Abstract：
:The activity of Nocardia water-soluble mitogen (NWSM) and LPS were compared in several experimental systems, since both compounds are B-cell mitogens and polyclonal activators in vitro. The results reported here demonstrated that NWSM like LPS also has a strong adjuvant activity in vivo if administered in saline with a strong antigen (heterologous red blood cells) or even with a weak immunogen such as theta alloantigen. However, in contrast to LPS, NWSM administered to mice failed to induce in vivo proliferation of lymphocytes, polyclonal activation and PFC against syngeneic bromelain-treated erythrocytes and thymocytes. It is possible therefore, that different mechanisms may be responsible for adjuvant activity of NWSM and LPS.
journal_name
Immunologyjournal_title
Immunologyauthors
Lowy I,Bona C,Ciorbaru R,Chedid Lsubject
Has Abstractpub_date
1977-06-01 00:00:00pages
975-80issue
6eissn
0019-2805issn
1365-2567journal_volume
32pub_type
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