Mast cell subsets in the rat distinguished immunohistochemically by their content of serine proteinases.

abstract：:Immunization of male rats and monkeys with gonadotropin-releasing hormone (GnRH) conjugated to a carrier results in a dramatic atrophy of the prostate. GnRH, linked to either diphtheria toxoid or tetanus toxoid as carrier, is now being evaluated for its use in the immunotherapy of hormone-dependent prostate enlargemen...

journal_title：Immunology

authors： Sad S,Gupta HM,Talwar GP,Raghupathy R

更新日期：1991-10-01 00:00:00

abstract：:Docosahexaenoic (22:6 n-3) and eicosapentaenoic acid (20:5 n-3) stimulated the oxygen-dependent respiratory burst in intact neutrophils in a dose-dependent manner as measured by either superoxide dismutase (SOD)-inhibitable cytochrome c reduction and lucigenin-dependent chemiluminescence. A number of longer chain hexa...

journal_title：Immunology

authors： Poulos A,Robinson BS,Ferrante A,Harvey DP,Hardy SJ,Murray AW

更新日期：1991-05-01 00:00:00

abstract：:Neuropeptides can influence immune effector cell function at both systemic and mucosal immune sites. We examined the ability of substance P (SP) to modulate the natural killer (NK) activity of intestinal intraepithelial leucocytes (IEL). Yac-1 killing by IEL but not splenic cells was increased after either 18 hr prein...

journal_title：Immunology

authors： Croitoru K,Ernst PB,Bienenstock J,Padol I,Stanisz AM

更新日期：1990-10-01 00:00:00

abstract：:Toll-like receptors (TLR) are sentinel receptors capable of recognizing pathogen-associated molecule patterns (PAMP) such as lipopolysaccharide (LPS) and CpG-containing oligonucleotides (CpG ODN). TLR2 and TLR4 are major receptors for Gram-positive and Gram-negative bacterial cell wall components, respectively. TLR9 i...

journal_title：Immunology

authors： An H,Yu Y,Zhang M,Xu H,Qi R,Yan X,Liu S,Wang W,Guo Z,Guo J,Qin Z,Cao X

更新日期：2002-05-01 00:00:00

abstract：:Toll-like receptors (TLRs) are important pattern recognition molecules that activate the nuclear factor (NF)-kappaB pathway leading to the production of antimicrobial immune mediators. As keratinocytes represent the first barrier against exogenous pathogens in human skin, we investigated their complete functional TLR1...

journal_title：Immunology

authors： Köllisch G,Kalali BN,Voelcker V,Wallich R,Behrendt H,Ring J,Bauer S,Jakob T,Mempel M,Ollert M

更新日期：2005-04-01 00:00:00

abstract：:Oral administration of a protein antigen generates a serum factor that induces tolerance when transferred into naïve recipients. This serum factor has been described in rats as consisting of exosome-like structures or tolerosomes, which express major histocompatibility complex class II molecules (MHCII) and mediate an...

journal_title：Immunology

authors： Ostman S,Taube M,Telemo E

更新日期：2005-12-01 00:00:00

abstract：:Four types of lymphocyte chemotactic factor (LCF-a, -b, -c and -d) could be isolated from extract of 24-hr-old delayed-type hypersensitivity (DTH) skin reaction sites induced with purified protein derivative (PPD) in guinea-pigs by gel filtration on Sephadex G-100 followed by chromatography with DEAE-Sephadex. Partial...

journal_title：Immunology

authors： Shimokawa Y,Harita S,Hayashi H

更新日期：1984-02-01 00:00:00

abstract：:Receptors for the Fc fragment of IgG (Fc gamma R) have a well-documented role in the generation of oxidative burst. It is tempting to speculate that the type of interaction with Fc gamma R could be a mechanism of regulation of this process. Here we report on a comparative study of the induction of oxidative burst in h...

journal_title：Immunology

authors： Casado JA,Merino J,Cid J,Subira ML,Sanchez-Ibarrola A

更新日期：1994-09-01 00:00:00

abstract：:The effect of a proline-rich polypeptide from ovine colostrum on the humoral immune response in mice against sheep red blood cells (SRBC) was studied. It was shown that the polypeptide had a regulatory activity stimulating or suppressing the immune response. The proline-rich polypeptide also increased the permeability...

journal_title：Immunology

authors： Wieczorek Z,Zimecki M,Janusz M,Staroscik K,Lisowski J

更新日期：1979-04-01 00:00:00

abstract：:Electron microscopic findings made on microsomal fractions of rat liver after treatment with microsomal antibodies obtained from the blood of patients diagnosed as having chronic aggressive hepatitis and liver cirrhosis and after incubation with peroxidase-labelled antihuman IgG are described and presented in this pap...

journal_title：Immunology

authors： Storch W,Cossel L,Dargel R

更新日期：1977-06-01 00:00:00

abstract：:Splenic immune responses having varying dependence on accessory cell co-operation have been studied after infection of mice with Friend virus. Infection has no effect on cell proliferation or antibody production in cultures stimulated with E. coli lipopolysaccharide. The response in vivo to type III pneumococcal polys...

journal_title：Immunology

authors： Dracott BN,Wedderburn N,Doenhoff MJ

更新日期：1978-04-01 00:00:00

abstract：:Collectins are a group of soluble proteins, each of which has collagenous and non-collagenous globular domains, and may be complement associated and/or have lectin activity. The complement protein C1q is structurally and functionally related to the collectins. Members of the collectin family are mannan-binding protein...

journal_title：Immunology

authors： Malhotra R,Willis AC,Lopez Bernal A,Thiel S,Sim RB

更新日期：1994-07-01 00:00:00

abstract：:Guinea-pig mitogenic factor(s) were found capable of stimulating both normal T and B cells. Preliminary physicochemical characterization could not dissociate the mitogenic factors for respective cell populations. Furthermore, both immune T and B cells could produce mitogenic factors upon stimulation with antigen in co...

journal_title：Immunology

authors： Bergenstock RW,Cohen S,Yoshida T

更新日期：1981-02-01 00:00:00

abstract：:Alteration in the frequency of monocyte subsets is a hallmark of tuberculosis-diabetes co-morbidity (TB-DM). To study this association, we examined the plasma levels of sCD14, sCD163, C-reactive protein (CRP) and soluble tissue factor (sTF) in individuals with TB-DM, TB or diabetes mellitus (DM), and in healthy contro...

journal_title：Immunology

authors： Kumar NP,Moideen K,Bhootra Y,Nancy A,Viswanathan V,Shruthi BS,Sivakumar S,Natarajan M,Kornfeld H,Babu S

更新日期：2019-03-01 00:00:00

abstract：:Chlamydia trachomatis is a major cause of sexually transmitted disease, infertility and reactive arthritis in the Western world, and of trachoma in the developing world. There is evidence that the chronic inflammatory reaction seen in diseases associated with chlamydiae represents a delayed-type hypersensitivity respo...

journal_title：Immunology

authors： Hassell AB,Reynolds DJ,Deacon M,Gaston JS,Pearce JH

更新日期：1993-08-01 00:00:00

abstract：:Dendritic cells (DC) generated from MUTZ-3, an immortalized acute myeloid leukaemia-derived cell line, have potential application as a model for the study of human DC, and as a tool with which to stimulate immunotherapeutic responses to cancer. However, the relationship of MUTZ-3 DC to their non-transformed counterpar...

journal_title：Immunology

authors： Rasaiyaah J,Noursadeghi M,Kellam P,Chain B

更新日期：2009-07-01 00:00:00

abstract：:A technique is reported here for the quantitative extraction of live cells from the lung interstitium; it involves the incubation of slices of perfused lung in a mixture containing optimal concentrations of collagenase, DNAse, and fetal calf serum, followed by the simultaneous recovery and fractionation of cells relea...

journal_title：Immunology

authors： Holt PG,Degebrodt A,Venaille T,O'Leary C,Krska K,Flexman J,Farrell H,Shellam G,Young P,Penhale J

更新日期：1985-01-01 00:00:00

abstract：:When Trypanosoma cruzi is co-cultured with activated human lymphocytes the latter manifest a marked level of suppression in their capacity to express high-affinity interleukin-2 receptors (IL-2R). In this study we asked whether this effect could result from reduced expression of the p75 component of the IL-2R, a condi...

journal_title：Immunology

authors： Kierszenbaum F,Sztein MB

更新日期：1992-03-01 00:00:00

abstract：:Recent studies in mice have highlighted the importance of polymorphic genetic loci such as the major histocompatibility complex (MHC) or minor lymphocyte-stimulating antigen (Mls) in determining the nature of the peripheral T-cell receptor (TcR) population. As our knowledge of the equivalent process in humans is incom...

journal_title：Immunology

authors： Loveridge JA,Rosenberg WM,Kirkwood TB,Bell JI

更新日期：1991-10-01 00:00:00

abstract：:The adult cockroach generates an adaptive humoral immune response exhibiting specificity and immunological memory when immunized with soluble proteins. In contrast, the response induced by bacteria in holometabolous insects is non-specific and short term, generally losing activity after 72 hr. We have found that the r...

journal_title：Immunology

authors： Faulhaber LM,Karp RD

更新日期：1992-02-01 00:00:00

abstract：:Activated T cells, through the production of the receptor activator of NF-kappaB ligand (RANKL) cytokine, have been implicated in the osteoclast development and bone loss that are associated with autoimmune diseases such as rheumatoid arthritis. However, the cellular pathways that regulate the expression of RANKL and ...

journal_title：Immunology

authors： Gendron S,Boisvert M,Chetoui N,Aoudjit F

更新日期：2008-11-01 00:00:00

abstract：:Human haematopoietic progenitor/stem cells (HPCs) differentiate into functional T cells in the thymus through a series of checkpoints. A convenient in vitro system will greatly facilitate the understanding of T-cell development and future engineering of therapeutic T cells. In this report, we established a lentiviral ...

journal_title：Immunology

authors： Patel E,Wang B,Lien L,Wang Y,Yang LJ,Moreb JS,Chang LJ

更新日期：2009-09-01 00:00:00

abstract：:Over the past years, increasing numbers of distinct subsets have been discovered and identified for a T lymphocytes' entity. Differentiation and function of each T cell subset are controlled by a specific master transcription factor. Importantly, Runt-related transcription factors, particularly Runx1 and Runx3, interp...

journal_title：Immunology

authors： Wong WF,Kohu K,Chiba T,Sato T,Satake M

更新日期：2011-02-01 00:00:00

abstract：:Human β-defensin 3 (hBD-3) activates antigen-presenting cells through Toll-like receptors (TLRs) 1/2. Several TLR1/2 agonists have been identified but little is known about how they might differentially affect cellular activation. We compared the effects of hBD-3 with those of another TLR1/2 agonist, Pam(3) CSK(4) , i...

journal_title：Immunology

authors： Funderburg NT,Jadlowsky JK,Lederman MM,Feng Z,Weinberg A,Sieg SF

更新日期：2011-10-01 00:00:00

abstract：:Microglia cells, the resident innate immune cells in the brain, are highly active, extending and retracting highly motile processes through which they continuously survey their microenvironment for 'danger signals' and interact dynamically with surrounding cells. Upon sensing changes in their central nervous system mi...

journal_title：Immunology

authors： Giunti D,Parodi B,Cordano C,Uccelli A,Kerlero de Rosbo N

更新日期：2014-03-01 00:00:00

abstract：:In Trichinella spiralis-infected rats, a population of cells in thoracic duct lymph (TDL) that can adoptively transfer protection to naive rats was identified and characterized. During the course of T. spiralis infection, blast cells appeared in lymph from Day 3-4, and only Day 3-4 TDL cells had protective properties ...

journal_title：Immunology

authors： Bell RG,Korenaga M,Wang CH

更新日期：1987-06-01 00:00:00

abstract：:Tumour necrosis factor-alpha (TNF-alpha) stimulated invasion by mouse T-cell hybridomas and cytotoxic T-lymphocyte clones into rat embryo fibroblast monolayers. The effect on these highly invasive cells was limited: invasion was stimulated maximally to 130% of controls. However, when cells were pretreated with pertuss...

journal_title：Immunology

authors： La Rivière G,Klein Gebbinck JW,Schipper CA,Roos E

更新日期：1992-02-01 00:00:00

abstract：:We have used in situ hybridization (ISH) and immunohistochemistry (IHC) to investigate the kinetics of the expression for Fc epsilon RI mRNA (alpha-, beta- and gamma-chains), the alpha-chain protein product, as well as the phenotype of the mRNA- or protein-positive cells in allergen-induced late-phase skin reactions i...

journal_title：Immunology

authors： Ying S,Barata LT,Meng Q,Grant JA,Barkans J,Durham SR,Kay AB

更新日期：1998-02-01 00:00:00

abstract：:The influence of intact influenza virus and purified detergent solubilized haemagglutinin (HA) subunits from these viruses on human natural killer (NK) cell activity was examined. Effector cells incubated with whole influenza virus for 18 hr initiated the production of alpha interferon which was associated with the en...

journal_title：Immunology

authors： Ali SA,Rees RC,Oxford J

更新日期：1984-08-01 00:00:00

abstract：:In many types of tumours, especially pancreatic adenocarcinoma, miR-301a is over-expressed. This over-expression results in negative regulation of the target gene of miR-301a, the nuclear factor-κB (NF-κB) repressing factor (NKRF), increasing the activation of NF-κB and production of NF-κB-responsive pro-inflammatory ...

journal_title：Immunology

authors： Huang L,Liu Y,Wang L,Chen R,Ge W,Lin Z,Zhang Y,Liu S,Shan Y,Lin Q,Jiang M

更新日期：2013-11-01 00:00:00