Role of mouse IgG and IgE homocytotropic antibodies in passive cutaneous anaphylaxis.

abstract：:Colorectal cancer is considered a non-immunogenic malignany. One strategy to augment the immunogenicity of such tumours is represented by the expression of costimulatory molecules by gene transfer. Using transfected variants of the human colorectal cancer cell line SW480 we tested various costimulatory molecules (CD80...

journal_title：Immunology

authors： Lindauer M,Rudy W,Gückel B,Doeberitz MV,Meuer SC,Moebius U

更新日期：1998-03-01 00:00:00

abstract：:Interleukin-2 (IL-2) is a critical regulator of immune homeostasis through its non-redundant role in regulatory T (Treg) cell biology. There is major interest in therapeutic modulation of the IL-2 pathway to promote immune activation in the context of tumour immunotherapy or to enhance immune suppression in the contex...

journal_title：Immunology

authors： Huss DJ,Pellerin AF,Collette BP,Kannan AK,Peng L,Datta A,Wipke BT,Fontenot JD

更新日期：2016-07-01 00:00:00

abstract：:The effect of disodium cromoglycate (DSCG) upon human immunoglobulin (Ig) isotypes and IgG subclasses production by purified B cells was studied. DSCG enhanced IgM, IgG1, IgG2, IgG3, IgG4 and IgA production in a dose-dependent fashion, while DSCG failed to induce IgE production at any concentrations tested by purified...

journal_title：Immunology

authors： Kimata H,Yoshida A,Ishioka C,Mikawa H

更新日期：1991-05-01 00:00:00

abstract：:T. brucei infection in mice causes generalized immunosuppression with multiple changes in the cells of the lymphoid tissue. Loss of B cell responsiveness to antigens and mitogens, and the induction of suppressive T-cells and macrophages, have been previously reported (Hudson, Byner, Freeman & Terry, 1976; Corsini, Cla...

journal_title：Immunology

authors： Askonas BA,Corsini AC,Clayton CE,Ogilvie BM

更新日期：1979-02-01 00:00:00

abstract：:Secretory component (SC or polymeric immunoglobulin receptor) on mucosal epithelial cells mediates transcytosis of polymeric immunoglobulin into external fluids and functions as a receptor for polymeric immunoglobulin. SC expression in a human colonic adenocarcinoma cell line, HT-29 has been reported to be up-regulate...

journal_title：Immunology

authors： Hayashi M,Takenouchi N,Asano M,Kato M,Tsurumachi T,Saito T,Moro I

更新日期：1997-10-01 00:00:00

abstract：:Among immunological abnormalities present in human immunodeficiency virus type 1 (HIV-1)-infected individuals are dysregulation of cytokine production and CD4 down-regulation in both T-helper cells and monocytes/macrophages. The HIV-1 envelope glycoprotein 120 (gp120) has the ability to induce different cytokines in p...

journal_title：Immunology

authors： Karsten V,Gordon S,Kirn A,Herbein G

更新日期：1996-05-01 00:00:00

abstract：:This study has examined the stimuli required for secretion of regulated upon activation, normal T-cell expressed, presumed secreted (RANTES) from T lymphocytes and found that stimuli such as phorbol 12-myristate 13-acetate (PMA), which are unable to support T-cell proliferation and interleukin-2 (IL-2) production, are...

journal_title：Immunology

authors： Sotsios Y,Blair PJ,Westwick J,Ward SG

更新日期：2000-09-01 00:00:00

abstract：:The phospholipid platelet-activating factor 1-0-hexadecyl-2-acetyl-SN-glycero-3-phosphorylcholine (AGEPC) initiates platelet function by interacting specifically with 1399 +/- 498 (mean +/- SD) high-affinity membrane receptors per platelet. In studies designated to characterize the high affinity binding site, AGEPC-hu...

journal_title：Immunology

authors： Valone FH

更新日期：1984-05-01 00:00:00

abstract：:Microbial adjuvants are essential for the development of T-cell-dependent antibody production, recall T-cell proliferation and interferon-gamma production following immunization with protein antigens. Using an adoptive transfer approach, we showed that the adjuvant lipopolysaccharide enhanced the frequency of cells pr...

journal_title：Immunology

authors： Costalonga M,Zell T

更新日期：2007-09-01 00:00:00

abstract：:The ability of preparations of cobra factor (CoF) to convert C3 via the properdin pathway (anticomplementary activity) has been demonstrated to be unrelated to its ascribed ability to convert a tolerogenic signal into an immunogenic stimulus (adjuvant activity). It has been shown that CoF preparations which have becom...

journal_title：Immunology

authors： Morrison DC,Louis JA,Weigle WO

更新日期：1976-03-01 00:00:00

abstract：:Synthesis of interferon (IFN)-gamma by natural killer (NK) cells is an important pro-inflammatory event with interleukin (IL)-12 and IL-18 playing major inductive roles. However, other temporal events are likely to regulate such processes and as prostaglandin E2 (PGE2) is ubiquitous during inflammation this study test...

journal_title：Immunology

authors： Walker W,Rotondo D

更新日期：2004-03-01 00:00:00

abstract：:After a primary infection of congenitally athymic nu/nu mice with Strongyloides ratti, worms were not expelled and the number of intestinal mucosal mast cells (MMC) remained at a low level. When S. ratti-infected nu/nu mice were treated by repetitive injections of semi-purified IL-3 from Day 5 to Day 10 post-infection...

journal_title：Immunology

authors： Abe T,Nawa Y

更新日期：1988-02-01 00:00:00

abstract：:Compared with adults, the circulating Vγ2Vδ2 T-cell population in cord blood is present at low levels and does not show the strong bias for Vγ2-Jγ1.2 rearrangements. These features may be a result of limited exposure to stimulatory phosphoantigens, lack of T-cell-derived interleukin-2 (IL-2) or both. In cord blood mon...

journal_title：Immunology

authors： Cairo C,Sagnia B,Cappelli G,Colizzi V,Leke RG,Leke RJ,Pauza CD

更新日期：2013-04-01 00:00:00

abstract：:The influence of pooled human IgG preparations for intravenous use (i.v.Ig) on in vitro-induced cytokine production was studied at the single-cell level using cytokine-specific monoclonal antibodies (mAb) and indirect immunofluorescent technique. Cultured mononuclear cells from peripheral blood from healthy adult dono...

journal_title：Immunology

authors： Andersson UG,Björk L,Skansén-Saphir U,Andersson JP

更新日期：1993-06-01 00:00:00

abstract：:The glucocorticoid-induced tumour necrosis factor receptor family related gene (GITR) has been reported to be expressed on the activated T and CD4(+)CD25(+) regulatory T cells (Treg). Signalling triggered by GITR not only neutralizes the suppressive effect of Treg cells, but also augments activation, proliferation and...

journal_title：Immunology

authors： Lee SK,Choi BK,Kim YH,Kang WJ,Kim KH,Sakaguchi S,Suh JH,Kim TY,Kwon BS

更新日期：2006-12-01 00:00:00

abstract：:Lymphocytes are heterogeneous with respect to their life-span. Typical B cells, bearing on their membranes immunoglobulin receptors, easily detectable by immunofluorescence, belong mainly to the long-lived population: this can be observed using combined autoradiography and immunofluorescence. However, when primed mice...

journal_title：Immunology

authors： Hooghe V,Urbain-Vansanten G,Richard C,Urbain J

更新日期：1975-05-01 00:00:00

abstract：:We hypothesized that the addition of polymer to the surface of liposome/DNA complexes may potentially enhance in vivo delivery of plasmid DNA to antigen-presenting cells and thereby facilitate enhanced immune responses to encoded protein. BALB/c mice were immunized subcutaneously or intramuscularly three times with a ...

journal_title：Immunology

authors： Bramwell VW,Eyles JE,Somavarapu S,Alpar HO

更新日期：2002-07-01 00:00:00

abstract：:Mice, immunized with liposome-associated bovine serum albumin (LSM-BSA), showed a significantly higher BSA-specific plaque-forming cell (PFC) response than did mice injected with fluid BSA (fBSA). Physical association between the liposome carrier and the protein antigen is imperative for potentiating the PFC response,...

journal_title：Immunology

authors： Shek PN,Sabiston BH

更新日期：1982-02-01 00:00:00

abstract：:Interleukin-31 (IL-31) is a novel T-helper-lymphocyte-derived cytokine that plays an important role in allergic skin inflammation and atopic dermatitis. It has recently been implicated in bronchial inflammation. We investigated the functions and mechanisms of IL-31-induced activation of human bronchial epithelial cell...

journal_title：Immunology

authors： Ip WK,Wong CK,Li ML,Li PW,Cheung PF,Lam CW

更新日期：2007-12-01 00:00:00

abstract：:Signaling by Kit has been extensively studied in hematopoietic cells and is essential for the survival, proliferation and maintenance of hematopoietic stem and progenitor cells. In addition to the activation of intrinsic signaling pathways, Kit has been shown to interact with lineage-restricted type I cytokine recepto...

journal_title：Immunology

authors： Sethumadhavan A,Mani M

更新日期：2020-04-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune chronic inflammatory disease of unknown etiology, although genetic and environmental factors appear to contribute to its pathogenesis. Specifically, infectious processes are associated with SLE onset and exacerbation. However, we are far from a complete understanding...

journal_title：Immunology

authors： Illescas-Montes R,Corona-Castro CC,Melguizo-Rodríguez L,Ruiz C,Costela-Ruiz VJ

更新日期：2019-11-01 00:00:00

abstract：:The cellular basis of the mechanism of immunological tolerance to human gamma-globulin (H gamma G) induced in foetal and neonatal mice by materno-foetal or materno-neonatal transfer after a single injection of tolerogen (deaggregated H gamma G) into the mothers was investigated using a cell transfer system and assays ...

journal_title：Immunology

authors： Shinka S,Komatsu T,Dohi Y,Amano T

更新日期：1979-05-01 00:00:00

abstract：:Class switch recombination (CSR) is a T-cell-dependent mechanism regulating isotype switching in activated mature B cells. Recently we showed that T-cell-independent CSRs occur spontaneously during B lymphopoiesis, but such cells are negatively selected by Fas signalling. In immunoglobulin mu-deficient mice, lack of F...

journal_title：Immunology

authors： Seagal J,Melamed D

更新日期：2004-06-01 00:00:00

abstract：:It has previously been demonstrated that a gene on chromosome 1 in or near Mls-1 controls, on the surface of B cells, the mobility and aggregability of major histocompatibility complex (MHC) class II molecules but not the mobility or aggregability of other B-cell molecules, such as immunoglobulin (Ig) and class I anti...

journal_title：Immunology

authors： Mecheri S,Dannecker G,Dennig D,Hoffmann MK

更新日期：1991-12-01 00:00:00

abstract：:We have isolated, characterized and quantified the immunocompetent cells present in the extravascular hepatic compartment at various stages after Plasmodium yoelii malaria infection with sporozoites. Cytological analyses revealed a predominantly lymphoid population. In mice with a primary infection, the predominant ce...

journal_title：Immunology

authors： Faure P,Marussig M,Goossens P,Miltgen F,Mazier D

更新日期：1994-08-01 00:00:00

abstract：:Activation of self-reactive T cells in healthy adults is prevented by the presence of autoantigen-specific CD4+CD25+ regulatory T cells (CD25+ Treg). To explore the functional development of autoantigen-reactive CD25+ Treg in humans we investigated if thymic CD25+ Treg from children aged 2 months to 11 years and cord ...

journal_title：Immunology

authors： Wing K,Larsson P,Sandström K,Lundin SB,Suri-Payer E,Rudin A

更新日期：2005-08-01 00:00:00

abstract：:The hepatic and splenic uptake of circulating, small-latticed immune complexes and the effect of these complexes on the hepatic mononuclear phagocyte system (MPS) were examined in mice. The small-latticed immune complexes were prepared at fifty-fold antigen excess. The clearance from circulation and uptake by the live...

journal_title：Immunology

authors： Jimenez RA,Haakenstad AO,Mannik M

更新日期：1983-02-01 00:00:00

abstract：:Antigen-induced allergic airway inflammation is mediated by T helper type 2 (Th2) cells and their cytokines, but the mechanism that initiates the Th2 immunity is not fully understood. Recent studies show that basophils play important roles in initiating Th2 immunity in some inflammatory models. Here we explored the ro...

journal_title：Immunology

authors： Zhong W,Su W,Zhang Y,Liu Q,Wu J,Di C,Zhang Z,Xia Z

更新日期：2014-06-01 00:00:00

abstract：:Binding of streptococcal antigen was compared between T8+ cells and monocytes (Mo) from DRw6+ and DRw6- subjects. Both T8+ cells and Mo from DRw6- subjects bind streptococcal antigen (SA) specifically and almost entirely at a concentration of 1000 ng per 0.1 ml. However, the DRw6+, T8+ cells bind SA at a concentration...

journal_title：Immunology

authors： Lehner T,Jones T

更新日期：1984-10-01 00:00:00

abstract：:Bone marrow cells from mice were cultured in vitro in the presence of interleukin-3 (IL-3). After 2 weeks, the majority of the cells differentiated towards mast cells as judged by morphological and biochemical criteria. When populations of 99% IL-3-dependent mast cells (IL-3 MC) were tested for their anti-tumour activ...

journal_title：Immunology

authors： Ghiara P,Boraschi D,Villa L,Scapigliati G,Taddei C,Tagliabue A

更新日期：1985-06-01 00:00:00