Glycosylation of IgA is required for optimal activation of the alternative complement pathway by immune complexes.

abstract：:Cancer immune surveillance is considered to be an important host protection process to inhibit carcinogenesis and to maintain cellular homeostasis. In the interaction of host and tumour cells, three essential phases have been proposed: elimination, equilibrium and escape, which are designated the 'three E's'. Several ...

journal_title：Immunology

authors： Kim R,Emi M,Tanabe K

更新日期：2007-05-01 00:00:00

abstract：:Type A chrysotile fibres (white asbestos) were tested in vitro for activation of the complement system. Fibres were incubated in normal human serum (NHS), factor B-depleted human serum, and normal and C4-deficient guinea-pig sera; the supernates were assayed for the remaining complement activity. Activation of the alt...

journal_title：Immunology

authors： Saint-Remy JM,Cole P

更新日期：1980-10-01 00:00:00

abstract：:Thoracic duct lymphocytes (TDL) from (AS2 x AS)F1 rats previously injected with human serum albumin (HSA) were transferred to 900 r irradiated syngeneic recipients which were challenged with various doses of soluble HSA (s-HSA). TDL from partially tolerant rats, which were deficient in high avidity B cells, produced a...

journal_title：Immunology

authors： Bell EB,Shand FL

更新日期：1977-10-01 00:00:00

abstract：:The role of T-cell receptor (TCR) gammadelta T cells in the induction of protective TCR alphabeta T cells against infection by the intracellular bacteria Listeria monocytogenes was analysed. We found that depletion of gammadelta T cells by anti-TCR delta monoclonal antibody treatment before intravenous immunization of...

journal_title：Immunology

authors： Nomura A,Matsuzaki G,Takada H,Hiromatsu K,Nabeshima S,Nakamura T,Kishihara K,Nomoto K

更新日期：1998-10-01 00:00:00

abstract：:Intestinal inflammatory disease or infection often results in the loss of the epithelial layer as a result mainly of the action of proteases, including the leucocyte serine proteinases (neutrophil elastase), lysosomal cathepsins and the matrix metalloproteinases from recruited inflammatory cells. Previous studies have...

journal_title：Immunology

authors： Miller TL,McGee DW

更新日期：2002-01-01 00:00:00

abstract：:Initial separation and concentration of Clq from fresh, normal equine serum was accomplished by precipitation in 0.02 M acetate buffer, pH 5.5, at 4 degrees for 24 h. The re-dissolved precipitate was clarified by centrifugation at 80,000 g for 1 h and then dialysed against Tris-HCl buffer (0.05 M, pH 8.0) containing 1...

journal_title：Immunology

authors： McDonald TL,Burger D

更新日期：1979-07-01 00:00:00

abstract：:A common factor existing among autoimmune target antigens was sought in association with their developmental expression during organogenesis. Autoimmunity against a certain organ was experimentally induced in rats by deliberate immunization with whole tissue extract of the respective organ. Histopathological changes i...

journal_title：Immunology

authors： Akashi T,Eishi Y

更新日期：1991-11-01 00:00:00

abstract：:Ultraviolet-B radiation (UVR) of mouse skin promotes both local and systemic immune aberrations that are thought to be important in the pathogenesis of cutaneous malignancies. Acute, low-dose UVR regimens inhibit the induction of contact hypersensitivity (CH) in genetically susceptible mice by TNF-alpha-dependent mech...

journal_title：Immunology

authors： Kitazawa T,Streilein JW

更新日期：2000-02-01 00:00:00

abstract：:Male and female spleen cells were compared before and after culture for their cytotoxicity to autologous-embryo fibroblasts. Cultures of male cells developed significantly greater reactivity than cultures of female cells. Moreover, while the cytotoxicity derived from cultures of male cells was totally abolished by tre...

journal_title：Immunology

authors： Gorczynski RM

更新日期：1976-10-01 00:00:00

abstract：:A decrease in the number of dendritic cells (DCs) is a major cause of post-sepsis immunosuppression and opportunistic infection and is closely associated with poor prognosis. Increasing the number of DCs to replenish their numbers post sepsis can improve the condition. This therapeutic approach could improve recovery ...

journal_title：Immunology

authors： Wang HW,Yang W,Gao L,Kang JR,Qin JJ,Liu YP,Lu JY

更新日期：2015-05-01 00:00:00

abstract：:BLT mice, constructed by surgical implantation of human fetal thymus-liver tissues and intravenous delivery of autologous CD34+ haematopoietic stem cells into adult non-obese diabetic/severe combined immunodeficiency mice, were evaluated for vaccine-induced humoral immune responses. Following engraftment, these mice d...

journal_title：Immunology

authors： Biswas S,Chang H,Sarkis PT,Fikrig E,Zhu Q,Marasco WA

更新日期：2011-12-01 00:00:00

abstract：:Prolonged exposure to ultraviolet light (UV) is known to lead to premature skin ageing, increased incidence of cataract and a high risk of developing skin cancers. UV-B irradiation, even if given as a single suberythemal dose, suppresses some immune responses, possibly reducing the production of T helper (Th) 1 cytoki...

journal_title：Immunology

authors： el-Ghorr AA,Norval M

更新日期：1997-09-01 00:00:00

abstract：:Immunization of male rats and monkeys with gonadotropin-releasing hormone (GnRH) conjugated to a carrier results in a dramatic atrophy of the prostate. GnRH, linked to either diphtheria toxoid or tetanus toxoid as carrier, is now being evaluated for its use in the immunotherapy of hormone-dependent prostate enlargemen...

journal_title：Immunology

authors： Sad S,Gupta HM,Talwar GP,Raghupathy R

更新日期：1991-10-01 00:00:00

abstract：:Monoclonal antibodies to human complement component C9 were used to localise the membrane attack complex (MAC) of human complement on muscle fibres from patients with autoimmune myositis. A pigeon erythrocyte 'model' system was used to screen the available monoclonal antibodies for their ability to bind C9 after its i...

journal_title：Immunology

authors： Morgan BP,Sewry CA,Siddle K,Luzio JP,Campbell AK

更新日期：1984-05-01 00:00:00

abstract：:A technique is reported here for the quantitative extraction of live cells from the lung interstitium; it involves the incubation of slices of perfused lung in a mixture containing optimal concentrations of collagenase, DNAse, and fetal calf serum, followed by the simultaneous recovery and fractionation of cells relea...

journal_title：Immunology

authors： Holt PG,Degebrodt A,Venaille T,O'Leary C,Krska K,Flexman J,Farrell H,Shellam G,Young P,Penhale J

更新日期：1985-01-01 00:00:00

abstract：:The activity of Nocardia water-soluble mitogen (NWSM) and LPS were compared in several experimental systems, since both compounds are B-cell mitogens and polyclonal activators in vitro. The results reported here demonstrated that NWSM like LPS also has a strong adjuvant activity in vivo if administered in saline with ...

journal_title：Immunology

authors： Lowy I,Bona C,Ciorbaru R,Chedid L

更新日期：1977-06-01 00:00:00

abstract：:FTY720, a novel immunosuppressant, sequesters circulating mature lymphocytes, especially T cells, within lymph nodes and Peyer's patches by accelerating lymphocyte homing, and thereby causes lymphocyte depletion in the blood. The FTY720-induced acceleration of lymphocyte homing appears to be mediated by lymphocyte hom...

journal_title：Immunology

authors： Yanagawa Y,Masubuchi Y,Chiba K

更新日期：1998-12-01 00:00:00

abstract：:Mast cell secretory granules contain unique tryptic and chymotryptic serine proteases that differ between species and tissues. Direct comparison of these proteases in single-cell types has been hindered by the difficulty of obtaining adequate numbers of pure mast cells. In this study, we were able to compare tryptic a...

journal_title：Immunology

authors： Caughey GH,Lazarus SC,Viro NF,Gold WM,Nadel JA

更新日期：1988-02-01 00:00:00

abstract：:The phospholipid platelet-activating factor 1-0-hexadecyl-2-acetyl-SN-glycero-3-phosphorylcholine (AGEPC) initiates platelet function by interacting specifically with 1399 +/- 498 (mean +/- SD) high-affinity membrane receptors per platelet. In studies designated to characterize the high affinity binding site, AGEPC-hu...

journal_title：Immunology

authors： Valone FH

更新日期：1984-05-01 00:00:00

abstract：:The properties of IgA and IgG anti-gliadin antibodies from the serum of patients with coeliac disease have been compared. The antibodies were quantified by ELISA using microtitre plates coated with crude gliadin fractions. Their specificity was confirmed by immunoblotting. Heat-treated sera containing IgA antibodies s...

journal_title：Immunology

authors： Stewart WW,Kerr MA

更新日期：1991-08-01 00:00:00

abstract：:The IgE antibody responses of inbred BALB/c mice to subcutaneously injected antigens, given without adjuvant, were studied. Cocksfoot grass pollen extract (GPE) (100-100,000 pnu) induced no detectable primary IgE antibody responses but following second and subsequent injections, substantial secondary responses were pr...

journal_title：Immunology

authors： Taylor WA,Sheldon D,Francis DH

更新日期：1980-04-01 00:00:00

abstract：:Purified pertussis toxin (PPT) is a potent mitogen for human T lymphocytes and is shown to cause rapid calcium mobilization in resting T cells, a T-cell line and CD3- lymphocytes with natural killer (NK) activity. In resting T cells the PPT activation is associated with cytoplasmic alkalinization. A similar rise in in...

journal_title：Immunology

authors： Macintyre EA,Tatham PE,Abdul-Gaffar R,Linch DC

更新日期：1988-07-01 00:00:00

abstract：:Clonal deletion of T cells capable of recognizing both host-type Mls and donor-type Mls occurred in the peripheral mature T-cell pool in radiation bone marrow chimeras of two H-2-compatible Mls-disparate strain combinations of AKR/J(H-2k,Thy-1.1,Mls-1a) and C3H/He(H-2k,Thy-1.2,Mls-1b). In order to determine further th...

journal_title：Immunology

authors： Ogimoto M,Yoshikai Y,Matsuzaki G,Ohga S,Matsumoto K,Nomoto K

更新日期：1990-03-01 00:00:00

abstract：:Mice injected with rat erythrocytes developed anti-erythrocyte autoantibodies which reached a plateau at 4-12 weeks, then gradually declined until at about 24 weeks the majority of mice were negative. In such recovered mice re-challenge with rat erythrocytes produced an accelerated peak of autoantibody and a much more...

journal_title：Immunology

authors： Naysmith JD,Elson CJ,Dallman M,Fletcher E,Ortega-Pierres MG

更新日期：1980-04-01 00:00:00

abstract：:Protein kinase C (PKC) form a key family of enzymes involved in signalling pathways that specifically phosphorylates substrates at serine/threonine residues. Phosphorylation by PKC is important in regulating a variety of cellular events such as cell proliferation and the regulation of gene expression. In the immune sy...

journal_title：Immunology

authors： Lim PS,Sutton CR,Rao S

更新日期：2015-12-01 00:00:00

abstract：:Collectins are a group of soluble proteins, each of which has collagenous and non-collagenous globular domains, and may be complement associated and/or have lectin activity. The complement protein C1q is structurally and functionally related to the collectins. Members of the collectin family are mannan-binding protein...

journal_title：Immunology

authors： Malhotra R,Willis AC,Lopez Bernal A,Thiel S,Sim RB

更新日期：1994-07-01 00:00:00

abstract：:Toll-like receptors (TLR) are sentinel receptors capable of recognizing pathogen-associated molecule patterns (PAMP) such as lipopolysaccharide (LPS) and CpG-containing oligonucleotides (CpG ODN). TLR2 and TLR4 are major receptors for Gram-positive and Gram-negative bacterial cell wall components, respectively. TLR9 i...

journal_title：Immunology

authors： An H,Yu Y,Zhang M,Xu H,Qi R,Yan X,Liu S,Wang W,Guo Z,Guo J,Qin Z,Cao X

更新日期：2002-05-01 00:00:00

abstract：:Neutrophils make up an essential part of the innate immune system, and are involved both in the initial responses to pathogens, and in orchestrating later immune responses. Neutrophils recognize pathogens through pattern-recognition receptors (PRRs), which are activated by microbial motifs. The Nod-like receptors (nuc...

journal_title：Immunology

authors： Ekman AK,Cardell LO

更新日期：2010-05-01 00:00:00

abstract：:Mucosal immunization offers the potential for inducing IgA antibody responses in the vagina, the site of infection for many viruses, including herpes simplex type 2 (HSV-2). To investigate this possibility, mice were immunized intranasally with 10 micrograms glycoprotein D2 (gD2) from HSV combined with a series of adj...

journal_title：Immunology

authors： Ugozzoli M,O'Hagan DT,Ott GS

更新日期：1998-04-01 00:00:00

abstract：:The capacity of the immune system to respond efficiently to new antigens depends upon a continuous source of naive CD4+ T cells. Such cells exit from the thymus and join the recirculated T-cell pool. Factors present at the sites of naive CD4+ T-cell circulation must be responsible for their survival, since upon remova...

journal_title：Immunology

authors： Webb LM,Foxwell BM,Feldmann M

更新日期：1999-11-01 00:00:00