Abstract：
:Preincubation of macrophages with immune complexes suppresses the interferon-gamma (IFN-gamma) induction of tumouricidal activity and Ia surface expression. The studies reported in this manuscript were designed to test if immune complexes alter the interaction of IFN-gamma with macrophages. The binding of IFN-gamma to its specific cellular receptor, the uptake or the degradation were not affected by preincubation of macrophages with immune complexes. Preincubation of macrophages with high doses of phorbol esters mimics the inhibitory effect of immune complexes. This suggests that a strong activation of protein kinase C suppresses a subsequent activation of macrophages by IFN-gamma.
journal_name
Immunologyjournal_title
Immunologyauthors
Celada Asubject
Has Abstractpub_date
1988-06-01 00:00:00pages
187-92issue
2eissn
0019-2805issn
1365-2567journal_volume
64pub_type
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