Abstract:
:The kinetics of ingestion and degradation of guinea-pig IgG2-containing soluble immune complexes by guinea-pig macrophages and neutrophils have been compared and aspects of the biochemical control of these events in neutrophils have been investigated using a selection of inhibitors. Differences were observed between the macrophages and neutrophils in the stability of complex attachment to their surface membranes, in the rates and modes of complex ingestion and in the relative and absolute rates of digestion of the antibody and antigen components within the complexes. On the other hand, the response of the neutrophils to different inhibitors was broadly similar to that previously observed with the macrophages. The differences observed are discussed and the importance of the Fc-receptor expression in determining these differences is assessed.
journal_name
Immunologyjournal_title
Immunologyauthors
Leslie RG,Coupland Ksubject
Has Abstractpub_date
1985-04-01 00:00:00pages
811-9issue
4eissn
0019-2805issn
1365-2567journal_volume
54pub_type
杂志文章相关文献
IMMUNOLOGY文献大全abstract::Mouse peritoneal macrophages (M phi) expressed enhanced tumoricidal activity upon in vitro stimulation either with the lymphokine M phi-activating factor (MAF) or with fibroblast interferon (IFN-beta). In contrast, M phi suppressive activity on lymphoproliferation was not affected by MAF pretreatment, but was drastica...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1983-11-01 00:00:00
abstract::The ability of the chemical carcinogen dimethylbenz(a)anthracene (DMBA) to deplete Langerhans' cells (LC) from murine skin is crucial to the development of antigen-specific suppression. This depletion is a consequence of the LC recognizing the DMBA as antigenic and migrating to the draining lymph nodes to attempt to e...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1046/j.1365-2567.1996.d01-645.x
更新日期:1996-05-01 00:00:00
abstract::We previously reported that FTY720 is an efficient inducer of apoptosis in lymphocytes and cultured cell lines. In the present study, HL-60 human promyerocytoma cells also induced apoptosis through in vitro treatment with the drug, demonstrating extensive DNA fragmentation 6 hr after incubation. The major target of FT...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1046/j.1365-2567.1997.d01-2281.x
更新日期:1997-08-01 00:00:00
abstract::The molecular characteristics of a serum IL-2 inhibitor were determined by fractionating active sera from normal and malaria-infected mice, and assaying inhibitory activity in blocking production and expression of IL-2 activity. Using isoelectric focusing and ion exchange chromatography, the activity resolved in a sin...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1985-09-01 00:00:00
abstract::The absence of complement receptor 1 (CR1) related gene/protein y (Crry) leads to embryonic lethality as a result of unrestricted complement activation and concomitant neutrophil infiltration. Here we used Crry(-/-)C3(+/-) mice to investigate the role of Crry in the pathogenesis of immune complex glomerulonephritis (G...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2009.03102.x
更新日期:2009-09-01 00:00:00
abstract::To assess the role of CD5 and CD28 in the pathogenesis of the decreased cellular immune function in patients with rheumatoid arthritis (RA) we analysed the expression and function of these T-cell surface molecules. The expression of CD5 as well as of CD28 in synovial and peripheral blood T cells was similar to that of...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1993-09-01 00:00:00
abstract::Induction of autoimmune antibodies against antigens of glomerular basement membrane (GBM) was studied in nine inbred strains of rats each with a different major histocompatibility complex H-1. Brown-Norway (BN) (H-1n), Lewis (H-1(1)), PVG/c (H-1c), AS2 (H-1f), AVN (H-1a), BD V (H-1d), DA (H-1a) and F344 (H-1(1)) rats ...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1979-04-01 00:00:00
abstract::The development of T lymphocytes in ovine fetal lymph nodes was studied immunohistologically using a panel of monoclonal antibodies. T lymphocyte subsets appeared within the ovine fetal lymph node in a specific sequence. SBU-T1- and SBU-T8-positive lymphocytes were seen at Day 47 of gestation. LCA, sIg, MHC I, MHC II,...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1987-09-01 00:00:00
abstract::When normal human spleen cells are pulsed with concanavalin A (Con A), a portion become suppressor cells which in co-culture can inhibit immunoglobulin synthesis by other normal spleen cells stimulated by pokeweed mitogen (PWM). One mechanism whereby these Con-A activated spleen cells suppress Ig synthesis appears to ...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1980-05-01 00:00:00
abstract::This study compares the effects of soluble intact (IgG) and F(ab')2 rabbit anti-mu and anti-delta antibodies on mouse B cells. The results show that while the F(ab')2 antibodies to both isotypes induce polyclonal B cell proliferation, the IgG antibodies are not mitogenic, but rather inhibit DNA synthesis induced by th...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1985-04-01 00:00:00
abstract::Cholera toxin (CT) or its subunits were given orally to mice and division of intestinal intraepithelial lymphocytes (IEL) in vivo measured by double immunofluorescence using 5-bromo-2'-deoxyuridine (BRdU) and membrane alpha beta T-cell receptors (TCR) or gamma delta TCR staining in frozen sections. Cholera toxin (10 m...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1046/j.1365-2567.1996.d01-721.x
更新日期:1996-09-01 00:00:00
abstract::Feeding antigens induces an immunological unresponsiveness termed oral tolerance but under some conditions, for example following the administration of cyclophosphamide (CY), immunity can be induced. These observations have usually been made by studying antibody production and delayed hypersensitivity with little atte...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1993-04-01 00:00:00
abstract::Toll-like receptors (TLRs) are important pattern recognition molecules that activate the nuclear factor (NF)-kappaB pathway leading to the production of antimicrobial immune mediators. As keratinocytes represent the first barrier against exogenous pathogens in human skin, we investigated their complete functional TLR1...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2005.02122.x
更新日期:2005-04-01 00:00:00
abstract::Age-related macular maculopathy (ARM) and age-related macular degeneration (AMD) are the leading causes of blindness in the Western world. Despite the magnitude of this clinical problem, very little is known about the pathogenesis of the disease. In this study, we analysed the sera (using indirect immunohistochemistry...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2005.02173.x
更新日期:2005-07-01 00:00:00
abstract::The defined antigen substrate spheres (DASS) system was employed for analysing reactions between solid state antibody or antigen and soluble immune complexes. Sepharose beads covalently coupled with ovalbumin were used to represent tumour cells and beads coupled with antibody against ovalbumin were used to represent a...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1975-06-01 00:00:00
abstract::The induction of T-cell growth by the T-cell antigen receptor (TcR) is dependent on a co-ordinated process of phosphorylation and dephosphorylation of intracellular proteins. An intermediary in this signalling pathway is the serine kinase, p42 mitogen-activated protein kinase (p42MAPK), also known as microtubule-assoc...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1993-05-01 00:00:00
abstract::Innate immune responses vary in a circadian manner, and more recent investigations aim to understand the underlying molecular mechanisms. Cytokine production varies significantly over the course of a day depending on the time of stimulation by pathogens or Toll-like receptor ligands, and multiple signaling pathways li...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.13053
更新日期:2019-06-01 00:00:00
abstract::Immunoglobulin G4 (IgG4) antibodies have been known for some time to be functionally monovalent. Recently, the structural basis for this monovalency has been elucidated: the in vivo exchange of IgG half-molecules (one H-plus one L-chain) among IgG4. This process results in bispecific antibodies that in most situations...
journal_title:Immunology
pub_type: 杂志文章,评审
doi:10.1046/j.0019-2805.2001.01341.x
更新日期:2002-01-01 00:00:00
abstract::Polyclonal rabbit anti-idiotypic (Ab2) antibodies raised against the antiprogesterone mAb DB3 (Ab1) were used to induce an Ab3 antiprogesterone response in BALB/c mice. While the affinity of Ab3 sera for progesterone was 10-50-times lower than that of DB3, their steroid-binding specificity showed considerable similari...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1046/j.1365-2567.2000.00006.x
更新日期:2000-06-01 00:00:00
abstract::Dibutyryl-cyclic adenosine 3'5'-monophosphate (cAMP) added to mouse spleen cell cultures under serum free conditions inhibited the stimulation of [3H]thymidine incorporation induced by T-cell mitogens much more than the one induced by B-cell mitogens. The inhibition was most impressive with phytohaemagglutinin, follow...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1976-05-01 00:00:00
abstract::Lysine prevented the activation of Cl at low ionic strength or by heat aggregated IgG (aggIgG) measured by the hydrolysis of acetyl tyrosine ethyl ester (ATEe) by Cls. When serum was mixed with aggIgG, complement was activated and consumed. If lysine was present in the serum containing aggIgG, the activation of comple...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1982-12-01 00:00:00
abstract::It has been reported previously that environmental antigens such as intestinal microflora play an important role in an age-associated increase in number of T-cell receptor gamma/delta-bearing T cells. To extend the scope of this finding, this study examined the influences of local inflammation on the accumulation and/...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1990-05-01 00:00:00
abstract::Evidence suggests that the immune and neuroendocrine systems cross talk by sharing ligands and receptors. Hormones and neuropeptides produced by the neuroendocrine system often modulate the function of lymphoid organs and immune cells. We have previously reported the intrathymic expression of somatostatin (SOM) in the...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2006.02351.x
更新日期:2006-05-01 00:00:00
abstract::C57BL/6 mice were injected with different doses of human T-cell receptor (TCR) V beta 8.1 CDR1 peptide at different times after murine retrovirus (LP-BM5) infection. Injection with TCR V beta 8.1 CDR1 peptide largely prevented the retrovirus-induced reduction in B- and T-cell proliferation, and T-helper 1 (Th1) cytoki...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1046/j.1365-2567.1996.449551.x
更新日期:1996-02-01 00:00:00
abstract::There is increasing evidence that primitive progenitors migrate from the bone marrow (BM) via the peripheral circulation to tissue sites where they undergo in situ differentiation to provide a continued source of effector cells, such as eosinophils, during an allergic inflammatory response. To study mechanisms of prog...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1046/j.1365-2567.2003.01686.x
更新日期:2003-08-01 00:00:00
abstract::Rhesus macaques (Macaca mulatta) are extensively used in vaccine development. Macaques infected with simian immunodeficiency viruses (SIV) or simian-human immunodeficiency viruses (SHIV) are the best animal model currently available for acquired-immune-deficiency-syndrome-related studies. Recent results emphasize the ...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2004.01767.x
更新日期:2004-01-01 00:00:00
abstract::MicroRNAs (miRNAs) regulate many aspects of helper T cell (Th) development and function. Here we found that they are required for the suppression of interleukin-9 (IL-9) expression in Th9 cells and other Th subsets. Two highly related miRNAs (miR-15b and miR-16) that we previously found to play an important role in re...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12631
更新日期:2016-09-01 00:00:00
abstract::Rapid expulsion of the nematode Trichinella spiralis from immune rats is associated with an increase in volume of intestinal exudate and the presence of large numbers of tissue mucosal mast cells (MMC) and eosinophils. We have measured the concentrations of leukotrienes (LT) C4 (LTC4) and B4 (LTB4) in gut perfusates a...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1987-03-01 00:00:00
abstract::The effect of E. coli lipopolysaccharide (LPS) on the induction of both hapten-specific immunity and tolerance was studied in an in vivo system utilizing putative T-cell dependent (TD) or T-cell independent (TI) challenge antigens. The administration of LPS 1 day prior to challenge preempted the response of C3D2 mice ...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1979-11-01 00:00:00
abstract::T cells play a key role in the pathogenesis of type 1 diabetes, and targeting the CD3 component of the T-cell receptor complex provides one therapeutic approach. Anti-CD3 treatment can reverse overt disease in spontaneously diabetic non-obese diabetic mice, an effect proposed to, at least in part, be caused by a selec...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12729
更新日期:2017-06-01 00:00:00