Abstract：
:Oral administration of a protein antigen generates a serum factor that induces tolerance when transferred into naïve recipients. This serum factor has been described in rats as consisting of exosome-like structures or tolerosomes, which express major histocompatibility complex class II molecules (MHCII) and mediate antigen-specific tolerance. In this study, we investigated the functions of serum-derived tolerosomes both in vivo and in vitro. Tolerosomes were purified from the 100,000 g pellet fraction of serum from ovalbumin (OVA)-fed mice. When transferred into naïve recipient mice, the tolerosomes mediated OVA-specific tolerance. We also found that tolerosomes from OVA-fed mice induced the activation of OVA-specific T cells both in vivo and in vitro. The inoculation of severe combined immunodeficiency (SCID) mice with an interferon-gamma-producing cell line normalized the expression of MHCII in the intestinal epithelial cells and restored their ability to generate tolerosomes. Syngeneic but not allogeneic transfer of tolerosomes from OVA-fed donors induced tolerance in the recipients. Our results show that tolerosomes can be isolated from mouse serum, that tolerosome-induced oral tolerance requires MHCII expression in intestinal epithelial cells, and that tolerosomes are functional only in syngeneic recipients.
journal_name
Immunologyjournal_title
Immunologyauthors
Ostman S,Taube M,Telemo Edoi
10.1111/j.1365-2567.2005.02245.xkeywords:
subject
Has Abstractpub_date
2005-12-01 00:00:00pages
464-76issue
4eissn
0019-2805issn
1365-2567pii
IMM2245journal_volume
116pub_type
杂志文章相关文献
IMMUNOLOGY文献大全abstract：:Polystyrene surfaces coated with proteins at alkaline pH were found to be useful to investigate the stimulation of neutrophils independently of phagocytosis. Human neutrophils, when exposed to appropriate stimuli, release superoxide anion (O2-). We have measured superoxide dismutase-inhibitable cytochrome c reduction ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1978-10-01 00:00:00
abstract：:A suppressive B-cell factor (SBF)-producing hybridoma termed TS-4.44 was established by fusion of B cells which possessed receptors for the Fc portion of IgG (FcR gamma + B cells) and thymidine kinase defective fibroblasts, 3T3-4E cells. The biological properties of hybridoma-produced SBF (Hyb-SBF) are almost the same...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1983-12-01 00:00:00
abstract：:Lymph nodes (LN) are secondary lymphoid organs spread throughout the lymphatic system. They function to filter pathogenic material from the lymphatic fluid to maintain the health of the organism. Subcapsular sinus macrophages (SCSM) are among the first-responders within the LN due to their strategic location within th...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.12727
更新日期：2017-06-01 00:00:00
abstract：:Polysorbate 80 (PS80 or Tween-80) is often used as an additive to promote the rapid solubilization of pharmaceuticals in aqueous solutions. We investigated whether coinjection of a minimal amount of PS80 had a modulatory effect on the immunotherapeutic effects of Cry (Cryptomeria)-consensus peptide, a novel peptide de...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2006.02390.x
更新日期：2006-07-01 00:00:00
abstract：:Goats were immunized with membrane fractions of the L5178Y tumour syngenic to DBA/2 mice. IgG fractions of this antiserum were made tumour specific by repeated in vitro and in vivo absorptions with normal cells and concentrated by adsorption to and elution from tumour cells. In vivo studies indicated that the accumula...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1982-02-01 00:00:00
abstract：:Secretory component (SC or polymeric immunoglobulin receptor) on mucosal epithelial cells mediates transcytosis of polymeric immunoglobulin into external fluids and functions as a receptor for polymeric immunoglobulin. SC expression in a human colonic adenocarcinoma cell line, HT-29 has been reported to be up-regulate...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1997.00341.x
更新日期：1997-10-01 00:00:00
abstract：:Despite the current availability of Salmonella vaccines, typhoid fever remains a significant public health problem in developing countries. A greater understanding of T-cell activation and the development of immunological memory during Salmonella infection should lead to the development of more effective prophylactic ...
journal_title：Immunology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2567.2005.02140.x
更新日期：2005-04-01 00:00:00
abstract：:The adoptive transfer of immunity by means of spleen and lymph node cells has been analysed in rabbits of defined major histocompatibility (RLA) types and immunoglobulin (Ig) allotypes. Previous results had shown that chimaeras formed by transplanting adult cells into RLA-matched newborn hosts become stable B-lymphocy...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:The addition of crude extracts from rat submandibular (SM) glands to murine spleen and lymph node cell cultures stimulated with concanavalin A (Con A) induced either suppression (at high concentrations) or further stimulation (at lower concentrations) or further stimulation (at lower concentrations) of proliferative a...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1985-10-01 00:00:00
abstract：:In understanding the regulation of the specific immune response to Salmonella typhimurium, the role of a surface major component (porins) was studied. In this study we demonstrate that purified porins are able to induce a different response to that induced by the porins present on the S. typhimurium cell surface. Pori...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1998.00492.x
更新日期：1998-05-01 00:00:00
abstract：:Factor B-like activity associated with human peripheral blood lymphocytes was first described by Halbwachs & Lachmann (1976), who employed a functional assay. In this present study, clones of B cells from patients with chronic lymphatic leukaemia (CLL) and lymphoblastoid 'Raji' cells were used. The surface of these ce...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1981-11-01 00:00:00
abstract：:While many aspects of memory T-cell immunobiology have been characterized, we suggest that we know only a fraction of the effector functions that CD4 T cells can bring to bear during secondary challenges. Exploring the full impact of memory CD4 T-cell responses is key to the development of improved vaccines against ma...
journal_title：Immunology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2567.2010.03259.x
更新日期：2010-05-01 00:00:00
abstract：:Fc-gamma receptor III (Fc gamma RIII, CD16) type A is expressed on natural killer cells, on a small subset of peripheral blood monocytes and on mature macrophages. Along with differentiation into macrophages, monocytes will express Fc gamma RIII when cultured with transforming growth factor-beta (TGF-beta). In view of...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:The studies were designed to investigate the effect of ageing and low protein (4%) diet on antibody-dependent cell-mediated cytotoxicity (ADCC) and IgA concentration in the intestine. Both ADCC activity and IgA concentration were shown to reach mature levels at 17 weeks old. The effect of ageing was greater on ADCC ac...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1981-07-01 00:00:00
abstract：:We hypothesized that the addition of polymer to the surface of liposome/DNA complexes may potentially enhance in vivo delivery of plasmid DNA to antigen-presenting cells and thereby facilitate enhanced immune responses to encoded protein. BALB/c mice were immunized subcutaneously or intramuscularly three times with a ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.2002.01448.x
更新日期：2002-07-01 00:00:00
abstract：:The role of the monocyte in human cytomegalovirus (HCMV)-induced immunosuppression was examined by assessing the ability of the virus to directly suppress various monocyte accessory cell functions. Both patient-derived and laboratory-adapted strains of HCMV were capable of impairing antigen-presenting functions of pur...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1989-02-01 00:00:00
abstract：:A technique is reported here for the quantitative extraction of live cells from the lung interstitium; it involves the incubation of slices of perfused lung in a mixture containing optimal concentrations of collagenase, DNAse, and fetal calf serum, followed by the simultaneous recovery and fractionation of cells relea...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:A large proportion of intestinal intraepithelial lymphocytes (IEL) comprises alpha beta and gamma delta T-cell receptor (TcR)-bearing T cells. The numbers of alpha beta and gamma delta IEL are reported to be very different between germ-free and conventional microbial conditions. In this study, we investigated the kine...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1993-05-01 00:00:00
abstract：:Electron microscopic study of the events occurring at the cell membrane during reactive lysis by complement, showed that a foliaceous particle was formed at the C5b-7 stage, that enlarged to a particle with a variable number of arms at the C5b-8 stage. Up to this point, no typical complement lesions were found. At the...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1978-08-01 00:00:00
abstract：:In lipopolysaccharide (LPS)-hyporesponsive C3H/HeJ mice, alveolar macrophages (AMphi) produce much more tumour necrosis factor-alpha than peritoneal macrophages (PMphi) when stimulated with LPS (10 microgram/ml), but the induction of inducible nitric oxide synthase (iNOS) gene expression and production of nitric oxide...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1999.00908.x
更新日期：1999-12-01 00:00:00
abstract：:We previously described the processing of antibodies to CD74 (the major histocompatibility complex class II-associated invariant chain, Ii), by B-cell lymphoma cell lines. These cells expressed relatively low levels of Ii on the surface, but the molecules were rapidly internalized and replaced by new molecules, so tha...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1999.00868.x
更新日期：1999-10-01 00:00:00
abstract：:Previously, a putative immunosuppressant-coding gene was identified from a complementary DNA library derived from the salivary glands of partially-fed Haemaphysalis longicornis. Using real-time polymerase chain reaction, the gene was shown to be predominantly expressed during blood feeding with the site of expression ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2008.02890.x
更新日期：2009-02-01 00:00:00
abstract：:Peripheral blood mononuclear cells (PBMC) from a patient suffering from the hyper IgE syndrome were used to generate phytohaemagglutinin (PHA)-expanded T-cell clones (all CD4+, CD8-, CD23-). A selection of the clones was tested for their ability to help IgE secretion by culturing with normal B cells in the presence of...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1989-05-01 00:00:00
abstract：:Major histocompatibility complex (MHC) class II molecules present antigenic peptides derived from engulfed exogenous proteins to CD4(+) T cells. Exogenous antigens are processed in mature endosomes and lysosomes where acidic proteases reside and peptide-binding to class II alleles is favoured. Hence, maintenance of th...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2010.03309.x
更新日期：2010-11-01 00:00:00
abstract：:Acute and chronic infusions of a lipophilic analogue of cyclic AP (dibutyryl cyclic AMP) into cannulated afferent lymphatics of popliteal lymph nodes of sheep have reduced the output of both small and blast lymphocytes into efferent lymph and have tended to reduce the volume of efferent lymph flow (collected by chroni...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1982-11-01 00:00:00
abstract：:In our efforts to identify products that might be used for active immunotherapy in human immunodeficiency virus (HIV) infection, we have studied synthetic peptides derived from the CD4 attachment site of gp120. Two peptides have emerged with particularly interesting properties. The first (B138) is linear and spans the...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1992-04-01 00:00:00
abstract：:Anti-idiotypic sera (aIds) were raised in C57BL/6 mice against monoclonal antibodies (McAbs) which bind poly(Tyr,Glu)-poly(DLAla)--poly(Lys)--abbreviated to (T,G)-A--L--and (Tyr-Tyr-Glu-Glu)-poly(DLAla)--poly(Lys)--abbreviated to (T-T-G-G)-A--L--(nos. 103 and 160) and McAbs which react only with (T-T-G-G)-A--L (nos. 1...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1984-02-01 00:00:00
abstract：:Mice of the strains A.TH and A.TL were rendered neonatally tolerant to class II major histocompatibility complex (MHC) by the injection of (A.TH x A.TL)F1 spleen and bone marrow cells within 24 hr of birth. Spleen and thymus cells from adult tolerant mice bearing long-term surviving skin grafts were compared with thos...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1993-08-01 00:00:00
abstract：:DNA breaks play an essential role in germinal centre B cells as intermediates to immunoglobulin class switching, a recombination process initiated by activation-induced cytidine deaminase (AID). Immunoglobulin gene hypermutation is likewise catalysed by AID but is believed to occur via single-strand DNA breaks. When i...
journal_title：Immunology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2567.2008.03050.x
更新日期：2009-03-01 00:00:00
abstract：:Activated T cells, through the production of the receptor activator of NF-kappaB ligand (RANKL) cytokine, have been implicated in the osteoclast development and bone loss that are associated with autoimmune diseases such as rheumatoid arthritis. However, the cellular pathways that regulate the expression of RANKL and ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2008.02858.x
更新日期：2008-11-01 00:00:00
