The effect of renin-angiotensin system inhibitors on pro- and anti-inflammatory cytokine production.

abstract：:The CTLL-2 bioassay is used frequently to determine interleukin-2 (IL-2) concentrations in experimental samples, including samples that contain reagents which affect the CD28-B7 interaction. We therefore evaluated whether the CD28-B7 pathway plays a role in the growth of CTLL-2 cells. Flow cytometry demonstrated that ...

journal_title：Immunology

authors： Belani R,Weiner GJ

更新日期：1996-02-01 00:00:00

abstract：:Environmental factors have significant effects on the development of autoimmune diseases. The ligand-activated transcription factor aryl hydrocarbon receptor (AHR) is controlled by endogenous and environmental small molecules. Hence, AHR provides a molecular pathway by which endogenous and environmental signals can in...

journal_title：Immunology

authors： Quintana FJ

更新日期：2013-03-01 00:00:00

abstract：:The effect of different macrophage populations and supernatants derived from these macrophages on Con-A induced lymphocyte activation in macrophage depleted lymph node cells has been investigated. All macrophage populations tested were able to restore the lymphocytic response to Con A. Macrophages of different origin ...

journal_title：Immunology

authors： Knop J

更新日期：1980-10-01 00:00:00

abstract：:Bisphenol A (BPA) and p-nonylphenol (NP) are representative endocrine disruptors (EDs) that may have adverse effects on human health. The influence of these compounds on allergic immune responses remains unclear. In this study, we have examined the effects of BPA and NP on production of interleukin-4 (IL-4), a pro-inf...

journal_title：Immunology

authors： Lee MH,Chung SW,Kang BY,Park J,Lee CH,Hwang SY,Kim TS

更新日期：2003-05-01 00:00:00

abstract：:In two consecutive studies, eighteen and forty-one normal subjects were given a standard tuberculin skin test of 1 tuberculin unit (0.02 mug of PPD). Two days later another skin test was given. Readings of the skin reactions showed that subjects exhibiting strongly positive skin reactions in their primary skin tests s...

journal_title：Immunology

authors： Thestrup-Pedersen K

更新日期：1975-02-01 00:00:00

abstract：:The intraperitoneal injection of lipopolysaccharide (LPS) (400 microg/kg body weight) induced the expression of mRNAs of inflammatory cytokines such as interleukin (IL)-1beta, IL-6 and tumour necrosis factor (TNF)-alpha in the submandibular gland (SMG) of C3H/HeN mice but not that of C3H/HeJ mice, a mutant strain for ...

journal_title：Immunology

authors： Yao C,Li X,Murdiastuti K,Kosugi-Tanaka C,Akamatsu T,Kanamori N,Hosoi K

更新日期：2005-10-01 00:00:00

abstract：:Mast cell secretory granules contain unique tryptic and chymotryptic serine proteases that differ between species and tissues. Direct comparison of these proteases in single-cell types has been hindered by the difficulty of obtaining adequate numbers of pure mast cells. In this study, we were able to compare tryptic a...

journal_title：Immunology

authors： Caughey GH,Lazarus SC,Viro NF,Gold WM,Nadel JA

更新日期：1988-02-01 00:00:00

abstract：:Interleukin-31 (IL-31) is a novel T-helper-lymphocyte-derived cytokine that plays an important role in allergic skin inflammation and atopic dermatitis. It has recently been implicated in bronchial inflammation. We investigated the functions and mechanisms of IL-31-induced activation of human bronchial epithelial cell...

journal_title：Immunology

authors： Ip WK,Wong CK,Li ML,Li PW,Cheung PF,Lam CW

更新日期：2007-12-01 00:00:00

abstract：:Although the co-stimulatory interaction between B and T cells is well defined, recent evidence suggests that B cells also have a regulatory role. Here, we show that B cells activated using anti-IgD conjugated to dextran (α-δ-dex) directly inhibit TCR-induced CD4 T cell activation, proliferation and cytokine production...

journal_title：Immunology

authors： Preciado-Llanes L,Wing JB,Foster RA,Carlring J,Lees A,Read RC,Heath AW

更新日期：2014-09-20 00:00:00

abstract：:The immunological outcome of infections and vaccinations is largely determined during the initial first days in which antigen-presenting cells instruct T cells to expand and differentiate into effector and memory cells. Besides the essential stimulation of the T-cell receptor complex a plethora of co-stimulatory signa...

journal_title：Immunology

authors： Bathke B,Pätzold J,Kassub R,Giessel R,Lämmermann K,Hinterberger M,Brinkmann K,Chaplin P,Suter M,Hochrein H,Lauterbach H

更新日期：2018-06-01 00:00:00

abstract：:During the immune response to H-2 and Mls alloantigens, murine lymphocytes showed altered sensitivity to polyclonal mitogens. The reactivity to the T-cell mitogen PHA followed a similar pattern in both H-2 and Mls-immunized mice while the reactivity to the B-cell mitogen LPS was contrasting in the two groups. In the f...

journal_title：Immunology

authors： Matossian-Rogers A

更新日期：1979-08-01 00:00:00

abstract：:T-cell-mediated immunity to a virulent strain of Plasmodium berghei NK65 (Pb NK65) and to an attenuated derivative (Pb XAT) of the strain were examined in CBA mice by the administration of monoclonal antibodies against T-cell subsets or interferon-gamma (IFN-gamma). The injection of anti-CD8+ or anti-IFN-gamma delayed...

journal_title：Immunology

authors： Waki S,Uehara S,Kanbe K,Ono K,Suzuki M,Nariuchi H

更新日期：1992-04-01 00:00:00

abstract：:We produced three murine monoclonal antibodies (mAb) directed against the human T-cell differentiation antigen CD2 (formerly T11) and analysed their epitope specificity by E-rosette inhibition, cross-blocking and proliferation-induction experiments. When added together, two mAb (both IgG1 kappa) were able to induce pr...

journal_title：Immunology

authors： van Lier R,Bloemena E,Brouwer M,Van Heijst J,Weinreich S,Aarden L

更新日期：1989-07-01 00:00:00

abstract：:A sudden upsurge of fever cases with joint pain was observed in the outpatient department, Community Health Centre, Rangat during July-August 2010 in Rangat Middle Andaman, India. The aetiological agent responsible for the outbreak was identified as chikungunya virus (CHIKV), by using RT-PCR and IgM ELISA. The study i...

journal_title：Immunology

authors： Chaaithanya IK,Muruganandam N,Anwesh M,Rajesh R,Ghosal SR,Kartick C,Prasad KN,Muthumani K,Vijayachari P

更新日期：2013-10-01 00:00:00

abstract：:All but one of nine Acholeplasma strains were susceptible to killing by gnotobiotic-calf serum while all but one of fifteen Mycoplasma strains were resistant. The mechanism of killing was examined using inhibitors of complement, viz. EDTA. MgEGTA. epsilon-amino caproic acid, and also by desalting serum and adding MgCl...

journal_title：Immunology

authors： Howard CJ

更新日期：1980-11-01 00:00:00

abstract：:Ribonucleic acid (immune RNA, iRNA), extracted from the spleens of mice immunized with sheep red blood cells (SRBC), induced specific immunological memory. The humoral immune responses of iRNA-treated animals were compared with in vivo and in vitro primary and secondary responses, using the haemolytic plaque-forming c...

journal_title：Immunology

authors： Kodama K,Yoshida T,Shibiya T,Kurashige S,Mitsuhashi S

更新日期：1981-11-01 00:00:00

abstract：:The primary immunoglobulin repertoire of chickens is generated not by gene rearrangement but by a subsequent process of gene conversion in proliferating immature B cells within the follicles of a specialized gut-associated lymphoid organ, the bursa of Fabricius. Neonatal infection with infectious bursal disease virus ...

journal_title：Immunology

authors： Withers DR,Davison TF,Young JR

更新日期：2006-04-01 00:00:00

abstract：:Four specific interleukin-2 (IL-2) surface binding proteins can be detected by covalent cross-linking of [125I]IL-2 to rat spleen cells that have been activated with various stimuli including concanavalin A (Con A), phytohaemagglutinin (PHA), calcium ionophore, and phorbol dibutyrate (PDB) with or without calcium iono...

journal_title：Immunology

authors： Chopra RK,Carroll MP,May WS,Bhatia SK,Margolick JB,Nagel JE,Adler WH

更新日期：1992-11-01 00:00:00

abstract：:The cellular basis of the mechanism of immunological tolerance to human gamma-globulin (H gamma G) induced in foetal and neonatal mice by materno-foetal or materno-neonatal transfer after a single injection of tolerogen (deaggregated H gamma G) into the mothers was investigated using a cell transfer system and assays ...

journal_title：Immunology

authors： Shinka S,Komatsu T,Dohi Y,Amano T

更新日期：1979-05-01 00:00:00

abstract：:T- and B-cell participation in the immune response induced by immune ribonucleic acid (iRNA) preparations against T-dependent antigens was studied using athymic nude, neonatally thymectomized (NT) and cyclophosphamide-treated (CY) mice. The iRNA(T + B) preparations were made from the spleen of BALB/c mice immunized wi...

journal_title：Immunology

authors： Saito K,Natsuno T,Mitsuhashi S

更新日期：1980-12-01 00:00:00

abstract：:The generation of effective immunity requires that antigen-specific T cells are activated, clonally expanded and ultimately eliminated by apoptosis. The involvement of CD95-mediated apoptosis in T-cell elimination is well established, but the conditions which regulate the death pathway under normal circumstances are s...

journal_title：Immunology

authors： Walker LS,McLeod JD,Boulougouris G,Patel YI,Ellwood CN,Hall ND,Sansom DM

更新日期：1999-12-01 00:00:00

abstract：:We have developed a hybridoma cell line which secretes monoclonal antibody to human basement membrane type IV collagen. The monoclonal antibody secreted by this hybridoma has been obtained in large amounts by either concentrating it from culture supernatants or from the ascites fluid of mice bearing the hybridoma tumo...

journal_title：Immunology

authors： Sundarraj N,Willson J

更新日期：1982-09-01 00:00:00

abstract：:We have previously reported that the 20-mer peptide p2340 (amino acids 2340-2359), of human thyroglobulin (Tg) has the unique feature that it causes experimental autoimmune thyroiditis (EAT) in mouse strains bearing high-responder (HR) or low-responder (LR) MHC haplotypes in Tg-induced EAT. In this study, we have empl...

journal_title：Immunology

authors： Hatzioannou A,Alevizaki M,Carayanniotis G,Lymberi P

更新日期：2012-03-01 00:00:00

abstract：:The process by which naive T cells become activated, differentiate into effector cells and ultimately generate long-lived memory cells is dependent upon a number of factors, including the costimulatory signals received by the T cell. To best understand the multiple events involved, it is important to understand the po...

journal_title：Immunology

authors： Kohlmeier JE,Chan MA,Benedict SH

更新日期：2006-08-01 00:00:00

abstract：:Induction of all forms of protective immunity by oral immunization with subunit vaccines is an ideal goal for the development of novel vaccines, but creates several theoretical problems from the point of view of antigen processing mechanisms. We show here that incorporation of the protein antigen ovalbumin (OVA) in li...

journal_title：Immunology

authors： Mowat AM,Donachie AM,Reid G,Jarrett O

更新日期：1991-03-01 00:00:00

abstract：:Rhesus macaques (Macaca mulatta) are extensively used in vaccine development. Macaques infected with simian immunodeficiency viruses (SIV) or simian-human immunodeficiency viruses (SHIV) are the best animal model currently available for acquired-immune-deficiency-syndrome-related studies. Recent results emphasize the ...

journal_title：Immunology

authors： Scinicariello F,Engleman CN,Jayashankar L,McClure HM,Attanasio R

更新日期：2004-01-01 00:00:00

abstract：:The association between three major spondyloarthritic diseases, ankylosing spondylitis, Reiter's syndrome, and reactive arthritis, and the major histocompatibility complex (MHC) class 1 antigen HLA-B27 is well documented. The hypothesis of cross-reactivity between HLA-B27 and the antecedent infection-causing Gram-nega...

journal_title：Immunology

authors： Kapasi K,Chui B,Inman RD

更新日期：1992-11-01 00:00:00

abstract：:Mouse spleen cells from animals immunized with bovine peripheral blood lymphocytes were fused to X63 . Ag8 myeloma cells and the activity of one of the resulting myeloma hybrids was characterized. The product of this clone (B5/4.1.4) binds to pentameric bovine IgM isolated from serum but not to serum IgG1 or IgG2. Thi...

journal_title：Immunology

authors： Pinder M,Musoke AJ,Morrison WI,Roelants GE

更新日期：1980-07-01 00:00:00

abstract：:Interleukin-12 (IL-12) is important in the regulation of resistance to Toxoplasma gondii in mice with severe combined immunodeficiency (SCID). The protective ability of IL-12 in SCID mice appears to be through its activity on natural killer (NK) cells to induce production of interferon-gamma (IFN-gamma). In this study...

journal_title：Immunology

authors： Hunter CA,Candolfi E,Subauste C,Van Cleave V,Remington JS

更新日期：1995-01-01 00:00:00

abstract：:Interleukin-2 (IL-2) is a mainstay for current immunotherapeutic protocols but its usefulness in patients is reduced by severe toxicities and because IL-2 facilitates regulatory T (Treg) cell development. IL-21 is a type I cytokine acting as a potent T-cell co-mitogen but less efficient than IL-2 in sustaining T-cell ...

journal_title：Immunology

authors： Battaglia A,Buzzonetti A,Baranello C,Fanelli M,Fossati M,Catzola V,Scambia G,Fattorossi A

更新日期：2013-05-01 00:00:00