Abstract：
:Microbial adjuvants are essential for the development of T-cell-dependent antibody production, recall T-cell proliferation and interferon-gamma production following immunization with protein antigens. Using an adoptive transfer approach, we showed that the adjuvant lipopolysaccharide enhanced the frequency of cells producing interleukin-2, enhanced clonal expansion by antigen-specific CD4 T cells and increased CD86 and interleukin-1alpha production by antigen-presenting cells. All of these effects were dependent on Toll-like receptor-4 (TLR4) expression by cells other than the antigen-specific CD4 T cells. The ability of lipopolysaccharides to increase the number of antigen-specific CD4 T cells that survive after immunization probably explains the previous finding that antigen-specific proliferation by T cells from normal mice depends on previous exposure to antigen and adjuvant.
journal_name
Immunologyjournal_title
Immunologyauthors
Costalonga M,Zell Tdoi
10.1111/j.1365-2567.2007.02620.xsubject
Has Abstractpub_date
2007-09-01 00:00:00pages
124-30issue
1eissn
0019-2805issn
1365-2567pii
IMM2620journal_volume
122pub_type
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