Preparation and characterization of the anti-idiotypic properties of rabbit anti-timothy antigen B helper factor and anti-mouse timothy IgE antisera.

abstract：:Five of twenty-three patients with paraproteinaemia (two IgM, three IgG) have been shown to exhibit marked classical pathway complement activation. The mechanisms of hypocomplementaemia proposed for the five patients are cryoglobulinaemia in one and in vivo immunoglobulin aggregation in the other four. Three further p...

journal_title：Immunology

authors： Naish PF,Collins C,Barratt J

更新日期：1977-10-01 00:00:00

abstract：:The interaction of mouse intestinal mast cell proteinase (IMCP) with serine proteinase inhibitors (serpins) in blood was analysed: (i) by examining the capacity of the inhibitors in blood to block the binding of the irreversible serine esterase inhibitor [3H]diisopropyl fluorophosphate (DFP); (ii) by Western blotting....

journal_title：Immunology

authors： Irvine J,Newlands GF,Huntley JF,Miller HR

更新日期：1990-01-01 00:00:00

abstract：:Co-expression of EP2 and EP3 subtypes of prostaglandin E2 (PGE2) receptors (R) by U937 human monocytic cells permitted comparative studies of desensitization of each subtype. Specific binding of [3H]PGE2 to membranes of U937 cells showed a Kd of 2.9 +/- 0.3 nM (mean +/- SEM) and a Bmax of 40.5 +/- 1.0 fmol/mg protein,...

journal_title：Immunology

authors： Zeng L,An S,Goetzl EJ

更新日期：1995-12-01 00:00:00

abstract：:CD4(+) FOXP3(+) regulatory T (Treg) cells constitute a heterogeneous and plastic T-cell lineage that plays a pivotal role in maintaining immune homeostasis and immune tolerance. However, the fate of human Treg cells after loss of FOXP3 expression and the epigenetic mechanisms contributing to such a phenotype switch re...

journal_title：Immunology

authors： He H,Ni B,Tian Y,Tian Z,Chen Y,Liu Z,Yang X,Lv Y,Zhang Y

更新日期：2014-03-01 00:00:00

abstract：:This study has examined the stimuli required for secretion of regulated upon activation, normal T-cell expressed, presumed secreted (RANTES) from T lymphocytes and found that stimuli such as phorbol 12-myristate 13-acetate (PMA), which are unable to support T-cell proliferation and interleukin-2 (IL-2) production, are...

journal_title：Immunology

authors： Sotsios Y,Blair PJ,Westwick J,Ward SG

更新日期：2000-09-01 00:00:00

abstract：:Plasma fibronectin (FN) has been demonstrated to serve as an opsonin involved in the ingestion of foreign particles by phagocytes. This study concerns the effect of FN exposure on the respiratory burst of normal human peripheral phagocytes, using a luminol-dependent chemiluminescence (CL) assay for measurement of reac...

journal_title：Immunology

authors： Kuroiwa A,Igisu K,Yano T,Okada N,Okada H

更新日期：1988-10-01 00:00:00

abstract：:The ability of freshly isolated primary human alveolar epithelial cells (type II pneumocytes) to induce leucocyte migration across an endothelial monolayer was investigated. Three-way factorial analysis of variance (ANOVA) demonstrated that resting alveolar endothelial cells (AEC) could produce detectable quantities o...

journal_title：Immunology

authors： Eghtesad M,Jackson HE,Cunningham AC

更新日期：2001-02-01 00:00:00

abstract：:Group 2 innate lymphoid cells (ILC2s) produce a significant amount of interleukin-5 (IL-5), which supports eosinophil responses in various tissues; they also produce IL-13, which induces mucus production and contributes to tissue repair or fibrosis. The ILC2s are activated by alarmins, such as IL-33 released from epit...

journal_title：Immunology

authors： Kudo F,Ikutani M,Seki Y,Otsubo T,Kawamura YI,Dohi T,Oshima K,Hattori M,Nakae S,Takatsu K,Takaki S

更新日期：2016-01-01 00:00:00

abstract：:The Ig subunit structure of murine B lymphocytes was studied by employing different radiolabelling techniques in combination with chemical cross-linking. The main membrane structure of IgM was a half molecule that was disulphide-linked to proteins with MW 30,000, 45,000 and 55,000, respectively. Small amounts of mu 2L...

journal_title：Immunology

authors： Vogel L,Haustein D

更新日期：1989-06-01 00:00:00

abstract：:Co-stimulation of highly purified peripheral T lymphocytes from healthy blood donors with the adhesion molecules CD2 and CD28 in association with recombinant interleukin-7 (rIL-7) induced T-cell proliferation, multiple cytokine secretion and IL-2 receptivity. We demonstrated that rIL-7 is as potent as rIL-2 in inducin...

journal_title：Immunology

authors： Costello R,Brailly H,Mallet F,Mawas C,Olive D

更新日期：1993-11-01 00:00:00

abstract：:We have analysed the heavy and light chain variable region genes of two monoclonal antibodies, specific for the Sm antigen (RSP1; IgG kappa) and for cardiolipin (RSP4; IgM lambda), derived from a patient with active systemic lupus erythematosus (SLE). We have established that the variable region genes of the RSP1 auto...

journal_title：Immunology

authors： Demaison C,Ravirajan CT,Isenberg DA,Zouali M

更新日期：1995-11-01 00:00:00

abstract：:Different cell types, including dendritic cells, macrophages and Ia+ B cells, have been described to present soluble antigen (Ag) to T-cell hybridomas. However, it is still not clear whether these different cell types can act as antigen-presenting cells (APC) for complex and insoluble Ag such as viral particles. Using...

journal_title：Immunology

authors： Scheerlinck JP,Burssens G,Brys L,Michel A,Hauser P,De Baetselier P

更新日期：1991-05-01 00:00:00

abstract：:To assess the role of the macrophage scavenger receptor type A (SRA) in immune activation by CpG DNA, cytokine induction and DNA uptake were tested in vitro and in vivo using SRA knockout (SRA-/-) and wild type (WT) mice. As a source of CpG DNA, Escherichia coli DNA (EC DNA) and a 20-mer phosphorothioate oligodeoxynuc...

journal_title：Immunology

authors： Zhu FG,Reich CF,Pisetsky DS

更新日期：2001-06-01 00:00:00

abstract：:Expression of CD45RO on intraepithelial lymphocytes (IEL) bearing the T-cell receptor (TcR) alpha/beta or gamma/delta was studied in situ by three-colour immunofluorescence on jejunal tissue sections from 21 patients with coeliac disease and eight controls. CD45RA-TcR alpha/beta+ IEL expressed CD45RO significantly mor...

journal_title：Immunology

authors： Halstensen TS,Farstad IN,Scott H,Fausa O,Brandtzaeg P

更新日期：1990-12-01 00:00:00

abstract：:The cloning and production of a human anti-rhesus (Rh) D monoclonal antibody (mAb) using the baculovirus-insect cell expression system is described. This monoclonal recombinant antibody R.D7C2 derived from a human parental IgM lambda immunoglobulin was obtained after immortalization of lymphocytes by Epstein-Barr viru...

journal_title：Immunology

authors： Edelman L,Margaritte C,Chaabihi H,Monchâtre E,Blanchard D,Cardona A,Morin F,Dumas G,Petres S,Kaczorek M

更新日期：1997-05-01 00:00:00

abstract：:Macrophage (MΦ) polarization is triggered during the innate immune response to defend against microbial pathogens, but can also contribute to disease pathogenesis. In a previous study, we found that interleukin-15 (IL-15) -derived classically activated macrophages (M1 MΦ) have enhanced antimicrobial activity, whereas ...

journal_title：Immunology

authors： Montoya D,Mehta M,Ferguson BG,Teles RMB,Krutzik SR,Cruz D,Pellegrini M,Modlin RL

更新日期：2019-02-01 00:00:00

abstract：:CD45 is known to regulate signalling through many different surface receptors in diverse haemopoietic cell types. Here we report for the first time that CD45-/- bone marrow dendritic cells (BMDC) are more activated than CD45+/+ cells and that tumour necrosis factor (TNF) and interleukin-6 (IL-6) production by BMDC and...

journal_title：Immunology

authors： Piercy J,Petrova S,Tchilian EZ,Beverley PC

更新日期：2006-06-01 00:00:00

abstract：:Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal tract. Its pathogenesis is not completely understood, though the prevailing model is that the intestinal flora drives a strong intestinal T helper 1 (Th1)/Th17 type immune response and inflammation in the genetically susceptible host. This ...

journal_title：Immunology

authors： Ricciardelli I,Lindley KJ,Londei M,Quaratino S

更新日期：2008-10-01 00:00:00

abstract：:Mercuric chloride (HgCl2)-induced autoimmunity in Brown Norway rats is a spontaneously resolving autoimmune response driven by the activation of T helper type 2 lymphocytes (Th2 cells). Treatment with antibody to OX40-ligand (OX40-L) from the time of the first HgCl2 injection for 12 days had little effect. Delayed tre...

journal_title：Immunology

authors： MacPhee IA,Yagita H,Oliveira DB

更新日期：2006-03-01 00:00:00

abstract：:Immunoglobulin G4 (IgG4) antibodies have been known for some time to be functionally monovalent. Recently, the structural basis for this monovalency has been elucidated: the in vivo exchange of IgG half-molecules (one H-plus one L-chain) among IgG4. This process results in bispecific antibodies that in most situations...

journal_title：Immunology

authors： Aalberse RC,Schuurman J

更新日期：2002-01-01 00:00:00

abstract：:To determine whether the paracrine secretion of interleukin-12 (IL-12) can efficiently stimulate the resistance to Mycobacterium avium complex (MAC) infection, 3T3 fibroblasts were stably transfected to secrete IL-12 (480 U/106 cells/48 hr) and their effect on MAC infection was investigated in genetically susceptible ...

journal_title：Immunology

authors： Kang BY,Chung SW,Lim YS,Kim EJ,Kim SH,Hwang SY,Kim TS

更新日期：1999-07-01 00:00:00

abstract：:Phagocytes such as dendritic cells (DC) and macrophages employ phagocytosis to take up pathogenic bacteria into phagosomes, digest the bacteria and present the bacteria-derived peptide antigens to the adaptive immunity. Hence, efficient antigen presentation depends greatly on a well-regulated phagocytosis process. Lip...

journal_title：Immunology

authors： Chua RY,Wong SH

更新日期：2013-05-01 00:00:00

abstract：:The discovery that corticosteroids can alter leucocyte distribution implies that suppression of PFC in the spleen is not necessarily indicative of suppression of the antibody response as a whole. Therefore we have examined IgM and IgG serum antibodies and PFC in the thymus, spleen, femoral marrow, popliteal, thoracic ...

journal_title：Immunology

authors： Dracott BN,Smith CE

更新日期：1979-10-01 00:00:00

abstract：:Invariant natural killer T (iNKT) cells are an innate population of T cells identified by the expression of an invariant T-cell receptor and reactivity to lipid-based antigens complexed with CD1d. They account for a small percentage of lymphocytes, but are extremely potent and play central roles in immunity to infecti...

journal_title：Immunology

authors： O'Keeffe J,Podbielska M,Hogan EL

更新日期：2015-08-01 00:00:00

abstract：:NKG2D is one of the best characterized activating receptors and is expressed on natural killer cells and on various T-cell subsets. This receptor recognizes several different ligands that are induced by cellular stresses. In this review, we described the mechanisms controlling the expression of NKG2D ligands, with the...

journal_title：Immunology

authors： Stern-Ginossar N,Mandelboim O

更新日期：2009-09-01 00:00:00

abstract：:Pre-exposure to bacterial lipopolysaccharide (LPS) or certain cytokines is known to enhance the ability of murine macrophages to generate a respiratory burst in response to subsequent stimulation, a phenomenon referred to as 'priming'. We report here that the cytokine interleukin-4 (IL-4) can prime murine macrophages....

journal_title：Immunology

authors： Phillips WA,Croatto M,Hamilton JA

更新日期：1990-08-01 00:00:00

abstract：:Although it is clear that the CD45 tyrosine phosphatase is required for efficient T-cell activation and T-cell development, the factors that regulate CD45 function remain uncertain. Previous data have indicated that there is an association of CD45 with CD4 and the T-cell receptor (TCR) complex controlled by the variab...

journal_title：Immunology

authors： Leitenberg D,Falahati R,Lu DD,Takeda A

更新日期：2007-08-01 00:00:00

abstract：:We report that interleukin (IL)-4 and IL-10 can significantly up- or down-regulate CXC chemokine receptor 4 (CXCR4) expression on CD4+ T lymphocytes, respectively. Stromal cell-derived factor-1alpha (SDF-1alpha)-induced CD4+ T-lymphocyte chemotaxis was also correspondingly regulated by IL-4 and IL-10. IL-4 and IL-10 u...

journal_title：Immunology

authors： Jinquan T,Quan S,Jacobi HH,Madsen HO,Glue C,Skov PS,Malling HJ,Poulsen LK

更新日期：2000-03-01 00:00:00

abstract：:HIV infection is associated with increased representation of T cells bearing an activated, memory (CD45RO+) phenotype. Although administration of antiretroviral agents and interleukin-2 (IL-2) augment depleted CD4+ T-cell numbers, such therapies have been preferentially beneficial for CD45RO+ T cells. Interleukin-15 (...

journal_title：Immunology

authors： Naora H,Gougeon M

更新日期：1999-06-01 00:00:00

abstract：:In an attempt to produce monoclonal antibodies against human large granular lymphocytes (LGL), the effector cells of natural killer (NK) and killer (K) activity, a monoclonal IgM antibody (VEP10) has been obtained. This antibody is reactive by indirect membrane immunofluorescence (IMF) with 14.7 +/- 8.5% peripheral bl...

journal_title：Immunology

authors： Rumpold H,Kraft D,Obexer G,Böck G,Möschl P

更新日期：1983-06-01 00:00:00