Abstract：
:Environmental factors have significant effects on the development of autoimmune diseases. The ligand-activated transcription factor aryl hydrocarbon receptor (AHR) is controlled by endogenous and environmental small molecules. Hence, AHR provides a molecular pathway by which endogenous and environmental signals can influence the immune response and the development of autoimmune diseases. AHR also provides a target for therapeutic intervention in immune-mediated disorders. In this review, we discuss the role of AHR in the regulation of T-cell differentiation and autoimmunity.
journal_name
Immunologyjournal_title
Immunologyauthors
Quintana FJdoi
10.1111/imm.12046subject
Has Abstractpub_date
2013-03-01 00:00:00pages
183-9issue
3eissn
0019-2805issn
1365-2567journal_volume
138pub_type
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