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Clonal deletion of self-Mls-reactive thymocytes at the early stage in H-2-compatible but Mls-disparate radiation chimeras.

Abstract：

:Clonal deletion of T cells capable of recognizing both host-type Mls and donor-type Mls occurred in the peripheral mature T-cell pool in radiation bone marrow chimeras of two H-2-compatible Mls-disparate strain combinations of AKR/J(H-2k,Thy-1.1,Mls-1a) and C3H/He(H-2k,Thy-1.2,Mls-1b). In order to determine further the stage at which the clonal deletion occurs in thymus, we examined the kinetics of thymocytes bearing V beta 6 capable of recognizing Mls-1a in both C3H/He----AKR/J and AKR/J----C3H/He chimeras. An almost complete replacement from host-derived cells to donor-derived cells occurred by Day 21 after reconstitution in both chimeras. At this stage, CD4+CD8+ double-positive thymocytes contained an appreciable number of cells that expressed V beta 6 on their surface, albeit at low intensity, whereas CD4 or CD8 single-positive thymocytes which expressed a high density of V beta 6 were virtually abolished in both C3H----AKR and AKR----C3H chimeras on Day 21. These results suggest that clonal deletion of self-Mls-reactive T cells begins at an early stage when the thymocytes interact with the early appearing donor-derived haemotopoietic cells and relatively radio-resistant host-derived cells in thymus of radiation bone marrow chimeras.

journal_name

Immunology

journal_title

Immunology

authors

Ogimoto M,Yoshikai Y,Matsuzaki G,Ohga S,Matsumoto K,Nomoto K

subject

Has Abstract

pub_date

1990-03-01 00:00:00

pages

482-6

issue

3

eissn

0019-2805

issn

1365-2567

journal_volume

69

pub_type

杂志文章

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