FACS analysis of changes in T and B lymphocyte populations in the blood, spleen and lymph nodes of pregnant mice.

Abstract:

:Using the fluorescence-activated cell sorter (FACS), the percentages of T and B lymphocytes in the peripheral blood, spleen and lymph nodes of CBA syngeneic and allogeneic pregnancies were determined. At 19 days of syngeneic pregnancy, the level of T cells in the blood had decreased and that of B cells had increased. In the spleen, a decrease in both T and B cells occurred earlier in pregnancy and had returned to control levels by 19 days. During the last few days of pregnancy, the para-aortic lymph nodes (PALN) draining the pregnant uterus of syngeneically mated mice showed a 1 . 7-fold increase in the level of B cells over that in virgin controls. The T-cell level dropped at the end of pregnancy by approximately 10%. There was no change in T- or B-cell status in the brachial (underarm) nodes taken from the same animals.

journal_name

Immunology

journal_title

Immunology

authors

Carter J,Newport A,Keeler KD,Dresser DW

subject

Has Abstract

pub_date

1983-04-01 00:00:00

pages

791-7

issue

4

eissn

0019-2805

issn

1365-2567

journal_volume

48

pub_type

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