Interferon decreases production of hydrogen peroxide by macrophages: correlation with reduction of suppressive capacity and of anti-microbial activity.

abstract：:It has been known for 15 years that the chicken epidermis contains ATPase+ and major histocompatibility complex class II-positive (MHCII+) dendritic cells. These cells were designated as Langerhans cells but neither their detailed phenotype nor their function was further investigated. In the present paper we demonstra...

journal_title：Immunology

authors： Igyártó BZ,Lackó E,Oláh I,Magyar A

更新日期：2006-10-01 00:00:00

abstract：:Class switching and plasma cell differentiation occur at a high level within all mucosa-associated lymphoid tissues. The different classes of membrane immunoglobulin heavy chains are associated with the Igα/Igβ heterodimer within the B-cell receptor (BCR). Whether BCR isotypes convey specific signals adapted to the co...

journal_title：Immunology

authors： Amin R,Carrion C,Decourt C,Pinaud E,Cogné M

更新日期：2012-05-01 00:00:00

abstract：:The absence of complement receptor 1 (CR1) related gene/protein y (Crry) leads to embryonic lethality as a result of unrestricted complement activation and concomitant neutrophil infiltration. Here we used Crry(-/-)C3(+/-) mice to investigate the role of Crry in the pathogenesis of immune complex glomerulonephritis (G...

journal_title：Immunology

authors： Bao L,Wang Y,Chen P,Sarav M,Haas M,Minto AW,Petkova M,Quigg RJ

更新日期：2009-09-01 00:00:00

abstract：:Studies have demonstrated that the anti-tumour effect of natural killer (NK) cells is successful for patients with several cancers. Although interleukin-32 (IL-32) is endogenously expressed in NK cells, cytolytic function of NK cells against cancer cells has not been fully demonstrated. In the present study, we found ...

journal_title：Immunology

authors： Park MH,Song MJ,Cho MC,Moon DC,Yoon DY,Han SB,Hong JT

更新日期：2012-01-01 00:00:00

abstract：:Animals contain an enormous load of non-pathogenic bacteria in the lower intestine, which exploit an environment with a stable temperature and abundant carbon sources. Our load of bacteria outnumbers our own cells. In order to survive with such a high number of organisms in very close proximity to host tissues the int...

journal_title：Immunology

authors： Macpherson AJ,Geuking MB,McCoy KD

更新日期：2005-06-01 00:00:00

abstract：:Mice were first primed with a type A or a type B influenza virus and then challenged intranasally at least 1 month later with another type A virus. Potent cytotoxic T cell populations were found in lung, and effector T cell function was also demonstrated in blood, spleen and mediastinal lymph nodes. Lymphocytes isolat...

journal_title：Immunology

authors： Bennink J,Effros RB,Doherty PC

更新日期：1978-09-01 00:00:00

abstract：:Eosinophil recruitment to the airways, including involvement of haemopoietic eosinophil-basophil progenitors (Eo/B-CFU), is primarily regulated by interleukin-5 (IL-5) and eotaxin. In this study, we investigated the haemopoietic mechanisms in upper and lower airway eosinophilic inflammation. Ovalbumin (OVA) sensitized...

journal_title：Immunology

authors： Li J,Saito H,Crawford L,Inman MD,Cyr MM,Denburg JA

更新日期：2005-03-01 00:00:00

abstract：:The level of circulating thymic factor (FTS) tested by its action on spleen rosette-forming cells from adult thymectomized mice, has been shown to be stable in young animals. This stability suggests a regulatory mechanism. An approach of this regulation has been attempted by disrupting the FTS level either by neonatal...

journal_title：Immunology

authors： Tubiana N,Dardenne M

更新日期：1979-02-01 00:00:00

abstract：:Preincubation of macrophages with immune complexes suppresses the interferon-gamma (IFN-gamma) induction of tumouricidal activity and Ia surface expression. The studies reported in this manuscript were designed to test if immune complexes alter the interaction of IFN-gamma with macrophages. The binding of IFN-gamma to...

journal_title：Immunology

authors： Celada A

更新日期：1988-06-01 00:00:00

abstract：:Aspergillus fumigatus is often associated in asthmatic patients with the exacerbation of asthma symptoms. The pathomechanism of this phenomenon has not been fully understood. Here, we evaluated the immunological mechanisms and the role of the prostaglandin D2 / Chemoattractant Receptor-Homologous Molecule Expressed on...

journal_title：Immunology

authors： Liu H,Zheng M,Qiao J,Dang Y,Zhang P,Jin X

更新日期：2014-05-01 00:00:00

abstract：:Staphylococcal protein A is a cell wall-attached polypeptide that acts as a B-lymphocyte superantigen. This activation correlates with specific VH gene segment usage in the B-cell receptor. B-cell receptor assembled from members of the VH3 family in humans, or S107 family in mice, has an intrinsic affinity for protein...

journal_title：Immunology

authors： Feijó GC,Sabbaga J,Carneiro CR,Brígido MM

更新日期：1997-07-01 00:00:00

abstract：:Environmental factors have significant effects on the development of autoimmune diseases. The ligand-activated transcription factor aryl hydrocarbon receptor (AHR) is controlled by endogenous and environmental small molecules. Hence, AHR provides a molecular pathway by which endogenous and environmental signals can in...

journal_title：Immunology

authors： Quintana FJ

更新日期：2013-03-01 00:00:00

abstract：:The gut microbiota provides an important stimulus for the induction of regulatory T (Treg) cells in mice, whether this applies to newborn children is unknown. In Swedish children, Staphylococcus aureus has become a common early colonizer of the gut. Here, we sought to study the effects of bacterial stimulation on neon...

journal_title：Immunology

authors： Rabe H,Nordström I,Andersson K,Lundell AC,Rudin A

更新日期：2014-03-01 00:00:00

abstract：:Cytokines are the most important inducers of T helper (Th) cell differentiation. Interleukin-12 (IL-12) and interferon-alpha (IFN-alpha) are responsible for human Th1-cell differentiation, while IL-4 is the critical cytokine promoting Th2-cell development. These two subsets of cells co-ordinate immunological responses...

journal_title：Immunology

authors： Aho TL,Lund RJ,Ylikoski EK,Matikainen S,Lahesmaa R,Koskinen PJ

更新日期：2005-09-01 00:00:00

abstract：:Donor mice were painted on the skin of the abdomen with the contact sensitizing agent, oxazolone. One day later 2-5 x 10(6) cells from the regional lymph nodes were injected into the footpads of recipient mice. Contact sensitivity was detected 6 days later by challenging the ears of the recipients and measuring the in...

journal_title：Immunology

authors： Asherson GL,Mayhew B,Perera MA

更新日期：1979-05-01 00:00:00

abstract：:Designing peptide-based vaccines for therapeutic applications in cancer immunotherapy requires detailed knowledge of the interactions between the antigenic peptide and major histocompatibility complex (MHC) in addition to that between the peptide-MHC complex and the T-cell receptor. Past efforts to immunize with high-...

journal_title：Immunology

authors： Lazoura E,Lodding J,Farrugia W,Ramsland PA,Stevens J,Wilson IA,Pietersz GA,Apostolopoulos V

更新日期：2006-11-01 00:00:00

abstract：:Oxidized low-density lipoprotein (OxLDL) plays a crucial role in the development of atherosclerosis. Carbamylated LDL has been suggested to promote atherogenesis in patients with chronic kidney disease. Here we observed that plasma IgG and IgM antibodies to carbamylated epitopes were associated with IgG and IgM antibo...

journal_title：Immunology

authors： Kummu O,Turunen SP,Prus P,Lehtimäki J,Veneskoski M,Wang C,Hörkkö S

更新日期：2014-03-01 00:00:00

abstract：:Adoptive transfer of anti-Listeria resistance by Listeria-immune spleen T cells was markedly reduced by pretreatment of the cells with monoclonal anti-Lyt 2.2 and complement (Lyt 2+C); pretreatment of cells with monoclonal anti-L3T4 and complement (L3T4+C) had a lesser effect on their ability to transfer resistance. L...

journal_title：Immunology

authors： Czuprynski CJ,Brown JF

更新日期：1987-02-01 00:00:00

abstract：:It has recently been shown that factors in addition to interleukin-2 (IL-2) are required for the proliferation or differentiation of at least some murine T-cell lines. We have previously shown that conditioned medium from human mononuclear cells stimulated with phorbol ester and staphylococcal enterotoxin A is superio...

journal_title：Immunology

authors： Mills BJ,Shively JE,Mitsky PS,Hawke DH,Forman SJ,Wright CL,Todd CW

更新日期：1986-09-01 00:00:00

abstract：:The in vitro frequency and proliferative capacity of B cells and B-cell precursors in old mice was assessed. The mitogenic response to the B-cell mitogens lipopolysaccharide (LPS) and dextran sulphate decline later and at a slower rate than the T-cell response to phytohaemagglutinin and concanavalin A. The response to...

journal_title：Immunology

authors： Duwe AK,Roder JC,Singhal SK

更新日期：1979-06-01 00:00:00

abstract：:Previously, a putative immunosuppressant-coding gene was identified from a complementary DNA library derived from the salivary glands of partially-fed Haemaphysalis longicornis. Using real-time polymerase chain reaction, the gene was shown to be predominantly expressed during blood feeding with the site of expression ...

journal_title：Immunology

authors： Konnai S,Nakajima C,Imamura S,Yamada S,Nishikado H,Kodama M,Onuma M,Ohashi K

更新日期：2009-02-01 00:00:00

abstract：:In order to elucidate possible roles of thymic nurse cells (TNC) we isolated them as lympho-epithelial cell complexes from spontaneous thymomas of BUF/Mna rats and characterized them using immuno- and enzyme-histochemical techniques. A remarkable increase in the number of TNC was seen at 8 months of age, immediately b...

journal_title：Immunology

authors： Ezaki T,Matsuno K,Kotani M

更新日期：1991-06-01 00:00:00

abstract：:Factor B-like activity associated with human peripheral blood lymphocytes was first described by Halbwachs & Lachmann (1976), who employed a functional assay. In this present study, clones of B cells from patients with chronic lymphatic leukaemia (CLL) and lymphoblastoid 'Raji' cells were used. The surface of these ce...

journal_title：Immunology

authors： Woo P,Lachmann PJ

更新日期：1981-11-01 00:00:00

abstract：:It has previously been shown in mice that activated peritoneal macrophages, when first removed from the peritoneal cavity, suppress mitogen-stimulated lymphocyte transformation in vitro as measured by [3H]-thymidine incorporation. In this study, it is demonstrated that activated macrophages that have been incubated al...

journal_title：Immunology

authors： Wing EJ,Remington JS

更新日期：1980-06-01 00:00:00

abstract：:Experiments were conducted to test the hypothesis that opsonic and non-opsonic phagocytic capacities are differentially regulated by resting and wound-derived macrophages. Furthermore, the phagocytosis of non-opsonized zymosan and beta-glucan particles was quantified to determine whether cells differentially regulate ...

journal_title：Immunology

authors： Reichner JS,Fitzpatrick PA,Wakshull E,Albina JE

更新日期：2001-10-01 00:00:00

abstract：:Acute and chronic infusions of a lipophilic analogue of cyclic AP (dibutyryl cyclic AMP) into cannulated afferent lymphatics of popliteal lymph nodes of sheep have reduced the output of both small and blast lymphocytes into efferent lymph and have tended to reduce the volume of efferent lymph flow (collected by chroni...

journal_title：Immunology

authors： Moore TC,Lachmann PJ

更新日期：1982-11-01 00:00:00

abstract：:The requirement for activity of the enzyme ADP-ribosyl transferase (ADPRT) and changes in single-strand DNA breaks were assessed during the initial stimulation of quiescent murine splenic lymphocytes with mitogen alone, the stimulation of activated blasts with IL-2-containing medium and, for comparison, the serum stim...

journal_title：Immunology

authors： Johnstone AP,Darling D

更新日期：1985-08-01 00:00:00

abstract：:The endogenous cannabinoid system plays an important role in regulating the immune system. Modulation of endogenous cannabinoids represents an attractive alternative for the treatment of inflammatory disorders. This study investigated the effects of URB597, a selective inhibitor of fatty acid amide hydrolase (FAAH), t...

journal_title：Immunology

authors： Roche M,Kelly JP,O'Driscoll M,Finn DP

更新日期：2008-10-01 00:00:00

abstract：:Macrophage activating factor (MAF) is produced by antigen-stimulated lymphocytes and activates macrophages for antimicrobial function. The capacity of individual microbial antigens to evoke and regulate this response has been explored using an affinity purified antigen (TB68) of Mycobacterium tuberculosis in combinati...

journal_title：Immunology

authors： Matthews R,Scoging A,Rees AD

更新日期：1985-01-01 00:00:00

abstract：:Cytokines and their receptors represent key targets for therapeutic intervention. Ligands are being used to supplement cell numbers that become depleted as a result of disease (organ failure, infection) or subsequent disease treatments (i.e. chemotherapy). Conversely, the inhibition of target cell binding by cytokines...

journal_title：Immunology

authors： Sivakumar PV,Foster DC,Clegg CH

更新日期：2004-06-01 00:00:00