Abstract：
:As the burden of infectious diseases becomes reduced in many countries, a remarkable increase in the incidence of allergies has occurred. The basis for the rise in atopic disorders as a correlate of the decline in infectious diseases has not been defined. In the present study, we tested experimentally whether prior systemic infection with Mycobacterium bovis bacillus Calmette Guérin (BCG) had any effect on ovalbumin (OVA) Al(OH)3 (alum)-induced immunoglobulin E (IgE) production, airway mucus production and eosinophilic inflammation. The data showed that allergen-specific IgE production and OVA-induced eosinophilia and goblet cell development were significantly inhibited by prior infection with BCG. Correspondingly, following immunization with OVA alum, BCG-infected mice exhibited significantly higher levels of allergen-driven interferon-gamma (IFN-gamma) production than the mice without infection. The ratio of IFN-gamma: interleukin (IL)-4 production was higher in OVA-sensitized mice with prior BCG infection than in those without infection. The abrogation of OVA-induced mucus production and pulmonary eosinophilia in BCG-infected mice correlated with significantly decreased IL-5 production and increased IFN-gamma and IL-12 production. These data provide direct evidence that intracellular bacterial infection (i.e. BCG) can inhibit antigen-specific IgE and airway reactivity induced by environmental allergen. Furthermore, the results suggest that changes in cytokine-producing patterns of T lymphocytes and other cells may be the mechanism by which infections influence allergies.
journal_name
Immunologyjournal_title
Immunologyauthors
Yang X,Wang S,Fan Y,Zhu Ldoi
10.1046/j.1365-2567.1999.00856.xkeywords:
subject
Has Abstractpub_date
1999-11-01 00:00:00pages
329-37issue
3eissn
0019-2805issn
1365-2567pii
imm856journal_volume
98pub_type
杂志文章相关文献
IMMUNOLOGY文献大全abstract：:Studies with gene-deficient and gnotobiotic mice have identified many host and microbial factors that contribute to induced colitis, but information on whether specific factors determine susceptibility under more physiological conditions is lacking. Using wild-type strains that differ in their IgA response but harbor ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.13091
更新日期：2019-09-01 00:00:00
abstract：:Some plasmacytomas produce myeloma proteins with known antibody specificities and the secretion of these proteins by individual tumour cells can be determined using haemolytic plaque assay. After a 3 day culture of mouse plasmacytoma cells in medium containing 10% normal mouse serum, the number of plaques was reduced ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1980-10-01 00:00:00
abstract：:Immune synapse formation is critical for T lymphocyte activation, and mitochondria have a role in this process, by localizing close to the immune synapse, regulating intracellular calcium concentration, and providing locally required ATP. The interaction between antigen presenting cells (APCs) and T lymphocytes is a t...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.12392
更新日期：2014-09-23 00:00:00
abstract：:To evaluate the role of the high-affinity monocyte receptor for lipopolysaccharide (LPS), CD14, in the process of tolerance to LPS, the human monocytic cell line Mono-Mac-6 was cultured in the absence or presence of different amounts of LPS. The kinetics of CD14 modulation in these cells showed an initial 4-day period...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1993-11-01 00:00:00
abstract：:A suspension of nucleated femoral (BALB/c x CBA) bone marrow cells was inoculated, either into glass flasks or into flasks coated with a preformed syngeneic marrow derived monolayer, and cultured for long periods in media supplemented with hydrocortisone sodium succinate. Long term analysis of the lymphoid status of t...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：:We investigated the individual CD8+ populations with natural killer (NK) cell markers (NK-type T cell); CD56 single positive (CD56)-T cells, CD56/CD57 double positive (DP)-T cells and CD57 single positive (CD57)-T cells in the peripheral blood. All NK-type T-cell populations expressed CD122 and intermediate levels of ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.2003.01575.x
更新日期：2003-02-01 00:00:00
abstract：:Interleukin-6 (IL-6) is a multifunctional cytokine with a broad range of activities and can affect a variety of target cells or systems in multiple ways. However, there is currently no consensus on how IL-6 directly affects the peripheral nervous tissue. We performed histopathological and immunohistochemical analyses ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1999.00808.x
更新日期：1999-08-01 00:00:00
abstract：:Anti-CD20 monoclonal antibodies are promising for the treatment of B-cell malignancies such as chronic lymphocytic leukaemia and autoimmune diseases where auto-antibodies play an important role. Anti-CD20 such as rituximab (RTX) mediates B-cell depletion through mechanisms such as complement-mediated cytotoxicity and ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2011.03434.x
更新日期：2011-06-01 00:00:00
abstract：:Immunoglobulin D (IgD) is normally present in only low concentrations in serum. In the hyper-IgD and periodic fever syndrome (HIDS), however, serum levels exceed 140 mg/l. This syndrome is further characterized by recurrent inflammatory febrile attacks together with an acute phase response and appearance of cytokines ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1996.d01-672.x
更新日期：1996-07-01 00:00:00
abstract：:Successful elimination of the hepatitis C virus (HCV) during acute infection has been linked to strong HCV-specific in vitro T-cell proliferation, whereas T cells from patients with chronic hepatitis C respond only weakly to HCV antigens. Lipid-coupled peptides are immunostimulants, which might provide a basis for nov...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.2001.01209.x
更新日期：2001-04-01 00:00:00
abstract：:Synthesis of interferon (IFN)-gamma by natural killer (NK) cells is an important pro-inflammatory event with interleukin (IL)-12 and IL-18 playing major inductive roles. However, other temporal events are likely to regulate such processes and as prostaglandin E2 (PGE2) is ubiquitous during inflammation this study test...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2004.01810.x
更新日期：2004-03-01 00:00:00
abstract：:Sodium penicillin was conjugated to sheep erythrocytes and optimal quantities, added to a 5% SRBC suspension, were determined for haemagglutination (12-5 mg/ml) and for haemolysis (50 mg/ml) using carp antibodies and carp complement. The epitope density on the BSA molecule was gradually increased, when increasing amou...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1976-10-01 00:00:00
abstract：:Cytokines are the most important inducers of T helper (Th) cell differentiation. Interleukin-12 (IL-12) and interferon-alpha (IFN-alpha) are responsible for human Th1-cell differentiation, while IL-4 is the critical cytokine promoting Th2-cell development. These two subsets of cells co-ordinate immunological responses...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2005.02201.x
更新日期：2005-09-01 00:00:00
abstract：:The affinity of anti-DNP antibodies produced by mice of various ages has been studied at the cellular level by the plaque inhibition technique. The affinity of PFC produced shortly after a single injection of antigen was found to increase during the first 6 weeks of life. The responses of 1- and 2-week-old animals als...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1975-09-01 00:00:00
abstract：:Several cloned, non-leukaemic mouse haemopoietic cell lines are believed to be uniquely dependent on interleukin-3 (IL-3) for their survival. All of these lines require the addition of WEHI-3B cell-conditioned medium for their growth. We have examined the growth requirements of four IL-3-dependent cell lines and found...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1986-08-01 00:00:00
abstract：:Activation of naive CD8(+) T cells in the presence of interleukin-4 modulates their CD8 co-receptor expression and functional differentiation, resulting in the generation of CD8(low) cells that produce type 2 cytokines and display poor cytolytic and anti-tumour activity. Although this CD8(low) phenotype becomes stable...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.12068
更新日期：2013-06-01 00:00:00
abstract：:To study the influence of macrophages on the migration and distribution of lymphocytes in the spleen, macrophages were eliminated from the spleen of mice by injection of liposomes in which DMDP was encapsulated. This leads to an elimination of macrophages in both the red pulp and marginal zone of the spleen within 1-2...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1989-10-01 00:00:00
abstract：:Cells expressing indoleamine 2,3-dioxygenase (IDO), an enzyme which catabolizes tryptophan, prevent T-cell proliferation in vitro, suppress maternal antifetal immunity during pregnancy and inhibit T-cell-mediated responses to tumour-associated antigens. To examine the mechanistic basis of these phenomena we activated ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.2002.01526.x
更新日期：2002-12-01 00:00:00
abstract：:It was found that spleen cells from mice injected i.v. with large doses of BCG respond to PHA stimulation less intensely than do normal spleen cells. We were able to show that nylon wool column purified BCG treated T cells also had a low PHA reactivity. Unfractionated spleen cells, adherent cells or T-enriched populat...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1978-03-01 00:00:00
abstract：:The opossum major histocompatibility complex (MHC) shares a similar organization with that of non-mammals while containing a diverse set of class I genes more like that of eutherian (placental) mammals. There are 11 class I loci in the opossum MHC region, seven of which are known to be transcribed. The previously desc...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2008.02994.x
更新日期：2009-09-01 00:00:00
abstract：:Immunoprecipitation of biosynthetically labelled interleukin-4 (IL-4) secreted by activated D10 cells yielded three bands after separation under non-reducing conditions by electrophoresis through gradient SDS polyacrylamide gels. This triplet consists of a closely spaced doublet at 23 and 22 kDa (23/22 kDa), and a thi...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:Interleukin-8 (IL-8) is a pro-angiogenic cytokine associated with aggressive prostate cancer (CaP). We detected high levels of IL-8 in sera from patients with CaP compared with healthy controls and patients with benign prostatic hypertrophy. This study examines the role of IL-8 in the pathogenesis of metastatic prosta...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.12618
更新日期：2016-08-01 00:00:00
abstract：:We have used in situ hybridization (ISH) and immunohistochemistry (IHC) to investigate the kinetics of the expression for Fc epsilon RI mRNA (alpha-, beta- and gamma-chains), the alpha-chain protein product, as well as the phenotype of the mRNA- or protein-positive cells in allergen-induced late-phase skin reactions i...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1998.00418.x
更新日期：1998-02-01 00:00:00
abstract：:Murine spleen cells were analysed for their capacity to lyse 51Cr-labelled antibody-sensitized erythrocytes and a human lymphoma cell line. Incubation of spleen cells with iron powder followed by removal of iron-containing cells with a magnet significantly decreased the lytic capacity of the remaining cells against er...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1981-08-01 00:00:00
abstract：:Forssman antiserum produced in rabbits immunized with sheep erythrocyte stromata was found to contain an IgG antibody which inhibited both passive anaphylactic sensitization of guinea-pig lung and also histamine-releasing activity of soluble immune complexes. This Forssman antibody did not itself cause histamine rele...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：:In the present study we have investigated whether bovine erythrocytes (Eb) specifically sensitized with human polyclonal IgA1 (Eb-IgA1) are able to bind to resident adherent rat peritoneal cells (PM phi). Rat PM phi formed rosettes with Eb-IgA1 at room temperature and at 37 degrees. The formation of these rosettes cou...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1988-06-01 00:00:00
abstract：:Cytotoxic T-lymphocytes (CTL) play an important role in the control of human immunodeficiency virus (HIV) and of human cytomegalovirus (HCMV) infection. Following highly active antiretroviral therapy (HAART), most studies have demonstrated a decline in the frequency of HIV-specific CTL. We analysed the effect of HAART...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2006.02334.x
更新日期：2006-05-01 00:00:00
abstract：:The tumour microenvironment is complex containing not only neoplastic cells but also a variety of host cells. The heterogeneous infiltrating immune cells include subsets of cells with opposing functions, whose activities are mediated either directly or through the cytokines they produce. Systemic delivery of cytokines...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.12037
更新日期：2013-03-01 00:00:00
abstract：:NKG2D is one of the best characterized activating receptors and is expressed on natural killer cells and on various T-cell subsets. This receptor recognizes several different ligands that are induced by cellular stresses. In this review, we described the mechanisms controlling the expression of NKG2D ligands, with the...
journal_title：Immunology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2567.2009.03147.x
更新日期：2009-09-01 00:00:00
abstract：:We hypothesized that the addition of polymer to the surface of liposome/DNA complexes may potentially enhance in vivo delivery of plasmid DNA to antigen-presenting cells and thereby facilitate enhanced immune responses to encoded protein. BALB/c mice were immunized subcutaneously or intramuscularly three times with a ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.2002.01448.x
更新日期：2002-07-01 00:00:00
