CD45 negatively regulates tumour necrosis factor and interleukin-6 production in dendritic cells.

abstract：:Bovine Concanavalin A-induced suppressor cells were generated from lymphocytes which were non-adherent to anti-immunoglobulin coated dishes and cells possessing receptors for peanut agglutinin. Bovine lymphocytes, preincubated with 25 microgram/ml of Con A for 40-45 hr, could suppress the responses of autologous cells...

journal_title：Immunology

authors： Smith WG,Usinger WR,Splitter GA

更新日期：1981-05-01 00:00:00

abstract：:Interleukin-19 (IL-19) plays an important role in asthma by stimulating T helper type 2 (Th2) cytokine production. Interestingly, IL-4, a key Th2 cytokine, in turn up-regulates IL-19 expression in bronchial epithelial cells, so forming a positive feedback loop. In atopic dermatitis (AD), another Th2 disease closely re...

journal_title：Immunology

authors： Bao L,Alexander JB,Shi VY,Mohan GC,Chan LS

更新日期：2014-12-01 00:00:00

abstract：:The role of anti-idiotypic subclass-specific antibodies was analysed in the regulation of the immune response to BCG in the guinea-pig. The idiotypes to BCG were separated into subclasses and anti-idiotypes were carried out by immunizing with the purified IgG1 and IgG2 anti-idiotypes. The in vivo T cell response was r...

journal_title：Immunology

authors： Daus H,Hammer HJ,Rajki K,Mauch H

更新日期：1984-08-01 00:00:00

abstract：:Bovine respiratory syncytial virus (RSV) is a major cause of respiratory disease in young calves. Recent studies in calves, in which different T-cell subsets were depleted, have shown that CD8+ T cells play a central role in recovery from RSV infection. The present study demonstrates that RSV-specific, major histocomp...

journal_title：Immunology

authors： Gaddum RM,Cook RS,Thomas LH,Taylor G

更新日期：1996-07-01 00:00:00

abstract：:The soluble cytoplasmic fraction of an homogenate from peritoneal rat mast cells, demonstrated a considerable amount of catalytic activity which promotes the transfer of phosphate from creatine phosphate to ADP. The plasma membrane, mitochondrial and microsomal fractions show negligible amounts of the catalyst. Enzyme...

journal_title：Immunology

authors： Magro AM

更新日期：1980-03-01 00:00:00

abstract：:Much of the pathology of malaria may be due to the interactions of cytokines, especially tumour necrosis factor (TNF), with various cell types, including endothelial cells, with consequent widespread systemic effects. It has been shown previously that heat-stable exoantigens in the supernatants of blood-stage parasite...

journal_title：Immunology

authors： Bate CA,Taverne J,Davé A,Playfair JH

更新日期：1990-07-01 00:00:00

abstract：:Interleukin-15 (IL-15) is a proinflammatory cytokine that is overexpressed in rheumatoid arthritis (RA), a disease characterized by activation of monocytes/macrophages (MPhi), and by expansion of autoreactive CD4(+) T cells. We hypothesized that IL-15 plays a major role for this expansion of CD4(+) T cells and modulat...

journal_title：Immunology

authors： Rückert R,Brandt K,Ernst M,Marienfeld K,Csernok E,Metzler C,Budagian V,Bulanova E,Paus R,Bulfone-Paus S

更新日期：2009-01-01 00:00:00

abstract：:Norovirus (NoV) -derived virus-like particles (VLPs) resemble empty shells of the virus and NoV P-particles contain only protruding domains of the NoV capsid. Both NoV-derived subviral particles show similar functionality and antigenicity in vitro and are considered to be potential vaccine candidates against NoV gastr...

journal_title：Immunology

authors： Tamminen K,Huhti L,Koho T,Lappalainen S,Hytönen VP,Vesikari T,Blazevic V

更新日期：2012-01-01 00:00:00

abstract：:Human papillomaviruses (HPVs) are obligate epithelial pathogens and typically cause localized mucosal infections. We therefore hypothesized that T-cell responses to HPV antigens would be greater at sites of pathology than in the blood. Focusing on HPV-16 because of its association with cervical cancer, the magnitude o...

journal_title：Immunology

authors： Passmore JA,Milner M,Denny L,Sampson C,Marais DJ,Allan B,Gumbi PP,Hitzeroth II,Rybicki EP,Williamson AL

更新日期：2006-12-01 00:00:00

abstract：:Large numbers of cells can be recovered from pig intestine with phenotypes suggesting lamina propria rather than intraepithelial origin. Following activation with concanavalin A these cells produced a T-cell growth factor (TCGF) activity which was not inhibited in the presence of a monoclonal antibody recognizing pig ...

journal_title：Immunology

authors： Bailey M,Hall L,Bland PW,Stokes CR

更新日期：1994-08-01 00:00:00

abstract：:The requirement for Ca2+, a divalent ion which plays a fundamental role in cell activation, has been analysed in cultures of PHA-stimulated human peripheral blood lymphocytes (PHA-PBL) from adult (range: 20-35 years) and old (over 70 years) subjects. For this purpose, increasing concentrations of Ca2+ chelators (EGTA ...

journal_title：Immunology

authors： Kennes B,Hubert C,Brohee D,Neve P

更新日期：1981-01-01 00:00:00

abstract：:The induction of proliferation of murine splenocytes by lipopolysaccharide (LPS) of Shigella dysenteriae type 1 and its polysaccharide (PS) and lipid A fractions was investigated. The LPS-induced proliferation reached a maximum at a concentration of 30 ng/ml. The PS and lipid A induced proliferation of murine splenocy...

journal_title：Immunology

authors： Biswas T,Roy S,Banerjee KK

更新日期：1995-02-01 00:00:00

abstract：:In this study, we describe the ability of hybrid mouse monoclonal antibody (mAb) to induce monocyte-mediated cytotoxicity towards human IgA1-coated E (HuIgA1-E), and the effect of mAb binding valency on Fc gamma RI-mediated ADCC. All hybrid monospecific (ms) anti-HuIgA1 and bispecific (bs) anti-HuIgA1/HRP mAb were cap...

journal_title：Immunology

authors： Koolwijk P,Van de Winkel JG,Otten I,Bast BJ

更新日期：1992-02-01 00:00:00

abstract：:Some plasmacytomas produce myeloma proteins with known antibody specificities and the secretion of these proteins by individual tumour cells can be determined using haemolytic plaque assay. After a 3 day culture of mouse plasmacytoma cells in medium containing 10% normal mouse serum, the number of plaques was reduced ...

journal_title：Immunology

authors： Kim BS,Chin DK

更新日期：1980-10-01 00:00:00

abstract：:Long-term bovine lymphocyte cultures were initiated by stimulation with alloantigens and maintained in continuous culture using medium containing recombinant human interleukin-2 (rh IL-2). The development of specific and lectin-dependent killing was monitored following primary alloantigen challenge. Cytolytic activity...

journal_title：Immunology

authors： Carter J,Magnuson NS,Davis WC,Mason PH,Magnuson JA,Talmadge JE,Barr PJ

更新日期：1986-01-01 00:00:00

abstract：:The induction of T-cell growth by the T-cell antigen receptor (TcR) is dependent on a co-ordinated process of phosphorylation and dephosphorylation of intracellular proteins. An intermediary in this signalling pathway is the serine kinase, p42 mitogen-activated protein kinase (p42MAPK), also known as microtubule-assoc...

journal_title：Immunology

authors： Amaral MC,Casillas AM,Nel AE

更新日期：1993-05-01 00:00:00

abstract：:Virus-specific cytotoxic T-cell (Tc) clones can lyse target cells in vitro in the presence of their specific peptide epitopes. The lytic potency of murine influenza nucleoprotein (NP)-specific Tc clones was investigated after observing that target cell killing was reduced in the presence of high (greater than 0.2 micr...

journal_title：Immunology

authors： Pemberton RM,Wraith DC,Askonas BA

更新日期：1990-06-01 00:00:00

abstract：:A common factor existing among autoimmune target antigens was sought in association with their developmental expression during organogenesis. Autoimmunity against a certain organ was experimentally induced in rats by deliberate immunization with whole tissue extract of the respective organ. Histopathological changes i...

journal_title：Immunology

authors： Akashi T,Eishi Y

更新日期：1991-11-01 00:00:00

abstract：:The in vitro migration activity of monocytic cells and the effect of lymphocytes in the delayed hypersensitivity (DH) reaction induced by intrapleural injection of PPD into FCA-sensitized guinea-pigs was investigated. The in vitro migration of exudate mononuclear cells was lower than that of comparable blood cells, an...

journal_title：Immunology

authors： Yamamoto S,Dunn CJ,Willoughby DA

更新日期：1976-04-01 00:00:00

abstract：:Therapeutic vaccination using T-cell receptor (TCR) peptides from V genes commonly expressed by potentially pathogenic T cells remains an approach of interest for treatment of multiple sclerosis (MS) and other autoimmune diseases. We developed a trivalent TCR vaccine containing complementarity determining region (CDR)...

journal_title：Immunology

authors： Vandenbark AA,Culbertson NE,Bartholomew RM,Huan J,Agotsch M,LaTocha D,Yadav V,Mass M,Whitham R,Lovera J,Milano J,Theofan G,Chou YK,Offner H,Bourdette DN

更新日期：2008-01-01 00:00:00

abstract：:Oral administration of a protein antigen generates a serum factor that induces tolerance when transferred into naïve recipients. This serum factor has been described in rats as consisting of exosome-like structures or tolerosomes, which express major histocompatibility complex class II molecules (MHCII) and mediate an...

journal_title：Immunology

authors： Ostman S,Taube M,Telemo E

更新日期：2005-12-01 00:00:00

abstract：:The mechanisms of action and the nature of the co-operating cells (CC) controlling human T-lymphocyte-colony formation were investigated. Media conditioned by PHA-stimulated blood mononuclear cells (MC) were tested for their capacity to induce T-colony formation in the effluent cell population, obtained after anti (Fa...

journal_title：Immunology

authors： Klein B,Caraux J,Thomas P,Goube De Laforest P

更新日期：1982-02-01 00:00:00

abstract：:Microglia cells, the resident innate immune cells in the brain, are highly active, extending and retracting highly motile processes through which they continuously survey their microenvironment for 'danger signals' and interact dynamically with surrounding cells. Upon sensing changes in their central nervous system mi...

journal_title：Immunology

authors： Giunti D,Parodi B,Cordano C,Uccelli A,Kerlero de Rosbo N

更新日期：2014-03-01 00:00:00

abstract：:Surface receptors on peripheral blood neutrophils and monocytes from normal and immunodeficient horses have been studied. Sheep erythrocytes (SRBC) coated with IgG, IgM, and complement but not IgG(T), readily bound to normal equine monocytes and neutrophils. More than 4000 molecules of IgG were required to sensitize e...

journal_title：Immunology

authors： Banks KL,McGuire TC

更新日期：1975-03-01 00:00:00

abstract：:The balance between pro- and anti-inflammatory cytokines has been implicated in the pathogenesis of infectious and auto-immune diseases, and its modulation has been proposed as a potential therapeutic target. The results reported in the present study show that modulators of the renin-angiotensin system, such as the an...

journal_title：Immunology

authors： Peeters AC,Netea MG,Kullberg BJ,Thien T,van der Meer JW

更新日期：1998-07-01 00:00:00

abstract：:Gammadelta T cells are unique, and their localization at sites of infection is considered critical in immune defence. We demonstrate the accumulation of gammadelta T cells in rat regional popliteal lymph nodes (PLNi) starting 2 days after inoculation of cytomegalovirus (CMV) into the footpad. Early-appearance PLNi gam...

journal_title：Immunology

authors： Dyugovskaya L,Hirsh M,Ginsburg H

更新日期：2003-02-01 00:00:00

abstract：:The glycoprotein counter-receptors for E-selectin borne on skin-homing T cells are poorly defined. In this study we have used flow cytometry to investigate the surface expression of potential carbohydrate ligands for E-selectin on HUT78, a skin-homing cutaneous T-cell lymphoma. These cells possessed high surface expre...

journal_title：Immunology

authors： Priest R,Bird MI,Malhotra R

更新日期：1998-08-01 00:00:00

abstract：:In order to analyse the effects of glucocorticoids on interleukin-8 (IL-8) production more precisely, we examined the effects of dexamethasone on IL-8 production at the molecular level in a human fibrosarcoma cell line, 8387, which IL-1 induces to express IL-8 messenger RNA (mRNA) and to secrete IL-8. Over a wide dose...

journal_title：Immunology

authors： Mukaida N,Gussella GL,Kasahara T,Ko Y,Zachariae CO,Kawai T,Matsushima K

更新日期：1992-04-01 00:00:00

abstract：:Undesired immunological responses to products of therapeutic gene replacement have been obstacles to successful gene therapy. Understanding such responses of the host immune system to achieve immunological tolerance to a transferred gene product is therefore crucial. In this article, we review relevant studies of immu...

journal_title：Immunology

authors： Eghtesad S,Morel PA,Clemens PR

更新日期：2009-05-01 00:00:00

abstract：:The shedding and resynthesis of Fc, C3 receptors, and receptors binding SRBC has been studied in normal peripheral lymphocytes, in lymphocytes from CLL patients and in a Raji cell line during 4 h incubation at 37 degrees. During the first part of the incubation, an increased release of receptors was observed. The shed...

journal_title：Immunology

authors： Sármay G,István L,Gergely J

更新日期：1978-02-01 00:00:00