B-cell production and differentiation in adult rats.

abstract：:Cytotoxic T-lymphocytes (CTL) play an important role in the control of human immunodeficiency virus (HIV) and of human cytomegalovirus (HCMV) infection. Following highly active antiretroviral therapy (HAART), most studies have demonstrated a decline in the frequency of HIV-specific CTL. We analysed the effect of HAART...

journal_title：Immunology

authors： Weekes MP,Wills MR,Sissons JG,Carmichael AJ

更新日期：2006-05-01 00:00:00

abstract：:Using a cell culture system, age-associated changes in immune activities were investigated in newly developed, short-lived mouse strains. These SAM-P strains of mice (H-2k), which have a remarkably short life span (around 9 months) under conventional breeding conditions, showed an age-associated early decline in sever...

journal_title：Immunology

authors： Hosokawa T,Hosono M,Higuchi K,Aoike A,Kawai K,Takeda T

更新日期：1987-11-01 00:00:00

abstract：:Macrophages play important roles in the clearance of dying and dead cells. Typically, and perhaps simplistically, they are viewed as the professional phagocytes of apoptotic cells. Clearance by macrophages of cells undergoing apoptosis is a non-phlogistic phenomenon which is often associated with actively anti-inflamm...

journal_title：Immunology

authors： Gregory CD,Devitt A

更新日期：2004-09-01 00:00:00

abstract：:Hyper-immunoglobulin M (IgM) syndrome (HIGM) is a rare primary immunodeficiency characterized by elevated or normal IgM and absent or markedly decreased amounts of IgG, IgA and IgE. The X-linked form (HIGM1) is the most common type and is caused by mutations in the gene for CD40L, a T-cell surface molecule required fo...

journal_title：Immunology

authors： Van Hoeyveld E,Zhang PX,De Boeck K,Fuleihan R,Bossuyt X

更新日期：2007-04-01 00:00:00

abstract：:Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal tract. Its pathogenesis is not completely understood, though the prevailing model is that the intestinal flora drives a strong intestinal T helper 1 (Th1)/Th17 type immune response and inflammation in the genetically susceptible host. This ...

journal_title：Immunology

authors： Ricciardelli I,Lindley KJ,Londei M,Quaratino S

更新日期：2008-10-01 00:00:00

abstract：:In this report the antigen and restriction specificity of human T-cell clones induced with Dermatophagoides farinae (D. farinae) and isolated from an atopic individual with perennial rhinitis has been investigated. Of the six clones analysed, four were species specific and two showed cross-reactivity for the closely r...

journal_title：Immunology

authors： O'Hehir RE,Eckels DD,Frew AJ,Kay AB,Lamb JR

更新日期：1988-08-01 00:00:00

abstract：:Aspergillus fumigatus is often associated in asthmatic patients with the exacerbation of asthma symptoms. The pathomechanism of this phenomenon has not been fully understood. Here, we evaluated the immunological mechanisms and the role of the prostaglandin D2 / Chemoattractant Receptor-Homologous Molecule Expressed on...

journal_title：Immunology

authors： Liu H,Zheng M,Qiao J,Dang Y,Zhang P,Jin X

更新日期：2014-05-01 00:00:00

abstract：:Individual young adult, middle-aged, and old C57BL/6J male mice were tested for in vitro generated proliferative and cytotoxic responses to H-2 alloantigens under a variety of sensitization conditions. Proliferation in mixed lymphocyte culture (MLC) had decreased by 14 months of age (middle-aged), whether measured by ...

journal_title：Immunology

authors： Gottesman SR,Kristie JA,Walford RL

更新日期：1981-11-01 00:00:00

abstract：:Silica, or silicon dioxide, has been shown to be toxic for macrophages. This is probably because it damages phagolysosomal membranes, allowing lysosomal enzymes to disrupt the cell. Neutrophils also take up particles such as silica and in addition they contain lysosomes. The purpose of this study was to determine whet...

journal_title：Immunology

authors： Zimmerman BT,Canono BP,Campbell PA

更新日期：1986-12-01 00:00:00

abstract：:Histamine not only mediates immediate allergic reactions, it also regulates cellular immune responses. H4R is the most recently identified histamine receptor (HR). In the present study, we examined the in vitro effect of histamine and H4R agonists on the responses of human T cells to purified protein derivative from M...

journal_title：Immunology

authors： Sugata Y,Okano M,Fujiwara T,Matsumoto R,Hattori H,Yamamoto M,Nishibori M,Nishizaki K

更新日期：2007-06-01 00:00:00

abstract：:Thymocytes incubated with either ATP or GTP exhibit a brief period of enhanced DNA synthesis in contrast to the prolonged period of enhanced synthesis observed when thymocytes were incubated with concanavalin A. The cells responding to nucleotides represent a sub-population of theta antigen-bearing T cells comprising ...

journal_title：Immunology

authors： Gregory SH,Kern M

更新日期：1981-03-01 00:00:00

abstract：:The immunological outcome of infections and vaccinations is largely determined during the initial first days in which antigen-presenting cells instruct T cells to expand and differentiate into effector and memory cells. Besides the essential stimulation of the T-cell receptor complex a plethora of co-stimulatory signa...

journal_title：Immunology

authors： Bathke B,Pätzold J,Kassub R,Giessel R,Lämmermann K,Hinterberger M,Brinkmann K,Chaplin P,Suter M,Hochrein H,Lauterbach H

更新日期：2018-06-01 00:00:00

abstract：:An adoptive transfer assay system was used to investigate the ability of serum from tolerant, liver-grafted rats to inactivate normal thoracic duct lymphocytes. PVG rats were rendered tolerant of DA alloantigens by liver grafting. Serum taken from such rats was used to treat normal PVG thoracic duct lymphocytes (TDL) ...

journal_title：Immunology

authors： Kamada N,Sumimoto R,Baguerizo A,Yoshimatsu A,Teramoto K,Yamaguchi A

更新日期：1988-06-01 00:00:00

abstract：:Cyclophosphamide was used to assess the role of suppressor cells in the contact sensitivity reaction. A single painting with 300 microgram and 30 microgram oxazolone produced poor contact sensitivity reactions (ear swelling). Cyclophosphamide (200 mg/kg) 2 days before painting increased the response to the lower doses...

journal_title：Immunology

authors： Asherson GL,Perera MA,Thomas WR

更新日期：1979-03-01 00:00:00

abstract：:Cancer immune surveillance is considered to be an important host protection process to inhibit carcinogenesis and to maintain cellular homeostasis. In the interaction of host and tumour cells, three essential phases have been proposed: elimination, equilibrium and escape, which are designated the 'three E's'. Several ...

journal_title：Immunology

authors： Kim R,Emi M,Tanabe K

更新日期：2007-05-01 00:00:00

abstract：:Mice of the strains A.TH and A.TL were rendered neonatally tolerant to class II major histocompatibility complex (MHC) by the injection of (A.TH x A.TL)F1 spleen and bone marrow cells within 24 hr of birth. Spleen and thymus cells from adult tolerant mice bearing long-term surviving skin grafts were compared with thos...

journal_title：Immunology

authors： Wood PJ,Cossens IA

更新日期：1993-08-01 00:00:00

abstract：:The soluble cytoplasmic fraction of an homogenate from peritoneal rat mast cells, demonstrated a considerable amount of catalytic activity which promotes the transfer of phosphate from creatine phosphate to ADP. The plasma membrane, mitochondrial and microsomal fractions show negligible amounts of the catalyst. Enzyme...

journal_title：Immunology

authors： Magro AM

更新日期：1980-03-01 00:00:00

abstract：:The concept of immunological tolerance--the state of specific unresponsiveness to allogeneic transplants and all manner of other antigens--began in 1945 with R.D. Owen's finding that cattle dizygotic twins are red blood cell chimeras. Peter Medawar's group in Birmingham likewise discovered, quite independently, that c...

journal_title：Immunology

authors： Brent L

更新日期：2016-03-01 00:00:00

abstract：:The phenotypes of lymphocytes in the large intestinal patches (LIP) of lambs were examined by flow cytometry and immunohistology, using a panel of monoclonal antibodies (mAb), and compared to those found in the jejunal (JPP) and ileal Peyer's patches (IPP). T-cell markers were detected on 25% of the LIP and JPP lympho...

journal_title：Immunology

authors： Aleksandersen M,Hein WR,Landsverk T,McClure S

更新日期：1990-07-01 00:00:00

abstract：:Resveratrol is a polyphenol that acts on multiple molecular targets important for cell differentiation and activation. Dendritic cells (DCs) are a functionally diverse cell type and represent the most potent antigen-presenting cells of the immune system. In this study, we investigated resveratrol-induced effects on DC...

journal_title：Immunology

authors： Svajger U,Obermajer N,Jeras M

更新日期：2010-04-01 00:00:00

abstract：:In this study we aimed to elucidate the physiological role of gammadelta intraepithelial lymphocytes (IEL) in the mouse intestine. For this purpose, we used T-cell receptor (TCR) Vgamma4/Vdelta5 transgenic mice (KN 6 Tg: BALB/c background, H-2d), and compared the immunological and physiological characteristics of the ...

journal_title：Immunology

authors： Matsumoto S,Nanno M,Watanabe N,Miyashita M,Amasaki H,Suzuki K,Umesaki Y

更新日期：1999-05-01 00:00:00

abstract：:Although it is well known that cases with silicosis exhibit various immunological abnormalities, the mechanisms involved in the occurrence of immuno-dysfunction or dysregulation induced by silica compounds have not yet been determined. Fas is a well-known cell surface molecule that is involved in the apoptosis pathway...

journal_title：Immunology

authors： Otsuki T,Sakaguchi H,Tomokuni A,Aikoh T,Matsuki T,Kawakami Y,Kusaka M,Ueki H,Kita S,Ueki A

更新日期：1998-06-01 00:00:00

abstract：:Injected recombinant interleukin-6 (IL-6), tumour necrosis factor (TNF) and IL-1 all protect mice against experimental infection with Listeria monocytogenes. We have therefore investigated the interaction of these cytokines during infection. Treatment with recombinant (r)IL-6 enhanced TNF production by spleen cells du...

journal_title：Immunology

authors： Liu Z,Simpson RJ,Cheers C

更新日期：1995-08-01 00:00:00

abstract：:Monoclonal antibodies to human complement component C9 were used to localise the membrane attack complex (MAC) of human complement on muscle fibres from patients with autoimmune myositis. A pigeon erythrocyte 'model' system was used to screen the available monoclonal antibodies for their ability to bind C9 after its i...

journal_title：Immunology

authors： Morgan BP,Sewry CA,Siddle K,Luzio JP,Campbell AK

更新日期：1984-05-01 00:00:00

abstract：:As the burden of infectious diseases becomes reduced in many countries, a remarkable increase in the incidence of allergies has occurred. The basis for the rise in atopic disorders as a correlate of the decline in infectious diseases has not been defined. In the present study, we tested experimentally whether prior sy...

journal_title：Immunology

authors： Yang X,Wang S,Fan Y,Zhu L

更新日期：1999-11-01 00:00:00

abstract：:Airway mucus hyperproduction is a common feature of chronic airway diseases such as severe asthma, chronic obstructive pulmonary disease and cystic fibrosis, which are closely associated with neutrophilic airway inflammation. S100A8, S100A9 and S100A12 are highly abundant proteins released by neutrophils and have been...

journal_title：Immunology

authors： Kang JH,Hwang SM,Chung IY

更新日期：2015-01-01 00:00:00

abstract：:We undertook a search for cytokine-inducible molecules present on brain endothelium and which are involved in the control of lymphocyte adhesion. We screened 39 monoclonal antibodies (mAb) against rat brain endothelium in vitro, and identified five recognizing cytokine-inducible molecules. None of the 39 antibodies bl...

journal_title：Immunology

authors： Male D,Rahman J,Linke A,Zhao W,Hickey W

更新日期：1995-03-01 00:00:00

abstract：:With an increase in the importance of umbilical cord blood (CB) as an alternative source of haematopoietic progenitors for allogenic transplantation, donor lymphocyte infusion (DLI) with donor CB-derived activated CD4(+) T cells in the unrelated CB transplantation setting is expected to be of increased usefulness as a...

journal_title：Immunology

authors： Miyagawa Y,Kiyokawa N,Ochiai N,Imadome K,Horiuchi Y,Onda K,Yajima M,Nakamura H,Katagiri YU,Okita H,Morio T,Shimizu N,Fujimoto J,Fujiwara S

更新日期：2009-11-01 00:00:00

abstract：:Antibodies against lymphocytes have been shown in human immunodeficiency virus (HIV)-infected patients, but their relevance in the pathogenesis of acquired immune deficiency syndrome (AIDS) remains controversial. We investigated increased levels of lymphocyte surface Ig and antibodies against CD4+ T cells in the plasm...

journal_title：Immunology

authors： Müller C,Kukel S,Bauer R

更新日期：1993-06-01 00:00:00

abstract：:Receptors for the Fc fragment of IgG (Fc gamma R) have a well-documented role in the generation of oxidative burst. It is tempting to speculate that the type of interaction with Fc gamma R could be a mechanism of regulation of this process. Here we report on a comparative study of the induction of oxidative burst in h...

journal_title：Immunology

authors： Casado JA,Merino J,Cid J,Subira ML,Sanchez-Ibarrola A

更新日期：1994-09-01 00:00:00