Abstract：
:Suramin, a polyanionic and polycyclic compound, was initially used for the treatment of trypanosomiasis and onchocerciasis. In the last decade, it has been used in therapy of cancer and acquired immune deficiency syndrome (AIDS). The influence of suramin on the expression of various markers by human mononuclear phagocytes is not known and was, therefore, presently investigated. Suramin inhibited the proliferation of U937 cells and mitogen-induced T-cell proliferation in a dose-dependent manner. The constitutive and cytokine-driven expression of Fc receptors for IgG (Fc gamma RI and Fc gamma RII), IgE (Fc epsilon RII) and IgA (Fc alpha R) on blood monocytes and U937 cells was suppressed by suramin. The basal level, as well as cytokine-induced major histocompatibility complex (MHC) class II antigens, was markedly diminished on suramin-treated monocytes. Furthermore, suramin dramatically reduced expression of CD14 and partially reduced complement receptor type 3 (CR3) and CR4 expression on monocytes. In contrast, suramin slightly induced MHC class I antigens on monocytes and CD71 on U937 cells. The capacity of monocytes to phagocytose IgG-sensitized ox erythrocytes, opsonized Escherichia coli, or fluorescein isothiocyanate (FITC)-conjugated latex beads was significantly inhibited. Northern blot analysis showed that the amount of Fc epsilon RII-specific mRNA was only partially reduced, suggesting that other mechanisms may be involved in the regulation of Fc epsilon RII expression. Our data demonstrate that suramin suppresses the expression of various cell-surface structures on human mononuclear phagocytes and impairs their phagocytic capacity.
journal_name
Immunologyjournal_title
Immunologyauthors
Schiller C,Spittler A,Willheim M,Szépfalusi Z,Agis H,Köller M,Peterlik M,Boltz-Nitulescu Gsubject
Has Abstractpub_date
1994-04-01 00:00:00pages
598-604issue
4eissn
0019-2805issn
1365-2567journal_volume
81pub_type
杂志文章相关文献
IMMUNOLOGY文献大全abstract：:The concept of immunological tolerance--the state of specific unresponsiveness to allogeneic transplants and all manner of other antigens--began in 1945 with R.D. Owen's finding that cattle dizygotic twins are red blood cell chimeras. Peter Medawar's group in Birmingham likewise discovered, quite independently, that c...
journal_title：Immunology
pub_type： 历史文章,杂志文章,评审
doi：10.1111/imm.12567
更新日期：2016-03-01 00:00:00
abstract：:Human plasma kallikrein can replace factor D for the activation of the alternative pathway C3 convertase of human complement. The factor B cleavage patterns by factor D and kallikrein are indistinguishable. The ability of kallikrein to cleave factor B is influenced by the magnesium ion concentration and the C3b concen...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1982-03-01 00:00:00
abstract：:Immunoglobulin E is quantitatively a minor immunoglobulin class in serum, but nevertheless the major class of antibody mediating type I hypersensitivity reactions and hence, type I allergic phenomena. The bovine epsilon gene is one of the as yet uncharacterized mammalian immunoglobulin genes. We have therefore cloned ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1997.00352.x
更新日期：1997-11-01 00:00:00
abstract：:Antibody-dependent cell-mediated cytotoxicity (ADCC) of infectious bovine rhinotracheitis (IBR)-infected bovine kidney cells (MDBK) by neutrophils was demonstrated. Neutrophils from bovine and sheep mammary exudate and peripheral blood, and also from human peripheral blood, were all active in the presence of anti-IBR ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1984-10-01 00:00:00
abstract：:Many experiments have demonstrated that the nervous and immune systems interact in a bidirectional fashion. Neuropeptides, including substance P, have been shown to modulate lymphocyte DNA, RNA and immunoglobulin synthesis in vitro and to play a role in inflammatory and hypersensitivity disease states. However, the ro...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1988-04-01 00:00:00
abstract：:Vitamin A and its active metabolite retinoic acid are essential for the development and function of many tissues including the immune system. The induction of mucosal homing receptors on T and B cells by mucosal dendritic cells (DC) depends on the presence of vitamin A. Recent studies indicate that also the differenti...
journal_title：Immunology
pub_type： 杂志文章,评审
doi：10.1111/imm.12228
更新日期：2014-05-01 00:00:00
abstract：:Supernatants of IL-2-activated mononuclear cells (MNC) that displayed an optimal lymphokine-activated killer (LAK) cell activity at 48-72 hr in culture were found to contain increased levels of tumour necrosis factor alpha (TNF alpha), interleukin-1 alpha (IL-1 alpha) and interferon-gamma (IFN-gamma) when compared wit...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1989-12-01 00:00:00
abstract：:In order to elucidate possible roles of thymic nurse cells (TNC) we isolated them as lympho-epithelial cell complexes from spontaneous thymomas of BUF/Mna rats and characterized them using immuno- and enzyme-histochemical techniques. A remarkable increase in the number of TNC was seen at 8 months of age, immediately b...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1991-06-01 00:00:00
abstract：:The capacity of the immune system to respond efficiently to new antigens depends upon a continuous source of naive CD4+ T cells. Such cells exit from the thymus and join the recirculated T-cell pool. Factors present at the sites of naive CD4+ T-cell circulation must be responsible for their survival, since upon remova...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1999.00906.x
更新日期：1999-11-01 00:00:00
abstract：:Mouse models and a recent vaccine trial have indicated the importance of T-cell immunity to the circumsporozoite protein (CSP) of malaria sporozoites. One of the major impediments for the development of a CSP-based vaccine is that human T-cell epitopes, identified on the CSP, span regions of significant point mutation...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1998.00514.x
更新日期：1998-07-01 00:00:00
abstract：:Studies of tuberculosis have suggested a shift in dominance from a T helper type 1 (Th1) towards a Th2 immune response that is associated with suppressed cell-mediated immune (CMI) responses and increased humoral responses as the disease progresses. In this study a natural host disease model was used to investigate th...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2004.02003.x
更新日期：2005-01-01 00:00:00
abstract：:Purified pertussis toxin (PPT) is a potent mitogen for human T lymphocytes and is shown to cause rapid calcium mobilization in resting T cells, a T-cell line and CD3- lymphocytes with natural killer (NK) activity. In resting T cells the PPT activation is associated with cytoplasmic alkalinization. A similar rise in in...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1988-07-01 00:00:00
abstract：:We found in previous experiments that fractionation of non-immune mouse spleen cells on bovine serum albumin density gradients yields two subpopulations of T cells, one of high, the other of low density. Both subopopulations could be stimulated in corporate thymidine by the T cell-specific mitogen concanavalin A (con ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1975-03-01 00:00:00
abstract：:Herpes simplex virus (HSV) encodes a protein, glycoprotein C (gC), which binds to the third complement component, the central mediator of complement activation. In this study the structural and functional relationships of gC from HSV type 1 (HSV-1) and known human complement regulatory proteins factor H, properdin, fa...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1993-08-01 00:00:00
abstract：:The effect of a proline-rich polypeptide from ovine colostrum on the humoral immune response in mice against sheep red blood cells (SRBC) was studied. It was shown that the polypeptide had a regulatory activity stimulating or suppressing the immune response. The proline-rich polypeptide also increased the permeability...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1979-04-01 00:00:00
abstract：:The classical acute phase reactant, C-reactive protein (CRP), appears in markedly elevated concentration in the sera of individuals undergoing reactions of acute inflammation and tissue degradation. We previously demonstrated that like IgG, appropriately purified CRP could be thermally modified (H-CRP) such that it en...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1982-09-01 00:00:00
abstract：:Immunoglobulin D (IgD) is normally present in only low concentrations in serum. In the hyper-IgD and periodic fever syndrome (HIDS), however, serum levels exceed 140 mg/l. This syndrome is further characterized by recurrent inflammatory febrile attacks together with an acute phase response and appearance of cytokines ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1996.d01-672.x
更新日期：1996-07-01 00:00:00
abstract：:Monocyte chemotactic protein-1 (MCP-1) is a proinflammatory cytokine that attracts and activates specific types of leucocytes. The purpose of this work was to analyse the generation of MCP-1 and mRNA transcript in a model of chronic inflammation using a granulomatous tissue induced by potassium permanganate (KMnO4; wa...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1997.00329.x
更新日期：1997-10-01 00:00:00
abstract：:We have studied the antibody response in vitro of spleen cells from C57BL/6 mice kept on a protein deficient (D) or a normal diet (N). Short or long term protein restriction initiated after weaning led to increased plaque forming cell (PFC) responses to sheep red blood cells (SRBC), TNP-ficoll and TNP lipopolysacchari...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1981-06-01 00:00:00
abstract：:We studied proliferative responses of bovine T lymphocytes to foot-and-mouth disease virus (FMDV) serotypes A, O and C as well as to three peptides including the two major B-cell epitopes of FMDV (VP1[141-156] and VP1[200-213]). Peripheral blood mononuclear cells (PBMC) from cattle previously vaccinated with monovalen...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1992-03-01 00:00:00
abstract：:The shedding and resynthesis of Fc, C3 receptors, and receptors binding SRBC has been studied in normal peripheral lymphocytes, in lymphocytes from CLL patients and in a Raji cell line during 4 h incubation at 37 degrees. During the first part of the incubation, an increased release of receptors was observed. The shed...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1978-02-01 00:00:00
abstract：:Mesangial hypercellularity is usually found in many models of nephritis characterized by monocyte/macrophage infiltration of the glomerulus. In order to examine the mechanism mediating these events, an in vitro model was used to study the effects of macrophage products on mouse mesangial cells, cultured under conditio...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1985-12-01 00:00:00
abstract：:The results presented in this paper demonstrate that a mouse IgM monoclonal antibody (T-80) recognizes an antigen on cells of the T-lymphocyte lineage of sheep. However, this antibody does not identify all T cells, as 10-20% of thymocytes and some peripheral-blood T cells are negative. T-80- thymocytes reside in the m...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1983-07-01 00:00:00
abstract：:Individual young adult, middle-aged, and old C57BL/6J male mice were tested for in vitro generated proliferative and cytotoxic responses to H-2 alloantigens under a variety of sensitization conditions. Proliferation in mixed lymphocyte culture (MLC) had decreased by 14 months of age (middle-aged), whether measured by ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1981-11-01 00:00:00
abstract：:Peripheral blood lymphocytes from patients with Hashimoto's thyroiditis have been cultured for 2--3 weeks in Marbrook flasks. During this period, readily detectable amounts of thyroglobulin and microsomal antibodies were synthesized by the cells and secreted into the culture medium. Gel filtration studies indicated th...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1979-01-01 00:00:00
abstract：:The contribution of B7 molecules to the induction and maintenance of the T-cell response to the human pathogenic fungus Cryptococcus neoformans was investigated. T-cell activation by C. neoformans was regulated by B7 molecules. This costimulatory signal was necessary for initiation and maintenance of the T-cell respon...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1999.00853.x
更新日期：1999-09-01 00:00:00
abstract：:Murine lymphokine-activated killer (LAK) cells induced by systemic high-dose recombinant human interleukin 2 (IL-2) administration lysed fresh syngeneic peritoneal macrophages (M phi). LAK cells lysed resident peritoneal M phi and M phi activated in vivo with thioglycollate (TG), Corynebacterium parvum (C. parvum), or...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1989-12-01 00:00:00
abstract：:To study the influence of macrophages on the migration and distribution of lymphocytes in the spleen, macrophages were eliminated from the spleen of mice by injection of liposomes in which DMDP was encapsulated. This leads to an elimination of macrophages in both the red pulp and marginal zone of the spleen within 1-2...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1989-10-01 00:00:00
abstract：:A major role has been recently ascribed to the neutrophil in the resistance to infection by Listeria monocytogenes (L. monocytogenes). Here we evaluated whether such neutrophils played a role in the non-specific resistance to listeriosis that develops in hosts infected by mycobacteria. We found that the depletion of n...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1996.d01-758.x
更新日期：1996-11-01 00:00:00
abstract：:Cyclophosphamide was used to assess the role of suppressor cells in the contact sensitivity reaction. A single painting with 300 microgram and 30 microgram oxazolone produced poor contact sensitivity reactions (ear swelling). Cyclophosphamide (200 mg/kg) 2 days before painting increased the response to the lower doses...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1979-03-01 00:00:00
