Active suppression of in vitro reactivity of spleen cells after BCG treatment.

Abstract:

:It was found that spleen cells from mice injected i.v. with large doses of BCG respond to PHA stimulation less intensely than do normal spleen cells. We were able to show that nylon wool column purified BCG treated T cells also had a low PHA reactivity. Unfractionated spleen cells, adherent cells or T-enriched populations from BCG treated mice, when added to normal T cells lowered their PHA reactivity. When the same BCG treated cell populations were added to tumor cells in vitro, they inhibited their growth.

journal_name

Immunology

journal_title

Immunology

authors

Orbach-Arbouys S,Poupon MF

subject

Has Abstract

pub_date

1978-03-01 00:00:00

pages

431-7

issue

3

eissn

0019-2805

issn

1365-2567

journal_volume

34

pub_type

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