differ from dendritic cells of humans and mice.

    abstract::Dendritic cells (DC) are the initiators of immune responses and are present in most tissues in vivo. To generate myeloid DC from monocytes (MoDC) in vitro the necessary cytokines are granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4). Using degenerated primers delineated from other spec...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2567.2005.02319.x

    authors: Mauel S,Steinbach F,Ludwig H

    更新日期:2006-04-01 00:00:00

  • The role of the macrophage in cutaneous leishmaniasis.

    abstract::The investigation of the role of the macrophage in cutaneous leishmaniasis has been prompted by observations of the clinical behaviour of the infection. In contrast to the self-healing oriental sore, chronic leishmaniasis is characterized by persistent lesions and leishmania recidiva by lesions that flare up locally l...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Farah FS,Samra SA,Nuwayri-Salti N

    更新日期:1975-10-01 00:00:00

  • Functional studies of rabbit T lymphocytes.

    abstract::Rabbit spleen and mesenteric lymph node cells were treated with a monoclonal anti-rabbit T-lymphocyte antibody (MAb) and complement and the effect of the treatment on various lymphocyte functions was determined. Lysis of spleen and mesenteric lymph node cells reactive with this MAb, 9AE10, essentially eliminated their...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: McNicholas JM,Watkins JR,Johnson AD,Knight KL

    更新日期:1981-08-01 00:00:00

  • Effect of uterine immunization and oestradiol on specific IgA and IgG antibodies in uterine, vaginal and salivary secretions.

    abstract::Levels of IgA and IgG antibodies were measured in uterine and vaginal secretions to examine the effect of uterine immunization on the genital tract humoral immune system. When ovariectomized animals were immunized on Day 0 and boosted 13 days later by placing sheep erythrocytes (SRBC) directly in the uterine lumen (UT...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Wira CR,Sandoe CP

    更新日期:1989-09-01 00:00:00

  • Evaluation of the immune response against Trypanosoma cruzi cytosolic tryparedoxin peroxidase in human natural infection.

    abstract::Trypanosoma cruzi, the aetiological agent of Chagas disease, has a highly efficient detoxification system to deal with the oxidative burst imposed by its host. One of the antioxidant enzymes involved is the cytosolic tryparedoxin peroxidase (c-TXNPx), which catalyses the reduction to hydrogen peroxide, small-chain org...

    journal_title:Immunology

    pub_type: 临床试验,杂志文章

    doi:10.1111/imm.12979

    authors: Girard MC,Acevedo GR,López L,Ossowski MS,Piñeyro MD,Grosso JP,Fernandez M,Hernández Vasquez Y,Robello C,Gómez KA

    更新日期:2018-11-01 00:00:00

  • Immunological unresponsiveness in mice. II. Cellular basis of immunological unresponsiveness induced in foetal and neonatal mice by transfer of human gamma-globulin by the maternal route.

    abstract::The cellular basis of the mechanism of immunological tolerance to human gamma-globulin (H gamma G) induced in foetal and neonatal mice by materno-foetal or materno-neonatal transfer after a single injection of tolerogen (deaggregated H gamma G) into the mothers was investigated using a cell transfer system and assays ...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Shinka S,Komatsu T,Dohi Y,Amano T

    更新日期:1979-05-01 00:00:00

  • Lectin-dependent cell-mediated cytotoxicity in an invertebrate model: Con A does not act as a bridge.

    abstract::The plant lectin concanavalin A (Con A) has been used in an invertebrate model of lectin-dependent cell-mediated cytotoxicity (LDCC). Macrophage-like cells from the susceptible host snail Biomphalaria glabrata become cytotoxic effectors when they encounter sporocysts of the parasitic trematode Schistosoma mansoni that...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Boswell CA,Bayne CJ

    更新日期:1986-02-01 00:00:00

  • Expression of an EL4 tumour-associated determinant on subpopulations of murine T cells in normal and lympho-proliferative autoimmune mice.

    abstract::It has been demonstrated that the single autosomal recessive lpr and gld genes are responsible for the accumulation of unusual T-cell subsets. Although these subsets have been assigned to the T-cell lineage, they share certain antigenic cell surface markers with mature B lymphocytes. Consequently the maturational path...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Waterfield JD,Fairhurst M

    更新日期:1991-02-01 00:00:00

  • Paradoxical stimulation and inhibition by protein kinase C modulating agents of lipopolysaccharide evoked production of tumour necrosis factor in human monocytes.

    abstract::Human blood monocytes were activated by bacterial lipopolysaccharide endotoxin (LPS) (10 ng/ml) for cytotoxicity of WEHI-164 mouse fibrosarcoma cells, determined by release of 51Cr from WEHI-164 tumour cells incubated with monocyte supernatants. The chemotactic peptide N-formylmethionyl-leucyl-phenylalanine (FMLP) aug...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Coffey RG,Weakland LL,Alberts VA

    更新日期:1992-05-01 00:00:00